Synthesis, characterization, and biological interaction of glyconanoparticles with controlled branching.

abstract：:The determination of the collagen and glycosaminoglycan (GAG) contents of native and particularly bioengineered tissues is of considerable interest because the collagen-to-GAG ratio determines the water content of the tissue, which is crucial regarding its mechanical properties. (1)H NMR spectroscopy subsequent to the...

journal_title：Biomacromolecules

authors： Riemer T,Nimptsch A,Nimptsch K,Schiller J

更新日期：2012-07-09 00:00:00

abstract：:Generation of bioenergy, new functional polymers, or chemicals and biomaterials from hemicelluloses are important uses for biomass. In this paper, a novel functional biopolymer with carbon-carbon double bond and carboxyl groups was prepared by a homogeneous esterification of xylan-rich hemicelluloses (XH) with maleic ...

journal_title：Biomacromolecules

authors： Peng XW,Ren JL,Sun RC

更新日期：2010-12-13 00:00:00

abstract：:A lamellar compound resulted from reaction of acrylic acid inside crystalline beta-chitin and the structure was investigated. Beta-chitin acts like a layered crystal, having stacked molecular sheets composed of parallel chains bound in one direction by intermolecular amide hydrogen bonding. Small guest molecules can b...

journal_title：Biomacromolecules

authors： Saito Y,Tomotake Y,Shida S

更新日期：2007-04-01 00:00:00

abstract：:A series of well-defined thermoresponsive diblock copolymers (PEO45-b-PtNEAn, n=22, 44, 63, 91, 172) were prepared by the atom transfer radical polymerization of trans-N-(2-ethoxy-1,3-dioxan-5-yl) acrylamide (tNEA) using a poly(ethylene oxide) (PEO45) macroinitiator. All copolymers are water-soluble at low temperature...

journal_title：Biomacromolecules

authors： Qiao ZY,Ji R,Huang XN,Du FS,Zhang R,Liang DH,Li ZC

更新日期：2013-05-13 00:00:00

abstract：:This paper describes the synthesis and evaluation of a series of multifunctional poly-l-glutamic acid derivatives that can be used as vectors for gene delivery. They readily form polyelectrolyte complexes with DNA, resulting in a reduced surface charge and size of the DNA. The formation of a polymer-DNA complex and th...

journal_title：Biomacromolecules

authors： Dubruel P,Dekie L,Schacht E

更新日期：2003-09-01 00:00:00

abstract：:We examine the protein distribution within an electrospun polymer nanofiber using polyvinyl alcohol and bovine serum albumin as a model system. We hypothesize that the location of the protein within the nanofiber can be controlled by carefully selecting the pH and the applied polarity of the electric field as the pH a...

journal_title：Biomacromolecules

authors： Tang C,Ozcam AE,Stout B,Khan SA

更新日期：2012-05-14 00:00:00

abstract：:In the fields of surgery and regenerative medicine, it is crucial to understand the interactions of proteins with the biomaterials used as implants. Protein adsorption directly influences cell-material interactions in vivo and, as a result, regulates, for example, cell adhesion on the surface of the implant. Therefore...

journal_title：Biomacromolecules

authors： Schönwälder SM,Bally F,Heinke L,Azucena C,Bulut ÖD,Heißler S,Kirschhöfer F,Gebauer TP,Neffe AT,Lendlein A,Brenner-Weiß G,Lahann J,Welle A,Overhage J,Wöll C

更新日期：2014-07-14 00:00:00

abstract：:Polymers are appealing as pH-responsive elements of multicomponent systems designed to promote cytosolic delivery of macromolecular drugs (including proteins and genes), but so far the delivery efficiency achieved has been relatively modest. Therefore, the aim of this study was to apply several physicochemical techniq...

journal_title：Biomacromolecules

authors： Griffiths PC,Khayat Z,Tse S,Heenan RK,King SM,Duncan R

更新日期：2007-03-01 00:00:00

abstract：:Adhesive hydrogels were prepared by copolymerizing dopamine methacrylamide with either acrylic acid (AAc) or N-(3-aminopropyl)methacrylamide hydrochloride (APMH). The effect of incorporating the anionic and cationic side chains on the oxidation state of catechol was characterized using the FOX assay to track the produ...

journal_title：Biomacromolecules

authors： Narkar AR,Kelley JD,Pinnaratip R,Lee BP

更新日期：2018-05-14 00:00:00

abstract：:We have developed herein an engineered polymer-based nanoplatform showing the convergence of two-photon fluorescence imaging and bimodal phototherapeutic activity in a single nanostructure. It was achieved through the appropriate choice of three different components: a β-cyclodextrin-based polymer acting as a suitable...

