Characterisation of "Positive" Behaviours in Primary Progressive Aphasias.

abstract：:Metrifonate, through its pharmacologically active metabolite 2,2-dichlorovinyl dimethylphosphate (DDVP), is a long-acting cholinesterase inhibitor for the symptomatic treatment of mild-to-moderate Alzheimer's disease. Clinical studies with Alzheimer patients have demonstrated the favourable safety and tolerability pro...

journal_title：Dementia and geriatric cognitive disorders

authors： Schmidt BH,Heinig R

更新日期：1998-01-01 00:00:00

abstract：:The present study investigated the accuracy of an extended version of the Delayed Word Recall (DWR) test in distinguishing patients with very mild Alzheimer's disease (AD) (Mini Mental State Examination score > or = 23) from community-dwelling depressed/dysthymic patients. The DWR test was administered to 26 non-depre...

journal_title：Dementia and geriatric cognitive disorders

authors： Coen RF,Kirby M,Swanwick GR,Maguire CP,Walsh JB,Coakley D,O'Neill D,Lawlor BA

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:To study undiagnosed diseases in older people with and without dementia. DESIGN:Cross-sectional population-based study in Lieto, southwestern Finland. PARTICIPANTS:All the inhabitants aged 64 and more in Lieto. Participation rate was 82% (n = 1,260). MEASUREMENTS:Dementia and its subtypes were diagnosed ac...

journal_title：Dementia and geriatric cognitive disorders

authors： Löppönen MK,Isoaho RE,Räihä IJ,Vahlberg TJ,Loikas SM,Takala TI,Puolijoki H,Irjala KM,Kivelä SL

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer's disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity. METHODS:A literature review and meta-analysis were conducted to estimate the prevalence of APOE4 by geographic area among AD patients. RESULT...

journal_title：Dementia and geriatric cognitive disorders

authors： Crean S,Ward A,Mercaldi CJ,Collins JM,Cook MN,Baker NL,Arrighi HM

更新日期：2011-01-01 00:00:00

abstract：:The membrane-bound glycoprotein, amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). The present paper investigates the neuritogenic-neurotoxic properties of this protein and relates them to possible aetiopathological mechanisms in AD. Marked differences in neuritic differentiation were ...

journal_title：Dementia and geriatric cognitive disorders

authors： Neill D,Hughes D,Leake A,Morris C,Jones D,Oakley A,Edwardson J,Estibeiro P

更新日期：2001-01-01 00:00:00

abstract：:In epidemiological, cross-sectional studies, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) prevented to a large extent the development of Alzheimer's disease (AD), but the results of randomized, placebo-controlled studies, focused on statin therapy in patients with ischemic heart ...

journal_title：Dementia and geriatric cognitive disorders

authors： Algotsson A,Winblad B

更新日期：2004-01-01 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) usually presents with clinical and neuroimaging findings consistent with single or multiple intracranial mass lesions. On cranial magnetic resonance imaging (MRI), such lesions are nearly always contrast enhancing, reflecting disruption of the blood-brain barrier at the ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bakshi R,Mazziotta JC,Mischel PS,Jahan R,Seligson DB,Vinters HV

更新日期：1999-03-01 00:00:00

abstract：:We screened for tau gene mutations among 24 Japanese (6 familial and 18 sporadic cases) and 4 Polish patients with frontotemporal dementia (FTD) using PCR-SSCP analysis followed by DNA sequencing. We identified 2 missense mutations in exon 10: N279K and P301L in 2 Japanese patients with familial FTD. Additionally 3 DN...

journal_title：Dementia and geriatric cognitive disorders

authors： Kowalska A,Asada T,Arima K,Kumakiri C,Kozubski W,Takahashi K,Tabira T

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Lacunar stroke (L) is the most common stroke subtype associated with vascular dementia (VaD-L). OBJECTIVE:To evaluate the cognitive and behavioral course in patients with probable VaD-L. METHODS:We longitudinally measured rates of change on MMSE, digit span, logical memory, Controlled Oral Word Association...

