Abstract:
:We compared the intact alpha7 nicotinic acetylcholine receptor (alpha7nAChR) protein levels in the peripheral blood leukocytes in 15 Alzheimer's disease (AD) patients and 13 normal elderly control subjects. Demographic data and Mini-Mental State Examination (MMSE) scores were obtained. Western blot analysis for alpha7nAChR protein levels in peripheral blood leukocytes was performed. There were no significant differences in sex and age between the AD and control groups. The mean MMSE score of the AD subjects was significantly lower than that of the normal control subjects (15.4 +/- 5.5 vs. 28.5 +/- 1.9 respectively; p < 0.001). The median value of normalized alpha7nAChR protein levels (optical density, arbitrary unit) of the AD group was significantly higher than that of the normal control group (0.6923 vs. 0.4803 respectively; p = 0.045, Mann-Whitney U test). The normalized alpha7nAChR protein levels showed a significant inverse correlation with the MMSE scores (Spearman rho = -0.45; p = 0.016; n = 28). Receiver Operating Characteristic curve analyses showed that the area under curve was 0.72 (95% CI 0.52- 0.87). If the cut-off of the alpha7nAChR protein level was >0.312, the sensitivity, specificity, positive predictive value and negative predictive value would be 80, 39, 60 and 63%, respectively. These findings showed that the alpha7nAChR protein levels would be a potentially useful diagnostic marker for AD.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Chu LW,Ma ES,Lam KK,Chan MF,Lee DHdoi
10.1159/000082661keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
106-12issue
2-3eissn
1420-8008issn
1421-9824pii
82661journal_volume
19pub_type
杂志文章abstract:BACKGROUND/AIM:3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are thought to reduce the amount of Abeta peptides by reducing cholesterol from blood and/or cerebrospinal fluid. We performed this meta-analysis to evaluate the preventive and treatment effects of statins on dementia and Alzheimer dise...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,meta分析
doi:10.1159/000099037
更新日期:2007-01-01 00:00:00
abstract::The study of the cerebral white matter (WM) in experimental models of hypoxia and ischemia has been for a long time neglected, the interest of investigators being focused on the response of the neuronal population. The increasing frequency with which modern neuroimaging techniques disclose alterations of the WM of pos...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000051185
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND/AIMS:Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS:O...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,随机对照试验
doi:10.1159/000492962
更新日期:2018-01-01 00:00:00
abstract::In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000106621
更新日期:1997-03-01 00:00:00
abstract::To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer's disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a neuronal loss and ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017190
更新日期:1999-11-01 00:00:00
abstract::The apolipoprotein E (APOE) gene has in many studies been identified as a susceptibility factor in Alzheimer's disease (AD). The APOE association is rather strong, but other not yet identified genetic factors are assumed to be involved in the pathogenesis of AD. Recently an association between an intronic polymorphism...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017037
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To investigate the relationships between cognitive impairment and apathy in patients with early Huntington's disease (HD) and to further explore the influence of depression on the outcome of cognitive changes associated with apathy. METHODS:We included 36 early HD patients, among them 20 were apathetic (HDA)...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000091523
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Corpus callosum atrophy possibly indicates neuronal degeneration in association cortex in Alzheimer's disease (AD). Water diffusivity allows detecting physiological changes that probably occur earlier than structural shrinkage in cerebral regions during the development of AD. OBJECTIVE:To simultaneously inv...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000094934
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:Increased cerebrospinal fluid (CSF) tau, decreased CSF amyloid-beta42 (Abeta42) and the apolipoprotein E gene (APOE) epsilon4 allele predict progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Here, we investigated these markers to assess their predictive value and influence on...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000216841
更新日期:2009-01-01 00:00:00
abstract:AIMS:To perform an item analysis of the Montreal Cognitive Assessment (MoCA) versus the Mini-Mental State Examination (MMSE) in the prediction of cognitive impairment, and to examine the characteristics of different MoCA threshold scores. METHODS:135 subjects enrolled in a longitudinal clinicopathologic study were adm...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000323867
更新日期:2011-01-01 00:00:00
abstract::We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a neg...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000119730
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Alzheimer's disease patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD); a genetic component to the development of BPSD has been demonstrated. Genetic risk factors for other psychiatric disorders have been implicated in BPSD; however, this is the first known investiga...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000160958
更新日期:2008-01-01 00:00:00