journal_title：Biomacromolecules

authors： Kandoth N,Kirejev V,Monti S,Gref R,Ericson MB,Sortino S

更新日期：2014-05-12 00:00:00

abstract：:We synthesized extremely deformable red blood cell-like microgel particles and loaded them with bovine hemoglobin (Hb) to potentiate oxygen transport. With similar shape and size as red blood cells (RBCs), the particles were fabricated using the PRINT (particle replication in nonwetting templates) technique. Low cross...

journal_title：Biomacromolecules

authors： Chen K,Merkel TJ,Pandya A,Napier ME,Luft JC,Daniel W,Sheiko S,DeSimone JM

更新日期：2012-09-10 00:00:00

abstract：:A porous scaffold as a cell-compatible material was designed and prepared using a phospholipid copolymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate, and enantiomeric macromonomers, the poly(L-lactic acid) (PLLA) macromonomer, and poly(D-lactic acid) (PDLA) macromonomer. On the bas...

journal_title：Biomacromolecules

authors： Watanabe J,Eriguchi T,Ishihara K

更新日期：2002-09-01 00:00:00

abstract：:The pressure and temperature dependence of the cloud point transition of an aqueous solution of an elastin-like polypeptide (MGLDGSMG(VPGIG)40VPLE), prepared by bacterial expression of the corresponding artificial gene, was measured. A temperature-pressure diagram was constructed over a wide range of conditions. The (...

journal_title：Biomacromolecules

authors： Tamura T,Yamaoka T,Kunugi S,Panitch A,Tirrell DA

更新日期：2000-01-01 00:00:00

abstract：:There has been little study on the effect of composition or molecular weight on the biodegradation rate of photo-cross-linked biodegradable aliphatic polyesters though such information is important for tissue engineering scaffolds. We have synthesized a new series of photopolymerizable linear poly(epsilon-caprolactone...

journal_title：Biomacromolecules

authors： Shen JY,Pan XY,Lim CH,Chan-Park MB,Zhu X,Beuerman RW

更新日期：2007-02-01 00:00:00

abstract：:Peptide self-assembly is a facile route to the development of bioorganic hybrid materials that have sophisticated nanostructures toward diverse applications. Here, we report the synthesis of self-assembled peptide (Fmoc-diphenylalanine, Fmoc-FF)/graphitic carbon nitride (g-C3N4) hydrogels for light harvesting and biom...

journal_title：Biomacromolecules

authors： Ko JW,Choi WS,Kim J,Kuk SK,Lee SH,Park CB

更新日期：2017-11-13 00:00:00

abstract：:A novel poly(epsilon-caprolactone)-organosiloxane hybrid material containing calcium salt (Si-O-PCL) was prepared and evaluated as a bioactive and degradable bone substitute material. The Si-O-PCL hybrid was synthesized by the end-capping of 3-isocyanatopropyl triethoxysilane with alpha,omega-hydroxyl PCL following so...

journal_title：Biomacromolecules

authors： Rhee SH,Lee YK,Lim BS,Yoo JJ,Kim HJ

更新日期：2004-07-01 00:00:00

abstract：:The islet amyloid polypeptide (IAPP) is a regulatory peptide that can aggregate into fibrillar structures associated with type 2 diabetes. In this study, the IAPP21-27 segment was modified with a biotin linker at the N-terminus (Btn-GNNFGAIL) to immobilize peptide fibrils on streptavidin-coated surfaces. Key residues ...

journal_title：Biomacromolecules

authors： John T,Bandak J,Sarveson N,Hackl C,Risselada HJ,Prager A,Elsner C,Abel B

更新日期：2020-02-10 00:00:00

abstract：:The formation of a suitable extracellular matrix (ECM) that promotes cell adhesion, organization, and proliferation is essential within biomaterial scaffolds for tissue engineering applications. In this work, short elastin mimetic peptide sequences, EM-19 and EM-23, were engineered to mimic the active motifs of human ...

journal_title：Biomacromolecules

authors： Patel D,Menon R,Taite LJ

更新日期：2011-02-14 00:00:00

abstract：:Biomimetic mineralization of collagen is an advantageous method to obtain resorbable collagen/hydroxy-apatite composites for application in bone regeneration. In this report, established procedures for mineralization of bovine collagen were adapted to a new promising source of collagen from salmon skin challenged by t...

journal_title：Biomacromolecules

authors： Hoyer B,Bernhardt A,Heinemann S,Stachel I,Meyer M,Gelinsky M

更新日期：2012-04-09 00:00:00

abstract：:Safe delivery systems that can not only encapsulate hydrophobic drug molecules, but also release them in response to specific triggers are important in several therapeutic and biomedical applications. In this paper, we have designed a nanogel based on molecules that are generally recognized as safe (GRAS). We have sho...