journal_title：Dementia and geriatric cognitive disorders

authors： Aharon-Peretz J,Daskovski E,Mashiach T,Kliot D,Tomer R

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Attention deficits are at the core of the defects in neuropsychological performance which define both dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Most studies have used separate tasks to test different attention abilities in patients with these diagnoses, precluding the assessment of any in...

journal_title：Dementia and geriatric cognitive disorders

authors： Fuentes LJ,Fernández PJ,Campoy G,Antequera MM,García-Sevilla J,Antúnez C

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:We have previously reported the results of an extended genome-wide scan of Swedish Alzheimer disease (AD)-affected families; in this paper, we analyzed a subset of these families with autopsy-confirmed AD. METHODS:We report the fine-mapping, using both microsatellite markers and single-nucleotide polym...

journal_title：Dementia and geriatric cognitive disorders

authors： Sillén A,Brohede J,Forsell C,Lilius L,Andrade J,Odeberg J,Kimura T,Winblad B,Graff C

更新日期：2011-01-01 00:00:00

abstract：:We compared the intact alpha7 nicotinic acetylcholine receptor (alpha7nAChR) protein levels in the peripheral blood leukocytes in 15 Alzheimer's disease (AD) patients and 13 normal elderly control subjects. Demographic data and Mini-Mental State Examination (MMSE) scores were obtained. Western blot analysis for alpha7...

journal_title：Dementia and geriatric cognitive disorders

authors： Chu LW,Ma ES,Lam KK,Chan MF,Lee DH

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Both personality changes and behavioural and psychological symptoms (BPS) may be associated with mild cognitive impairment (MCI) in later life and help identify incipient dementia. We wished to investigate the links between personality and BPS in MCI. METHOD:We studied premorbid personality traits ...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez Rubio M,Antonietti JP,Donati A,Rossier J,von Gunten A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In...

journal_title：Dementia and geriatric cognitive disorders

authors： Fujimi K,Noda K,Sasaki K,Wakisaka Y,Tanizaki Y,Iida M,Kiyohara Y,Kanba S,Iwaki T

更新日期：2007-01-01 00:00:00

abstract：:Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...

journal_title：Dementia and geriatric cognitive disorders

authors： Perry RJ,Hodges JR

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIMS:Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cogni...

journal_title：Dementia and geriatric cognitive disorders

authors： Rinehardt E,Eichstaedt K,Schinka JA,Loewenstein DA,Mattingly M,Fils J,Duara R,Schoenberg MR

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; as such, it has been associated with dementia. Studies in Latin-American older adults showing this association are scarce. This study aimed to evaluate the relationship between GS and d...

journal_title：Dementia and geriatric cognitive disorders

authors： Garcia-Cifuentes E,Márquez I,Vasquez D,Aguillon D,Borda MG,Lopera F,Cano-Gutierrez C

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...

journal_title：Dementia and geriatric cognitive disorders

authors： Montreuil S,Poulin E,Bergeron D,Sellami L,Verret L,Fortin MP,Poulin S,Macoir J,Hudon C,Bouchard RW,Lavoie M,Laforce R

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Memantine is a moderate affinity N-methyl-D-aspartate receptor antagonist approved for treatment of Alzheimer's disease (AD). In AD, tau is abnormally hyperphosphorylated. However, no significant changes of phosphorylated tau levels in CSF are found at follow-up in studies with AD patients. It has been shown...

journal_title：Dementia and geriatric cognitive disorders

authors： Degerman Gunnarsson M,Kilander L,Basun H,Lannfelt L

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We ai...

journal_title：Dementia and geriatric cognitive disorders

authors： Martin E,Velayudhan L

更新日期：2020-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is often misdiagnosed as Alzheimer's disease (AD). We hypothesized that the first symptoms associated with FTD would be different from those seen in AD and that the first symptoms in FTD would reflect loss of function in the frontal region with the greatest degree of degeneration. The obj...

