Cerebrospinal Fluid Biomarker-Based Diagnosis of Sporadic Creutzfeldt-Jakob Disease: A Validation Study for Previously Established Cutoffs.

abstract：:The apolipoprotein E (APOE) gene epsilon 4 allele is known to be associated with late-onset familial and sporadic Alzheimer's disease (AD). We assessed the possible relationship between APOE genotypes and morphological or functional changes in AD brains by x-ray computed tomography (CT), magnetic resonance imaging (MR...

journal_title：Dementia and geriatric cognitive disorders

authors： Tanaka S,Kawamata J,Shimohama S,Akaki H,Akiguchi I,Kimura J,Ueda K

更新日期：1998-03-01 00:00:00

abstract：:We investigated regional cerebral glucose metabolic rates (rCMRgluc) with positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in 7 monozygotic twin pairs discordant for Alzheimer's disease (AD). Ten healthy volunteers with comparable mean age and educational level served as controls. In the hippoc...

journal_title：Dementia and geriatric cognitive disorders

authors： Järvenpää T,Räihä I,Kaprio J,Koskenvuo M,Laine M,Kurki T,Vahlberg T,Viljanen T,Ahonen K,Rinne JO

更新日期：2003-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is generally understood as primarily affecting cognition while sparing motor function, at least until the later stages of the disease. Studies reported over the past 10 years, however, have documented a prevalence of falls in AD patients significantly higher than in age-matched normal elders; ...

journal_title：Dementia and geriatric cognitive disorders

authors： Sheridan PL,Hausdorff JM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The prevalence of mild cognitive impairment (MCI) and its subtypes among Chinese older adults, and the contribution of vascular risk factors (VRF) and vascular disorders to MCI remain unclear. This study aims to investigate the prevalence of MCI and its different subtypes, and clarify the role of VRF an...

journal_title：Dementia and geriatric cognitive disorders

authors： Ma F,Wu T,Zhao J,Ji L,Song A,Zhang M,Huang G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The Frontal Assessment Battery (FAB) and the EXIT-25 have emerged as 2 widely used screening instruments for executive dysfunction, but their screening properties have not been evaluated in a head-to-head comparison. METHODS:Prospective cohort study of 92 individuals presenting for cognitive assessment...

journal_title：Dementia and geriatric cognitive disorders

authors： Moorhouse P,Gorman M,Rockwood K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS:Our hypothesis was that subtle pre-operative ...

journal_title：Dementia and geriatric cognitive disorders

authors： Lowery DP,Wesnes K,Ballard CG

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF). METHODS:In 58 patients with HF neuropsychological assessment was performed including tests of mental spee...

journal_title：Dementia and geriatric cognitive disorders

authors： Vogels RL,Oosterman JM,van Harten B,Gouw AA,Schroeder-Tanka JM,Scheltens P,van der Flier WM,Weinstein HC

更新日期：2007-01-01 00:00:00

abstract：:Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...

journal_title：Dementia and geriatric cognitive disorders

authors： Perry RJ,Hodges JR

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate whether dementia patients prescribed antipsychotic drugs have a higher mortality compared to unexposed patients, and to investigate whether there are differences in mortality associated with exposure to conventional versus atypical antipsychotic drugs. METHODS:Retrospective population cohor...

journal_title：Dementia and geriatric cognitive disorders

authors： Musicco M,Palmer K,Russo A,Caltagirone C,Adorni F,Pettenati C,Bisanti L

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To estimate life expectancy of psychogeriatric patients having participated in a reactivation program. To identify prognostic characteristics - on admission - for survival after discharge. DESIGN:A prospective, clinical-empirical observational study. SETTING:A Dutch psychiatric-skilled nursing home. PARTI...

journal_title：Dementia and geriatric cognitive disorders

authors： Bakker TJ,Duivenvoorden HJ,van der Lee J,Schudel WJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The Baylor Profound Mental Status Examination (BPMSE) was modeled to provide a brief patient-derived rating scale for staging and tracking patients with severe stages of Alzheimer's disease (AD). METHODS:The BPMSE was administered to 91 patients with probable AD (Korean version of the MMSE less than 16) acc...

journal_title：Dementia and geriatric cognitive disorders

authors： Na HR,Lee SH,Lee JS,Doody RS,Kim SY

更新日期：2009-01-01 00:00:00

abstract：:Age-related changes and the effects of dementia of the Alzheimer type (DAT) were investigated during a visual orienting attention task in which attention was pre-cued to one or other hemifields. Central cues were either valid, neutral, invalid or NoGo (inhibitory). The response time cost-benefit analysis showed a decr...

journal_title：Dementia and geriatric cognitive disorders

authors： Wright M,Geffen G,Geffen L

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND/AIMS:We have previously reported the results of an extended genome-wide scan of Swedish Alzheimer disease (AD)-affected families; in this paper, we analyzed a subset of these families with autopsy-confirmed AD. METHODS:We report the fine-mapping, using both microsatellite markers and single-nucleotide polym...

journal_title：Dementia and geriatric cognitive disorders

authors： Sillén A,Brohede J,Forsell C,Lilius L,Andrade J,Odeberg J,Kimura T,Winblad B,Graff C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. METHODS:Participants (n = 933) were investigated using ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tufvesson E,Melander O,Minthon L,Persson M,Nilsson PM,Struck J,Nägga K

更新日期：2013-01-01 00:00:00

abstract：:The amygdala is severely atrophied at post-mortem in frontotemporal lobar degeneration (FTLD), and may contribute to the prominent behavioural changes that are early features of FTLD. The aim of this study was to assess amygdala atrophy using MRI in the main syndromic variants of FTLD and Alzheimer's disease (AD). Bra...

