Abstract:
:Thirty patients had mild cognitive impairment and increased homocysteine levels in serum. On average, they were supplemented orally with a high dose of a vitamin B12-B6-folate combination for 270 days. All patients had normal serum B12 and folate levels at baseline. Cerebrospinal fluid levels of the tau protein (CSF-tau) and the albumin ratio were measured before and after treatment. The serum homocysteine levels were normalised after treatment. The albumin ratio significantly correlated with vascular risk factors. At baseline, the ratio was higher in the patients in comparison with age-matched controls. After treatment, the ratio was significantly reduced, which may indicate a tightening of the blood-brain barrier. The CSF-tau levels did not change significantly although there was a numeric decline. None of the patients progressed into dementia during the treatment period. When treated with a vitamin B12-B6-folate combination, patients with mild cognitive impairment and hyperhomocysteinaemia appear to improve their blood-brain barrier function. They may also stabilise their cognitive status. Further investigations are warranted on the role of blood-brain barrier dysfunction in the pathogenesis of dementia.
journal_name
Dement Geriatr Cogn Disordjournal_title
Dementia and geriatric cognitive disordersauthors
Lehmann M,Regland B,Blennow K,Gottfries CGdoi
10.1159/000071002keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
145-50issue
3eissn
1420-8008issn
1421-9824pii
71002journal_volume
16pub_type
杂志文章abstract::In spite of the fact that delirium is a common and often severe cognitive disturbance in the elderly, quite few intervention studies are performed. Descriptive studies of variable quality are much more common. For example, in hip fracture patients delirium is a common complication and the cause of nursing problems tha...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000017181
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Memantine is a moderate affinity N-methyl-D-aspartate receptor antagonist approved for treatment of Alzheimer's disease (AD). In AD, tau is abnormally hyperphosphorylated. However, no significant changes of phosphorylated tau levels in CSF are found at follow-up in studies with AD patients. It has been shown...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000107099
更新日期:2007-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000017127
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to elucidate the relationship between Alzheimer's disease (AD) and the serotonin transporter gene (SLC6A4). METHODS:AD subjects (n = 43) and controls (n = 47) were recruited and evaluated. In leukocytes, we evaluated two polymorphisms in SLC6A4, the serotonin transporter length...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,meta分析
doi:10.1159/000447324
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:(1) To investigate the prevalence and characteristics of agitation in patients with Alzheimer's disease (AD) and other forms of dementia; (2) to explore the association between agitation and other clinical variables, including disease severity, functional impairment and other neuropsychiatric symptoms, and (...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000074080
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To study undiagnosed diseases in older people with and without dementia. DESIGN:Cross-sectional population-based study in Lieto, southwestern Finland. PARTICIPANTS:All the inhabitants aged 64 and more in Lieto. Participation rate was 82% (n = 1,260). MEASUREMENTS:Dementia and its subtypes were diagnosed ac...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000080126
更新日期:2004-01-01 00:00:00
abstract::In 21 patients suffering from Binswanger's disease (BD) and in 53 patients suffering from Alzheimer's disease, we measured cerebrospinal fluid (CSF) concentrations of somatostatin-like immunoreactivity (SLI), high molecular weight form somatostatin (HMV-SST), somatostatin-25/28 (SST-25/28), somatostatin-14 (SST-14), D...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000106598
更新日期:1997-01-01 00:00:00
abstract:AIM:The aims of the present study were to report on the psychometric properties of the Pain Assessment in Advanced Dementia (PAINAD) scale by comparing it with the gold standard method of self-reporting on a numerical rating scale (NRS), and to provide a categorical version of the PAINAD scale comparable with the verba...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000341582
更新日期:2012-01-01 00:00:00
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journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000017200
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND/AIMS:Alzheimer's disease patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD); a genetic component to the development of BPSD has been demonstrated. Genetic risk factors for other psychiatric disorders have been implicated in BPSD; however, this is the first known investiga...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000160958
更新日期:2008-01-01 00:00:00
abstract::We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion invol...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051222
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:To describe how dementia assessment could be organized in primary health care and how it works. METHODS:The project had two phases. In phase one 104 elderly patients were assessed by a local authority dementia team that used a standardized examination protocol, which enabled the family doctors to establish ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000345435
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000094974
更新日期:2006-01-01 00:00:00