journal_title：Dementia and geriatric cognitive disorders

authors： Lindau M,Almkvist O,Kushi J,Boone K,Johansson SE,Wahlund LO,Cummings JL,Miller BL

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Predominant and progressive complex visual disorders are often due to posterior cortical atrophy (PCA), a rare early-onset dementing syndrome presenting with visual complaints. In clinicopathological studies, PCA is most commonly considered a form of Alzheimer's disease (AD); no prior study has evaluated cli...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez MF,Ghajarania M,Perryman KM

更新日期：2002-01-01 00:00:00

abstract：:In 21 patients suffering from Binswanger's disease (BD) and in 53 patients suffering from Alzheimer's disease, we measured cerebrospinal fluid (CSF) concentrations of somatostatin-like immunoreactivity (SLI), high molecular weight form somatostatin (HMV-SST), somatostatin-25/28 (SST-25/28), somatostatin-14 (SST-14), D...

journal_title：Dementia and geriatric cognitive disorders

authors： Strittmatter M,Hamann GF,Grauer MT,Cramer H,Schimrigk K

更新日期：1997-01-01 00:00:00

abstract：:Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD) and has also been implicated in cardiovascular disease, cognitive decline and cognitive changes in healthy ageing. The aim of this paper is to systematically review and critically assess the association between the APOE ge...

journal_title：Dementia and geriatric cognitive disorders

authors： Cherbuin N,Leach LS,Christensen H,Anstey KJ

更新日期：2007-01-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is regarded as a precursor to dementia, but not all patients with MCI develop dementia. We followed up 165 elderly outpatients with MCI for a mean of 3 years. The aims were (1) to investigate the risk of conversion to dementia for different MCI subtypes diagnosed according to standardiz...

journal_title：Dementia and geriatric cognitive disorders

authors： Ravaglia G,Forti P,Maioli F,Martelli M,Servadei L,Brunetti N,Pantieri G,Mariani E

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:Conversion rates to dementia are known to be high for patients with mild cognitive impairment (MCI), but the diagnosis of MCI is very time-consuming. Since the Clock Drawing Test (CDT) is quick to administer, it will be of interest to compare the predictive validity of the CDT and of an MCI diagnosis fo...

journal_title：Dementia and geriatric cognitive disorders

authors： Ehreke L,Luppa M,König HH,Villringer A,Riedel-Heller SG

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Depressive symptoms are commonly observed in Alzheimer's disease (AD). The underlying mechanisms of depressive symptoms in AD remain unclear; frontolimbic circuitry dysfunction may play a role. We aimed to investigate the microstructural integrity of frontolimbic connectivity of specific fiber tracts in...

journal_title：Dementia and geriatric cognitive disorders

authors： Zhu Q,Lin M,Bi S,Ni Z,Zhao J,Chen B,Fan G,Shang X

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress. BACKGROUND:FTLD is a progressive neurodegenerative disease associated with behavioral disturbances. Group studies have related these behaviors to volume loss on ...

journal_title：Dementia and geriatric cognitive disorders

authors： Massimo L,Powers C,Moore P,Vesely L,Avants B,Gee J,Libon DJ,Grossman M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two common forms of primary neurodegenerative dementia. Mutations in 3 genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset AD. METHODS:We performed gene sequencing in PSEN1, PSEN2, and APP in 61 AD and 35 FTD Chinese ...

journal_title：Dementia and geriatric cognitive disorders

authors： Shi Z,Wang Y,Liu S,Liu M,Liu S,Zhou Y,Wang J,Cai L,Huo YR,Gao S,Ji Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder with a strong genetic background. It has been reported that modifiable factors, i.e. education (E), might act as proxies for reserve capacity. OBJECTIVE:To evaluate the impact of genetic background (positive family history,...

journal_title：Dementia and geriatric cognitive disorders

authors： Premi E,Garibotto V,Alberici A,Paghera B,Giubbini R,Padovani A,Borroni B

更新日期：2012-01-01 00:00:00