Abstract:
BACKGROUND:Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. METHODS:Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests assessing caregiver burden, functionality and cognition according to blood pressure (BP) variations and APOE haplotypes, while also taking into account differential effects of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, β-blockers, calcium channel blockers, diuretics, or no antihypertensive medication on score changes. The diagnosis and treatment of arterial hypertension followed the JNC 7 report. RESULTS:Variations in systolic BP (-11.76 ± 17.1 mm Hg), diastolic BP (-4.92 ± 10.3 mm Hg) and pulse pressure (-6.84 ± 12.6 mm Hg) were significant after 1 year (n = 191; x03C1; < 0.01). For APOE4+ carriers, rises in systolic or diastolic BP improved Clinical Dementia Rating Scale Sum of Boxes scores (x03C1; < 0.04), with marginally significant improvements in Mini-Mental State Examination scores resulting from risen systolic (x03C1; = 0.069) or diastolic BP (x03C1; = 0.079), and in basic independence only regarding risen diastolic BP (x03C1; = 0.055). APOE4- carriers resisted any functional or cognitive effects of BP variations. No differences were found regarding any antihypertensive class for variations in BP or any test scores, regardless of APOE haplotypes. CONCLUSIONS:Targeting mild BP elevations brings better functional and cognitive results for APOE4+ carriers with AD.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
de Oliveira FF,Chen ES,Smith MC,Bertolucci PHdoi
10.1159/000447585subject
Has Abstractpub_date
2016-01-01 00:00:00pages
314-23issue
5-6eissn
1420-8008issn
1421-9824pii
000447585journal_volume
41pub_type
杂志文章abstract:BACKGROUND:There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elder...
journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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更新日期:2004-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000093478
更新日期:2006-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000119594
更新日期:2008-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000094974
更新日期:2006-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000356726
更新日期:2014-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000454802
更新日期:2017-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
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更新日期:2013-01-01 00:00:00