Abstract：
:Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease remains unknown. In the present study, the neuropathological changes and levels of both core PHF-tau and normal tau protein in 4 neocortical areas, cerebellum and medial temporal cortex were determined in 18 AD cases. The extent of these changes was compared between 10 cases possessing an epsilon 4 allele and 8 cases without. These two groups were indistinguishable in terms of neurofibrillary pathology, whereas cases with an epsilon 4 allele had more diffuse plaques, particularly in the temporal neocortex. Biochemically, there was no difference in the levels of PHF-tau protein between the two groups. These data indicate that APOE epsilon 4 allele may influence deposition of diffuse amyloid, but altered tau protein processing, which underlies the development of the neurofibrillary pathology in AD, is not influenced by this allele.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Mukaetova-Ladinska EB,Harrington CR,Roth M,Wischik CMdoi
10.1159/000106646subject
Has Abstractpub_date
1997-09-01 00:00:00pages
288-95issue
5eissn
1420-8008issn
1421-9824journal_volume
8pub_type
杂志文章abstract：:Numerous groups have confirmed that apolipoprotein E allelic variation accounts for a proportion of the genetic risk for late-onset Alzheimer's disease (AD). However, there is a paucity of data on the impact of this locus on the overall risk of dementia (as opposed to AD) in the elderly. Most studies have ascertained ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000017046
更新日期：1998-07-01 00:00:00
abstract：:To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000057698
更新日期：2002-01-01 00:00:00
abstract：:We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion invol...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000051222
更新日期：1999-01-01 00:00:00
abstract：AIMS:We aimed to establish the prevalence of depression among recently admitted long-term care patients and to examine associations with diagnostic initiatives and treatment as recorded in patients' medical records. MATERIALS AND METHODS:Eighty-eight long-term care patients were included. Depression was diagnosed acco...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000355427
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND/AIMS:The relationship between subcortical hyperintensities (SH) on brain MRI and gait parameters in aging and Alzheimer's disease (AD) is unclear. This study compared gait in 42 mild AD patients to 22 normal controls (NC) based on their SH severity and correlated them to SH burden in these groups. METHODS:G...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000245158
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND/AIMS:Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS:O...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,随机对照试验
doi：10.1159/000492962
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND/AIMS:The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. METHODS:A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and A...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000351671
更新日期：2013-01-01 00:00:00
abstract：:In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000106621
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND/AIMS:We have previously reported the results of an extended genome-wide scan of Swedish Alzheimer disease (AD)-affected families; in this paper, we analyzed a subset of these families with autopsy-confirmed AD. METHODS:We report the fine-mapping, using both microsatellite markers and single-nucleotide polym...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000323808
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND/AIMS:To evaluate whether dementia patients prescribed antipsychotic drugs have a higher mortality compared to unexposed patients, and to investigate whether there are differences in mortality associated with exposure to conventional versus atypical antipsychotic drugs. METHODS:Retrospective population cohor...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000326213
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND/AIMS:We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. METHODS:Participants (n = 933) were investigated using ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000346292
更新日期：2013-01-01 00:00:00
abstract：:Primary central nervous system lymphoma (PCNSL) usually presents with clinical and neuroimaging findings consistent with single or multiple intracranial mass lesions. On cranial magnetic resonance imaging (MRI), such lesions are nearly always contrast enhancing, reflecting disruption of the blood-brain barrier at the ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000017116
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND/AIMS:Depressive symptoms are commonly observed in Alzheimer's disease (AD). The underlying mechanisms of depressive symptoms in AD remain unclear; frontolimbic circuitry dysfunction may play a role. We aimed to investigate the microstructural integrity of frontolimbic connectivity of specific fiber tracts in...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000447056
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Estimations of life expectancies (LE) in health and ill health are important for planning future health care support. This study aimed at quantifying whether an increased LE is accompanied by an increase in the duration of life with dementia (DemLE) in Hong Kong SAR. METHODS:Two parameters from a logistic m...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000381848
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To study the progression of Alzheimer's disease (AD) at a very early stage and to evaluate clinical markers of presymptomatic AD. SETTING:Longitudinal study at a university hospital. SUBJECTS:A Swedish family harboring a double mutation at codons 670/671 of the APP gene on chromosome 21 was followed longitu...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 临床试验,杂志文章
doi：10.1159/000017200
更新日期：1999-11-01 00:00:00
abstract：:In 21 patients suffering from Binswanger's disease (BD) and in 53 patients suffering from Alzheimer's disease, we measured cerebrospinal fluid (CSF) concentrations of somatostatin-like immunoreactivity (SLI), high molecular weight form somatostatin (HMV-SST), somatostatin-25/28 (SST-25/28), somatostatin-14 (SST-14), D...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000106598
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:Frontotemporal dementia (FTD) is a more common cause of dementia than previously recognised. Few data are available regarding the natural course of FTD in terms of survival, nursing home admission and causes of death. METHODS:An observational study of all consecutive patients referred to the memory centre...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,多中心研究
doi：10.1159/000077148
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND/AIMS:A large proportion of patients at memory disorders clinics are classified as having subjective cognitive impairment (SCI). Previous research has investigated whether particular lifestyle factors known to affect cognition can be useful in differentiating patients who do not show objective evidence of mem...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000505573
更新日期：2019-01-01 00:00:00
abstract：:The degeneration of dopaminergic cells in dementia with Lewy bodies (DLB) may provide an important source of additional free radical generation. As a result, the oxidative stress status in DLB could be significantly enhanced. Subsequently, the levels of endogenous antioxidants, which are an indirect measure of free ra...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000069993
更新日期：2003-01-01 00:00:00
abstract：AIM:To conduct a prospective analysis of the neuropsychiatric symptoms (NPS) across the three categories of primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS), compare the prevalence and nature of the symptoms, and look at which symptoms could be helpful to better differentiate these PPA and PAO...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000369062
更新日期：2015-01-01 00:00:00
abstract：:Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000017161
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We ai...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000507078
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND/AIMS:The Frontal Assessment Battery (FAB) and the EXIT-25 have emerged as 2 widely used screening instruments for executive dysfunction, but their screening properties have not been evaluated in a head-to-head comparison. METHODS:Prospective cohort study of 92 individuals presenting for cognitive assessment...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000212755
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS:Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoi...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000448805
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND/AIM:The prevalence of cognitive symptoms in recently diagnosed Parkinson's disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms. METHODS:A PD patient diagnosed with mild cognitive impairment underwent DBS surgery tar...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000493094
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. METHODS:One hundred Caucasian ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000356483
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Lifestyle and vascular factors have been linked to dementia and Alzheimer's disease (AD), but the role of dietary fats in the development of dementia is less clear. METHODS:Participants were derived from random, population-based samples initially studied in midlife (1972, 1977, 1982, or 1987). Fat intake fr...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000093478
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:(1) To investigate the prevalence and characteristics of agitation in patients with Alzheimer's disease (AD) and other forms of dementia; (2) to explore the association between agitation and other clinical variables, including disease severity, functional impairment and other neuropsychiatric symptoms, and (...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000074080
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS:We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000469658
更新日期：2017-01-01 00:00:00
abstract：:Frontotemporal dementia (FTD) is the second most prevalent dementia after Alzheimer's disease (AD). We compared 29 FTD and 90 AD caregivers with respect to burden, health-related quality of life (HQoL) and coping. FTD caregivers were more burdened than AD caregivers, and caregivers of patients who were demented for sh...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000095750
更新日期：2006-01-01 00:00:00
