Plasma homocysteine is elevated in elderly patients with memory complaints and vascular disease.

abstract：AIMS:The goal of this study is to assess the relationship between quality of life (QoL), neuropsychiatric symptoms (NPS), psychotropic drug use (PDU) and patient characteristics in a large group of nursing home residents with dementia. METHODS:This cross-sectional observational study included 288 individuals with deme...

journal_title：Dementia and geriatric cognitive disorders

authors： Wetzels RB,Zuidema SU,de Jonghe JF,Verhey FR,Koopmans RT

更新日期：2010-01-01 00:00:00

abstract：AIM:To conduct a prospective analysis of the neuropsychiatric symptoms (NPS) across the three categories of primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS), compare the prevalence and nature of the symptoms, and look at which symptoms could be helpful to better differentiate these PPA and PAO...

journal_title：Dementia and geriatric cognitive disorders

authors： Singh TD,Duffy JR,Strand EA,Machulda MM,Whitwell JL,Josephs KA

更新日期：2015-01-01 00:00:00

abstract：AIM:The aims of the present study were to report on the psychometric properties of the Pain Assessment in Advanced Dementia (PAINAD) scale by comparing it with the gold standard method of self-reporting on a numerical rating scale (NRS), and to provide a categorical version of the PAINAD scale comparable with the verba...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosele M,Inelmen EM,Toffanello ED,Girardi A,Coin A,Sergi G,Manzato E

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In...

journal_title：Dementia and geriatric cognitive disorders

authors： Fujimi K,Noda K,Sasaki K,Wakisaka Y,Tanizaki Y,Iida M,Kiyohara Y,Kanba S,Iwaki T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cogni...

journal_title：Dementia and geriatric cognitive disorders

authors： Rinehardt E,Eichstaedt K,Schinka JA,Loewenstein DA,Mattingly M,Fils J,Duara R,Schoenberg MR

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to determine the frequency of ubiquitin-positive inclusions (UPI) in dementia lacking distinctive histology (DLDH), and their relationship to other pathologic features, such as hippocampal sclerosis (HpScl), as well as genetic factors. Routine and immunohistochemical studies were carried out ...

journal_title：Dementia and geriatric cognitive disorders

authors： Josephs KA,Jones AG,Dickson DW

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The study was designed to determine the acceptability, feasibility and validity of measuring quality of life in a representative sample of dementia patients with a generic instrument, the Duke Health Profile. METHOD:The French version of the Duke Health Profile was administered to 148 subjects with a mental ...

journal_title：Dementia and geriatric cognitive disorders

authors： Novella J,Ankri J,Morrone I,Guillemin F,Jolly D,Jochum C,Ploton L,Blanchard F

更新日期：2001-03-01 00:00:00

abstract：:We investigated whether an index based on clinical features, electroencephalogram and computed tomography is useful to predict survival in early Alzheimer's disease. One hundred and sixty-three consecutively referred patients to an outpatient memory clinic and first diagnosed with Alzheimer's disease (105 'probable' a...

journal_title：Dementia and geriatric cognitive disorders

authors： Claus JJ,van Gool WA,Teunisse S,Walstra GJ,Kwa VI,Hijdra A,Verbeeten B Jr,Koelman JH,Bour LJ,Ongerboer De Visser BW

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND/AIMS:Since detection of the prion protein gene (PRNP) more than 30 mutations have been discovered. Some have only been found in single case reports without known intrafamilial accumulation or neuropathological proof so that the causal connection between mutation and disease could not be proved. Those patient...

journal_title：Dementia and geriatric cognitive disorders

authors： Schelzke G,Stoeck K,Eigenbrod S,Grasbon-Frodl E,Raddatz LM,Ponto C,Kretzschmar HA,Zerr I

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:Catechol-O-methyltransferase, encoded by the COMT gene, is one of the enzymes that degrade dopamine. The aim of this study was to investigate whether polymorphisms in the COMT gene were associated with delirium. METHODS:Patients aged 65 years and older, acutely admitted to the medical department or to ...

