Infrastructure to support learning health systems: are we there yet? Innovative solutions and lessons learned from American Recovery and Reinvestment Act CER investments.


:The 11 big health data networks participating in the AcademyHealth Electronic Data Methods Forum represent cutting-edge efforts to harness the power of big health data for research and quality improvement. This paper is a comparative case study based on site visits conducted with a subset of these large infrastructure grants funded through the Recovery Act, in which four key issues emerge that can inform the evolution of learning health systems, including the importance of acknowledging the challenges of scaling specialized expertise needed to manage and run CER networks; the delicate balance between privacy protections and the utility of distributed networks; emerging community engagement strategies; and the complexities of developing a robust business model for multi-use networks.


J Comp Eff Res


Holve E,Segal C




Has Abstract


2014-11-01 00:00:00












  • Young adult and parent stakeholder perspectives on participation in patient-centered comparative effectiveness research.

    abstract:AIM:Explore perspectives of adolescent and young adult (AYA) and parent stakeholders regarding their engagement in comparative effectiveness research (CER) evaluating cholesterol screening and treatment strategies for 17-21 year olds. METHODS:All nine AYAs and parent stakeholders participating in a 20-member panel of ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Saunders T,Mackie TI,Shah S,Gooding H,de Ferranti SD,Leslie LK

    更新日期:2016-08-01 00:00:00

  • Ongoing initiatives within the Scottish National Health Service to affect the prescribing of selective serotonin reuptake inhibitors and their influence.

    abstract::Aim: Increasing use of selective serotonin-reuptake inhibitors (SSRIs) in Scotland, coupled with safety concerns with some SSRIs, and the increasing availability of generic SSRIs, have resulted in multiple initiatives to improve the quality and efficiency of their prescribing in Scotland. Our aim is to assess their in...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Godman B,Kurdi A,McCabe H,Johnson CF,Barbui C,MacBride-Stewart S,Hurding S,Leporowski A,Bennie M,Morton A

    更新日期:2019-05-01 00:00:00

  • Proximal gastrectomy versus total gastrectomy for adenocarcinoma of the esophagogastric junction: a meta-analysis.

    abstract::Aim: To compare efficacy between total gastrectomy (TG) and proximal gastrectomy (PG) for upper-third gastric cancer. Materials & methods: PubMed, Embase and Cochrane library were searched to select suitable researches. Stata was used for meta-analysis including 5-year overall survival rate, recurrence rate, complicat...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,meta分析


    authors: Chen YC,Lu L,Fan KH,Wang DH,Fu WH

    更新日期:2019-07-01 00:00:00

  • Principles for planning and conducting comparative effectiveness research.

    abstract:AIMS:To develop principles for planning and conducting comparative effectiveness research (CER). METHODS:Beginning with a modified existing list of health technology assessment principles, we developed a set of CER principles using literature review, engagement of multiple experts and broad stakeholder feedback. RESU...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Luce BR,Drummond MF,Dubois RW,Neumann PJ,Jönsson B,Siebert U,Schwartz JS

    更新日期:2012-09-01 00:00:00

  • The mixed randomized trial: combining randomized, pragmatic and observational clinical trial designs.

    abstract::Clinical trial designs often fail to deliver data that jointly satisfy evolving demands of both regulatory and reimbursement authorities. We propose a new multi-tiered trial design to integrate efficacy and effectiveness, and address the evolving needs of authorities. The mixed randomized trial allocates patients firs...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Alsop J,Scott M,Archey W

    更新日期:2016-11-01 00:00:00

  • Dissemination and implementation of comparative effectiveness evidence: key informant interviews with Clinical and Translational Science Award institutions.

    abstract:AIM:To identify ongoing practices and opportunities for improving national comparative effectiveness research (CER) translation through dissemination and implementation (D&I) via NIH-funded Clinical and Translational Science Award (CTSA) institutions. MATERIALS & METHODS:Key informant interviews were conducted with 18...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Morrato EH,Concannon TW,Meissner P,Shah ND,Turner BJ

    更新日期:2013-03-01 00:00:00

  • Building useful evidence: changing the clinical research paradigm to account for comparative effectiveness research.

