Abstract:
BACKGROUND:The capacity to mitigate dementia symptomology despite the prevailing brain pathology has been attributed to cognitive reserve. OBJECTIVES:This study aimed to investigate how psychometric performance differs between individuals with a high school versus college education (surrogate measures for medium and high cognitive reserves) given the same level of brain pathology assessed using quantitative structural MRI. METHODS:We used data from the Aging Brain: Vasculature, Ischemia, and Behavior Study (ABVIB). Cognition was assessed using a neuropsychological battery that included those contained in the National Alzheimer's Coordinating Center (NACC) uniform data set. Participants with a medium and high cognitive reserve were matched by level of structural MRI changes, gender, and age. RESULTS:Matched-pair regression analyses indicated that individuals with a higher education had a significantly better performance in recognition and verbal fluency animals, working memory, and processing speed in complex tasks. Moreover, they had a better performance in interference trails compared to individuals with a high school education (medium cognitive reserve). CONCLUSIONS:Our findings suggest that, given the same level of brain pathology, individuals with a higher education (cognitive reserve) benefit from a superior performance in semantic memory and executive functioning. Differences in these cognitive domains may be key pathways explaining how individuals with a high cognitive reserve are able to diminish dementia symptomatology despite physical changes in the brain.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Rodriguez FS,Zheng L,Chui HC,Aging Brain: Vasculature, Ischemia, and Behavior Study.doi
10.1159/000501150subject
Has Abstractpub_date
2019-01-01 00:00:00pages
335-344issue
4-6eissn
1420-8008issn
1421-9824pii
000501150journal_volume
47pub_type
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017211
更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051222
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
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更新日期:1997-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000017127
更新日期:1999-07-01 00:00:00
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