Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS).

abstract：:We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion invol...

journal_title：Dementia and geriatric cognitive disorders

authors： Ashworth A,Lloyd S,Brown J,Gydesen S,Sorensen SA,Brun A,Englund E,Humphreys C,Housman D,Badura M,Stanton V Jr,Taylor K,Cameron J,Munroe D,Johansson J,Rossor M,Fisher EM,Collinge J

更新日期：1999-01-01 00:00:00

abstract：:We screened for tau gene mutations among 24 Japanese (6 familial and 18 sporadic cases) and 4 Polish patients with frontotemporal dementia (FTD) using PCR-SSCP analysis followed by DNA sequencing. We identified 2 missense mutations in exon 10: N279K and P301L in 2 Japanese patients with familial FTD. Additionally 3 DN...

journal_title：Dementia and geriatric cognitive disorders

authors： Kowalska A,Asada T,Arima K,Kumakiri C,Kozubski W,Takahashi K,Tabira T

更新日期：2001-11-01 00:00:00

abstract：:There is growing evidence for a role of apoptosis in Alzheimer's disease (AD). Recent findings suggest an increased susceptibility of lymphocytes to apoptosis in AD. To prove the hypothesis of systemic alterations in the apoptotic balance in AD, serum and cerebrospinal fluid levels of soluble CD95, which is known to m...

journal_title：Dementia and geriatric cognitive disorders

authors： Richartz E,Noda S,Schott K,Günthner A,Lewczuk P,Bartels M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. METHODS:This prospective inception cohort included 37...

journal_title：Dementia and geriatric cognitive disorders

authors： van Dam R,Van Ancum JM,Verlaan S,Scheerman K,Meskers CGM,Maier AB

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:With an increasing life expectancy, the number of people suffering from dementia globally will rise to about 115.4 million by 2050. It is projected that in the 21st century, the majority of the world's older people will be living in Asia. This paper examines the global issues of family caregiving for ol...

journal_title：Dementia and geriatric cognitive disorders

authors： Chan SW

更新日期：2010-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPLAb) may cause both focal ischemic and diffuse brain damage and may be associated with dementia. We have examined the relationship of aPLAb to dementia in the elderly. Blood samples were obtained from 87 consecutive patients with dementia (74 +/- 11 years old) and 69 controls (78 +/- 9 y...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosek A,Yust I,Treves TA,Vardinon N,Korczyn AD,Chapman J

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In...

journal_title：Dementia and geriatric cognitive disorders

authors： Fujimi K,Noda K,Sasaki K,Wakisaka Y,Tanizaki Y,Iida M,Kiyohara Y,Kanba S,Iwaki T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...

journal_title：Dementia and geriatric cognitive disorders

authors： Egberts A,Wijnbeld EH,Fekkes D,van der Ploeg MA,Ziere G,Hooijkaas H,van der Cammen TJ,Mattace-Raso FU

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To estimate life expectancy of psychogeriatric patients having participated in a reactivation program. To identify prognostic characteristics - on admission - for survival after discharge. DESIGN:A prospective, clinical-empirical observational study. SETTING:A Dutch psychiatric-skilled nursing home. PARTI...

journal_title：Dementia and geriatric cognitive disorders

authors： Bakker TJ,Duivenvoorden HJ,van der Lee J,Schudel WJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS:O...

journal_title：Dementia and geriatric cognitive disorders

authors： Lachmann G,Feinkohl I,Borchers F,Ottens TH,Nathoe HM,Sauer AM,Dieleman JM,Radtke FM,van Dijk D,Spies C,Pischon T

更新日期：2018-01-01 00:00:00

abstract：:The amygdala is severely atrophied at post-mortem in frontotemporal lobar degeneration (FTLD), and may contribute to the prominent behavioural changes that are early features of FTLD. The aim of this study was to assess amygdala atrophy using MRI in the main syndromic variants of FTLD and Alzheimer's disease (AD). Bra...

journal_title：Dementia and geriatric cognitive disorders

authors： Whitwell JL,Sampson EL,Watt HC,Harvey RJ,Rossor MN,Fox NC

更新日期：2005-01-01 00:00:00

abstract：:A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metapho...

journal_title：Dementia and geriatric cognitive disorders

authors： Nicosia F,Alberici A,Benussi L,Gasparini L,Ghidoni R,Mazzoli F,Zanetti O,Frisoni GB,Geroldi C,Binetti G

更新日期：2001-09-01 00:00:00

abstract：:We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a neg...

journal_title：Dementia and geriatric cognitive disorders

authors： Giannattasio C,Poleggi A,Puopolo M,Pocchiari M,Antuono P,Dal Forno G,Wekstein DR,Matera MG,Seripa D,Acciarri A,Bizzarro A,Lauria A,Masullo C

更新日期：2008-01-01 00:00:00

abstract：:A substantive overlap between the clinical syndromes of frontal lobe dementia (FLD), frontotemporal dementia (FTD), or primary progressive aphasia (PPA), and corticobasal degeneration syndrome (CBDS) has been demonstrated in a population of 55 patients followed for more than 3 years in a cognitive neurology clinic. Pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Kertesz A,Davidson W,Munoz DG

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS:Our hypothesis was that subtle pre-operative ...

journal_title：Dementia and geriatric cognitive disorders

authors： Lowery DP,Wesnes K,Ballard CG

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate the possible association of regional cerebral perfusion and sleep loss in Alzheimer's disease (AD). METHODS:55 AD patients were characterized as having (SL) or not having (NSL) nocturnal sleep loss based on standard AD scales assessing sleep over the previous 4 weeks. (9...

