Cognitive impairment is the major risk factor for development of geriatric syndromes during hospitalization: results from the GIFA study.

Abstract:

OBJECTIVE:To detect the main factors associated with the occurrence of specific geriatric syndromes (namely pressure sores, fecal incontinence, urinary incontinence and falls) in elderly patients during hospitalization. DESIGN:Observational prospective study. SETTING:Eighty-one community and university hospitals throughout Italy. PARTICIPANTS:13,729 patients aged 65 years and more, consecutively admitted to medical or geriatric acute wards during 20 months in the period between 1991 and 1998. MEASUREMENTS:Occurrence of pressure sores, fecal incontinence, urinary incontinence and falls during the stay in hospital. RESULTS:Pressure sores were already present in 3% of hospitalized subjects, fecal incontinence in 7.3%, while urinary incontinence, evaluated on a subgroup of total population (4,268 subjects), had a prevalence of 22.3%. During hospitalization (mean stay of 15 days), 74 subjects developed new pressure sores, 55 became fecal and 35 urinary incontinent, and 279 subjects had at least one episode of fall. In multivariate analyses, cognitive impairment, advanced age (85+ years), length of stay (more than 3 weeks) and severe disability were the main independent predictors of development of the four geriatric syndromes, with cognitive impairment as the most significant risk factor for all the four outcomes (OR 4.9, 95% CI 2.4-9.9 for pressure sores; OR 6.3, 95% CI 3.0-13.0 for fecal incontinence; OR 5.3, 95% CI 2.3-12.0 for urinary incontinence; OR 1.6, 95% CI 1.2-2.3 for falls). CONCLUSION:Very old people have a significant increased risk of several geriatric syndromes during the stay in hospital, particularly if it is long and they are cognitively impaired. A standardized comprehensive geriatric evaluation at admission could be helpful in detecting all subjects at risk and preventing the development of hospital-acquired geriatric syndromes.

authors

Mecocci P,von Strauss E,Cherubini A,Ercolani S,Mariani E,Senin U,Winblad B,Fratiglioni L

doi

10.1159/000087440

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

262-9

issue

4

eissn

1420-8008

issn

1421-9824

pii

87440

journal_volume

20

pub_type

杂志文章
  • Variability in the prescription of cholinesterase inhibitors and memantine.

    abstract:BACKGROUND/AIM:To estimate the prevalence of Alzheimer's disease (AD) treatment in Aragon (Spain), analyzing differences according to age, gender and health area. METHODS:Retrospective study on AD treatment prevalence of cholinesterase inhibitors and memantine during 2005, using pharmaco-epidemiological data from pres...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000253845

    authors: Villar-Fernández I,Bjerrum L,Feja C,Rabanaque MJ

    更新日期:2009-01-01 00:00:00

  • Perspectives in the management of Alzheimer's disease: clinical profile of donepezil.

    abstract::Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer's disease (AD). It is highly selective for AChE in the central nervous system (CNS), with little or no affinity...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,评审

    doi:10.1159/000051201

    authors: Rogers SL

    更新日期:1998-01-01 00:00:00

  • Usefulness of Discriminability and Response Bias Indices for the Evaluation of Recognition Memory in Mild Cognitive Impairment and Alzheimer Disease.

    abstract:BACKGROUND:Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE:To evaluate the recognition memory performance by u...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000452255

    authors: Russo MJ,Cohen G,Campos J,Martin ME,Clarens MF,Sabe L,Barcelo E,Allegri RF

    更新日期:2017-01-01 00:00:00

  • Postoperative Treatment of Pain after Hip Fracture in Elderly Patients with Dementia.

    abstract:BACKGROUND/AIMS:Prior studies have shown that patients with dementia are at risk of receiving insufficient treatment for pain after a hip fracture. We therefore hypothesized that elderly hip fracture patients with dementia received less postoperative pain treatment than those without dementia. METHOD:All patients (age...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000444704

    authors: Jensen-Dahm C,Palm H,Gasse C,Dahl JB,Waldemar G

    更新日期:2016-01-01 00:00:00

  • The Montreal Cognitive Assessment and the mini-mental state examination as screening instruments for cognitive impairment: item analyses and threshold scores.

