The use of SPECT in a multidisciplinary memory clinic.

abstract：BACKGROUND:Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS:Our hypothesis was that subtle pre-operative ...

journal_title：Dementia and geriatric cognitive disorders

authors： Lowery DP,Wesnes K,Ballard CG

更新日期：2007-01-01 00:00:00

abstract：:To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer's disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a neuronal loss and ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tao Z,Van Gool D,Lammens M,Dom R

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. METHODS:Data were collected from the Erlangen Stroke Projec...

journal_title：Dementia and geriatric cognitive disorders

authors： Liman TG,Heuschmann PU,Endres M,Flöel A,Schwab S,Kolominsky-Rabas PL

更新日期：2011-01-01 00:00:00

abstract：:This cross-sectional study aimed at determining the clinical and structural brain magnetic resonance imaging correlates of mild cognitive impairment (MCI). The data presented here are from the first wave of the longitudinal Personality and Total Health through Life 60+ project. 2,551 community-dwelling individuals in ...

journal_title：Dementia and geriatric cognitive disorders

authors： Kumar R,Parslow RA,Jorm AF,Rosenman SJ,Maller J,Meslin C,Anstey KJ,Christensen H,Sachdev PS

更新日期：2006-01-01 00:00:00

abstract：:Thirty patients had mild cognitive impairment and increased homocysteine levels in serum. On average, they were supplemented orally with a high dose of a vitamin B12-B6-folate combination for 270 days. All patients had normal serum B12 and folate levels at baseline. Cerebrospinal fluid levels of the tau protein (CSF-t...

journal_title：Dementia and geriatric cognitive disorders

authors： Lehmann M,Regland B,Blennow K,Gottfries CG

更新日期：2003-01-01 00:00:00

abstract：:Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately...

journal_title：Dementia and geriatric cognitive disorders

authors： Bucht G,Gustafson Y,Sandberg O

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:The Baylor Profound Mental Status Examination (BPMSE) was modeled to provide a brief patient-derived rating scale for staging and tracking patients with severe stages of Alzheimer's disease (AD). METHODS:The BPMSE was administered to 91 patients with probable AD (Korean version of the MMSE less than 16) acc...

journal_title：Dementia and geriatric cognitive disorders

authors： Na HR,Lee SH,Lee JS,Doody RS,Kim SY

更新日期：2009-01-01 00:00:00

abstract：:Central cholinergic circuits of human brain can be tested non-invasively by coupling electrical peripheral stimulation with transcranial magnetic stimulation (TMS) of the motor cortex. The short-latency afferent inhibition (SAI) is reduced in cholinergic forms of dementia, such as Alzheimer disease (AD) and dementia w...

journal_title：Dementia and geriatric cognitive disorders

authors： Nardone R,Golaszewski S,Ladurner G,Tezzon F,Trinka E

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS:Secondary analysis of 1,629 adults between 48 ...

journal_title：Dementia and geriatric cognitive disorders

authors： Mecca AP,Michalak HR,McDonald JW,Kemp EC,Pugh EA,Becker ML,Mecca MC,van Dyck CH,The Alzheimer’s Disease Neuroimaging Initiative (ADNI).

更新日期：2018-01-01 00:00:00

abstract：:Abnormal tau hyperphosphorylation has been suggested as being one of the central events in the development of neurofibrillary tangles, which are one of the characteristic neuropathological lesions found in Alzheimer's disease (AD) brains. 14-3-3 zeta protein is associated with tau in brain and stimulates tau phosphory...

journal_title：Dementia and geriatric cognitive disorders

authors： Mateo I,Sánchez-Juan P,Rodríguez-Rodríguez E,Infante J,Fernández-Viadero C,Peña N,Berciano J,Combarros O

更新日期：2008-01-01 00:00:00

abstract：AIM:To determine the applicability and psychometric properties of the Italian version of the Disability Assessment of Dementia scale (DAD-I) in a community-residing population with early-stage Alzheimer's disease (AD). METHODS:The DAD-I was administered to the primary caregivers of 159 patients (mean age +/- SD 77.1 +...

journal_title：Dementia and geriatric cognitive disorders

authors： De Vreese LP,Caffarra P,Savarè R,Cerutti R,Franceschi M,Grossi E,Multicentre Study Group.

更新日期：2008-01-01 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) usually presents with clinical and neuroimaging findings consistent with single or multiple intracranial mass lesions. On cranial magnetic resonance imaging (MRI), such lesions are nearly always contrast enhancing, reflecting disruption of the blood-brain barrier at the ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bakshi R,Mazziotta JC,Mischel PS,Jahan R,Seligson DB,Vinters HV

更新日期：1999-03-01 00:00:00

abstract：AIMS:The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. METHODS:This cross-sectional observational study included 288 individuals with deme...

journal_title：Dementia and geriatric cognitive disorders

authors： Wetzels RB,Zuidema SU,de Jonghe JF,Verhey FR,Koopmans RT

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF). METHODS:In 58 patients with HF neuropsychological assessment was performed including tests of mental spee...

journal_title：Dementia and geriatric cognitive disorders

authors： Vogels RL,Oosterman JM,van Harten B,Gouw AA,Schroeder-Tanka JM,Scheltens P,van der Flier WM,Weinstein HC

更新日期：2007-01-01 00:00:00

abstract：:The current increase in aged individuals in number and proportion of the general population warrants dependable strategies to improve early detection of cognitive impairment. It was the goal of the present study to develop a triage for bedside testing and outpatient services. In a prospective clinical cohort study at ...

