Abstract:
BACKGROUND/AIMS:Current findings suggest the existence of a category of fast cognitive decliners with a poorer prognosis but better treatment response. Our study aimed at confirming the concept of fast decliners at the time of Alzheimer's disease (AD) diagnosis which best predicts mortality, in an unselected sample. METHODS:245 incident cases of AD were selected from the French longitudinal cohort PAQUID. We investigated a different threshold of cognitive decline [measured by the annual loss of points in the Mini Mental State Examination (MMSE) score] to define when a subject could be considered as a fast decliner. We used Cox proportional hazards models to study the relation between cognitive decline and mortality. RESULTS:The significant threshold of decline associated with a higher mortality rate was a loss of 3 points per year in the MMSE score. Among the 245 AD cases, 83 (33.9%) subjects were considered as fast decliners. Of them, 78.3% died during the follow-up compared with 63.0% of the slow decliners (RR = 1.7, 95% CI 1.2-2.5). CONCLUSION:These results constitute an empirical validation of the concept of fast decliners in community-based AD patients and justify the cutoff of 3 points for the definition of this condition.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Carcaillon L,Pérès K,Péré JJ,Helmer C,Orgogozo JM,Dartigues JFdoi
10.1159/000102017subject
Has Abstractpub_date
2007-01-01 00:00:00pages
439-45issue
6eissn
1420-8008issn
1421-9824pii
000102017journal_volume
23pub_type
杂志文章abstract::Alzheimer's disease (AD) is generally understood as primarily affecting cognition while sparing motor function, at least until the later stages of the disease. Studies reported over the past 10 years, however, have documented a prevalence of falls in AD patients significantly higher than in age-matched normal elders; ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
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journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000088249
更新日期:2005-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000315498
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000355427
更新日期:2014-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000071002
更新日期:2003-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000089251
更新日期:2006-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000192585
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To study undiagnosed diseases in older people with and without dementia. DESIGN:Cross-sectional population-based study in Lieto, southwestern Finland. PARTICIPANTS:All the inhabitants aged 64 and more in Lieto. Participation rate was 82% (n = 1,260). MEASUREMENTS:Dementia and its subtypes were diagnosed ac...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000080126
更新日期:2004-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
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doi:10.1159/000323317
更新日期:2011-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000510501
更新日期:2020-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000100927
更新日期:2007-01-01 00:00:00
abstract::To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially de...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000057698
更新日期:2002-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000106598
更新日期:1997-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000356726
更新日期:2014-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051222
更新日期:1999-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000323808
更新日期:2011-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000488671
更新日期:2018-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000086473
更新日期:2005-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000085068
更新日期:2005-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000058331
更新日期:2002-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000077168
更新日期:2004-01-01 00:00:00
abstract::Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD) and has also been implicated in cardiovascular disease, cognitive decline and cognitive changes in healthy ageing. The aim of this paper is to systematically review and critically assess the association between the APOE ge...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000109150
更新日期:2007-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000084400
更新日期:2005-01-01 00:00:00