    abstract:AIMS:To perform an item analysis of the Montreal Cognitive Assessment (MoCA) versus the Mini-Mental State Examination (MMSE) in the prediction of cognitive impairment, and to examine the characteristics of different MoCA threshold scores. METHODS:135 subjects enrolled in a longitudinal clinicopathologic study were adm...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000323867

    authors: Damian AM,Jacobson SA,Hentz JG,Belden CM,Shill HA,Sabbagh MN,Caviness JN,Adler CH

    更新日期:2011-01-01 00:00:00

  • Neuroanatomical correlates of unawareness of memory deficits in early Alzheimer's disease.

    abstract:BACKGROUND/AIMS:To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS:We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000119594

    authors: Hanyu H,Sato T,Akai T,Shimizu S,Hirao K,Kanetaka H,Iwamoto T,Koizumi K

    更新日期:2008-01-01 00:00:00

  • Staging dementia using proxy-reported activities of daily living.

    abstract:BACKGROUND/AIM:It has been questioned whether cognitive and behavioral scales sufficiently address the impact of dementia on the everyday life of patients. Therefore, other instruments are used, such as scales of activities of daily living (ADL). Our goal was to analyze variables influencing the appraisal of ADL. METH...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000331420

    authors: Jonas C,Schiffczyk C,Lahmeyer C,Mueller F,Riepe MW

    更新日期:2011-01-01 00:00:00

  • Microstructure of Strategic White Matter Tracts and Cognition in Memory Clinic Patients with Vascular Brain Injury.

    abstract:BACKGROUND:White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS:We included 159 pa...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000485376

    authors: Biesbroek JM,Leemans A,den Bakker H,Duering M,Gesierich B,Koek HL,van den Berg E,Postma A,Biessels GJ

    更新日期:2017-01-01 00:00:00

  • Functional disability in early Alzheimer's disease - a validation study of the Italian version of the disability assessment for dementia scale.

    abstract:AIM:To determine the applicability and psychometric properties of the Italian version of the Disability Assessment of Dementia scale (DAD-I) in a community-residing population with early-stage Alzheimer's disease (AD). METHODS:The DAD-I was administered to the primary caregivers of 159 patients (mean age +/- SD 77.1 +...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000113415

    authors: De Vreese LP,Caffarra P,Savarè R,Cerutti R,Franceschi M,Grossi E,Multicentre Study Group.

    更新日期:2008-01-01 00:00:00

  • Polymorphisms of fas gene: relationship with Alzheimer's disease and cognitive decline.

    abstract::The Fas antigen (CD95) is a cell surface receptor that mediates cell apoptosis signalling. Recent investigations have shown that Fas-regulated apoptosis was linked to neurodegenerative lesions in the brain of patients with Alzheimer's disease (AD). Here data regarding the association of two polymorphisms of the Fas pr...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000095160

    authors: Chiappelli M,Nasi M,Cossarizza A,Porcellini E,Tumini E,Pinti M,Troiano L,Franceschi M,Licastro F

    更新日期:2006-01-01 00:00:00

  • A follow-up study of the family with the Swedish APP 670/671 Alzheimer's disease mutation.

    abstract:OBJECTIVE:To study the progression of Alzheimer's disease (AD) at a very early stage and to evaluate clinical markers of presymptomatic AD. SETTING:Longitudinal study at a university hospital. SUBJECTS:A Swedish family harboring a double mutation at codons 670/671 of the APP gene on chromosome 21 was followed longitu...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 临床试验,杂志文章

    doi:10.1159/000017200

    authors: Wahlund LO,Basun H,Almkvist O,Julin P,Axelman K,Shigeta M,Jelic V,Nordberg A,Lannfelt L

    更新日期:1999-11-01 00:00:00

  • Cognitive Impairment Is Associated with a Low Omega-3 Index in the Elderly: Results from the KORA-Age Study.

    abstract:BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS:Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoi...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000448805

    authors: Lukaschek K,von Schacky C,Kruse J,Ladwig KH

    更新日期:2016-01-01 00:00:00

  • Clinical assessment of amyloid imaging in Alzheimer's disease: a systematic review of the literature.

