Abstract:
BACKGROUND/AIMS:We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF). METHODS:In 58 patients with HF neuropsychological assessment was performed including tests of mental speed, executive functions, memory, language and visuospatial functions. Deep, periventricular and total white matter hyperintensities (WMH), lacunar and cortical infarcts, global and medial temporal lobe atrophy (MTA) were investigated on MRI of the brain. Correlations between MRI findings and the cognitive measures were calculated. RESULTS:MTA correlated with memory (r = -0.353, p < 0.01), with executive functions (r = -0.383, p < 0.01) and the Mini Mental State Examination (r = -0.343, p < 0.05). Total WMH and deep WMH were found to correlate with depression and anxiety scores, but not with cognitive measures. Age, estimated premorbid intelligence and MTA were independent predictors of diminished cognitive performance. CONCLUSIONS:In HF patients, MTA was related to cognitive dysfunction, involving memory impairment and executive dysfunction, whereas WMH was related to depression and anxiety.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Vogels RL,Oosterman JM,van Harten B,Gouw AA,Schroeder-Tanka JM,Scheltens P,van der Flier WM,Weinstein HCdoi
10.1159/000109811subject
Has Abstractpub_date
2007-01-01 00:00:00pages
418-23issue
6eissn
1420-8008issn
1421-9824pii
000109811journal_volume
24pub_type
杂志文章abstract:BACKGROUND/AIMS:The frontal assessment battery (FAB) is reported to be a useful tool for screening frontal function. However, the neural substrates involved remain to be elucidated. The aim of the present study was to identify the brain regions responsible for FAB performance in patients with early dementia. We sought ...
journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000048639
更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000444704
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000106657
更新日期:1997-11-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000017242
更新日期:2000-07-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,多中心研究
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更新日期:2008-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000381848
更新日期:2015-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00