    abstract::Comparative effectiveness research (CER) calls for substantial changes in the way clinical research is conducted, interpreted and practically applied in the USA, in order to produce useful clinical evidence. Departing from classic efficacy and effectiveness research, the evolving CER paradigm requires structural and s...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,评审


    authors: Greenfield S,Kaplan SH

    更新日期:2012-05-01 00:00:00

  • Stroke Administrative Severity Index: using administrative data for 30-day poststroke outcomes prediction.

    abstract:AIM:Current stroke severity scales cannot be used for archival data. We develop and validate a measure of stroke severity at hospital discharge (Stroke Administrative Severity Index [SASI]) for use in billing data. METHODS:We used the NIH Stroke Scale (NIHSS) as the theoretical framework and identified 285 relevant In...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Simpson AN,Wilmskoetter J,Hong I,Li CY,Jauch EC,Bonilha HS,Anderson K,Harvey J,Simpson KN

    更新日期:2018-04-01 00:00:00

  • Revascularization options in stable coronary artery disease: it is not how to revascularize, it is whether and when to revascularize.

    abstract::Patients with acute coronary syndromes and severe multivessel or left main coronary artery disease have better outcomes when prompt revascularization is performed in addition to optimal medical therapy (OMT). However, in patients with stable ischemic heart disease, randomized strategy trials have revealed equipoise be...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,评审


    authors: Torosoff MT,Sidhu MS,Desai KP,Fein SA,Boden WE

    更新日期:2015-09-01 00:00:00

  • Survival in unresectable AJCC stage I and II HCC and the effect of DEB-TACE: SEER versus tertiary cancer center cohort study.

    abstract:AIM:To evaluate overall survival (OS) in unresectable American Joint Committee on Cancer (AJCC) stage I/II hepatocellular carcinoma (HCC) treated with drug-eluting-bead transarterial chemoembolization (DEB-TACE) versus best supportive care. MATERIALS & METHODS:OS in consecutive patients with AJCC stage I/II unresectab...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Xing M,Kokabi N,Prajapati HJ,Close O,Ludwig JM,Kim HS

    更新日期:2016-03-01 00:00:00

  • Healthcare resource utilization and costs in amyloid light-chain amyloidosis: a real-world study using US claims data.

    abstract:AIM:To estimate healthcare utilization and costs in amyloid light-chain (AL) amyloidosis. PATIENTS & METHODS:AL amyloidosis patients were identified in 2007-2015 claims databases if they had ≥1 inpatient/≥2 outpatient claims consistent with AL amyloidosis and received ≥1 AL-specific treatment. Descriptive statistics w...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Quock TP,Yan T,Chang E,Guthrie S,Broder MS

    更新日期:2018-06-01 00:00:00

  • Medicaid insurance status predicts postoperative mortality after total knee arthroplasty in state inpatient databases.

    abstract::Aim: Medicaid versus private primary insurance status may predict in-hospital mortality and morbidity after total knee arthroplasty (TKA). Materials & methods: Regression models were used to test our hypothesis in patients in the State Inpatient Database (SID) from five states who underwent primary TKA from January 20...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Maman SR,Andreae MH,Gaber-Baylis LK,Turnbull ZA,White RS

    更新日期:2019-10-01 00:00:00

  • Cost associated with hematopoietic stem cell transplantation: a retrospective claims data analysis in Germany.

    abstract:AIM:Quantify hematopoietic stem cell transplantation (HSCT) costs in German patients with acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). METHODS:The primary outcome was direct and indirect costs in patients with ALL/DLBCL/FL who received HSCT between 2010 and 20...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Mayerhoff L,Lehne M,Hickstein L,Salimullah T,Prieur S,Thomas SK,Zhang J

    更新日期:2019-01-01 00:00:00

  • Comparison of amlodipine versus other calcium channel blockers on blood pressure variability in hypertensive patients in China: a retrospective propensity score-matched analysis.

    abstract:AIM:Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-establishe...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Zhang L,Yang J,Li L,Liu D,Xie X,Dong P,Lin Y