abstract::Frontotemporal dementia (FTD) is the second most prevalent dementia after Alzheimer's disease (AD). We compared 29 FTD and 90 AD caregivers with respect to burden, health-related quality of life (HQoL) and coping. FTD caregivers were more burdened than AD caregivers, and caregivers of patients who were demented for sh...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000095750
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. METHODS:Participants (n = 933) were investigated using ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000346292
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We ai...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000507078
更新日期:2020-01-01 00:00:00
abstract::The Non-Communicative Patient's Pain Assessment Instrument (NOPPAIN) is a nursing assistant-administered instrument for assessing pain behaviors in patients with dementia. This study investigated the validity of the NOPPAIN. Twenty-one nursing assistants (NAs) with no prior training in using the NOPPAIN watched six vi...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000076446
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND/AIMS:To explore the presenting and early symptoms of dementia with Lewy bodies (DLB). METHOD:Patients with mild dementia fulfilling diagnostic criteria for DLB (n = 61) and Alzheimer's disease (AD) (n = 109) were recruited from outpatient dementia clinics in western Norway. At diagnosis, caregivers were ask...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000333072
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress. BACKGROUND:FTLD is a progressive neurodegenerative disease associated with behavioral disturbances. Group studies have related these behaviors to volume loss on ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000194658
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIM:The objective was to examine cohort changes in cognitive function in 2 cohorts of centenarians born 10 years apart. METHODS:The Longitudinal Study of Danish Centenarians comprises all Danes reaching the age of 100 in the period April 1, 1995 through May 31, 1996. A total of 207 out of 276 persons partic...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000149819
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Catechol-O-methyltransferase, encoded by the COMT gene, is one of the enzymes that degrade dopamine. The aim of this study was to investigate whether polymorphisms in the COMT gene were associated with delirium. METHODS:Patients aged 65 years and older, acutely admitted to the medical department or to ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000327353
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The preclinical patterns of biological markers for Alzheimer's disease (AD) in vivo need further exploration. The aim of this study was therefore to investigate CSF biomarkers, regional cerebral blood flow (rCBF) and cognitive performance in cognitively healthy older individuals. METHOD:Within a 2-week peri...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000338185
更新日期:2012-01-01 00:00:00
abstract::N-methyl-D-aspartate (NMDA) receptor dysfunction has been implicated in the pathogenesis of Alzheimer's disease (AD). The NMDA receptor is composed of several subunits, of which the receptor 2b subunit (NR2b) is of particular significance for AD. Abundant in the hippocampus of normal subjects, reductions in NR2b have ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000048639
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elder...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000100927
更新日期:2007-01-01 00:00:00
abstract::The following areas are discussed in this review: atherogenesis; cerebrovascular factors; hypoperfusion; beta-amyloid production; beta-amyloid fibril formation; beta-sheets; metal cations; reactive oxygen species/free radicals; chronic inflammatory factors; endogenous plasma heparin; lipoprotein lipase; polyamines; pr...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000080034
更新日期:2004-01-01 00:00:00
abstract::In spite of the fact that delirium is a common and often severe cognitive disturbance in the elderly, quite few intervention studies are performed. Descriptive studies of variable quality are much more common. For example, in hip fracture patients delirium is a common complication and the cause of nursing problems tha...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000017181
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND/AIMS:Since detection of the prion protein gene (PRNP) more than 30 mutations have been discovered. Some have only been found in single case reports without known intrafamilial accumulation or neuropathological proof so that the causal connection between mutation and disease could not be proved. Those patient...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000345991
更新日期:2013-01-01 00:00:00
abstract:UNLABELLED:The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients s...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000234912
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:With an increasing life expectancy, the number of people suffering from dementia globally will rise to about 115.4 million by 2050. It is projected that in the 21st century, the majority of the world's older people will be living in Asia. This paper examines the global issues of family caregiving for ol...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000322086
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000510501
更新日期:2020-01-01 00:00:00
abstract::Alzheimer's disease (AD) is generally understood as primarily affecting cognition while sparing motor function, at least until the later stages of the disease. Studies reported over the past 10 years, however, have documented a prevalence of falls in AD patients significantly higher than in age-matched normal elders; ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000105126
更新日期:2007-01-01 00:00:00