Pathological correlates of white matter hyperintensities on magnetic resonance imaging.

abstract：BACKGROUND/AIMS:The frontal assessment battery (FAB) is reported to be a useful tool for screening frontal function. However, the neural substrates involved remain to be elucidated. The aim of the present study was to identify the brain regions responsible for FAB performance in patients with early dementia. We sought ...

journal_title：Dementia and geriatric cognitive disorders

authors： Yoshida H,Terada S,Sato S,Kishimoto Y,Ata T,Ohshima E,Honda H,Ishihara T,Kuroda S

更新日期：2009-01-01 00:00:00

abstract：:This cross-sectional study aimed at determining the clinical and structural brain magnetic resonance imaging correlates of mild cognitive impairment (MCI). The data presented here are from the first wave of the longitudinal Personality and Total Health through Life 60+ project. 2,551 community-dwelling individuals in ...

journal_title：Dementia and geriatric cognitive disorders

authors： Kumar R,Parslow RA,Jorm AF,Rosenman SJ,Maller J,Meslin C,Anstey KJ,Christensen H,Sachdev PS

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:Prior studies have shown that patients with dementia are at risk of receiving insufficient treatment for pain after a hip fracture. We therefore hypothesized that elderly hip fracture patients with dementia received less postoperative pain treatment than those without dementia. METHOD:All patients (age...

journal_title：Dementia and geriatric cognitive disorders

authors： Jensen-Dahm C,Palm H,Gasse C,Dahl JB,Waldemar G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. METHODS:One hundred Caucasian ...

journal_title：Dementia and geriatric cognitive disorders

authors： Annweiler C,Maby E,Meyerber M,Beauchet O

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Existing cognitive measures for moderate-to-severe dementia have shown floor effects and an inability to assess the remaining cognitive function, especially for profound dementia. METHODS:We constructed the Cognitive Test for Severe Dementia (CTSD), which consists of 13 items covering 7 cognitive domai...

journal_title：Dementia and geriatric cognitive disorders

authors： Tanaka H,Nagata Y,Uematsu M,Takebayashi T,Hanada K,Inokawa M,Fukuhara K,Ogawa Y,Haga D,Kakegawa Y,Nishikawa T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cogni...

journal_title：Dementia and geriatric cognitive disorders

authors： Rinehardt E,Eichstaedt K,Schinka JA,Loewenstein DA,Mattingly M,Fils J,Duara R,Schoenberg MR

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Differences in the gross shape of the corpus callosum (CC) and its subregional areas were investigated on brain MRI of patients with probable Alzheimer's disease (AD) and age- and gender-matched healthy normal control subjects. The AD patients differed from the normal control subjects in terms of a more...

journal_title：Dementia and geriatric cognitive disorders

authors： Tomaiuolo F,Scapin M,Di Paola M,Le Nezet P,Fadda L,Musicco M,Caltagirone C,Collins DL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...

journal_title：Dementia and geriatric cognitive disorders

authors： Montreuil S,Poulin E,Bergeron D,Sellami L,Verret L,Fortin MP,Poulin S,Macoir J,Hudon C,Bouchard RW,Lavoie M,Laforce R

更新日期：2020-01-01 00:00:00

abstract：:Antioxidants prevent oxidative stress that possibly causes neuronal loss in Alzheimer's disease (AD). We examined whether high plasma levels of the antioxidant vitamins A and E were associated with lower prevalence of AD or cognitive decline (CD). We performed a cross-sectional study within the Rotterdam Study. In an ...

journal_title：Dementia and geriatric cognitive disorders

authors： Engelhart MJ,Ruitenberg A,Meijer J,Kiliaan A,van Swieten JC,Hofman A,Witteman JC,Breteler MM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:A large proportion of patients at memory disorders clinics are classified as having subjective cognitive impairment (SCI). Previous research has investigated whether particular lifestyle factors known to affect cognition can be useful in differentiating patients who do not show objective evidence of mem...

