Variability in the prescription of cholinesterase inhibitors and memantine.

abstract：BACKGROUND:Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy depends on the PRNP codon 129 genotype, leaving it unclear how well established markers behave in untested conditions. METHODS:We analyzed ...

journal_title：Dementia and geriatric cognitive disorders

authors： Llorens F,Karch A,Golanska E,Schmitz M,Lange P,Sikorska B,Liberski PP,Zerr I

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Both personality changes and behavioural and psychological symptoms (BPS) may be associated with mild cognitive impairment (MCI) in later life and help identify incipient dementia. We wished to investigate the links between personality and BPS in MCI. METHOD:We studied premorbid personality traits ...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez Rubio M,Antonietti JP,Donati A,Rossier J,von Gunten A

更新日期：2013-01-01 00:00:00

abstract：AIMS:Mild cognitive impairment (MCI) usually represents a transitional phase between normal cognitive function and dementia, but not all people with MCI develop dementia because MCI is a clinically and etiologically heterogeneous grouping. The aim of this study was to compare progression rates to Alzheimer's disease (A...

journal_title：Dementia and geriatric cognitive disorders

authors： Lee YM,Park JM,Lee BD,Moon E,Chung YI,Kang CJ

更新日期：2012-01-01 00:00:00

abstract：:Ten years after the introduction of the first drug, tacrine, in the treatment of Alzheimer's disease, it seems appropriate to re-appraise the pharmacological processes of innovation in the research field of dementia. The aim of this review is to pinpoint concrete improvements achieved in this field, regarding experime...

journal_title：Dementia and geriatric cognitive disorders

authors： Sellal F,Nieoullon A,Michel G,Michel BF,Lacomblez L,Geerts H,Delini Stula A,Bordet R,Bentué-Ferrer D,Allain H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:The prevalence of mild cognitive impairment (MCI) and its subtypes among Chinese older adults, and the contribution of vascular risk factors (VRF) and vascular disorders to MCI remain unclear. This study aims to investigate the prevalence of MCI and its different subtypes, and clarify the role of VRF an...

journal_title：Dementia and geriatric cognitive disorders

authors： Ma F,Wu T,Zhao J,Ji L,Song A,Zhang M,Huang G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Prior studies have shown that patients with dementia are at risk of receiving insufficient treatment for pain after a hip fracture. We therefore hypothesized that elderly hip fracture patients with dementia received less postoperative pain treatment than those without dementia. METHOD:All patients (age...

journal_title：Dementia and geriatric cognitive disorders

authors： Jensen-Dahm C,Palm H,Gasse C,Dahl JB,Waldemar G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The apolipoprotein E (APOE) e4 genetic polymorphism is a major risk factor for Alzheimer' s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. METHODS:We used linear regression models to assess associations of APOE e4 with cognitive performance in a populati...

journal_title：Dementia and geriatric cognitive disorders

authors： Perna L,Mons U,Rujescu D,Kliegel M,Brenner H

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:To explore the presenting and early symptoms of dementia with Lewy bodies (DLB). METHOD:Patients with mild dementia fulfilling diagnostic criteria for DLB (n = 61) and Alzheimer's disease (AD) (n = 109) were recruited from outpatient dementia clinics in western Norway. At diagnosis, caregivers were ask...

journal_title：Dementia and geriatric cognitive disorders

authors： Auning E,Rongve A,Fladby T,Booij J,Hortobágyi T,Siepel FJ,Ballard C,Aarsland D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIM:The objective was to examine cohort changes in cognitive function in 2 cohorts of centenarians born 10 years apart. METHODS:The Longitudinal Study of Danish Centenarians comprises all Danes reaching the age of 100 in the period April 1, 1995 through May 31, 1996. A total of 207 out of 276 persons partic...

journal_title：Dementia and geriatric cognitive disorders

authors： Engberg H,Christensen K,Andersen-Ranberg K,Jeune B

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The impact of occupational exposure to solvents on cognitive ageing remains unclear. We examined whether long-term occupational exposure is associated with poor cognitive performance in late midlife. METHODS:Participants in the GAZEL cohort, set up in 1989, are employees of the French national electricity a...