    abstract:BACKGROUND/AIMS:Healthcare systems face an increased prevalence of Alzheimer's disease and increasing costs. The use of molecular biomarkers and imaging could offer an effective solution for these issues. The objective of this study was to assess amyloid imaging regarding clinical utility and impact. METHODS:A literat...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,评审

    doi:10.1159/000351679

    authors: Wahlster P,Niederländer C,Kriza C,Schaller S,Kolominsky-Rabas PL

    更新日期:2013-01-01 00:00:00

  • In vivo dopamine pre-synaptic receptors and antioxidant activities in patients with Alzheimer's disease, dementia with Lewy bodies and in controls. A preliminary report.

    abstract::The degeneration of dopaminergic cells in dementia with Lewy bodies (DLB) may provide an important source of additional free radical generation. As a result, the oxidative stress status in DLB could be significantly enhanced. Subsequently, the levels of endogenous antioxidants, which are an indirect measure of free ra...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000069993

    authors: Tabet N,Walker Z,Mantle D,Costa D,Orrell M

    更新日期:2003-01-01 00:00:00

  • Neuroimaging and APOE genotype: a systematic qualitative review.

    abstract::Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD) and has also been implicated in cardiovascular disease, cognitive decline and cognitive changes in healthy ageing. The aim of this paper is to systematically review and critically assess the association between the APOE ge...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,评审

    doi:10.1159/000109150

    authors: Cherbuin N,Leach LS,Christensen H,Anstey KJ

    更新日期:2007-01-01 00:00:00

  • Simultaneous Stimulation of the Globus Pallidus Interna and the Nucleus Basalis of Meynert in the Parkinson-Dementia Syndrome.

    abstract:BACKGROUND/AIM:The prevalence of cognitive symptoms in recently diagnosed Parkinson's disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms. METHODS:A PD patient diagnosed with mild cognitive impairment underwent DBS surgery tar...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000493094

    authors: Nombela C,Lozano A,Villanueva C,Barcia JA

    更新日期:2019-01-01 00:00:00

  • Psychosis and antipsychotic medications in Alzheimer's disease: clinical management and research perspectives.

    abstract::Psychosis is common in patients with Alzheimer's disease (AD) and contributes substantially to patient morbidity and caregiver distress. Antipsychotic medications are used to treat psychosis and other psychiatric or behavioral symptoms in AD, although optimal treatment guidelines have been elusive. Choosing the most a...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,评审

    doi:10.1159/000074279

    authors: Sultzer DL

    更新日期:2004-01-01 00:00:00

  • Regional cerebral glucose metabolism in monozygotic twins discordant for Alzheimer's disease.

    abstract::We investigated regional cerebral glucose metabolic rates (rCMRgluc) with positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in 7 monozygotic twin pairs discordant for Alzheimer's disease (AD). Ten healthy volunteers with comparable mean age and educational level served as controls. In the hippoc...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000072809

    authors: Järvenpää T,Räihä I,Kaprio J,Koskenvuo M,Laine M,Kurki T,Vahlberg T,Viljanen T,Ahonen K,Rinne JO

    更新日期:2003-01-01 00:00:00

  • Longitudinal changes of cerebral glucose metabolism in semantic dementia.

    abstract:BACKGROUND:Semantic dementia (SD). OBJECTIVE:To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET). METHODS:Eight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000095624

    authors: Diehl-Schmid J,Grimmer T,Drzezga A,Bornschein S,Perneczky R,Forstl H,Schwaiger M,Kurz A

    更新日期:2006-01-01 00:00:00

  • Can the Clinical Dementia Rating Scale Identify Mild Cognitive Impairment and Predict Cognitive and Functional Decline?

    abstract:BACKGROUND:The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS:The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether basel...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000447057

    authors: Woolf C,Slavin MJ,Draper B,Thomassen F,Kochan NA,Reppermund S,Crawford JD,Trollor JN,Brodaty H,Sachdev PS

    更新日期:2016-01-01 00:00:00

  • Care of the delirious patient.

    abstract::In spite of the fact that delirium is a common and often severe cognitive disturbance in the elderly, quite few intervention studies are performed. Descriptive studies of variable quality are much more common. For example, in hip fracture patients delirium is a common complication and the cause of nursing problems tha...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,评审

    doi:10.1159/000017181

    authors: Brännström B

    更新日期:1999-09-01 00:00:00

  • White Matter Changes and Cognitive Decline in a Ten-Year Follow-Up Period: A Pilot Study on a Single-Center Cohort from the Leukoaraiosis and Disability Study.

