Abstract：
BACKGROUND/AIMS:Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS:Original data from 3 randomised controlled trials (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis on diabetes, hypertension, baseline blood pressure, obesity (BMI ≥30 kg/m2), and BMI as risk factors for POCD in multiple logistic regression models. Risk estimates were pooled across the 3 studies. RESULTS:Analyses totalled 1,034 patients. POCD occurred in 5.2% of patients in DECS, in 9.4% in SuDoCo, and in 32.1% of patients in OCTOPUS. After adjustment for age, sex, surgery type, randomisation, obesity, and hypertension, diabetes was associated with a 1.84-fold increased risk of POCD (OR 1.84; 95% CI 1.14, 2.97; p = 0.01). Obesity, BMI, hypertension, and baseline blood pressure were each not associated with POCD in fully adjusted models (all p > 0.05). CONCLUSION:Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Lachmann G,Feinkohl I,Borchers F,Ottens TH,Nathoe HM,Sauer AM,Dieleman JM,Radtke FM,van Dijk D,Spies C,Pischon Tdoi
10.1159/000492962subject
Has Abstractpub_date
2018-01-01 00:00:00pages
193-206issue
3-4eissn
1420-8008issn
1421-9824pii
000492962journal_volume
46pub_type
杂志文章,随机对照试验abstract：:The study of the cerebral white matter (WM) in experimental models of hypoxia and ischemia has been for a long time neglected, the interest of investigators being focused on the response of the neuronal population. The increasing frequency with which modern neuroimaging techniques disclose alterations of the WM of pos...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,评审
doi：10.1159/000051185
更新日期：1998-07-01 00:00:00
abstract：AIMS:The objective of this study was to investigate the relation between impaired fine motor skills in Parkinson disease (PD) patients and their cognitive status, and to determine whether fine motor skills are more impaired in PD patients with mild cognitive impairment (MCI) than in non-MCI patients. METHODS:Twenty PD...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000448751
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To detect the main factors associated with the occurrence of specific geriatric syndromes (namely pressure sores, fecal incontinence, urinary incontinence and falls) in elderly patients during hospitalization. DESIGN:Observational prospective study. SETTING:Eighty-one community and university hospitals thro...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000087440
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Semantic dementia (SD). OBJECTIVE:To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET). METHODS:Eight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000095624
更新日期：2006-01-01 00:00:00
abstract：UNLABELLED:The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients s...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000234912
更新日期：2009-01-01 00:00:00
abstract：:Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000106646
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND/AIMS:The aim of the present study was to provide normative data and determine the validity of the Czech version of the Mattis Dementia Rating Scale 2 (czDRS-2) in screening for mild cognitive impairment in Parkinson's disease (PD-MCI) based on the Movement Disorder Society (MDS) Level II criteria. METHODS:F...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000375365
更新日期：2015-01-01 00:00:00
abstract：AIMS:To perform an item analysis of the Montreal Cognitive Assessment (MoCA) versus the Mini-Mental State Examination (MMSE) in the prediction of cognitive impairment, and to examine the characteristics of different MoCA threshold scores. METHODS:135 subjects enrolled in a longitudinal clinicopathologic study were adm...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000323867
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND/AIMS:The Frontal Assessment Battery (FAB) and the EXIT-25 have emerged as 2 widely used screening instruments for executive dysfunction, but their screening properties have not been evaluated in a head-to-head comparison. METHODS:Prospective cohort study of 92 individuals presenting for cognitive assessment...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000212755
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Corpus callosum atrophy possibly indicates neuronal degeneration in association cortex in Alzheimer's disease (AD). Water diffusivity allows detecting physiological changes that probably occur earlier than structural shrinkage in cerebral regions during the development of AD. OBJECTIVE:To simultaneously inv...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000094934
更新日期：2006-01-01 00:00:00
abstract：:We compared the intact alpha7 nicotinic acetylcholine receptor (alpha7nAChR) protein levels in the peripheral blood leukocytes in 15 Alzheimer's disease (AD) patients and 13 normal elderly control subjects. Demographic data and Mini-Mental State Examination (MMSE) scores were obtained. Western blot analysis for alpha7...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000082661
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The assessment of executive function (EF) and activities of daily living (ADL) are important elements in the diagnosis of Alzheimer's disease. METHODS:Following a comprehensive search in three databases, a random-effects meta-analysis was used to investigate the association between ADL ability and seventeen...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,meta分析
doi：10.1159/000338233
更新日期：2012-01-01 00:00:00
abstract：AIM:To analyze the relationship between periventricular (PV) and subcortical (SC) white matter lesions (WML) and cognitive function in patients with memory impairment. METHODS:In total, 253 patients with Global Deterioration Scale scores >or=3 who had been referred to a university-based memory unit due to memory compl...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000165355