journal_title：Dementia and geriatric cognitive disorders

authors： Whitwell JL,Sampson EL,Watt HC,Harvey RJ,Rossor MN,Fox NC

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB). METHODS:Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bjoerke-Bertheussen J,Ehrt U,Rongve A,Ballard C,Aarsland D

更新日期：2012-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPLAb) may cause both focal ischemic and diffuse brain damage and may be associated with dementia. We have examined the relationship of aPLAb to dementia in the elderly. Blood samples were obtained from 87 consecutive patients with dementia (74 +/- 11 years old) and 69 controls (78 +/- 9 y...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosek A,Yust I,Treves TA,Vardinon N,Korczyn AD,Chapman J

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:Existing cognitive measures for moderate-to-severe dementia have shown floor effects and an inability to assess the remaining cognitive function, especially for profound dementia. METHODS:We constructed the Cognitive Test for Severe Dementia (CTSD), which consists of 13 items covering 7 cognitive domai...

journal_title：Dementia and geriatric cognitive disorders

authors： Tanaka H,Nagata Y,Uematsu M,Takebayashi T,Hanada K,Inokawa M,Fukuhara K,Ogawa Y,Haga D,Kakegawa Y,Nishikawa T

更新日期：2015-01-01 00:00:00

abstract：:There is growing evidence for a role of apoptosis in Alzheimer's disease (AD). Recent findings suggest an increased susceptibility of lymphocytes to apoptosis in AD. To prove the hypothesis of systemic alterations in the apoptotic balance in AD, serum and cerebrospinal fluid levels of soluble CD95, which is known to m...

journal_title：Dementia and geriatric cognitive disorders

authors： Richartz E,Noda S,Schott K,Günthner A,Lewczuk P,Bartels M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS:We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties...

journal_title：Dementia and geriatric cognitive disorders

authors： Matías-Guiu JA,Valles-Salgado M,Rognoni T,Hamre-Gil F,Moreno-Ramos T,Matías-Guiu J

更新日期：2017-01-01 00:00:00

abstract：:Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer's disease (AD). It is highly selective for AChE in the central nervous system (CNS), with little or no affinity...

journal_title：Dementia and geriatric cognitive disorders

authors： Rogers SL

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. METHODS:A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and A...

journal_title：Dementia and geriatric cognitive disorders

authors： Hsieh S,Schubert S,Hoon C,Mioshi E,Hodges JR

更新日期：2013-01-01 00:00:00

abstract：:We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion invol...

journal_title：Dementia and geriatric cognitive disorders

authors： Ashworth A,Lloyd S,Brown J,Gydesen S,Sorensen SA,Brun A,Englund E,Humphreys C,Housman D,Badura M,Stanton V Jr,Taylor K,Cameron J,Munroe D,Johansson J,Rossor M,Fisher EM,Collinge J

更新日期：1999-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is often misdiagnosed as Alzheimer's disease (AD). We hypothesized that the first symptoms associated with FTD would be different from those seen in AD and that the first symptoms in FTD would reflect loss of function in the frontal region with the greatest degree of degeneration. The obj...

journal_title：Dementia and geriatric cognitive disorders

authors： Lindau M,Almkvist O,Kushi J,Boone K,Johansson SE,Wahlund LO,Cummings JL,Miller BL

更新日期：2000-09-01 00:00:00

abstract：AIMS:The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. METHODS:This cross-sectional observational study included 288 individuals with deme...

journal_title：Dementia and geriatric cognitive disorders

authors： Wetzels RB,Zuidema SU,de Jonghe JF,Verhey FR,Koopmans RT

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. METHODS:Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests as...

journal_title：Dementia and geriatric cognitive disorders

authors： de Oliveira FF,Chen ES,Smith MC,Bertolucci PH

更新日期：2016-01-01 00:00:00

abstract：:The present study investigated the accuracy of an extended version of the Delayed Word Recall (DWR) test in distinguishing patients with very mild Alzheimer's disease (AD) (Mini Mental State Examination score > or = 23) from community-dwelling depressed/dysthymic patients. The DWR test was administered to 26 non-depre...

journal_title：Dementia and geriatric cognitive disorders

authors： Coen RF,Kirby M,Swanwick GR,Maguire CP,Walsh JB,Coakley D,O'Neill D,Lawlor BA

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Both personality changes and behavioural and psychological symptoms (BPS) may be associated with mild cognitive impairment (MCI) in later life and help identify incipient dementia. We wished to investigate the links between personality and BPS in MCI. METHOD:We studied premorbid personality traits ...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez Rubio M,Antonietti JP,Donati A,Rossier J,von Gunten A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:We investigated the histopathological correlates of white matter hyperintensities (WMHs) in participants with Alzheimer's disease (AD) or cerebrovascular disease, and in aged controls. METHODS:We reviewed 57 participants who had neuropathology and in whom neuroimaging was done. In addition to AD pathol...

journal_title：Dementia and geriatric cognitive disorders

authors： Shim YS,Yang DW,Roe CM,Coats MA,Benzinger TL,Xiong C,Galvin JE,Cairns NJ,Morris JC

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:Depressive symptoms are commonly observed in Alzheimer's disease (AD). The underlying mechanisms of depressive symptoms in AD remain unclear; frontolimbic circuitry dysfunction may play a role. We aimed to investigate the microstructural integrity of frontolimbic connectivity of specific fiber tracts in...

journal_title：Dementia and geriatric cognitive disorders

authors： Zhu Q,Lin M,Bi S,Ni Z,Zhao J,Chen B,Fan G,Shang X

更新日期：2016-01-01 00:00:00