Abstract:
:Diseases like tropical ataxic neuropathy and endemic goitre have been reported to have definite correlation with a chronic ingestion of cassava (Manihot esculenta Crantz). The toxicity of cassava has been attributed to its two cyanogenic glycosides, linamarin and lotaustralin. In this study, an attempt has been made to understand the pattern of changes in certain clinically significant enzymes brought about by the chronic administration of sublethal doses of linamarin to rabbits. The profound elevation in rhodanese activity observed in the linamarin and cyanide treated rabbits indicated the attempt of the tissues to detoxify cyanide. That intact linamarin could be hydrolysed in vivo was a significant finding from the study. The mode of toxicity of linamarin was similar to that of cyanide by producing a gradual shift from aerobic to anaerobic metabolism.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Padmaja G,Panikkar KRsubject
Has Abstractpub_date
1989-06-01 00:00:00pages
551-5issue
6eissn
0019-5189issn
0975-1009journal_volume
27pub_type
杂志文章abstract::A new gamma-aminobutyric acid derivative, N-phthaloyl GABA (P-GABA), was synthesised and its anticonvulsant activity was tested and compared with sodium valproate for efficacy against experimentally induced convulsions in mice. At a dose of 80 mg/kg, P-GABA rendered more protection than sodium valproate. ED50 of P-GAB...
journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
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journal_title:Indian journal of experimental biology
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doi:
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2013-07-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
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journal_title:Indian journal of experimental biology
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doi:
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
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journal_title:Indian journal of experimental biology
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doi:
更新日期:1993-01-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2014-12-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
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journal_title:Indian journal of experimental biology
pub_type: 杂志文章
doi:
更新日期:2013-12-01 00:00:00