journal_title：Dementia and geriatric cognitive disorders

authors： Andersson C,Marklund K,Walles H,Hagman G,Miley-Akerstedt A

更新日期：2019-01-01 00:00:00

abstract：UNLABELLED:The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients s...

journal_title：Dementia and geriatric cognitive disorders

authors： Rolstad S,Nordlund A,Eckerström C,Gustavsson MH,Zetterberg H,Wallin A

更新日期：2009-01-01 00:00:00

abstract：:Although myoclonus commonly occurs in a later stage of Alzheimer's disease (AD), the pathological basis of this symptom is still unclear. In order to elucidate the neuropathological substrate of myoclonus in AD, we quantitatively assessed neuronal density and volume, with a discrimination between small and large neuro...

journal_title：Dementia and geriatric cognitive disorders

authors： Fukutani Y,Cairns NJ,Everall IP,Chadwick A,Isaki K,Lantos PL

更新日期：1999-03-01 00:00:00

abstract：AIM:To analyze the relationship between periventricular (PV) and subcortical (SC) white matter lesions (WML) and cognitive function in patients with memory impairment. METHODS:In total, 253 patients with Global Deterioration Scale scores >or=3 who had been referred to a university-based memory unit due to memory compl...

journal_title：Dementia and geriatric cognitive disorders

authors： Stenset V,Hofoss D,Berstad AE,Negaard A,Gjerstad L,Fladby T

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS:We included 159 pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Biesbroek JM,Leemans A,den Bakker H,Duering M,Gesierich B,Koek HL,van den Berg E,Postma A,Biessels GJ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS:We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method...

journal_title：Dementia and geriatric cognitive disorders

authors： Hanyu H,Sato T,Akai T,Shimizu S,Hirao K,Kanetaka H,Iwamoto T,Koizumi K

更新日期：2008-01-01 00:00:00

abstract：:The apolipoprotein E (APOE) gene epsilon 4 allele is known to be associated with late-onset familial and sporadic Alzheimer's disease (AD). We assessed the possible relationship between APOE genotypes and morphological or functional changes in AD brains by x-ray computed tomography (CT), magnetic resonance imaging (MR...

journal_title：Dementia and geriatric cognitive disorders

authors： Tanaka S,Kawamata J,Shimohama S,Akaki H,Akiguchi I,Kimura J,Ueda K

更新日期：1998-03-01 00:00:00

abstract：AIMS:To describe the contribution of white matter lesions to the long-term neuropsychological profiles of different groups of clinical diagnoses, and to identify neuropsychological predictors of cognitive impairment in a 10-year follow-up. METHODS:The Lisbon subcohort of the Leukoaraiosis and Disability (LADIS) study ...

journal_title：Dementia and geriatric cognitive disorders

authors： Madureira S,Verdelho A,Moleiro C,Santos C,Scheltens P,Gouw A,Ferro J

更新日期：2016-01-01 00:00:00

abstract：AIMS:To describe central nervous system (CNS) drug consumption patterns depending on the time to diagnosis of Alzheimer's disease (AD), and to check whether the cases diagnosed later are associated with greater severity and consuming more CNS drugs. METHODS:Cross-sectional study using 952 cases of the Registry of Deme...

journal_title：Dementia and geriatric cognitive disorders

authors： Calvó-Perxas L,López-Pousa S,Vilalta-Franch J,Turró-Garriga O,Blankenburg M,Febrer L,Flaqué M,Vallmajó N,Aguirregomozcorta M,Genís D,Casas I,Perkal H,Coromina J,Garre-Olmo J,Registry of Dementias of Girona Study Group.