journal_title：Dementia and geriatric cognitive disorders

authors： Ismail Z,Herrmann N,Francis PL,Rothenburg LS,Lobaugh NJ,Leibovitch FS,Black SE,Lanctôt KL

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the differential patterns of brain atrophy in early- and late-onset Alzheimer's disease (AD) by measuring regional z-scores of voxel-based morphometry and assessed the availability of the method for clinical use. METHODS:The first 50 patients with probable AD were compared to 83 age-matche...

journal_title：Dementia and geriatric cognitive disorders

authors： Shiino A,Watanabe T,Kitagawa T,Kotani E,Takahashi J,Morikawa S,Akiguchi I

更新日期：2008-01-01 00:00:00

abstract：:The H63D mutation in the hemochromatosis gene (HFE) has recently been considered as a risk factor in Alzheimer's disease (AD) with advancing age at onset of the disease, independently of the apolipoprotein E (ApoE) epsilon4 allele effect. We examined the distribution of the H63D mutation and ApoE genotypes as a functi...

journal_title：Dementia and geriatric cognitive disorders

authors： Combarros O,García-Román M,Fontalba A,Fernández-Luna JL,Llorca J,Infante J,Berciano J

更新日期：2003-01-01 00:00:00

abstract：:Thirty patients had mild cognitive impairment and increased homocysteine levels in serum. On average, they were supplemented orally with a high dose of a vitamin B12-B6-folate combination for 270 days. All patients had normal serum B12 and folate levels at baseline. Cerebrospinal fluid levels of the tau protein (CSF-t...

journal_title：Dementia and geriatric cognitive disorders

authors： Lehmann M,Regland B,Blennow K,Gottfries CG

更新日期：2003-01-01 00:00:00

abstract：:Heart rate variability is used to assess cardiovascular autonomic function. The cholinesterase inhibitor donepezil potentially affects parasympathetic activity. Twenty participants with Alzheimer's disease or dementia with Lewy bodies were treated with donepezil in a pilot study. Power spectral analysis was used to an...

journal_title：Dementia and geriatric cognitive disorders

authors： McLaren AT,Allen J,Murray A,Ballard CG,Kenny RA

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate whether the serial position effects in memory can differentiate patients with different subtypes of mild cognitive impairment (MCI) from healthy controls and patients with different stages of Alzheimer's disease (AD). METHODS:The serial position effects was tested with t...

journal_title：Dementia and geriatric cognitive disorders

authors： Moser B,Deisenhammer EA,Marksteiner J,Papousek I,Fink A,Weiss EM

更新日期：2014-01-01 00:00:00

abstract：:Metrifonate, through its pharmacologically active metabolite 2,2-dichlorovinyl dimethylphosphate (DDVP), is a long-acting cholinesterase inhibitor for the symptomatic treatment of mild-to-moderate Alzheimer's disease. Clinical studies with Alzheimer patients have demonstrated the favourable safety and tolerability pro...

journal_title：Dementia and geriatric cognitive disorders

authors： Schmidt BH,Heinig R

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the present study was to provide normative data and determine the validity of the Czech version of the Mattis Dementia Rating Scale 2 (czDRS-2) in screening for mild cognitive impairment in Parkinson's disease (PD-MCI) based on the Movement Disorder Society (MDS) Level II criteria. METHODS:F...

journal_title：Dementia and geriatric cognitive disorders

authors： Bezdicek O,Michalec J,Nikolai T,Havránková P,Roth J,Jech R,Růžička E

更新日期：2015-01-01 00:00:00

abstract：:Age-related changes and the effects of dementia of the Alzheimer type (DAT) were investigated during a visual orienting attention task in which attention was pre-cued to one or other hemifields. Central cues were either valid, neutral, invalid or NoGo (inhibitory). The response time cost-benefit analysis showed a decr...

journal_title：Dementia and geriatric cognitive disorders

authors： Wright M,Geffen G,Geffen L

更新日期：1997-11-01 00:00:00

abstract：:We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination...

journal_title：Dementia and geriatric cognitive disorders

authors： Bier JC,Donckels V,Van Eyll E,Claes T,Slama H,Fery P,Vokaer M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. METHODS:Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests as...

journal_title：Dementia and geriatric cognitive disorders

authors： de Oliveira FF,Chen ES,Smith MC,Bertolucci PH

更新日期：2016-01-01 00:00:00

abstract：:To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...

journal_title：Dementia and geriatric cognitive disorders

authors： Bronge L,Bogdanovic N,Wahlund LO

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Possession of one or more apolipoprotein E (APOE) epsilon4 alleles may influence the distribution of atrophy and clinical phenotype. We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease). METHODS:We included 38 patients (9 epsilon4 non...

journal_title：Dementia and geriatric cognitive disorders

authors： Gutiérrez-Galve L,Lehmann M,Hobbs NZ,Clarkson MJ,Ridgway GR,Crutch S,Ourselin S,Schott JM,Fox NC,Barnes J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate whether dementia patients prescribed antipsychotic drugs have a higher mortality compared to unexposed patients, and to investigate whether there are differences in mortality associated with exposure to conventional versus atypical antipsychotic drugs. METHODS:Retrospective population cohor...

journal_title：Dementia and geriatric cognitive disorders

authors： Musicco M,Palmer K,Russo A,Caltagirone C,Adorni F,Pettenati C,Bisanti L

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS:We included 159 pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Biesbroek JM,Leemans A,den Bakker H,Duering M,Gesierich B,Koek HL,van den Berg E,Postma A,Biessels GJ

更新日期：2017-01-01 00:00:00