Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up.

abstract：BACKGROUND:Studies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias. METHODS:For 358 nursing home residents, serum lipids were studied at admission and diagnoses established at autopsy...

journal_title：Dementia and geriatric cognitive disorders

authors： Lesser GT,Haroutunian V,Purohit DP,Schnaider Beeri M,Schmeidler J,Honkanen L,Neufeld R,Libow LS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate whether the serial position effects in memory can differentiate patients with different subtypes of mild cognitive impairment (MCI) from healthy controls and patients with different stages of Alzheimer's disease (AD). METHODS:The serial position effects was tested with t...

journal_title：Dementia and geriatric cognitive disorders

authors： Moser B,Deisenhammer EA,Marksteiner J,Papousek I,Fink A,Weiss EM

更新日期：2014-01-01 00:00:00

abstract：:Although myoclonus commonly occurs in a later stage of Alzheimer's disease (AD), the pathological basis of this symptom is still unclear. In order to elucidate the neuropathological substrate of myoclonus in AD, we quantitatively assessed neuronal density and volume, with a discrimination between small and large neuro...

journal_title：Dementia and geriatric cognitive disorders

authors： Fukutani Y,Cairns NJ,Everall IP,Chadwick A,Isaki K,Lantos PL

更新日期：1999-03-01 00:00:00

abstract：:The H63D mutation in the hemochromatosis gene (HFE) has recently been considered as a risk factor in Alzheimer's disease (AD) with advancing age at onset of the disease, independently of the apolipoprotein E (ApoE) epsilon4 allele effect. We examined the distribution of the H63D mutation and ApoE genotypes as a functi...

journal_title：Dementia and geriatric cognitive disorders

authors： Combarros O,García-Román M,Fontalba A,Fernández-Luna JL,Llorca J,Infante J,Berciano J

更新日期：2003-01-01 00:00:00

abstract：:Alcoholics often develop personality and behavioural changes, social and personal neglect, confabulation, lack of insight, empathy and emotional control. Such symptoms would increase the risk of engagement in and exposure to acts of violence and criminal activities carrying a risk of physical damage including head tra...

journal_title：Dementia and geriatric cognitive disorders

authors： Brun A,Andersson J

更新日期：2001-07-01 00:00:00

abstract：:We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a neg...

journal_title：Dementia and geriatric cognitive disorders

authors： Giannattasio C,Poleggi A,Puopolo M,Pocchiari M,Antuono P,Dal Forno G,Wekstein DR,Matera MG,Seripa D,Acciarri A,Bizzarro A,Lauria A,Masullo C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. METHODS:Hip surgery patients aged 60 years or over (n = 200) underwent preoperative and daily postoperative assessment of their cognitive status ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bickel H,Gradinger R,Kochs E,Förstl H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Differences in the gross shape of the corpus callosum (CC) and its subregional areas were investigated on brain MRI of patients with probable Alzheimer's disease (AD) and age- and gender-matched healthy normal control subjects. The AD patients differed from the normal control subjects in terms of a more...

journal_title：Dementia and geriatric cognitive disorders

authors： Tomaiuolo F,Scapin M,Di Paola M,Le Nezet P,Fadda L,Musicco M,Caltagirone C,Collins DL

更新日期：2007-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is often misdiagnosed as Alzheimer's disease (AD). We hypothesized that the first symptoms associated with FTD would be different from those seen in AD and that the first symptoms in FTD would reflect loss of function in the frontal region with the greatest degree of degeneration. The obj...

journal_title：Dementia and geriatric cognitive disorders

authors： Lindau M,Almkvist O,Kushi J,Boone K,Johansson SE,Wahlund LO,Cummings JL,Miller BL

