Abstract:
BACKGROUND/AIMS:The relationship between subcortical hyperintensities (SH) on brain MRI and gait parameters in aging and Alzheimer's disease (AD) is unclear. This study compared gait in 42 mild AD patients to 22 normal controls (NC) based on their SH severity and correlated them to SH burden in these groups. METHODS:Gait velocity, stride length, cadence and step width were captured on an automated walkway. Severity of SH on MRI was visually scored, which was used to dichotomize the AD and NC groups into high and low SH severity subgroups. Correlations between gait parameters and total and regional distribution of SH were explored. RESULTS:Compared to both AD subgroups and the NC subgroup with high SH severity, the NC subgroup with low SH severity had a significantly faster velocity (127 cm/s). Overall SH severity correlated significantly with stride length and velocity in the AD (r = -0.4, p = 0.01) and NC (r = -0.4, p = 0.02) groups, respectively, specifically with SH severity in the frontal and basal ganglion regions. CONCLUSION:SH burden may have a relatively stronger association with slower gait velocity in NC than in patients with mild AD. The fronto-subcortical SH load may influence gait in AD and aging.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Nadkarni NK,McIlroy WE,Mawji E,Black SEdoi
10.1159/000245158subject
Has Abstractpub_date
2009-01-01 00:00:00pages
295-301issue
4eissn
1420-8008issn
1421-9824pii
000245158journal_volume
28pub_type
杂志文章abstract:AIM:The aims of the present study were to report on the psychometric properties of the Pain Assessment in Advanced Dementia (PAINAD) scale by comparing it with the gold standard method of self-reporting on a numerical rating scale (NRS), and to provide a categorical version of the PAINAD scale comparable with the verba...
journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000341582
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abstract:OBJECTIVES:(1) To investigate the prevalence and characteristics of agitation in patients with Alzheimer's disease (AD) and other forms of dementia; (2) to explore the association between agitation and other clinical variables, including disease severity, functional impairment and other neuropsychiatric symptoms, and (...
journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000074080
更新日期:2004-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000356726
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000504799
更新日期:2019-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000151241
更新日期:2008-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,meta分析
doi:10.1159/000099037
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000101453
更新日期:2007-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000084705
更新日期:2005-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,meta分析,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000077158
更新日期:2004-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,多中心研究
doi:10.1159/000144073
更新日期:2008-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000366272
更新日期:2015-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000068781
更新日期:2003-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000084555
更新日期:2005-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000272423
更新日期:2010-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000119123
更新日期:2008-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000356483
更新日期:2014-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000320589
更新日期:2010-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000106646
更新日期:1997-09-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000095750
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017190
更新日期:1999-11-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051241
更新日期:2001-03-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000106598
更新日期:1997-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000105126
更新日期:2007-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000488671
更新日期:2018-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,meta分析
doi:10.1159/000447324
更新日期:2016-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000082661
更新日期:2005-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000381848
更新日期:2015-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000234912
更新日期:2009-01-01 00:00:00