journal_title：Dementia and geriatric cognitive disorders

authors： van Munster BC,Baas F,Tanck MW,de Rooij SE

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To study the progression of Alzheimer's disease (AD) at a very early stage and to evaluate clinical markers of presymptomatic AD. SETTING:Longitudinal study at a university hospital. SUBJECTS:A Swedish family harboring a double mutation at codons 670/671 of the APP gene on chromosome 21 was followed longitu...

journal_title：Dementia and geriatric cognitive disorders

authors： Wahlund LO,Basun H,Almkvist O,Julin P,Axelman K,Shigeta M,Jelic V,Nordberg A,Lannfelt L

更新日期：1999-11-01 00:00:00

abstract：:The membrane-bound glycoprotein, amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). The present paper investigates the neuritogenic-neurotoxic properties of this protein and relates them to possible aetiopathological mechanisms in AD. Marked differences in neuritic differentiation were ...

journal_title：Dementia and geriatric cognitive disorders

authors： Neill D,Hughes D,Leake A,Morris C,Jones D,Oakley A,Edwardson J,Estibeiro P

更新日期：2001-01-01 00:00:00

abstract：:The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) (Abeta(1-42)). An assay for tau phosphorylated at threonine 181 (phospho-tau) has recently been developed. We studied these three markers in patients with possible Alzheimer's disease (AD; ...

journal_title：Dementia and geriatric cognitive disorders

authors： Nägga K,Gottfries J,Blennow K,Marcusson J

更新日期：2002-01-01 00:00:00

abstract：:This intent-to-treat (ITT) analysis was performed to provide a realistic image of the efficacy that could be expected after 26 weeks treatment with a 120-mg dose (40 mg t.i.d.) of EGb 761 (EGb). The data were collected during a 52-week, double-blind, placebo-controlled, fixed dose, parallel-group, multicenter study. P...

journal_title：Dementia and geriatric cognitive disorders

authors： Le Bars PL,Kieser M,Itil KZ

更新日期：2000-07-01 00:00:00

abstract：INTRODUCTION:Frontotemporal dementia (FTD) is a more common cause of dementia than previously recognised. Few data are available regarding the natural course of FTD in terms of survival, nursing home admission and causes of death. METHODS:An observational study of all consecutive patients referred to the memory centre...

journal_title：Dementia and geriatric cognitive disorders

authors： Pasquier F,Richard F,Lebert F

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer's disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity. METHODS:A literature review and meta-analysis were conducted to estimate the prevalence of APOE4 by geographic area among AD patients. RESULT...

journal_title：Dementia and geriatric cognitive disorders

authors： Crean S,Ward A,Mercaldi CJ,Collins JM,Cook MN,Baker NL,Arrighi HM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:The relationship between subcortical hyperintensities (SH) on brain MRI and gait parameters in aging and Alzheimer's disease (AD) is unclear. This study compared gait in 42 mild AD patients to 22 normal controls (NC) based on their SH severity and correlated them to SH burden in these groups. METHODS:G...

journal_title：Dementia and geriatric cognitive disorders

authors： Nadkarni NK,McIlroy WE,Mawji E,Black SE

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We ai...

journal_title：Dementia and geriatric cognitive disorders

authors： Martin E,Velayudhan L

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To examine the influence of cognitive impairment on the functional outcomes and complication rates of patients with hip fracture during in-patient treatment. METHODS:A total of 402 patients who were surgically treated for hip fractures were consecutively enrolled at a single trauma center. The patients were ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bliemel C,Lechler P,Oberkircher L,Colcuc C,Balzer-Geldsetzer M,Dodel R,Ruchholtz S,Buecking B

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients s...

journal_title：Dementia and geriatric cognitive disorders

authors： Rolstad S,Nordlund A,Eckerström C,Gustavsson MH,Zetterberg H,Wallin A

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:(1) To investigate the prevalence and characteristics of agitation in patients with Alzheimer's disease (AD) and other forms of dementia; (2) to explore the association between agitation and other clinical variables, including disease severity, functional impairment and other neuropsychiatric symptoms, and (...

journal_title：Dementia and geriatric cognitive disorders

authors： Senanarong V,Cummings JL,Fairbanks L,Mega M,Masterman DM,O'Connor SM,Strickland TL

