当前位置： SCI文献检索 > DEMENTIA AND GERIATRIC COGNITIVE DISORDERS期刊下所有文献 > Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study.

Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study.

Abstract：

BACKGROUND:It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In addition, it has been suggested that alterations in the balance of polyunsaturated fatty acids are associated with brain dysfunctions such as neurodegerative pathologies of the aging brain. METHOD:To explore COX-2 expression in the hippocampus, we analyzed 45 consecutive autopsy subjects without dementia and 25 AD patients derived from the town of Hisayama, Japan. RESULTS:The neuronal expression of COX-2 in the CA3 subdivision of the hippocampus, subiculum, entorhinal cortex and transentorhinal cortex were consistently observed in both nondemented and AD brains, and COX-2 immunoreactivity correlated with age in nondemented brains. In AD patients, neurons of CA1 exhibited increased COX-2 immunoreactivity which correlated with the severity of AD pathology. This correlation was not apparent in nondemented subjects. CONCLUSION:These results suggest that COX-2 expression may be differentially regulated among subdivisions of the hippocampus and that elevated COX-2 expression in the CA1 of AD brains may be associated with AD pathology and thus cognitive dysfunction.

journal_name

Dement Geriatr Cogn Disord

journal_title

Dementia and geriatric cognitive disorders

authors

Fujimi K,Noda K,Sasaki K,Wakisaka Y,Tanizaki Y,Iida M,Kiyohara Y,Kanba S,Iwaki T

doi

10.1159/000101957

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

423-31

issue

6

eissn

1420-8008

issn

1421-9824

pii

000101957

journal_volume

23

pub_type

杂志文章

相关文献

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS文献大全
  • Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - a histopathological assessment.

    abstract：:To test the hypothesis that the cerebral amyloid angiopathy (CAA) of Alzheimer's disease (AD) is quantitatively associated with white matter lesions (WML), the brains of 63 demented patients exhibiting varying degrees of Alzheimer encephalopathy (AE) were examined, along with those of 10 nondemented control cases. The...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000063606

    authors： Haglund M,Englund E

    更新日期：2002-01-01 00:00:00

  • Ginkgo biloba compared with cholinesterase inhibitors in the treatment of dementia: a review based on meta-analyses by the cochrane collaboration.

    abstract：:Data were derived from the Cochrane Collaboration meta-analyses of the efficacies of ginkgo, donepezil, rivastigmine and galantamine on changes in cognitive function in patients with dementia and, where necessary, were transformed to standardized mean differences. The proportion of patients discontinuing trials was us...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章,meta分析

    doi：10.1159/000079388

    authors： Kurz A,Van Baelen B

    更新日期：2004-01-01 00:00:00

  • Personality traits and behavioural and psychological symptoms in patients with mild cognitive impairment.

    abstract：BACKGROUND AND AIMS:Both personality changes and behavioural and psychological symptoms (BPS) may be associated with mild cognitive impairment (MCI) in later life and help identify incipient dementia. We wished to investigate the links between personality and BPS in MCI. METHOD:We studied premorbid personality traits ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000346129

    authors： Mendez Rubio M,Antonietti JP,Donati A,Rossier J,von Gunten A

    更新日期：2013-01-01 00:00:00

  • High risk of cognitive and functional decline after postoperative delirium. A three-year prospective study.

    abstract：BACKGROUND/AIMS:The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. METHODS:Hip surgery patients aged 60 years or over (n = 200) underwent preoperative and daily postoperative assessment of their cognitive status ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000140804

    authors： Bickel H,Gradinger R,Kochs E,Förstl H

    更新日期：2008-01-01 00:00:00

  • Plasma homocysteine is elevated in elderly patients with memory complaints and vascular disease.

    abstract：BACKGROUND:There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elder...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000100927

    authors： Nilsson K,Gustafson L,Hultberg B

    更新日期：2007-01-01 00:00:00

  • Subtle attentional deficits in the absence of dementia are associated with an increased risk of post-operative delirium.

    abstract：BACKGROUND:Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS:Our hypothesis was that subtle pre-operative ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000101453

    authors： Lowery DP,Wesnes K,Ballard CG

    更新日期：2007-01-01 00:00:00

  • Clinical and neuroimaging characterization of Chinese dementia patients with PSEN1 and PSEN2 mutations.