abstract::We screened for tau gene mutations among 24 Japanese (6 familial and 18 sporadic cases) and 4 Polish patients with frontotemporal dementia (FTD) using PCR-SSCP analysis followed by DNA sequencing. We identified 2 missense mutations in exon 10: N279K and P301L in 2 Japanese patients with familial FTD. Additionally 3 DN...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000051285
更新日期:2001-11-01 00:00:00
abstract::Currently used criteria for the diagnosis of probable Alzheimer's disease requires the presence of cognitive deficit in addition to loss of episodic memory. The recent developments in drug treatments for Alzheimer's disease have highlighted the importance of early diagnosis and the need to characterise the cognitive p...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 临床试验,杂志文章
doi:10.1159/000017264
更新日期:2000-11-01 00:00:00
abstract::This paper reviews the history of the development of the American Psychiatric Association's Diagnostic and Statistical Manual (DSM) using the diagnostic category of delirium as an example. It also attempts to show how clinical practice and experience has molded the current conceptualization of delirium in DSM-IV. The ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 历史文章,杂志文章
doi:10.1159/000017171
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND/AIM:The objective was to examine cohort changes in cognitive function in 2 cohorts of centenarians born 10 years apart. METHODS:The Longitudinal Study of Danish Centenarians comprises all Danes reaching the age of 100 in the period April 1, 1995 through May 31, 1996. A total of 207 out of 276 persons partic...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000149819
更新日期:2008-01-01 00:00:00
abstract::Frontotemporal dementia (FTD) is the second most prevalent dementia after Alzheimer's disease (AD). We compared 29 FTD and 90 AD caregivers with respect to burden, health-related quality of life (HQoL) and coping. FTD caregivers were more burdened than AD caregivers, and caregivers of patients who were demented for sh...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000095750
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:Dementia cafés are becoming widespread as a new approach to dementia care, but their operational procedures and significance have not been adequately studied. METHODS:On-the-job training (OJT) for professionals planning to operate a dementia café in the future was conducted in a pioneering dementia caf...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000492174
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000510501
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE:To evaluate the recognition memory performance by u...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000452255
更新日期:2017-01-01 00:00:00
abstract:AIM:To determine the applicability and psychometric properties of the Italian version of the Disability Assessment of Dementia scale (DAD-I) in a community-residing population with early-stage Alzheimer's disease (AD). METHODS:The DAD-I was administered to the primary caregivers of 159 patients (mean age +/- SD 77.1 +...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000113415
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Because poor lung function may be a risk factor for cognitive decline, we aimed to test the association of respiratory function with cognitive function and dementia later in life, as well as potential effect modification by APOE epsilon4 carrier status. METHODS:In a prospective population-based cohort ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000255600
更新日期:2009-01-01 00:00:00
abstract::Alzheimer's disease (AD) is generally understood as primarily affecting cognition while sparing motor function, at least until the later stages of the disease. Studies reported over the past 10 years, however, have documented a prevalence of falls in AD patients significantly higher than in age-matched normal elders; ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000105126
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:Conversion rates to dementia are known to be high for patients with mild cognitive impairment (MCI), but the diagnosis of MCI is very time-consuming. Since the Clock Drawing Test (CDT) is quick to administer, it will be of interest to compare the predictive validity of the CDT and of an MCI diagnosis fo...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000323317
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. METHODS:One hundred Caucasian ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000356483
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:To characterize loss of basic activities of daily living (BADL) in 687 Alzheimer's disease (AD) community-dwelling patients included in the French REAL cohort. METHODS:Patients had mild to moderately severe AD, and the mean age was 77.8 years. Patterns of loss of the 6 BADL were described at inclusion ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000264632
更新日期:2010-01-01 00:00:00
abstract::Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000106646
更新日期:1997-09-01 00:00:00
abstract::To elucidate the influence of the alpha1-antichymotrypsin (ACT) polymorphism on Alzheimer-type neuropathological changes and the development of sporadic Alzheimer's disease (AD), we studied the relationship between the ACT polymorphism and the severity of Alzheimer-type neuropathological changes in the brains from AD ...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章
doi:10.1159/000017123
更新日期:1999-05-01 00:00:00
abstract::Psychosis is common in patients with Alzheimer's disease (AD) and contributes substantially to patient morbidity and caregiver distress. Antipsychotic medications are used to treat psychosis and other psychiatric or behavioral symptoms in AD, although optimal treatment guidelines have been elusive. Choosing the most a...
journal_title:Dementia and geriatric cognitive disorders
pub_type: 杂志文章,评审
doi:10.1159/000074279
更新日期:2004-01-01 00:00:00