Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort.

Abstract:

BACKGROUND:We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS:Secondary analysis of 1,629 adults between 48 and 91 years of age with up to 24 months of follow-up from the ADNI (Alzheimer's Disease Neuroimaging Initiative), a longitudinal cohort study. RESULTS:Sleep disturbance was not associated with decline in memory, executive function, or global cognition. The presence of sleep disturbance did not significantly increase the risk of diagnostic conversion in CN, early MCI, or late MCI participants. CONCLUSION:This study investigated the effect of sleep disturbance on cognitive decline using several outcomes and does not support the hypothesis that sleep disturbance predicts subsequent cognitive decline.

authors

Mecca AP,Michalak HR,McDonald JW,Kemp EC,Pugh EA,Becker ML,Mecca MC,van Dyck CH,The Alzheimer’s Disease Neuroimaging Initiative (ADNI).

doi

10.1159/000488671

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

232-242

issue

3-4

eissn

1420-8008

issn

1421-9824

pii

000488671

journal_volume

45

pub_type

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