    abstract：BACKGROUND:Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two common forms of primary neurodegenerative dementia. Mutations in 3 genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset AD. METHODS:We performed gene sequencing in PSEN1, PSEN2, and APP in 61 AD and 35 FTD Chinese ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000366272

    authors： Shi Z,Wang Y,Liu S,Liu M,Liu S,Zhou Y,Wang J,Cai L,Huo YR,Gao S,Ji Y

    更新日期：2015-01-01 00:00:00

  • Frontal assessment battery and brain perfusion imaging in early dementia.

    abstract：BACKGROUND/AIMS:The frontal assessment battery (FAB) is reported to be a useful tool for screening frontal function. However, the neural substrates involved remain to be elucidated. The aim of the present study was to identify the brain regions responsible for FAB performance in patients with early dementia. We sought ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000198687

    authors： Yoshida H,Terada S,Sato S,Kishimoto Y,Ata T,Ohshima E,Honda H,Ishihara T,Kuroda S

    更新日期：2009-01-01 00:00:00

  • Hippocampal sclerosis and ubiquitin-positive inclusions in dementia lacking distinctive histopathology.

    abstract：:The aim of this study was to determine the frequency of ubiquitin-positive inclusions (UPI) in dementia lacking distinctive histology (DLDH), and their relationship to other pathologic features, such as hippocampal sclerosis (HpScl), as well as genetic factors. Routine and immunohistochemical studies were carried out ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000077168

    authors： Josephs KA,Jones AG,Dickson DW

    更新日期：2004-01-01 00:00:00

  • Lack of association between an intronic polymorphism in the presenilin-1 gene and sporadic late-onset Alzheimer disease in Polish patients.

    abstract：:The apolipoprotein E (APOE) gene has in many studies been identified as a susceptibility factor in Alzheimer's disease (AD). The APOE association is rather strong, but other not yet identified genetic factors are assumed to be involved in the pathogenesis of AD. Recently an association between an intronic polymorphism...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000017037

    authors： Kowalska A,Wender M,Lannfelt L

    更新日期：1998-05-01 00:00:00

  • Interaction of the H63D mutation in the hemochromatosis gene with the apolipoprotein E epsilon 4 allele modulates age at onset of Alzheimer's disease.

    abstract：:The H63D mutation in the hemochromatosis gene (HFE) has recently been considered as a risk factor in Alzheimer's disease (AD) with advancing age at onset of the disease, independently of the apolipoprotein E (ApoE) epsilon4 allele effect. We examined the distribution of the H63D mutation and ApoE genotypes as a functi...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000068480

    authors： Combarros O,García-Román M,Fontalba A,Fernández-Luna JL,Llorca J,Infante J,Berciano J

    更新日期：2003-01-01 00:00:00

  • Microstructure of Strategic White Matter Tracts and Cognition in Memory Clinic Patients with Vascular Brain Injury.

    abstract：BACKGROUND:White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS:We included 159 pa...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000485376

    authors： Biesbroek JM,Leemans A,den Bakker H,Duering M,Gesierich B,Koek HL,van den Berg E,Postma A,Biessels GJ

    更新日期：2017-01-01 00:00:00

  • Perspectives in the management of Alzheimer's disease: clinical profile of donepezil.

    abstract：:Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer's disease (AD). It is highly selective for AChE in the central nervous system (CNS), with little or no affinity...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章,评审

    doi：10.1159/000051201

    authors： Rogers SL

    更新日期：1998-01-01 00:00:00

  • Presence of the apolipoprotein E type epsilon 4 allele is not associated with neurofibrillary pathology or biochemical changes to tau protein.

    abstract：:Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000106646

    authors： Mukaetova-Ladinska EB,Harrington CR,Roth M,Wischik CM

    更新日期：1997-09-01 00:00:00

  • Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS).

    abstract：BACKGROUND/AIMS:The aims of this study were to determine baseline factors related to the progression of subjective memory impairment (SMI) in elderly subjects and to develop a new modeling scale to predict progression. METHODS:Elderly subjects with SMI were recruited from the nationwide Clinical Research Centers for D...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000430807

    authors： Hong YJ,Yoon B,Shim YS,Kim SO,Kim HJ,Choi SH,Jeong JH,Yoon SJ,Yang DW,Lee JH