更新日期：2000-09-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptor dysfunction has been implicated in the pathogenesis of Alzheimer's disease (AD). The NMDA receptor is composed of several subunits, of which the receptor 2b subunit (NR2b) is of particular significance for AD. Abundant in the hippocampus of normal subjects, reductions in NR2b have ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tsai SJ,Liu HC,Liu TY,Cheng CY,Hong CJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:We have previously reported the results of an extended genome-wide scan of Swedish Alzheimer disease (AD)-affected families; in this paper, we analyzed a subset of these families with autopsy-confirmed AD. METHODS:We report the fine-mapping, using both microsatellite markers and single-nucleotide polym...

journal_title：Dementia and geriatric cognitive disorders

authors： Sillén A,Brohede J,Forsell C,Lilius L,Andrade J,Odeberg J,Kimura T,Winblad B,Graff C

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The study was designed to determine the acceptability, feasibility and validity of measuring quality of life in a representative sample of dementia patients with a generic instrument, the Duke Health Profile. METHOD:The French version of the Duke Health Profile was administered to 148 subjects with a mental ...

journal_title：Dementia and geriatric cognitive disorders

authors： Novella J,Ankri J,Morrone I,Guillemin F,Jolly D,Jochum C,Ploton L,Blanchard F

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND/AIMS:Although some patients with primary progressive aphasia (PPA) exhibit novel or improved skills after the onset of dementia, these changes have yet to be quantified. Therefore, this study systematically explored and identified the emergence of positive behaviours after dementia onset. METHODS:This study...

journal_title：Dementia and geriatric cognitive disorders

authors： Midorikawa A,Kumfor F,Leyton CE,Foxe D,Landin-Romero R,Hodges JR,Piguet O

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Estimations of life expectancies (LE) in health and ill health are important for planning future health care support. This study aimed at quantifying whether an increased LE is accompanied by an increase in the duration of life with dementia (DemLE) in Hong Kong SAR. METHODS:Two parameters from a logistic m...

journal_title：Dementia and geriatric cognitive disorders

authors： Cheung SL,Yip SF,Branch LG,Robine JM

更新日期：2015-01-01 00:00:00

abstract：:Psychosis is common in patients with Alzheimer's disease (AD) and contributes substantially to patient morbidity and caregiver distress. Antipsychotic medications are used to treat psychosis and other psychiatric or behavioral symptoms in AD, although optimal treatment guidelines have been elusive. Choosing the most a...

journal_title：Dementia and geriatric cognitive disorders

authors： Sultzer DL

更新日期：2004-01-01 00:00:00

abstract：AIMS:To examine the effects of galantamine and risperidone on agitation in patients with dementia. METHODS:A total of 100 patients with dementia and neuropsychiatric symptoms (mean age ± SD: 78.6 ± 7.5 years; 67% female) were included in this 12-week, randomized, parallel-group, controlled, single-center trial. The pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Freund-Levi Y,Bloniecki V,Auestad B,Tysen Bäckström AC,Lärksäter M,Aarsland D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:With an increasing life expectancy, the number of people suffering from dementia globally will rise to about 115.4 million by 2050. It is projected that in the 21st century, the majority of the world's older people will be living in Asia. This paper examines the global issues of family caregiving for ol...

journal_title：Dementia and geriatric cognitive disorders

authors： Chan SW

更新日期：2010-01-01 00:00:00

abstract：AIM:The aim of this study was standardization and validation of the Mini-Mental State Examination (MMSE) in the general Croatian aging population. METHODS:Three-hundred and forty-four participants underwent the MMSE test, 217 cognitively healthy subjects without neurological and psychiatric disorders and 127 patients ...

journal_title：Dementia and geriatric cognitive disorders

authors： Boban M,Malojčić B,Mimica N,Vuković S,Zrilić I,Hof PR,Simić G

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIM:It has been questioned whether cognitive and behavioral scales sufficiently address the impact of dementia on the everyday life of patients. Therefore, other instruments are used, such as scales of activities of daily living (ADL). Our goal was to analyze variables influencing the appraisal of ADL. METH...

