Cerebellar dentate nucleus in Alzheimer's disease with myoclonus.

abstract：:To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer's disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a neuronal loss and ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tao Z,Van Gool D,Lammens M,Dom R

更新日期：1999-11-01 00:00:00

abstract：:We have previously reported that epidermal growth factor receptor (EGFR) was expressed on vascular endothelial cells from postmortem specimens of demented but not cognitively normal subjects. In the present study, we examined skin biopsies from 35 living patients who were either normal or had a clinical diagnosis of p...

journal_title：Dementia and geriatric cognitive disorders

authors： Styren SD,Styren GC,DeKosky ST

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS:We included 159 pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Biesbroek JM,Leemans A,den Bakker H,Duering M,Gesierich B,Koek HL,van den Berg E,Postma A,Biessels GJ

更新日期：2017-01-01 00:00:00

abstract：:There is growing evidence for a role of apoptosis in Alzheimer's disease (AD). Recent findings suggest an increased susceptibility of lymphocytes to apoptosis in AD. To prove the hypothesis of systemic alterations in the apoptotic balance in AD, serum and cerebrospinal fluid levels of soluble CD95, which is known to m...

journal_title：Dementia and geriatric cognitive disorders

authors： Richartz E,Noda S,Schott K,Günthner A,Lewczuk P,Bartels M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate whether dementia patients prescribed antipsychotic drugs have a higher mortality compared to unexposed patients, and to investigate whether there are differences in mortality associated with exposure to conventional versus atypical antipsychotic drugs. METHODS:Retrospective population cohor...

journal_title：Dementia and geriatric cognitive disorders

authors： Musicco M,Palmer K,Russo A,Caltagirone C,Adorni F,Pettenati C,Bisanti L

更新日期：2011-01-01 00:00:00

abstract：:The membrane-bound glycoprotein, amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). The present paper investigates the neuritogenic-neurotoxic properties of this protein and relates them to possible aetiopathological mechanisms in AD. Marked differences in neuritic differentiation were ...

journal_title：Dementia and geriatric cognitive disorders

authors： Neill D,Hughes D,Leake A,Morris C,Jones D,Oakley A,Edwardson J,Estibeiro P

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIMS:Since detection of the prion protein gene (PRNP) more than 30 mutations have been discovered. Some have only been found in single case reports without known intrafamilial accumulation or neuropathological proof so that the causal connection between mutation and disease could not be proved. Those patient...

journal_title：Dementia and geriatric cognitive disorders

authors： Schelzke G,Stoeck K,Eigenbrod S,Grasbon-Frodl E,Raddatz LM,Ponto C,Kretzschmar HA,Zerr I

更新日期：2013-01-01 00:00:00

abstract：:This cross-sectional study aimed at determining the clinical and structural brain magnetic resonance imaging correlates of mild cognitive impairment (MCI). The data presented here are from the first wave of the longitudinal Personality and Total Health through Life 60+ project. 2,551 community-dwelling individuals in ...

journal_title：Dementia and geriatric cognitive disorders

authors： Kumar R,Parslow RA,Jorm AF,Rosenman SJ,Maller J,Meslin C,Anstey KJ,Christensen H,Sachdev PS

更新日期：2006-01-01 00:00:00

abstract：AIMS:To investigate the effects of rivastigmine capsule 3-12 mg/day over 24 weeks on activities of daily living (ADLs) in patients with dementia associated with Parkinson's disease (PDD). METHODS:Post hocanalysis of a prospective, multicenter, randomized, double-blind, placebo-controlled trial in patients with PDD (>o...

journal_title：Dementia and geriatric cognitive disorders

authors： Olin JT,Aarsland D,Meng X

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Alzheimer's disease patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD); a genetic component to the development of BPSD has been demonstrated. Genetic risk factors for other psychiatric disorders have been implicated in BPSD; however, this is the first known investiga...

journal_title：Dementia and geriatric cognitive disorders

authors： Pritchard AL,Pritchard CW,Bentham P,Lendon CL

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The apolipoprotein E (APOE) e4 genetic polymorphism is a major risk factor for Alzheimer' s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. METHODS:We used linear regression models to assess associations of APOE e4 with cognitive performance in a populati...

journal_title：Dementia and geriatric cognitive disorders

authors： Perna L,Mons U,Rujescu D,Kliegel M,Brenner H

更新日期：2016-01-01 00:00:00

abstract：:In epidemiological, cross-sectional studies, treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) prevented to a large extent the development of Alzheimer's disease (AD), but the results of randomized, placebo-controlled studies, focused on statin therapy in patients with ischemic heart ...

journal_title：Dementia and geriatric cognitive disorders

authors： Algotsson A,Winblad B

更新日期：2004-01-01 00:00:00

abstract：:Seventeen patients with probable Alzheimer's disease (AD), 7 patients with frontal lobe dementia (FLD) and 19 control subjects (NOR) were examined by (99m)Tc-d,l- hexamethylpropylene amine oxime ((99m)Tc-HMPAO) SPECT. Images were standardised in the same 3D space and averaged within each group. After normalisation, th...

journal_title：Dementia and geriatric cognitive disorders

authors： Pagani M,Salmaso D,Ramström C,Jonsson C,Lundqvist R,Thurfjell L,Schnell PO,Wägner A,Jacobsson H,Larsson SA

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:The study was designed to determine the acceptability, feasibility and validity of measuring quality of life in a representative sample of dementia patients with a generic instrument, the Duke Health Profile. METHOD:The French version of the Duke Health Profile was administered to 148 subjects with a mental ...