    abstract:AIMS:To describe the contribution of white matter lesions to the long-term neuropsychological profiles of different groups of clinical diagnoses, and to identify neuropsychological predictors of cognitive impairment in a 10-year follow-up. METHODS:The Lisbon subcohort of the Leukoaraiosis and Disability (LADIS) study ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000447121

    authors: Madureira S,Verdelho A,Moleiro C,Santos C,Scheltens P,Gouw A,Ferro J

    更新日期:2016-01-01 00:00:00

  • The French Addenbrooke's cognitive examination is effective in detecting dementia in a French-speaking population.

    abstract::We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000080965

    authors: Bier JC,Donckels V,Van Eyll E,Claes T,Slama H,Fery P,Vokaer M

    更新日期:2005-01-01 00:00:00

  • Slowing of alternating forearm movements is associated with cognitive impairment in community-dwelling older people.

    abstract:BACKGROUND/AIMS:Motor impairment is an important aspect of cognitive decline in older adults. It has been suggested that complex motor control is affected earlier than gross motor control. The aims were to investigate if complex hand motor function was more affected than gross motor function in cognitively impaired old...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000305093

    authors: Bramell-Risberg E,Jarnlo GB,Elmståhl S

    更新日期:2010-01-01 00:00:00

  • Risk factors of transition from normal cognition to mild cognitive disorder: the PATH through Life Study.

    abstract:AIMS:The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). METHODS:A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. ...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000229025

    authors: Cherbuin N,Reglade-Meslin C,Kumar R,Jacomb P,Easteal S,Christensen H,Sachdev P,Anstey KJ

    更新日期:2009-01-01 00:00:00

  • Molecular genetic characterisation of frontotemporal dementia on chromosome 3.

    abstract::We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion invol...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000051222

    authors: Ashworth A,Lloyd S,Brown J,Gydesen S,Sorensen SA,Brun A,Englund E,Humphreys C,Housman D,Badura M,Stanton V Jr,Taylor K,Cameron J,Munroe D,Johansson J,Rossor M,Fisher EM,Collinge J

    更新日期:1999-01-01 00:00:00

  • Association between prescription of conventional or atypical antipsychotic drugs and mortality in older persons with Alzheimer's disease.

    abstract:BACKGROUND/AIMS:To evaluate whether dementia patients prescribed antipsychotic drugs have a higher mortality compared to unexposed patients, and to investigate whether there are differences in mortality associated with exposure to conventional versus atypical antipsychotic drugs. METHODS:Retrospective population cohor...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000326213

    authors: Musicco M,Palmer K,Russo A,Caltagirone C,Adorni F,Pettenati C,Bisanti L

    更新日期:2011-01-01 00:00:00

  • Lifestyle Factors and Subjective Cognitive Impairment in Patients Seeking Help at a Memory Disorder Clinic: The Role of Negative Life Events.

    abstract:BACKGROUND/AIMS:A large proportion of patients at memory disorders clinics are classified as having subjective cognitive impairment (SCI). Previous research has investigated whether particular lifestyle factors known to affect cognition can be useful in differentiating patients who do not show objective evidence of mem...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000505573

    authors: Andersson C,Marklund K,Walles H,Hagman G,Miley-Akerstedt A

    更新日期:2019-01-01 00:00:00

  • Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease.

    abstract:OBJECTIVE:The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD. METHODS:The occurrence of AD was examined in 1,420 first-degree relati...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000079195

    authors: Heun R,Ptok U,Kölsch H,Maier W,Jessen F

    更新日期:2004-01-01 00:00:00

  • Memory for performed actions in dementia of Alzheimer type: further evidence for a global semantic memory deficit.

    abstract::Findings in patients with dementia of the Alzheimer type (AD patients) concerning the enactment effect, i.e. reaching a better memory performance after encoding actions by performing them in contrast to encoding them by reading, are ambiguous. In order to get more insight into memory deterioration in patients sufferin...

    journal_title:Dementia and geriatric cognitive disorders

    pub_type: 杂志文章

    doi:10.1159/000089135

    authors: Mack W,Eberle C,Frölich L,Knopf M

    更新日期:2005-01-01 00:00:00