The Role of Gait Speed in Dementia: A Secondary Analysis from the SABE Colombia Study.

abstract：BACKGROUND:Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy depends on the PRNP codon 129 genotype, leaving it unclear how well established markers behave in untested conditions. METHODS:We analyzed ...

journal_title：Dementia and geriatric cognitive disorders

authors： Llorens F,Karch A,Golanska E,Schmitz M,Lange P,Sikorska B,Liberski PP,Zerr I

更新日期：2017-01-01 00:00:00

abstract：:Basic mobility, balance, gait and dual-task performance were characterised in 140 consecutive subjects referred to a multidisciplinary university hospital in a geriatric setting for cognitive symptoms and possible dementia. After completion of an extensive diagnostic evaluation, subjects were classified into four diag...

journal_title：Dementia and geriatric cognitive disorders

authors： Pettersson AF,Olsson E,Wahlund LO

更新日期：2005-01-01 00:00:00

abstract：:The apolipoprotein E (APOE) gene epsilon 4 allele is known to be associated with late-onset familial and sporadic Alzheimer's disease (AD). We assessed the possible relationship between APOE genotypes and morphological or functional changes in AD brains by x-ray computed tomography (CT), magnetic resonance imaging (MR...

journal_title：Dementia and geriatric cognitive disorders

authors： Tanaka S,Kawamata J,Shimohama S,Akaki H,Akiguchi I,Kimura J,Ueda K

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:The ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer's disease (AD). However, attributable risk due to APOE4 varies by region and by race/ethnicity. METHODS:A literature review and meta-analysis were conducted to estimate the prevalence of APOE4 by geographic area among AD patients. RESULT...

journal_title：Dementia and geriatric cognitive disorders

authors： Crean S,Ward A,Mercaldi CJ,Collins JM,Cook MN,Baker NL,Arrighi HM

更新日期：2011-01-01 00:00:00

abstract：:The present study investigated the sensitivity and specificity of the Hopkins Verbal Learning Test (HVLT) for demented patients (n = 82, using NINCDS criteria) and 114 healthy controls--equivalent in age, years of education and gender-ratio--from the Oxford Project to Investigate Memory and Ageing. The HVLT 'Total Rec...

journal_title：Dementia and geriatric cognitive disorders

authors： Hogervorst E,Combrinck M,Lapuerta P,Rue J,Swales K,Budge M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Predominant and progressive complex visual disorders are often due to posterior cortical atrophy (PCA), a rare early-onset dementing syndrome presenting with visual complaints. In clinicopathological studies, PCA is most commonly considered a form of Alzheimer's disease (AD); no prior study has evaluated cli...

journal_title：Dementia and geriatric cognitive disorders

authors： Mendez MF,Ghajarania M,Perryman KM

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB). METHODS:Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bjoerke-Bertheussen J,Ehrt U,Rongve A,Ballard C,Aarsland D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS:We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method...

journal_title：Dementia and geriatric cognitive disorders

authors： Hanyu H,Sato T,Akai T,Shimizu S,Hirao K,Kanetaka H,Iwamoto T,Koizumi K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIM:To estimate the prevalence of Alzheimer's disease (AD) treatment in Aragon (Spain), analyzing differences according to age, gender and health area. METHODS:Retrospective study on AD treatment prevalence of cholinesterase inhibitors and memantine during 2005, using pharmaco-epidemiological data from pres...

journal_title：Dementia and geriatric cognitive disorders

authors： Villar-Fernández I,Bjerrum L,Feja C,Rabanaque MJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Healthcare systems face an increased prevalence of Alzheimer's disease and increasing costs. The use of molecular biomarkers and imaging could offer an effective solution for these issues. The objective of this study was to assess amyloid imaging regarding clinical utility and impact. METHODS:A literat...

journal_title：Dementia and geriatric cognitive disorders

authors： Wahlster P,Niederländer C,Kriza C,Schaller S,Kolominsky-Rabas PL

更新日期：2013-01-01 00:00:00

abstract：:The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) (Abeta(1-42)). An assay for tau phosphorylated at threonine 181 (phospho-tau) has recently been developed. We studied these three markers in patients with possible Alzheimer's disease (AD; ...

journal_title：Dementia and geriatric cognitive disorders

authors： Nägga K,Gottfries J,Blennow K,Marcusson J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:Catechol-O-methyltransferase, encoded by the COMT gene, is one of the enzymes that degrade dopamine. The aim of this study was to investigate whether polymorphisms in the COMT gene were associated with delirium. METHODS:Patients aged 65 years and older, acutely admitted to the medical department or to ...

journal_title：Dementia and geriatric cognitive disorders

authors： van Munster BC,Baas F,Tanck MW,de Rooij SE

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. METHODS:One hundred Caucasian ...

journal_title：Dementia and geriatric cognitive disorders

authors： Annweiler C,Maby E,Meyerber M,Beauchet O

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes ...

journal_title：Dementia and geriatric cognitive disorders

authors： Montreuil S,Poulin E,Bergeron D,Sellami L,Verret L,Fortin MP,Poulin S,Macoir J,Hudon C,Bouchard RW,Lavoie M,Laforce R

更新日期：2020-01-01 00:00:00

abstract：:Recent studies have implicated interleukin-6 (IL-6) in the pathogenesis of Alzheimer's disease (AD). Neuro-inflammatory processes surrounding the amyloid plaques contribute to the progression of AD-related neurodegeneration. IL-6 is a multifunctional inflammatory cytokine which possibly acts as a mediator in the local...