journal_title：Dementia and geriatric cognitive disorders

authors： Novella J,Ankri J,Morrone I,Guillemin F,Jolly D,Jochum C,Ploton L,Blanchard F

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:The Baylor Profound Mental Status Examination (BPMSE) was modeled to provide a brief patient-derived rating scale for staging and tracking patients with severe stages of Alzheimer's disease (AD). METHODS:The BPMSE was administered to 91 patients with probable AD (Korean version of the MMSE less than 16) acc...

journal_title：Dementia and geriatric cognitive disorders

authors： Na HR,Lee SH,Lee JS,Doody RS,Kim SY

更新日期：2009-01-01 00:00:00

abstract：:The amygdala is severely atrophied at post-mortem in frontotemporal lobar degeneration (FTLD), and may contribute to the prominent behavioural changes that are early features of FTLD. The aim of this study was to assess amygdala atrophy using MRI in the main syndromic variants of FTLD and Alzheimer's disease (AD). Bra...

journal_title：Dementia and geriatric cognitive disorders

authors： Whitwell JL,Sampson EL,Watt HC,Harvey RJ,Rossor MN,Fox NC

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To examine the influence of cognitive impairment on the functional outcomes and complication rates of patients with hip fracture during in-patient treatment. METHODS:A total of 402 patients who were surgically treated for hip fractures were consecutively enrolled at a single trauma center. The patients were ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bliemel C,Lechler P,Oberkircher L,Colcuc C,Balzer-Geldsetzer M,Dodel R,Ruchholtz S,Buecking B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Studies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias. METHODS:For 358 nursing home residents, serum lipids were studied at admission and diagnoses established at autopsy...

journal_title：Dementia and geriatric cognitive disorders

authors： Lesser GT,Haroutunian V,Purohit DP,Schnaider Beeri M,Schmeidler J,Honkanen L,Neufeld R,Libow LS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. METHODS:This prospective inception cohort included 37...

journal_title：Dementia and geriatric cognitive disorders

authors： van Dam R,Van Ancum JM,Verlaan S,Scheerman K,Meskers CGM,Maier AB

更新日期：2018-01-01 00:00:00

abstract：:To elucidate the influence of the alpha1-antichymotrypsin (ACT) polymorphism on Alzheimer-type neuropathological changes and the development of sporadic Alzheimer's disease (AD), we studied the relationship between the ACT polymorphism and the severity of Alzheimer-type neuropathological changes in the brains from AD ...

journal_title：Dementia and geriatric cognitive disorders

authors： Sodeyama N,Yamada M,Itoh Y,Suematsu N,Matsushita M,Otomo E,Mizusawa H

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early ...

journal_title：Dementia and geriatric cognitive disorders

authors： Missonnier P,Gold G,Herrmann FR,Fazio-Costa L,Michel JP,Deiber MP,Michon A,Giannakopoulos P

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS:We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method...

journal_title：Dementia and geriatric cognitive disorders

authors： Hanyu H,Sato T,Akai T,Shimizu S,Hirao K,Kanetaka H,Iwamoto T,Koizumi K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Both personality changes and behavioural and psychological symptoms (BPS) may be associated with mild cognitive impairment (MCI) in later life and help identify incipient dementia. We wished to investigate the links between personality and BPS in MCI. METHOD:We studied premorbid personality traits ...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez Rubio M,Antonietti JP,Donati A,Rossier J,von Gunten A

更新日期：2013-01-01 00:00:00

abstract：:Alcoholics often develop personality and behavioural changes, social and personal neglect, confabulation, lack of insight, empathy and emotional control. Such symptoms would increase the risk of engagement in and exposure to acts of violence and criminal activities carrying a risk of physical damage including head tra...

journal_title：Dementia and geriatric cognitive disorders

authors： Brun A,Andersson J

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress. BACKGROUND:FTLD is a progressive neurodegenerative disease associated with behavioral disturbances. Group studies have related these behaviors to volume loss on ...

journal_title：Dementia and geriatric cognitive disorders

authors： Massimo L,Powers C,Moore P,Vesely L,Avants B,Gee J,Libon DJ,Grossman M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF). METHODS:In 58 patients with HF neuropsychological assessment was performed including tests of mental spee...

journal_title：Dementia and geriatric cognitive disorders

authors： Vogels RL,Oosterman JM,van Harten B,Gouw AA,Schroeder-Tanka JM,Scheltens P,van der Flier WM,Weinstein HC

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. METHODS:Hip surgery patients aged 60 years or over (n = 200) underwent preoperative and daily postoperative assessment of their cognitive status ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bickel H,Gradinger R,Kochs E,Förstl H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:The prevalence of mild cognitive impairment (MCI) and its subtypes among Chinese older adults, and the contribution of vascular risk factors (VRF) and vascular disorders to MCI remain unclear. This study aims to investigate the prevalence of MCI and its different subtypes, and clarify the role of VRF an...

journal_title：Dementia and geriatric cognitive disorders

authors： Ma F,Wu T,Zhao J,Ji L,Song A,Zhang M,Huang G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS:The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether basel...

journal_title：Dementia and geriatric cognitive disorders

authors： Woolf C,Slavin MJ,Draper B,Thomassen F,Kochan NA,Reppermund S,Crawford JD,Trollor JN,Brodaty H,Sachdev PS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS:Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoi...

journal_title：Dementia and geriatric cognitive disorders

authors： Lukaschek K,von Schacky C,Kruse J,Ladwig KH

更新日期：2016-01-01 00:00:00