journal_title：Dementia and geriatric cognitive disorders

authors： Berr C,Vercambre MN,Bonenfant S,Manoux AS,Zins M,Goldberg M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the influence of established genetic risk factors for Alzheimer's disease on the speed of disease progression. METHODS:Polymorphisms (in ACE, ApoE, BIN1, CLU, CR1, CST3, EXOC3L2, GWA14q32.13, IL8, LDLR, PICALM, TNK1) of 40 Alzheimer's disease patients from a longitudinal study were analyz...

journal_title：Dementia and geriatric cognitive disorders

authors： Schmidt C,Wolff M,von Ahsen N,Zerr I

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIM:It has been questioned whether cognitive and behavioral scales sufficiently address the impact of dementia on the everyday life of patients. Therefore, other instruments are used, such as scales of activities of daily living (ADL). Our goal was to analyze variables influencing the appraisal of ADL. METH...

journal_title：Dementia and geriatric cognitive disorders

authors： Jonas C,Schiffczyk C,Lahmeyer C,Mueller F,Riepe MW

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aims of this study were to determine baseline factors related to the progression of subjective memory impairment (SMI) in elderly subjects and to develop a new modeling scale to predict progression. METHODS:Elderly subjects with SMI were recruited from the nationwide Clinical Research Centers for D...

journal_title：Dementia and geriatric cognitive disorders

authors： Hong YJ,Yoon B,Shim YS,Kim SO,Kim HJ,Choi SH,Jeong JH,Yoon SJ,Yang DW,Lee JH

更新日期：2015-01-01 00:00:00

abstract：:To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer's disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a neuronal loss and ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tao Z,Van Gool D,Lammens M,Dom R

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND/AIMS:Depressive symptoms are commonly observed in Alzheimer's disease (AD). The underlying mechanisms of depressive symptoms in AD remain unclear; frontolimbic circuitry dysfunction may play a role. We aimed to investigate the microstructural integrity of frontolimbic connectivity of specific fiber tracts in...

journal_title：Dementia and geriatric cognitive disorders

authors： Zhu Q,Lin M,Bi S,Ni Z,Zhao J,Chen B,Fan G,Shang X

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to elucidate the relationship between Alzheimer's disease (AD) and the serotonin transporter gene (SLC6A4). METHODS:AD subjects (n = 43) and controls (n = 47) were recruited and evaluated. In leukocytes, we evaluated two polymorphisms in SLC6A4, the serotonin transporter length...

journal_title：Dementia and geriatric cognitive disorders

authors： Yamazaki K,Yoshino Y,Mori T,Okita M,Yoshida T,Mori Y,Ozaki Y,Sao T,Iga J,Ueno S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the differential patterns of brain atrophy in early- and late-onset Alzheimer's disease (AD) by measuring regional z-scores of voxel-based morphometry and assessed the availability of the method for clinical use. METHODS:The first 50 patients with probable AD were compared to 83 age-matche...

journal_title：Dementia and geriatric cognitive disorders

authors： Shiino A,Watanabe T,Kitagawa T,Kotani E,Takahashi J,Morikawa S,Akiguchi I

更新日期：2008-01-01 00:00:00

abstract：:In epidemiological, cross-sectional studies, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) prevented to a large extent the development of Alzheimer's disease (AD), but the results of randomized, placebo-controlled studies, focused on statin therapy in patients with ischemic heart ...

journal_title：Dementia and geriatric cognitive disorders

authors： Algotsson A,Winblad B

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate the possible association of regional cerebral perfusion and sleep loss in Alzheimer's disease (AD). METHODS:55 AD patients were characterized as having (SL) or not having (NSL) nocturnal sleep loss based on standard AD scales assessing sleep over the previous 4 weeks. (9...

journal_title：Dementia and geriatric cognitive disorders

authors： Ismail Z,Herrmann N,Francis PL,Rothenburg LS,Lobaugh NJ,Leibovitch FS,Black SE,Lanctôt KL

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Because poor lung function may be a risk factor for cognitive decline, we aimed to test the association of respiratory function with cognitive function and dementia later in life, as well as potential effect modification by APOE epsilon4 carrier status. METHODS:In a prospective population-based cohort ...