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS:Secondary analysis of 1,629 adults between 48 ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000488671
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND/AIMS:Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cogni...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000355558
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elder...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000100927
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000366410
更新日期：2015-01-01 00:00:00
abstract：:Heart rate variability is used to assess cardiovascular autonomic function. The cholinesterase inhibitor donepezil potentially affects parasympathetic activity. Twenty participants with Alzheimer's disease or dementia with Lewy bodies were treated with donepezil in a pilot study. Power spectral analysis was used to an...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 临床试验,杂志文章
doi：10.1159/000068781
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND/AIMS:We identified and studied 13 patients carrying the P301L mutation in the MAPT gene from the same area (Baix Llobregat County) in Barcelona, Spain. METHODS:The demographic and clinical features were reviewed retrospectively. Detailed neuropathological characterization was obtained in 9 subjects. To inve...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000480077
更新日期：2017-01-01 00:00:00
abstract：:The present investigation reports the application of regional cerebral blood flow (rCBF; (133)Xe method) to prognostic purposes in a consecutive series of 76 patients (mean age 68.4 +/- 8.7 years) with probable Alzheimer's disease (AD; NINCDS-ADRDA criteria). The likelihood that rCBF from a posterior temporal-inferior...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000051241
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000094974
更新日期：2006-01-01 00:00:00
abstract：:Age-related changes and the effects of dementia of the Alzheimer type (DAT) were investigated during a visual orienting attention task in which attention was pre-cued to one or other hemifields. Central cues were either valid, neutral, invalid or NoGo (inhibitory). The response time cost-benefit analysis showed a decr...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000106657
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND/AIMS:Elderly patients with dementia have a higher risk of falls and fractures as compared to cognitively intact elderly subjects. To investigate whether psychological distress of the caregiver might predispose older persons with Alzheimer disease (AD) to falls and fractures, we performed a prospective cohort...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000288774
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:The capacity to mitigate dementia symptomology despite the prevailing brain pathology has been attributed to cognitive reserve. OBJECTIVES:This study aimed to investigate how psychometric performance differs between individuals with a high school versus college education (surrogate measures for medium and h...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000501150
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:Frontotemporal dementia (FTD) is a more common cause of dementia than previously recognised. Few data are available regarding the natural course of FTD in terms of survival, nursing home admission and causes of death. METHODS:An observational study of all consecutive patients referred to the memory centre...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,多中心研究
doi：10.1159/000077148
更新日期：2004-01-01 00:00:00
abstract：:In Switzerland (7 million inhabitants), the organization of health care is in the hand of the cantons and not of the Confederation. The canton of Vaud (600,000 inhabitants), in the south-west part of the country, counts 4 psychiatric sectors, each with a psychogeriatric service. Otherwise the canton has 146 long-stay ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000106621
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:To describe a case of early-onset Alzheimer's disease (AD) in an apolipoprotein (Apo) ε2/ε2 homozygote. BACKGROUND:Apo ε2/ε2 is the rarest of the ApoE genotypes, representing only 1.4% of the population. Cognitive decline in ApoE ε2 homozygotes has rarely been reported. CASE REPORT/METHODS:We report a 58-ye...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000320589
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Given the poorer prognosis of Alzheimer's disease (AD) patients with rapid cognitive decline (RCD), there is a need for a clinical assessment tool to detect these patients. OBJECTIVE:To investigate if there is a Mini Mental State Examination (MMSE) threshold of decline during 6 months of follow-up which pre...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章,多中心研究
doi：10.1159/000144073
更新日期：2008-01-01 00:00:00
abstract：:Recent studies have implicated interleukin-6 (IL-6) in the pathogenesis of Alzheimer's disease (AD). Neuro-inflammatory processes surrounding the amyloid plaques contribute to the progression of AD-related neurodegeneration. IL-6 is a multifunctional inflammatory cytokine which possibly acts as a mediator in the local...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000076352
更新日期：2004-01-01 00:00:00
abstract：:The membrane-bound glycoprotein, amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). The present paper investigates the neuritogenic-neurotoxic properties of this protein and relates them to possible aetiopathological mechanisms in AD. Marked differences in neuritic differentiation were ...
journal_title：Dementia and geriatric cognitive disorders
pub_type： 杂志文章
doi：10.1159/000051234
更新日期：2001-01-01 00:00:00