    更新日期：2015-01-01 00:00:00

  • NOPPAIN: a nursing assistant-administered pain assessment instrument for use in dementia.

    abstract：:The Non-Communicative Patient's Pain Assessment Instrument (NOPPAIN) is a nursing assistant-administered instrument for assessing pain behaviors in patients with dementia. This study investigated the validity of the NOPPAIN. Twenty-one nursing assistants (NAs) with no prior training in using the NOPPAIN watched six vi...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000076446

    authors： Snow AL,Weber JB,O'Malley KJ,Cody M,Beck C,Bruera E,Ashton C,Kunik ME

    更新日期：2004-01-01 00:00:00

  • The reliability and validity of the mini-mental state examination in the elderly Croatian population.

    abstract：AIM:The aim of this study was standardization and validation of the Mini-Mental State Examination (MMSE) in the general Croatian aging population. METHODS:Three-hundred and forty-four participants underwent the MMSE test, 217 cognitively healthy subjects without neurological and psychiatric disorders and 127 patients ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000339596

    authors： Boban M,Malojčić B,Mimica N,Vuković S,Zrilić I,Hof PR,Simić G

    更新日期：2012-01-01 00:00:00

  • Fast cognitive decline at the time of dementia diagnosis: a major prognostic factor for survival in the community.

    abstract：BACKGROUND/AIMS:Current findings suggest the existence of a category of fast cognitive decliners with a poorer prognosis but better treatment response. Our study aimed at confirming the concept of fast decliners at the time of Alzheimer's disease (AD) diagnosis which best predicts mortality, in an unselected sample. M...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000102017

    authors： Carcaillon L,Pérès K,Péré JJ,Helmer C,Orgogozo JM,Dartigues JF

    更新日期：2007-01-01 00:00:00

  • Experimental approaches to white matter disease.

    abstract：:The study of the cerebral white matter (WM) in experimental models of hypoxia and ischemia has been for a long time neglected, the interest of investigators being focused on the response of the neuronal population. The increasing frequency with which modern neuroimaging techniques disclose alterations of the WM of pos...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章,评审

    doi：10.1159/000051185

    authors： Pantoni L

    更新日期：1998-07-01 00:00:00

  • Lack of genetic associations of alpha-1-antichymotrypsin polymorphism with alzheimer-type neuropathological changes or sporadic Alzheimer's disease.

    abstract：:To elucidate the influence of the alpha1-antichymotrypsin (ACT) polymorphism on Alzheimer-type neuropathological changes and the development of sporadic Alzheimer's disease (AD), we studied the relationship between the ACT polymorphism and the severity of Alzheimer-type neuropathological changes in the brains from AD ...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000017123

    authors： Sodeyama N,Yamada M,Itoh Y,Suematsu N,Matsushita M,Otomo E,Mizusawa H

    更新日期：1999-05-01 00:00:00

  • Regional cerebral glucose metabolism in monozygotic twins discordant for Alzheimer's disease.

    abstract：:We investigated regional cerebral glucose metabolic rates (rCMRgluc) with positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in 7 monozygotic twin pairs discordant for Alzheimer's disease (AD). Ten healthy volunteers with comparable mean age and educational level served as controls. In the hippoc...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000072809

    authors： Järvenpää T,Räihä I,Kaprio J,Koskenvuo M,Laine M,Kurki T,Vahlberg T,Viljanen T,Ahonen K,Rinne JO

    更新日期：2003-01-01 00:00:00

  • Characterisation of "Positive" Behaviours in Primary Progressive Aphasias.

    abstract：BACKGROUND/AIMS:Although some patients with primary progressive aphasia (PPA) exhibit novel or improved skills after the onset of dementia, these changes have yet to be quantified. Therefore, this study systematically explored and identified the emergence of positive behaviours after dementia onset. METHODS:This study...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000478852

    authors： Midorikawa A,Kumfor F,Leyton CE,Foxe D,Landin-Romero R,Hodges JR,Piguet O

    更新日期：2017-01-01 00:00:00

  • Motor function in subjects with mild cognitive impairment and early Alzheimer's disease.