journal_title：Dementia and geriatric cognitive disorders

authors： Depboylu C,Lohmüller F,Gocke P,Du Y,Zimmer R,Gasser T,Klockgether T,Dodel RC

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The apolipoprotein E (APOE) e4 genetic polymorphism is a major risk factor for Alzheimer' s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. METHODS:We used linear regression models to assess associations of APOE e4 with cognitive performance in a populati...

journal_title：Dementia and geriatric cognitive disorders

authors： Perna L,Mons U,Rujescu D,Kliegel M,Brenner H

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIM:The prevalence of cognitive symptoms in recently diagnosed Parkinson's disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms. METHODS:A PD patient diagnosed with mild cognitive impairment underwent DBS surgery tar...

journal_title：Dementia and geriatric cognitive disorders

authors： Nombela C,Lozano A,Villanueva C,Barcia JA

更新日期：2019-01-01 00:00:00

abstract：:Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic muta...

journal_title：Dementia and geriatric cognitive disorders

authors： Ostojic J,Elfgren C,Passant U,Nilsson K,Gustafson L,Lannfelt L,Froelich Fabre S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:Increased cerebrospinal fluid (CSF) tau, decreased CSF amyloid-beta42 (Abeta42) and the apolipoprotein E gene (APOE) epsilon4 allele predict progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Here, we investigated these markers to assess their predictive value and influence on...

journal_title：Dementia and geriatric cognitive disorders

authors： Blom ES,Giedraitis V,Zetterberg H,Fukumoto H,Blennow K,Hyman BT,Irizarry MC,Wahlund LO,Lannfelt L,Ingelsson M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. METHODS:A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and A...

journal_title：Dementia and geriatric cognitive disorders

authors： Hsieh S,Schubert S,Hoon C,Mioshi E,Hodges JR

更新日期：2013-01-01 00:00:00

abstract：AIM:The aims of the present study were to report on the psychometric properties of the Pain Assessment in Advanced Dementia (PAINAD) scale by comparing it with the gold standard method of self-reporting on a numerical rating scale (NRS), and to provide a categorical version of the PAINAD scale comparable with the verba...

journal_title：Dementia and geriatric cognitive disorders

authors： Mosele M,Inelmen EM,Toffanello ED,Girardi A,Coin A,Sergi G,Manzato E

更新日期：2012-01-01 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) usually presents with clinical and neuroimaging findings consistent with single or multiple intracranial mass lesions. On cranial magnetic resonance imaging (MRI), such lesions are nearly always contrast enhancing, reflecting disruption of the blood-brain barrier at the ...

journal_title：Dementia and geriatric cognitive disorders

authors： Bakshi R,Mazziotta JC,Mischel PS,Jahan R,Seligson DB,Vinters HV

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. METHODS:This prospective inception cohort included 37...

journal_title：Dementia and geriatric cognitive disorders

authors： van Dam R,Van Ancum JM,Verlaan S,Scheerman K,Meskers CGM,Maier AB

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The Baylor Profound Mental Status Examination (BPMSE) was modeled to provide a brief patient-derived rating scale for staging and tracking patients with severe stages of Alzheimer's disease (AD). METHODS:The BPMSE was administered to 91 patients with probable AD (Korean version of the MMSE less than 16) acc...

journal_title：Dementia and geriatric cognitive disorders

authors： Na HR,Lee SH,Lee JS,Doody RS,Kim SY

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD. METHODS:The occurrence of AD was examined in 1,420 first-degree relati...

journal_title：Dementia and geriatric cognitive disorders

authors： Heun R,Ptok U,Kölsch H,Maier W,Jessen F

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the present study was to provide normative data and determine the validity of the Czech version of the Mattis Dementia Rating Scale 2 (czDRS-2) in screening for mild cognitive impairment in Parkinson's disease (PD-MCI) based on the Movement Disorder Society (MDS) Level II criteria. METHODS:F...

journal_title：Dementia and geriatric cognitive disorders

authors： Bezdicek O,Michalec J,Nikolai T,Havránková P,Roth J,Jech R,Růžička E

更新日期：2015-01-01 00:00:00

abstract：:In spite of the fact that delirium is a common and often severe cognitive disturbance in the elderly, quite few intervention studies are performed. Descriptive studies of variable quality are much more common. For example, in hip fracture patients delirium is a common complication and the cause of nursing problems tha...

journal_title：Dementia and geriatric cognitive disorders

authors： Brännström B

更新日期：1999-09-01 00:00:00

abstract：:Findings in patients with dementia of the Alzheimer type (AD patients) concerning the enactment effect, i.e. reaching a better memory performance after encoding actions by performing them in contrast to encoding them by reading, are ambiguous. In order to get more insight into memory deterioration in patients sufferin...

journal_title：Dementia and geriatric cognitive disorders

authors： Mack W,Eberle C,Frölich L,Knopf M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress. BACKGROUND:FTLD is a progressive neurodegenerative disease associated with behavioral disturbances. Group studies have related these behaviors to volume loss on ...

journal_title：Dementia and geriatric cognitive disorders

authors： Massimo L,Powers C,Moore P,Vesely L,Avants B,Gee J,Libon DJ,Grossman M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with a postoperative delirium. In the present study, we investigated levels of neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in acutely ill admi...

journal_title：Dementia and geriatric cognitive disorders

authors： Egberts A,Wijnbeld EH,Fekkes D,van der Ploeg MA,Ziere G,Hooijkaas H,van der Cammen TJ,Mattace-Raso FU

更新日期：2015-01-01 00:00:00