journal_title：Dementia and geriatric cognitive disorders

authors： Jonas C,Schiffczyk C,Lahmeyer C,Mueller F,Riepe MW

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF). METHODS:In 58 patients with HF neuropsychological assessment was performed including tests of mental spee...

journal_title：Dementia and geriatric cognitive disorders

authors： Vogels RL,Oosterman JM,van Harten B,Gouw AA,Schroeder-Tanka JM,Scheltens P,van der Flier WM,Weinstein HC

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS:We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties...

journal_title：Dementia and geriatric cognitive disorders

authors： Matías-Guiu JA,Valles-Salgado M,Rognoni T,Hamre-Gil F,Moreno-Ramos T,Matías-Guiu J

更新日期：2017-01-01 00:00:00

abstract：AIMS:To describe the contribution of white matter lesions to the long-term neuropsychological profiles of different groups of clinical diagnoses, and to identify neuropsychological predictors of cognitive impairment in a 10-year follow-up. METHODS:The Lisbon subcohort of the Leukoaraiosis and Disability (LADIS) study ...

journal_title：Dementia and geriatric cognitive disorders

authors： Madureira S,Verdelho A,Moleiro C,Santos C,Scheltens P,Gouw A,Ferro J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS:We included 159 pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Biesbroek JM,Leemans A,den Bakker H,Duering M,Gesierich B,Koek HL,van den Berg E,Postma A,Biessels GJ

更新日期：2017-01-01 00:00:00

abstract：:Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately...

journal_title：Dementia and geriatric cognitive disorders

authors： Bucht G,Gustafson Y,Sandberg O

更新日期：1999-09-01 00:00:00

abstract：AIMS:We aimed to establish the prevalence of depression among recently admitted long-term care patients and to examine associations with diagnostic initiatives and treatment as recorded in patients' medical records. MATERIALS AND METHODS:Eighty-eight long-term care patients were included. Depression was diagnosed acco...

journal_title：Dementia and geriatric cognitive disorders

authors： Iden KR,Engedal K,Hjorleifsson S,Ruths S

更新日期：2014-01-01 00:00:00

abstract：:Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...

journal_title：Dementia and geriatric cognitive disorders

authors： Perry RJ,Hodges JR

更新日期：2000-11-01 00:00:00

abstract：AIMS:Limited research has been done on the functional connectivity in visuoperceptual regions in dementia with Lewy bodies (DLB) patients. This study aimed to investigate the functional connectivity differences between a task condition and an inter-task resting state condition within a visuoperceptual paradigm, in DLB ...

journal_title：Dementia and geriatric cognitive disorders

authors： Chabran E,Roquet D,Gounot D,Sourty M,Armspach JP,Blanc F

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early ...

journal_title：Dementia and geriatric cognitive disorders

authors： Missonnier P,Gold G,Herrmann FR,Fazio-Costa L,Michel JP,Deiber MP,Michon A,Giannakopoulos P

更新日期：2006-01-01 00:00:00

abstract：:We compared the intact alpha7 nicotinic acetylcholine receptor (alpha7nAChR) protein levels in the peripheral blood leukocytes in 15 Alzheimer's disease (AD) patients and 13 normal elderly control subjects. Demographic data and Mini-Mental State Examination (MMSE) scores were obtained. Western blot analysis for alpha7...

journal_title：Dementia and geriatric cognitive disorders

authors： Chu LW,Ma ES,Lam KK,Chan MF,Lee DH

更新日期：2005-01-01 00:00:00

abstract：AIM:To analyze the relationship between periventricular (PV) and subcortical (SC) white matter lesions (WML) and cognitive function in patients with memory impairment. METHODS:In total, 253 patients with Global Deterioration Scale scores >or=3 who had been referred to a university-based memory unit due to memory compl...

journal_title：Dementia and geriatric cognitive disorders

authors： Stenset V,Hofoss D,Berstad AE,Negaard A,Gjerstad L,Fladby T

更新日期：2008-01-01 00:00:00