更新日期：2012-01-01 00:00:00

abstract：:A substantive overlap between the clinical syndromes of frontal lobe dementia (FLD), frontotemporal dementia (FTD), or primary progressive aphasia (PPA), and corticobasal degeneration syndrome (CBDS) has been demonstrated in a population of 55 patients followed for more than 3 years in a cognitive neurology clinic. Pa...

journal_title：Dementia and geriatric cognitive disorders

authors： Kertesz A,Davidson W,Munoz DG

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusion...

journal_title：Dementia and geriatric cognitive disorders

authors： Mitolo M,Tonon C,La Morgia C,Testa C,Carelli V,Lodi R

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:We have previously reported the results of an extended genome-wide scan of Swedish Alzheimer disease (AD)-affected families; in this paper, we analyzed a subset of these families with autopsy-confirmed AD. METHODS:We report the fine-mapping, using both microsatellite markers and single-nucleotide polym...

journal_title：Dementia and geriatric cognitive disorders

authors： Sillén A,Brohede J,Forsell C,Lilius L,Andrade J,Odeberg J,Kimura T,Winblad B,Graff C

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study was to determine the frequency of ubiquitin-positive inclusions (UPI) in dementia lacking distinctive histology (DLDH), and their relationship to other pathologic features, such as hippocampal sclerosis (HpScl), as well as genetic factors. Routine and immunohistochemical studies were carried out ...

journal_title：Dementia and geriatric cognitive disorders

authors： Josephs KA,Jones AG,Dickson DW

更新日期：2004-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is generally understood as primarily affecting cognition while sparing motor function, at least until the later stages of the disease. Studies reported over the past 10 years, however, have documented a prevalence of falls in AD patients significantly higher than in age-matched normal elders; ...

journal_title：Dementia and geriatric cognitive disorders

authors： Sheridan PL,Hausdorff JM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Corpus callosum atrophy possibly indicates neuronal degeneration in association cortex in Alzheimer's disease (AD). Water diffusivity allows detecting physiological changes that probably occur earlier than structural shrinkage in cerebral regions during the development of AD. OBJECTIVE:To simultaneously inv...

journal_title：Dementia and geriatric cognitive disorders

authors： Wang H,Su MY

更新日期：2006-01-01 00:00:00

abstract：AIMS:The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). METHODS:A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. ...

journal_title：Dementia and geriatric cognitive disorders

authors： Cherbuin N,Reglade-Meslin C,Kumar R,Jacomb P,Easteal S,Christensen H,Sachdev P,Anstey KJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIM:The objective was to examine cohort changes in cognitive function in 2 cohorts of centenarians born 10 years apart. METHODS:The Longitudinal Study of Danish Centenarians comprises all Danes reaching the age of 100 in the period April 1, 1995 through May 31, 1996. A total of 207 out of 276 persons partic...

journal_title：Dementia and geriatric cognitive disorders

authors： Engberg H,Christensen K,Andersen-Ranberg K,Jeune B

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:To characterize loss of basic activities of daily living (BADL) in 687 Alzheimer's disease (AD) community-dwelling patients included in the French REAL cohort. METHODS:Patients had mild to moderately severe AD, and the mean age was 77.8 years. Patterns of loss of the 6 BADL were described at inclusion ...

journal_title：Dementia and geriatric cognitive disorders

authors： Lechowski L,Van Pradelles S,Le Crane M,d'Arailh L,Tortrat D,Teillet L,Vellas B,REAL Group.

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS:Our hypothesis was that subtle pre-operative ...

journal_title：Dementia and geriatric cognitive disorders

authors： Lowery DP,Wesnes K,Ballard CG

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence indicates that vascular risk factors play a role in the development of cogn...

journal_title：Dementia and geriatric cognitive disorders

authors： Nilsson K,Gustafson L,Hultberg B

更新日期：2010-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is the second most prevalent dementia after Alzheimer's disease (AD). We compared 29 FTD and 90 AD caregivers with respect to burden, health-related quality of life (HQoL) and coping. FTD caregivers were more burdened than AD caregivers, and caregivers of patients who were demented for sh...

journal_title：Dementia and geriatric cognitive disorders

authors： Riedijk SR,De Vugt ME,Duivenvoorden HJ,Niermeijer MF,Van Swieten JC,Verhey FR,Tibben A

更新日期：2006-01-01 00:00:00