更新日期：2004-01-01 00:00:00

abstract：:The present study investigated the accuracy of an extended version of the Delayed Word Recall (DWR) test in distinguishing patients with very mild Alzheimer's disease (AD) (Mini Mental State Examination score > or = 23) from community-dwelling depressed/dysthymic patients. The DWR test was administered to 26 non-depre...

journal_title：Dementia and geriatric cognitive disorders

authors： Coen RF,Kirby M,Swanwick GR,Maguire CP,Walsh JB,Coakley D,O'Neill D,Lawlor BA

更新日期：1997-07-01 00:00:00

abstract：:Recent studies have implicated interleukin-6 (IL-6) in the pathogenesis of Alzheimer's disease (AD). Neuro-inflammatory processes surrounding the amyloid plaques contribute to the progression of AD-related neurodegeneration. IL-6 is a multifunctional inflammatory cytokine which possibly acts as a mediator in the local...

journal_title：Dementia and geriatric cognitive disorders

authors： Depboylu C,Lohmüller F,Gocke P,Du Y,Zimmer R,Gasser T,Klockgether T,Dodel RC

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIM:To estimate the prevalence of Alzheimer's disease (AD) treatment in Aragon (Spain), analyzing differences according to age, gender and health area. METHODS:Retrospective study on AD treatment prevalence of cholinesterase inhibitors and memantine during 2005, using pharmaco-epidemiological data from pres...

journal_title：Dementia and geriatric cognitive disorders

authors： Villar-Fernández I,Bjerrum L,Feja C,Rabanaque MJ

更新日期：2009-01-01 00:00:00

abstract：:Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer's disease (AD). It is highly selective for AChE in the central nervous system (CNS), with little or no affinity...

journal_title：Dementia and geriatric cognitive disorders

authors： Rogers SL

更新日期：1998-01-01 00:00:00

abstract：AIMS:To describe central nervous system (CNS) drug consumption patterns depending on the time to diagnosis of Alzheimer's disease (AD), and to check whether the cases diagnosed later are associated with greater severity and consuming more CNS drugs. METHODS:Cross-sectional study using 952 cases of the Registry of Deme...

journal_title：Dementia and geriatric cognitive disorders

authors： Calvó-Perxas L,López-Pousa S,Vilalta-Franch J,Turró-Garriga O,Blankenburg M,Febrer L,Flaqué M,Vallmajó N,Aguirregomozcorta M,Genís D,Casas I,Perkal H,Coromina J,Garre-Olmo J,Registry of Dementias of Girona Study Group.

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the differential patterns of brain atrophy in early- and late-onset Alzheimer's disease (AD) by measuring regional z-scores of voxel-based morphometry and assessed the availability of the method for clinical use. METHODS:The first 50 patients with probable AD were compared to 83 age-matche...

journal_title：Dementia and geriatric cognitive disorders

authors： Shiino A,Watanabe T,Kitagawa T,Kotani E,Takahashi J,Morikawa S,Akiguchi I

更新日期：2008-01-01 00:00:00

abstract：:To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer's disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a neuronal loss and ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tao Z,Van Gool D,Lammens M,Dom R

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND/AIMS:Elderly patients with dementia have a higher risk of falls and fractures as compared to cognitively intact elderly subjects. To investigate whether psychological distress of the caregiver might predispose older persons with Alzheimer disease (AD) to falls and fractures, we performed a prospective cohort...

journal_title：Dementia and geriatric cognitive disorders

authors： Maggio D,Ercolani S,Andreani S,Ruggiero C,Mariani E,Mangialasche F,Palmari N,Mecocci P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Although some patients with primary progressive aphasia (PPA) exhibit novel or improved skills after the onset of dementia, these changes have yet to be quantified. Therefore, this study systematically explored and identified the emergence of positive behaviours after dementia onset. METHODS:This study...

journal_title：Dementia and geriatric cognitive disorders

authors： Midorikawa A,Kumfor F,Leyton CE,Foxe D,Landin-Romero R,Hodges JR,Piguet O

更新日期：2017-01-01 00:00:00