Abstract:
BACKGROUND:Semantic dementia (SD). OBJECTIVE:To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET). METHODS:Eight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average 15 months later. RESULTS:Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). CONCLUSION:Subtle functional changes suffice to produce significant neuropsycho- logical deterioration.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Diehl-Schmid J,Grimmer T,Drzezga A,Bornschein S,Perneczky R,Forstl H,Schwaiger M,Kurz Adoi
10.1159/000095624subject
Has Abstractpub_date
2006-01-01 00:00:00pages
346-51issue
4eissn
1420-8008issn
1421-9824pii
95624journal_volume
22pub_type
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