Hippocampal sclerosis and ubiquitin-positive inclusions in dementia lacking distinctive histopathology.

abstract：AIMS:To describe central nervous system (CNS) drug consumption patterns depending on the time to diagnosis of Alzheimer's disease (AD), and to check whether the cases diagnosed later are associated with greater severity and consuming more CNS drugs. METHODS:Cross-sectional study using 952 cases of the Registry of Deme...

journal_title：Dementia and geriatric cognitive disorders

authors： Calvó-Perxas L,López-Pousa S,Vilalta-Franch J,Turró-Garriga O,Blankenburg M,Febrer L,Flaqué M,Vallmajó N,Aguirregomozcorta M,Genís D,Casas I,Perkal H,Coromina J,Garre-Olmo J,Registry of Dementias of Girona Study Group.

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate the possible association of regional cerebral perfusion and sleep loss in Alzheimer's disease (AD). METHODS:55 AD patients were characterized as having (SL) or not having (NSL) nocturnal sleep loss based on standard AD scales assessing sleep over the previous 4 weeks. (9...

journal_title：Dementia and geriatric cognitive disorders

authors： Ismail Z,Herrmann N,Francis PL,Rothenburg LS,Lobaugh NJ,Leibovitch FS,Black SE,Lanctôt KL

更新日期：2009-01-01 00:00:00

abstract：:We have previously reported that epidermal growth factor receptor (EGFR) was expressed on vascular endothelial cells from postmortem specimens of demented but not cognitively normal subjects. In the present study, we examined skin biopsies from 35 living patients who were either normal or had a clinical diagnosis of p...

journal_title：Dementia and geriatric cognitive disorders

authors： Styren SD,Styren GC,DeKosky ST

更新日期：1998-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is often misdiagnosed as Alzheimer's disease (AD). We hypothesized that the first symptoms associated with FTD would be different from those seen in AD and that the first symptoms in FTD would reflect loss of function in the frontal region with the greatest degree of degeneration. The obj...

journal_title：Dementia and geriatric cognitive disorders

authors： Lindau M,Almkvist O,Kushi J,Boone K,Johansson SE,Wahlund LO,Cummings JL,Miller BL

更新日期：2000-09-01 00:00:00

abstract：:Central cholinergic circuits of human brain can be tested non-invasively by coupling electrical peripheral stimulation with transcranial magnetic stimulation (TMS) of the motor cortex. The short-latency afferent inhibition (SAI) is reduced in cholinergic forms of dementia, such as Alzheimer disease (AD) and dementia w...

journal_title：Dementia and geriatric cognitive disorders

authors： Nardone R,Golaszewski S,Ladurner G,Tezzon F,Trinka E

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer's disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity. METHODS:A literature review and meta-analysis were conducted to estimate the prevalence of APOE4 by geographic area among AD patients. RESULT...

journal_title：Dementia and geriatric cognitive disorders

authors： Crean S,Ward A,Mercaldi CJ,Collins JM,Cook MN,Baker NL,Arrighi HM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The preclinical patterns of biological markers for Alzheimer's disease (AD) in vivo need further exploration. The aim of this study was therefore to investigate CSF biomarkers, regional cerebral blood flow (rCBF) and cognitive performance in cognitively healthy older individuals. METHOD:Within a 2-week peri...

journal_title：Dementia and geriatric cognitive disorders

authors： Stomrud E,Forsberg A,Hägerström D,Ryding E,Blennow K,Zetterberg H,Minthon L,Hansson O,Londos E

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To investigate the relationships between cognitive impairment and apathy in patients with early Huntington's disease (HD) and to further explore the influence of depression on the outcome of cognitive changes associated with apathy. METHODS:We included 36 early HD patients, among them 20 were apathetic (HDA)...

journal_title：Dementia and geriatric cognitive disorders

authors： Baudic S,Maison P,Dolbeau G,Boissé MF,Bartolomeo P,Dalla Barba G,Traykov L,Bachoud-Lévi AC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS:We included 159 pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Biesbroek JM,Leemans A,den Bakker H,Duering M,Gesierich B,Koek HL,van den Berg E,Postma A,Biessels GJ

