Abstract:
BACKGROUND AND PURPOSE:Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. METHODS:Data were collected from the Erlangen Stroke Project, an ongoing population-based stroke registry. The Mini-Mental State Examination (MMSE) for assessing global cognitive function was used; CI was defined as an MMSE score <24. RESULTS:From February 1998 to January 2006, 630 patients with first-ever stroke were included. Prevalence rates of CI at 3 months, 1 and 3 years were 15, 13, and 12%. In multivariable analysis, stroke severity, i.e. Barthel index (p < 0.001), age (OR = 1.03; 95% CI = 1.00-1.05) and diabetes mellitus (OR = 2.03; 95% CI = 1.13-3.67) were associated with CI at 3 months. Recovery rate from CI at 3 months after stroke was found to be 31% over the following 3 years. Intact cognitive function rate was 71% over 3 years and inversely associated with age (OR = 0.96; 95% CI = 0.96-0.94) and stroke severity (p < 0.001). CONCLUSION:CI is frequent among stroke survivors and associated with age, stroke severity, and diabetes mellitus, but recovery occurs in approximately one third of the patients over the course of 3 years. Factors affecting intact cognitive function over time are increasing age and stroke severity.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Liman TG,Heuschmann PU,Endres M,Flöel A,Schwab S,Kolominsky-Rabas PLdoi
10.1159/000327358subject
Has Abstractpub_date
2011-01-01 00:00:00pages
291-9issue
4eissn
1420-8008issn
1421-9824pii
000327358journal_volume
31pub_type
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000080965
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017037
更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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journal_title:Dementia and geriatric cognitive disorders
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更新日期:2016-01-01 00:00:00
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更新日期:2001-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000494921
更新日期:2018-01-01 00:00:00
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doi:10.1159/000447056
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000091523
更新日期:2006-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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