    abstract：:Basic mobility, balance, gait and dual-task performance were characterised in 140 consecutive subjects referred to a multidisciplinary university hospital in a geriatric setting for cognitive symptoms and possible dementia. After completion of an extensive diagnostic evaluation, subjects were classified into four diag...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000084555

    authors： Pettersson AF,Olsson E,Wahlund LO

    更新日期：2005-01-01 00:00:00

  • Development of the Cognitive Test for Severe Dementia.

    abstract：BACKGROUND/AIMS:Existing cognitive measures for moderate-to-severe dementia have shown floor effects and an inability to assess the remaining cognitive function, especially for profound dementia. METHODS:We constructed the Cognitive Test for Severe Dementia (CTSD), which consists of 13 items covering 7 cognitive domai...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000430089

    authors： Tanaka H,Nagata Y,Uematsu M,Takebayashi T,Hanada K,Inokawa M,Fukuhara K,Ogawa Y,Haga D,Kakegawa Y,Nishikawa T

    更新日期：2015-01-01 00:00:00

  • Influence of insulin-like growth factor-1 and hepatocyte growth factor on carotid atherosclerosis and cognitive function in the elderly.

    abstract：OBJECTIVE:This study investigated the relationship between serum levels of two neurotrophic factors, insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF), and carotid atherosclerosis and cognitive function in the elderly. METHODS:Serum levels of IGF-1 and HGF, carotid artery intima-media thickness (...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 临床试验,杂志文章

    doi：10.1159/000077812

    authors： Watanabe T,Yamamoto H,Idei T,Iguchi T,Katagiri T

    更新日期：2004-01-01 00:00:00

  • Determinants of the quality of life in Alzheimer's disease patients as assessed by the Japanese version of the Quality of Life-Alzheimer's disease scale.

    abstract：BACKGROUND:Although QOL is an important indicator to assess multiple facets of life, the QOL of Alzheimer's disease (AD) subjects with impaired cognitive ability due to dementia has not yet been fully investigated. In this study, we developed the Japanese version of the Quality of Life-Alzheimer's disease (QOL-AD) scal...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000090744

    authors： Matsui T,Nakaaki S,Murata Y,Sato J,Shinagawa Y,Tatsumi H,Furukawa TA

    更新日期：2006-01-01 00:00:00

  • Clinical validity of the Mattis Dementia Rating Scale in differentiating mild cognitive impairment in Parkinson's disease and normative data.

    abstract：BACKGROUND/AIMS:The aim of the present study was to provide normative data and determine the validity of the Czech version of the Mattis Dementia Rating Scale 2 (czDRS-2) in screening for mild cognitive impairment in Parkinson's disease (PD-MCI) based on the Movement Disorder Society (MDS) Level II criteria. METHODS:F...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000375365

    authors： Bezdicek O,Michalec J,Nikolai T,Havránková P,Roth J,Jech R,Růžička E

    更新日期：2015-01-01 00:00:00

  • Fate of patients with questionable (very mild) Alzheimer's disease: longitudinal profiles of individual subjects' decline.

    abstract：:Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 临床试验,杂志文章

    doi：10.1159/000017264

    authors： Perry RJ,Hodges JR

    更新日期：2000-11-01 00:00:00

  • Distinguishing between patients with depression or very mild Alzheimer's disease using the Delayed-Word-Recall test.

    abstract：:The present study investigated the accuracy of an extended version of the Delayed Word Recall (DWR) test in distinguishing patients with very mild Alzheimer's disease (AD) (Mini Mental State Examination score > or = 23) from community-dwelling depressed/dysthymic patients. The DWR test was administered to 26 non-depre...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 临床试验,杂志文章

    doi：10.1159/000106638

    authors： Coen RF,Kirby M,Swanwick GR,Maguire CP,Walsh JB,Coakley D,O'Neill D,Lawlor BA

    更新日期：1997-07-01 00:00:00

  • Neopterin: a potential biomarker for delirium in elderly patients.

    abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...

    journal_title：Dementia and geriatric cognitive disorders

    pub_type： 杂志文章

    doi：10.1159/000366410

    authors： Egberts A,Wijnbeld EH,Fekkes D,van der Ploeg MA,Ziere G,Hooijkaas H,van der Cammen TJ,Mattace-Raso FU

    更新日期：2015-01-01 00:00:00