    更新日期:2018-07-01 00:00:00

  • Is routine baseline brain imaging needed for all newly diagnosed non-small-cell lung cancer patients?

    abstract::Aim: Dedicated brain imaging is advocated by the National Comprehensive Cancer Network guidelines for newly diagnosed non-small-cell cancer (NSCLC) patients beyond stage I. The current study assessed the performance characteristics of this recommendation. Methods: Through accessing the Surveillance, Epidemiology and E...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Abdel-Rahman O

    更新日期:2019-06-01 00:00:00

  • Low-dose computed tomography screening for lung cancer: results of the first screening round.

    abstract::Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 评论,杂志文章


    authors: Horeweg N,Nackaerts K,Oudkerk M,de Koning HJ

    更新日期:2013-09-01 00:00:00

  • Study protocol for the dabigatran, apixaban, rivaroxaban, edoxaban, warfarin comparative effectiveness research study.

    abstract::Since 2010, four oral anticoagulants have been approved for marketing in addition to warfarin for treatment of thromboembolic disease. Limited head-to-head data exist comparing these treatments, leaving patients and clinicians with little guidance for selecting a strategy that balances recurrence reduction with bleedi...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Krumme AA,Pawar A,Schneeweiss S,Glynn RJ,Choudhry NK,Kulldorff M,Ortiz AS,Avorn J,Gagne JJ

    更新日期:2018-01-01 00:00:00

  • Approaches to the management of functional tricuspid regurgitation.

    abstract::Functional tricuspid regurgitation (FTR) is an acquired valvular abnormality that is most frequently encountered during the evaluation and operative management of left-sided heart failure and left heart valve disease. Observational studies have demonstrated that uncorrected significant FTR during mitral valve surgery ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Rogers JH,Bolling SF

    更新日期:2015-11-01 00:00:00

  • Treatment patterns among elderly patients with stage IV breast cancer treated with HER-2-targeted therapy.

    abstract:AIM:To evaluate treatment patterns among elderly, newly diagnosed stage IV breast cancer patients receiving HER-2-targeted therapy. METHODS:Women aged 65+ with an incident diagnosis of stage IV breast cancer (index) and no history of other cancer were identified from 2006 to 2010 linked Surveillance, Epidemiology and ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Lang K,Hao Y,Huang H,Lin I,Rogerio JW,Menzin J

    更新日期:2014-09-01 00:00:00

  • Welcome to the Journal of Comparative Effectiveness Research.

    abstract::As the Senior Editors of the Journal of Comparative Effectiveness Research (JCER) we are delighted to present you with the first issue of this exciting new publication, focusing on the socially and clinically impactful field of comparative effectiveness research (CER). ...

    journal_title:Journal of comparative effectiveness research



    authors: Greenfield S,Rich E

    更新日期:2012-01-01 00:00:00

  • Hospital cost impact of orbital atherectomy with angioplasty for critical limb ischemia treatment: a modeling approach.

    abstract:AIM:The incremental cost of peripheral orbital atherectomy system (OAS) plus balloon angioplasty (BA) versus BA-only for critical limb ischemia was estimated. MATERIALS & METHODS:A deterministic simulation model used clinical and healthcare utilization data from the CALCIUM 360° trial and current cost data. Incrementa...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Shammas NW,Boyes CW,Palli SR,Rizzo JA,Martinsen BJ,Kotlarz H,Mustapha JA

    更新日期:2018-04-01 00:00:00

  • Systematic overview of cost-effectiveness thresholds in ten countries across four continents.

    abstract:AIM:To provide an overview of thresholds for incremental cost-effectiveness ratios (ICERs) representing willingness-to-pay (WTP) across multiple countries and insights into exemptions pertaining to the ICER (e.g., cancer). To compare ICER thresholds to individual country's estimated ability-to-pay. MATERIALS & METHODS...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Schwarzer R,Rochau U,Saverno K,Jahn B,Bornschein B,Muehlberger N,Flatscher-Thoeni M,Schnell-Inderst P,Sroczynski G,Lackner M,Schall I,Hebborn A,Pugner K,Fehervary A,Brixner D,Siebert U

    更新日期:2015-09-01 00:00:00

  • When is evidence sufficient for decision-making? A framework for understanding the pace of evidence adoption.

    abstract::Translation of medical evidence into practice has not kept pace with the growth of medical technology and knowledge. We present three case studies--statins, drug eluting stents and bone marrow transplantation for breast cancer--to propose a framework for describing five factors that may influence the rate of adoption....