更新日期：2017-01-01 00:00:00

abstract：:Antioxidants prevent oxidative stress that possibly causes neuronal loss in Alzheimer's disease (AD). We examined whether high plasma levels of the antioxidant vitamins A and E were associated with lower prevalence of AD or cognitive decline (CD). We performed a cross-sectional study within the Rotterdam Study. In an ...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelhart MJ,Ruitenberg A,Meijer J,Kiliaan A,van Swieten JC,Hofman A,Witteman JC,Breteler MM

更新日期：2005-01-01 00:00:00

abstract：:This intent-to-treat (ITT) analysis was performed to provide a realistic image of the efficacy that could be expected after 26 weeks treatment with a 120-mg dose (40 mg t.i.d.) of EGb 761 (EGb). The data were collected during a 52-week, double-blind, placebo-controlled, fixed dose, parallel-group, multicenter study. P...

journal_title：Dementia and geriatric cognitive disorders

authors： Le Bars PL,Kieser M,Itil KZ

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. METHODS:Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests as...

journal_title：Dementia and geriatric cognitive disorders

authors： de Oliveira FF,Chen ES,Smith MC,Bertolucci PH

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To detect the main factors associated with the occurrence of specific geriatric syndromes (namely pressure sores, fecal incontinence, urinary incontinence and falls) in elderly patients during hospitalization. DESIGN:Observational prospective study. SETTING:Eighty-one community and university hospitals thro...

journal_title：Dementia and geriatric cognitive disorders

authors： Mecocci P,von Strauss E,Cherubini A,Ercolani S,Mariani E,Senin U,Winblad B,Fratiglioni L

更新日期：2005-01-01 00:00:00

abstract：:The amygdala is severely atrophied at post-mortem in frontotemporal lobar degeneration (FTLD), and may contribute to the prominent behavioural changes that are early features of FTLD. The aim of this study was to assess amygdala atrophy using MRI in the main syndromic variants of FTLD and Alzheimer's disease (AD). Bra...

journal_title：Dementia and geriatric cognitive disorders

authors： Whitwell JL,Sampson EL,Watt HC,Harvey RJ,Rossor MN,Fox NC

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early ...

journal_title：Dementia and geriatric cognitive disorders

authors： Missonnier P,Gold G,Herrmann FR,Fazio-Costa L,Michel JP,Deiber MP,Michon A,Giannakopoulos P

更新日期：2006-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic muta...

journal_title：Dementia and geriatric cognitive disorders

authors： Ostojic J,Elfgren C,Passant U,Nilsson K,Gustafson L,Lannfelt L,Froelich Fabre S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In...

journal_title：Dementia and geriatric cognitive disorders

authors： Fujimi K,Noda K,Sasaki K,Wakisaka Y,Tanizaki Y,Iida M,Kiyohara Y,Kanba S,Iwaki T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. METHODS:Hip surgery patients aged 60 years or over (n = 200) underwent preoperative and daily postoperative assessment of their cognitive status ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bickel H,Gradinger R,Kochs E,Förstl H

更新日期：2008-01-01 00:00:00

abstract：:The current increase in aged individuals in number and proportion of the general population warrants dependable strategies to improve early detection of cognitive impairment. It was the goal of the present study to develop a triage for bedside testing and outpatient services. In a prospective clinical cohort study at ...

journal_title：Dementia and geriatric cognitive disorders

authors： Beinhoff U,Hilbert V,Bittner D,Gron G,Riepe MW

更新日期：2005-01-01 00:00:00

abstract：:Although myoclonus commonly occurs in a later stage of Alzheimer's disease (AD), the pathological basis of this symptom is still unclear. In order to elucidate the neuropathological substrate of myoclonus in AD, we quantitatively assessed neuronal density and volume, with a discrimination between small and large neuro...

journal_title：Dementia and geriatric cognitive disorders

authors： Fukutani Y,Cairns NJ,Everall IP,Chadwick A,Isaki K,Lantos PL

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND/AIMS:Although some patients with primary progressive aphasia (PPA) exhibit novel or improved skills after the onset of dementia, these changes have yet to be quantified. Therefore, this study systematically explored and identified the emergence of positive behaviours after dementia onset. METHODS:This study...