journal_title：Biomacromolecules

authors： Prasad P,Molla MR,Cui W,Canakci M,Osborne B,Mager J,Thayumanavan S

更新日期：2015-11-09 00:00:00

abstract：:A variety of important biological events are mediated by the multivalent interaction between relevant oligosaccharides and multiple saccharide receptors on lectins, toxins, and cell surfaces; a variety of glycopolymeric materials have therefore been investigated in studies aimed at manipulating these events. The synth...

journal_title：Biomacromolecules

authors： Polizzotti BD,Kiick KL

更新日期：2006-02-01 00:00:00

abstract：:Surface modification of biodegradable vascular grafts is an important strategy to improve the in situ endothelialization of tissue engineered vascular grafts (TEVGs) and prevent major complications associated with current synthetic grafts. Important strategies for improving endothelialization include increasing endoth...

journal_title：Biomacromolecules

authors： Melchiorri AJ,Hibino N,Yi T,Lee YU,Sugiura T,Tara S,Shinoka T,Breuer C,Fisher JP

更新日期：2015-02-09 00:00:00

abstract：:This paper presents the formation of a novel biomimetic interface consisting of an electrolessly deposited gold film overlaid with a tethered bilayer lipid membrane (tBLM). Self-assembly of colloidal gold particles was used to create an electrolessly deposited gold film on a glass slide. The properties of the film wer...

journal_title：Biomacromolecules

authors： Kohli N,Hassler BL,Parthasarathy L,Richardson RJ,Ofoli RY,Worden RM,Lee I

更新日期：2006-12-01 00:00:00

abstract：:The antiproliferative activity of alkylated heparin, in which the terminal end of heparin is derivatized with an alkyl group (butyl, octyl, lauryl, stearyl), was examined using vascular smooth muscle cells. The proliferation of cells, which were growth-arrested prior to addition of heparin, was inhibited in proportion...

journal_title：Biomacromolecules

authors： Gohda M,Magoshi T,Kato S,Noguchi T,Yasuda S,Nonogi H,Matsuda T

更新日期：2001-01-01 00:00:00

abstract：:A combination of chemo-photodynamic therapy has been manifested as a promising strategy for efficient cancer treatment due to the enhanced therapeutic efficacy. Here, we designed doxorubicin (DOX)-loaded photoresponsive micelles (DPRMs) based on a combination of chlorin e6 (Ce6) and lipoic acid (LA) conjugated methoxy...

journal_title：Biomacromolecules

authors： Kim DH,Hwang HS,Na K

更新日期：2018-08-13 00:00:00

abstract：:The dynamics of silk protein in the presence and absence of water has been investigated by dielectric relaxation spectroscopy (DRS). The silk fibroin film cast from its water solution contains 4-7 wt % bound water molecules, which can be removed by dehydration at 165 °C. Temperature and frequency scans were performed ...

journal_title：Biomacromolecules

authors： Yu L,Hu X,Kaplan D,Cebe P

更新日期：2010-10-11 00:00:00

abstract：:Electrospun biopolyelectrolyte nanofibers hold potential for use in a range of biomedical applications, but eliminating toxic chemicals involved in their production remains a key challenge. In this study, we successfully electrospun nanofibers from an aqueous complex coacervate solution composed of chitosan and hyalur...

journal_title：Biomacromolecules

authors： Sun J,Perry SL,Schiffman JD

更新日期：2019-11-11 00:00:00

abstract：:Immunological detection has been developed into a sensitive and versatile technique and is based on two requisite elements: targeting antibodies and an indicator, usually in the form of horseradish peroxidase or alkaline phosphatase. The specificity and turnover rate of these enzymes provide an efficient means of sign...

journal_title：Biomacromolecules

authors： Wurtzler EM,Wendell D

更新日期：2014-01-13 00:00:00

abstract：:A series of chitosan/chitin samples with DA's varying between 5.2 and 89% was prepared from the reacetylation under soft conditions of a unique chitosan sample allowing the preservation of the chain distribution. The study of the variation of pH for the same concentration of amine groups, at different ionic strengths,...

journal_title：Biomacromolecules

authors： Sorlier P,Denuzière A,Viton C,Domard A

更新日期：2001-10-01 00:00:00

abstract：:Wheat arabinoxylan was treated with two α-arabinofuranosidases exhibiting different mode of action to create three different polymeric substrates. These three substrate preparations were characterized by xylopyranose backbone sugars that are (1) singly substituted by arabinose at C2 or C3, (2) doubly substituted by ar...

journal_title：Biomacromolecules

authors： Littunen K,Mai-Gisondi G,Seppälä J,Master ER

更新日期：2017-05-08 00:00:00