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Dubois RW,Lauer M,Perfetto E

    更新日期:2013-07-01 00:00:00

  • Experiences of cancer patients with outpatient care in the USA: a population-based study.

    abstract::Aim: To evaluate the patterns of cancer patients-assessed quality of outpatient care in the USA. Materials & methods: Medical Expenditure Panel Survey datasets for the years 2011, 2013, 2015 and 2017 were accessed and adult participants with a history of cancer diagnosis were reviewed. Participants' assessments of dif...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Abdel-Rahman O

    更新日期:2020-09-01 00:00:00

  • Venous stenting for patients with outflow obstruction and leg ulcers: cost-effectiveness and budget impact analyses.

    abstract::Aim: To perform cost-effectiveness analysis (CEA) and budget impact analysis (BIA) comparing stenting to standard medical treatment (SMT) for the management of deep venous outflow obstruction and leg ulcers from the Italian Healthcare Service perspective. Materials & methods: A Markov model was developed to project co...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Rognoni C,Lugli M,Maleti O,Tarricone R

    更新日期:2020-07-01 00:00:00

  • Policy perspectives on alternative models for pharmaceutical rebates: a report from the Institute for Clinical and Economic Review Policy Summit.

    abstract::Alternative approaches to the current rebate system are being considered by policymakers and stakeholders in the private insurance market. This paper presents an analysis of three alternative options to the current rebate model: retaining retroactive rebates but requiring 100% pass-through of rebates and fees to plan ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Pearson SD,Segel C,Cole A,Henshall C,Towse A

    更新日期:2019-10-01 00:00:00

  • Missing laboratory results data in electronic health databases: implications for monitoring diabetes risk.

    abstract:AIM:Laboratory test (lab) results may be useful to detect incident diabetes in electronic health record and claims-based studies. RESEARCH DESIGN & METHODS:Using the Mini-Sentinel distributed database, we assessed the value of lab results added to diagnosis codes and dispensing claims to identify incident diabetes. R...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Flory JH,Roy J,Gagne JJ,Haynes K,Herrinton L,Lu C,Patorno E,Shoaibi A,Raebel MA

    更新日期:2017-01-01 00:00:00

  • Development and preliminary evidence of the psychometric properties of the GNE myopathy functional activity scale.

    abstract:AIM:GNE myopathy, a rare, severe, progressive myopathy, presents with lower extremity distal muscle weakness. The GNE myopathy functional activity scale (GNEM-FAS) evaluates the impact of GNE myopathy on functioning in adults. This paper presents the psychometric validation of the GNEM-FAS. PATIENTS & METHODS:Validati...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Mayhew J,Bonner N,Arbuckle R,Turnbull A,Bowden A,Skrinar A

    更新日期:2018-04-01 00:00:00

  • Matching-adjusted indirect comparison: secukinumab versus infliximab in biologic-naive patients with psoriatic arthritis.

    abstract::Aim: To compare secukinumab with infliximab in biologic-naive patients with psoriatic arthritis using matching-adjusted indirect comparison. Patients & methods: Individual patient baseline data for secukinumab were matched to published aggregate data for infliximab by key baseline characteristics, with matching weight...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Strand V,McInnes I,Mease P,Nash P,Thom H,Kalyvas C,Hunger M,Gandhi K,Pricop L,Jugl S,Choy E

    更新日期:2019-05-01 00:00:00

  • Donor insemination: Israel as a representative case of a competitive market examining the possibility of policy reform.

    abstract:AIM:To measure the private and social benefits of donor insemination (DI). METHODS:An empirical model investigates the general public and DI clients' willingness to pay (WTP) for DI, and the willingness of potential donors to become altruistic or paid sperm donors. RESULTS:The general public and DI clients value DI a...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Gonen LD

    更新日期:2017-03-01 00:00:00