journal_title：Dementia and geriatric cognitive disorders

authors： Beinhoff U,Hilbert V,Bittner D,Gron G,Riepe MW

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Lacunar stroke (L) is the most common stroke subtype associated with vascular dementia (VaD-L). OBJECTIVE:To evaluate the cognitive and behavioral course in patients with probable VaD-L. METHODS:We longitudinally measured rates of change on MMSE, digit span, logical memory, Controlled Oral Word Association...

journal_title：Dementia and geriatric cognitive disorders

authors： Aharon-Peretz J,Daskovski E,Mashiach T,Kliot D,Tomer R

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIM:3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are thought to reduce the amount of Abeta peptides by reducing cholesterol from blood and/or cerebrospinal fluid. We performed this meta-analysis to evaluate the preventive and treatment effects of statins on dementia and Alzheimer dise...

journal_title：Dementia and geriatric cognitive disorders

authors： Zhou B,Teramukai S,Fukushima M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS:We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method...

journal_title：Dementia and geriatric cognitive disorders

authors： Hanyu H,Sato T,Akai T,Shimizu S,Hirao K,Kanetaka H,Iwamoto T,Koizumi K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The capacity to mitigate dementia symptomology despite the prevailing brain pathology has been attributed to cognitive reserve. OBJECTIVES:This study aimed to investigate how psychometric performance differs between individuals with a high school versus college education (surrogate measures for medium and h...

journal_title：Dementia and geriatric cognitive disorders

authors： Rodriguez FS,Zheng L,Chui HC,Aging Brain: Vasculature, Ischemia, and Behavior Study.

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The impact of occupational exposure to solvents on cognitive ageing remains unclear. We examined whether long-term occupational exposure is associated with poor cognitive performance in late midlife. METHODS:Participants in the GAZEL cohort, set up in 1989, are employees of the French national electricity a...

journal_title：Dementia and geriatric cognitive disorders

authors： Berr C,Vercambre MN,Bonenfant S,Manoux AS,Zins M,Goldberg M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:The Frontal Assessment Battery (FAB) and the EXIT-25 have emerged as 2 widely used screening instruments for executive dysfunction, but their screening properties have not been evaluated in a head-to-head comparison. METHODS:Prospective cohort study of 92 individuals presenting for cognitive assessment...

journal_title：Dementia and geriatric cognitive disorders

authors： Moorhouse P,Gorman M,Rockwood K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Lifestyle and vascular factors have been linked to dementia and Alzheimer's disease (AD), but the role of dietary fats in the development of dementia is less clear. METHODS:Participants were derived from random, population-based samples initially studied in midlife (1972, 1977, 1982, or 1987). Fat intake fr...

journal_title：Dementia and geriatric cognitive disorders

authors： Laitinen MH,Ngandu T,Rovio S,Helkala EL,Uusitalo U,Viitanen M,Nissinen A,Tuomilehto J,Soininen H,Kivipelto M

更新日期：2006-01-01 00:00:00

abstract：:To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...

journal_title：Dementia and geriatric cognitive disorders

authors： Bronge L,Bogdanovic N,Wahlund LO

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusion...

journal_title：Dementia and geriatric cognitive disorders

authors： Mitolo M,Tonon C,La Morgia C,Testa C,Carelli V,Lodi R

更新日期：2018-01-01 00:00:00

abstract：:The gene for apolipoprotein E (APOE) is polymorphic, and its variant APOE4 is a major risk factor for the development of Alzheimer-type dementia (AD). Another risk factor for AD appears to be negative cobalamin balance, which is very common in elderly people. Cobalamin and folate are interdependent and essential compo...

journal_title：Dementia and geriatric cognitive disorders

authors： Regland B,Blennow K,Germgård T,Koch-Schmidt AC,Gottfries CG

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. METHODS:Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests as...

journal_title：Dementia and geriatric cognitive disorders

authors： de Oliveira FF,Chen ES,Smith MC,Bertolucci PH

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Estimations of life expectancies (LE) in health and ill health are important for planning future health care support. This study aimed at quantifying whether an increased LE is accompanied by an increase in the duration of life with dementia (DemLE) in Hong Kong SAR. METHODS:Two parameters from a logistic m...

journal_title：Dementia and geriatric cognitive disorders

authors： Cheung SL,Yip SF,Branch LG,Robine JM

更新日期：2015-01-01 00:00:00

abstract：AIMS:To examine the effects of galantamine and risperidone on agitation in patients with dementia. METHODS:A total of 100 patients with dementia and neuropsychiatric symptoms (mean age ± SD: 78.6 ± 7.5 years; 67% female) were included in this 12-week, randomized, parallel-group, controlled, single-center trial. The pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Freund-Levi Y,Bloniecki V,Auestad B,Tysen Bäckström AC,Lärksäter M,Aarsland D

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to determine the frequency of ubiquitin-positive inclusions (UPI) in dementia lacking distinctive histology (DLDH), and their relationship to other pathologic features, such as hippocampal sclerosis (HpScl), as well as genetic factors. Routine and immunohistochemical studies were carried out ...

journal_title：Dementia and geriatric cognitive disorders

authors： Josephs KA,Jones AG,Dickson DW

更新日期：2004-01-01 00:00:00

abstract：AIM:To conduct a prospective analysis of the neuropsychiatric symptoms (NPS) across the three categories of primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS), compare the prevalence and nature of the symptoms, and look at which symptoms could be helpful to better differentiate these PPA and PAO...

journal_title：Dementia and geriatric cognitive disorders

authors： Singh TD,Duffy JR,Strand EA,Machulda MM,Whitwell JL,Josephs KA

更新日期：2015-01-01 00:00:00