journal_title：Dementia and geriatric cognitive disorders

authors： Giltay EJ,Nissinen A,Giampaoli S,Kromhout D

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder with a strong genetic background. It has been reported that modifiable factors, i.e. education (E), might act as proxies for reserve capacity. OBJECTIVE:To evaluate the impact of genetic background (positive family history,...

journal_title：Dementia and geriatric cognitive disorders

authors： Premi E,Garibotto V,Alberici A,Paghera B,Giubbini R,Padovani A,Borroni B

更新日期：2012-01-01 00:00:00

abstract：AIM:To analyze the relationship between periventricular (PV) and subcortical (SC) white matter lesions (WML) and cognitive function in patients with memory impairment. METHODS:In total, 253 patients with Global Deterioration Scale scores >or=3 who had been referred to a university-based memory unit due to memory compl...

journal_title：Dementia and geriatric cognitive disorders

authors： Stenset V,Hofoss D,Berstad AE,Negaard A,Gjerstad L,Fladby T

更新日期：2008-01-01 00:00:00

abstract：AIM:To determine the applicability and psychometric properties of the Italian version of the Disability Assessment of Dementia scale (DAD-I) in a community-residing population with early-stage Alzheimer's disease (AD). METHODS:The DAD-I was administered to the primary caregivers of 159 patients (mean age +/- SD 77.1 +...

journal_title：Dementia and geriatric cognitive disorders

authors： De Vreese LP,Caffarra P,Savarè R,Cerutti R,Franceschi M,Grossi E,Multicentre Study Group.

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early ...

journal_title：Dementia and geriatric cognitive disorders

authors： Missonnier P,Gold G,Herrmann FR,Fazio-Costa L,Michel JP,Deiber MP,Michon A,Giannakopoulos P

更新日期：2006-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic muta...

journal_title：Dementia and geriatric cognitive disorders

authors： Ostojic J,Elfgren C,Passant U,Nilsson K,Gustafson L,Lannfelt L,Froelich Fabre S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIM:3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are thought to reduce the amount of Abeta peptides by reducing cholesterol from blood and/or cerebrospinal fluid. We performed this meta-analysis to evaluate the preventive and treatment effects of statins on dementia and Alzheimer dise...

journal_title：Dementia and geriatric cognitive disorders

authors： Zhou B,Teramukai S,Fukushima M

更新日期：2007-01-01 00:00:00

abstract：AIM:The aims of the present study were to report on the psychometric properties of the Pain Assessment in Advanced Dementia (PAINAD) scale by comparing it with the gold standard method of self-reporting on a numerical rating scale (NRS), and to provide a categorical version of the PAINAD scale comparable with the verba...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosele M,Inelmen EM,Toffanello ED,Girardi A,Coin A,Sergi G,Manzato E

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Predominant and progressive complex visual disorders are often due to posterior cortical atrophy (PCA), a rare early-onset dementing syndrome presenting with visual complaints. In clinicopathological studies, PCA is most commonly considered a form of Alzheimer's disease (AD); no prior study has evaluated cli...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez MF,Ghajarania M,Perryman KM

更新日期：2002-01-01 00:00:00

abstract：AIMS:To examine the effects of galantamine and risperidone on agitation in patients with dementia. METHODS:A total of 100 patients with dementia and neuropsychiatric symptoms (mean age ± SD: 78.6 ± 7.5 years; 67% female) were included in this 12-week, randomized, parallel-group, controlled, single-center trial. The pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Freund-Levi Y,Bloniecki V,Auestad B,Tysen Bäckström AC,Lärksäter M,Aarsland D

更新日期：2014-01-01 00:00:00

abstract：AIMS:To describe central nervous system (CNS) drug consumption patterns depending on the time to diagnosis of Alzheimer's disease (AD), and to check whether the cases diagnosed later are associated with greater severity and consuming more CNS drugs. METHODS:Cross-sectional study using 952 cases of the Registry of Deme...

journal_title：Dementia and geriatric cognitive disorders

authors： Calvó-Perxas L,López-Pousa S,Vilalta-Franch J,Turró-Garriga O,Blankenburg M,Febrer L,Flaqué M,Vallmajó N,Aguirregomozcorta M,Genís D,Casas I,Perkal H,Coromina J,Garre-Olmo J,Registry of Dementias of Girona Study Group.

更新日期：2012-01-01 00:00:00