journal_title：Dementia and geriatric cognitive disorders

authors： Midorikawa A,Kumfor F,Leyton CE,Foxe D,Landin-Romero R,Hodges JR,Piguet O

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the influence of established genetic risk factors for Alzheimer's disease on the speed of disease progression. METHODS:Polymorphisms (in ACE, ApoE, BIN1, CLU, CR1, CST3, EXOC3L2, GWA14q32.13, IL8, LDLR, PICALM, TNK1) of 40 Alzheimer's disease patients from a longitudinal study were analyz...

journal_title：Dementia and geriatric cognitive disorders

authors： Schmidt C,Wolff M,von Ahsen N,Zerr I

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Memantine is a moderate affinity N-methyl-D-aspartate receptor antagonist approved for treatment of Alzheimer's disease (AD). In AD, tau is abnormally hyperphosphorylated. However, no significant changes of phosphorylated tau levels in CSF are found at follow-up in studies with AD patients. It has been shown...

journal_title：Dementia and geriatric cognitive disorders

authors： Degerman Gunnarsson M,Kilander L,Basun H,Lannfelt L

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:Elderly patients with dementia have a higher risk of falls and fractures as compared to cognitively intact elderly subjects. To investigate whether psychological distress of the caregiver might predispose older persons with Alzheimer disease (AD) to falls and fractures, we performed a prospective cohort...

journal_title：Dementia and geriatric cognitive disorders

authors： Maggio D,Ercolani S,Andreani S,Ruggiero C,Mariani E,Mangialasche F,Palmari N,Mecocci P

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress. BACKGROUND:FTLD is a progressive neurodegenerative disease associated with behavioral disturbances. Group studies have related these behaviors to volume loss on ...

journal_title：Dementia and geriatric cognitive disorders

authors： Massimo L,Powers C,Moore P,Vesely L,Avants B,Gee J,Libon DJ,Grossman M

更新日期：2009-01-01 00:00:00

abstract：:We compared the intact alpha7 nicotinic acetylcholine receptor (alpha7nAChR) protein levels in the peripheral blood leukocytes in 15 Alzheimer's disease (AD) patients and 13 normal elderly control subjects. Demographic data and Mini-Mental State Examination (MMSE) scores were obtained. Western blot analysis for alpha7...

journal_title：Dementia and geriatric cognitive disorders

authors： Chu LW,Ma ES,Lam KK,Chan MF,Lee DH

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. METHODS:Data were collected from the Erlangen Stroke Projec...

journal_title：Dementia and geriatric cognitive disorders

authors： Liman TG,Heuschmann PU,Endres M,Flöel A,Schwab S,Kolominsky-Rabas PL

更新日期：2011-01-01 00:00:00

abstract：:A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metapho...

journal_title：Dementia and geriatric cognitive disorders

authors： Nicosia F,Alberici A,Benussi L,Gasparini L,Ghidoni R,Mazzoli F,Zanetti O,Frisoni GB,Geroldi C,Binetti G

更新日期：2001-09-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is the second most prevalent dementia after Alzheimer's disease (AD). We compared 29 FTD and 90 AD caregivers with respect to burden, health-related quality of life (HQoL) and coping. FTD caregivers were more burdened than AD caregivers, and caregivers of patients who were demented for sh...

journal_title：Dementia and geriatric cognitive disorders

authors： Riedijk SR,De Vugt ME,Duivenvoorden HJ,Niermeijer MF,Van Swieten JC,Verhey FR,Tibben A

更新日期：2006-01-01 00:00:00

abstract：:To investigate the involvement of NADPH-diaphorase (NADPH-d)-containing neurons in Alzheimer's disease (AD), NADPH-d enzyme histochemistry in vibratome sections was applied to the superior frontal and superior temporal cortex and the neostriatum in 5 AD and 6 aged control brains. Overall there was a neuronal loss and ...

journal_title：Dementia and geriatric cognitive disorders

authors： Tao Z,Van Gool D,Lammens M,Dom R

更新日期：1999-11-01 00:00:00