当前位置： SCI文献检索 > DEMENTIA AND GERIATRIC COGNITIVE DISORDERS期刊下所有文献 > Ginkgo biloba compared with cholinesterase inhibitors in the treatment of dementia: a review based on meta-analyses by the cochrane collaboration.

Ginkgo biloba compared with cholinesterase inhibitors in the treatment of dementia: a review based on meta-analyses by the cochrane collaboration.

Abstract：

:Data were derived from the Cochrane Collaboration meta-analyses of the efficacies of ginkgo, donepezil, rivastigmine and galantamine on changes in cognitive function in patients with dementia and, where necessary, were transformed to standardized mean differences. The proportion of patients discontinuing trials was used as a proxy measure of tolerability. Outcomes were assessed after 6 months of treatment. Trial data for cholinesterase inhibitors were more consistent than those for ginkgo, particularly regarding patient populations and outcome measures. Significant benefits on cognition vs. placebo were seen with donepezil, 5 and 10 mg, rivastigmine, 6-12 mg, and galantamine, 16 and 24 mg. Significant benefit vs. placebo with ginkgo was seen only when all doses were pooled. Similar proportions of patients discontinued treatment with ginkgo and placebo. Cholinesterase inhibitors were also well tolerated, although a significantly greater proportion of patients receiving active treatment discontinued vs. placebo with some doses. An evidence-based medicine approach, taking into account the quality of clinical trials, is essential when assessing the safety and efficacy of medications.

journal_name

Dement Geriatr Cogn Disord

journal_title

Dementia and geriatric cognitive disorders

authors

Kurz A,Van Baelen B

doi

10.1159/000079388

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

217-26

issue

2

eissn

1420-8008

issn

1421-9824

pii

79388

journal_volume

18

pub_type

杂志文章,meta分析

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