Systematic overview of cost-effectiveness thresholds in ten countries across four continents.


AIM:To provide an overview of thresholds for incremental cost-effectiveness ratios (ICERs) representing willingness-to-pay (WTP) across multiple countries and insights into exemptions pertaining to the ICER (e.g., cancer). To compare ICER thresholds to individual country's estimated ability-to-pay. MATERIALS & METHODS:We included AHRQ/USA, BIQG-GOEG/Austria, CADTH/Canada, DAHTA@DIMDI/Germany, DECIT-CGATS/Brazil, HAS/France, HITAP/Thailand, IQWiG/Germany, LBI-HTA/Austria, MSAC/Australia, NICE/England/Wales and SBU/Sweden. ICER thresholds were derived from systematic literature/website search/expert surveys. WTP was compared with ATP using Spearman's rank correlation. RESULTS:Two general and explicitly acknowledged thresholds (England/Wales, Thailand), implicit thresholds in six countries and different ICER thresholds/decision-making rules in oncology were identified. Correlation between WTP and ability-to-pay was moderate. DISCUSSION:Our overview supports country-specific discussions on WTP and on how to define value(s) within societies.


J Comp Eff Res


Schwarzer R,Rochau U,Saverno K,Jahn B,Bornschein B,Muehlberger N,Flatscher-Thoeni M,Schnell-Inderst P,Sroczynski G,Lackner M,Schall I,Hebborn A,Pugner K,Fehervary A,Brixner D,Siebert U




Has Abstract


2015-09-01 00:00:00












  • A national data infrastructure for patient-centered outcomes research.

    abstract::Concerted efforts are underway to improve healthcare decision-making through patient-centered outcomes research. These efforts are supported by the Patient-Centered Outcomes Research Trust Fund, which was established within the Patient Protection and Affordable Care Act. This article focuses on describing national dat...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Dymek C,Gingold J,Shanbhag A,Fridsma D,Yong PL

    更新日期:2015-01-01 00:00:00

  • Health researcher views on comparative effectiveness research and research engagement.

    abstract:AIM:To understand researcher capability for and interest in patient-centered comparative effectiveness research (PC-CER), particularly related to engaging with patients/caregivers. MATERIALS & METHODS:Web-based survey of 508 health researchers recruited via professional health research organizations. RESULTS:Most res...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Forsythe LP,Frank LB,Workman TA,Borsky A,Hilliard T,Harwell D,Fayish L

    更新日期:2017-05-01 00:00:00

  • Experiences of cancer patients with outpatient care in the USA: a population-based study.

    abstract::Aim: To evaluate the patterns of cancer patients-assessed quality of outpatient care in the USA. Materials & methods: Medical Expenditure Panel Survey datasets for the years 2011, 2013, 2015 and 2017 were accessed and adult participants with a history of cancer diagnosis were reviewed. Participants' assessments of dif...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Abdel-Rahman O

    更新日期:2020-09-01 00:00:00

  • The utilization of telephone follow-up in the advanced cancer population: a review of the literature.

    abstract:BACKGROUND:Palliative cancer patients often require clinic or hospital follow-up after any treatment intervention they may have received. This is typically done in person at either a hospital or a clinic. In these advanced cancer patients, this may be burdensome and result in attrition. Telephone follow-up is becoming ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,评审


    authors: Zhou M,Holden L,Bedard G,Zeng L,Lam H,Chu D,Lao N,Lauzon N,Chow E

    更新日期:2012-11-01 00:00:00

  • Donor insemination: Israel as a representative case of a competitive market examining the possibility of policy reform.

    abstract:AIM:To measure the private and social benefits of donor insemination (DI). METHODS:An empirical model investigates the general public and DI clients' willingness to pay (WTP) for DI, and the willingness of potential donors to become altruistic or paid sperm donors. RESULTS:The general public and DI clients value DI a...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Gonen LD

    更新日期:2017-03-01 00:00:00

  • Comparison between oral and intravenous application of tranexamic acid for total hip arthroplasty: a meta-analysis.

    abstract:AIM:We conducted a meta-analysis to compare the efficacy and safety of oral and intravenous applications of tranexamic acid (TXA) in total hip arthroplasty (THA). MATERIALS & METHODS:Electronic databases, including PubMed, Cochrane CENTRAL, ScienceDirect and Embase, were searched to identify the studies comparing the ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,meta分析


    authors: Wang L,Cao JG,Liu J

    更新日期:2019-04-01 00:00:00

  • Engaging hard-to-reach patients in patient-centered outcomes research.

    abstract:AIMS:This study aimed to identify methods to engage hard-to-reach patients in the research process. MATERIALS & METHODS:With funding from the Patient-Centered Outcomes Research Institute (Washington, DC, USA), the University of Maryland (MD, USA) conducted 20 focus groups and one individual interview. The sample consi...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Kauffman KS,Dosreis S,Ross M,Barnet B,Onukwugha E,Mullins CD

    更新日期:2013-05-01 00:00:00

  • Show me the money! An analysis of underserved stakeholders' funding priorities in Patient Centered Outcomes Research domains.

    abstract:AIM:Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS:Academic and community partners coll...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Cargill SS,Baker LL,Goold SD

    更新日期:2017-07-01 00:00:00

  • Survival in unresectable AJCC stage I and II HCC and the effect of DEB-TACE: SEER versus tertiary cancer center cohort study.

    abstract:AIM:To evaluate overall survival (OS) in unresectable American Joint Committee on Cancer (AJCC) stage I/II hepatocellular carcinoma (HCC) treated with drug-eluting-bead transarterial chemoembolization (DEB-TACE) versus best supportive care. MATERIALS & METHODS:OS in consecutive patients with AJCC stage I/II unresectab...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Xing M,Kokabi N,Prajapati HJ,Close O,Ludwig JM,Kim HS

    更新日期:2016-03-01 00:00:00

  • Antithrombotic use and bleeding risk in patients with atrial fibrillation: findings from a multipayer analysis.

    abstract:AIMS:To analyze administrative claims data from Medicaid, Medicare and commercial insurance sources to estimate stroke risk, bleeding risk, and the use of antithrombotic treatment in patients with atrial fibrillation (AF). METHODS:Included patients were aged ≥18 years with a new or existing diagnosis of AF. Outcomes w...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Lang K,Federico V,Patel AA,Munsell M,Nelson WW,Owens G,Mody SH,Schein J,Menzin J

    更新日期:2016-01-01 00:00:00

  • Comparison of amlodipine versus other calcium channel blockers on blood pressure variability in hypertensive patients in China: a retrospective propensity score-matched analysis.

    abstract:AIM:Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-establishe...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Zhang L,Yang J,Li L,Liu D,Xie X,Dong P,Lin Y

    更新日期:2018-07-01 00:00:00

  • Low-dose computed tomography screening for lung cancer: results of the first screening round.

    abstract::Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 评论,杂志文章


    authors: Horeweg N,Nackaerts K,Oudkerk M,de Koning HJ

    更新日期:2013-09-01 00:00:00

  • Medicaid insurance status predicts postoperative mortality after total knee arthroplasty in state inpatient databases.

    abstract::Aim: Medicaid versus private primary insurance status may predict in-hospital mortality and morbidity after total knee arthroplasty (TKA). Materials & methods: Regression models were used to test our hypothesis in patients in the State Inpatient Database (SID) from five states who underwent primary TKA from January 20...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Maman SR,Andreae MH,Gaber-Baylis LK,Turnbull ZA,White RS

    更新日期:2019-10-01 00:00:00

  • Treatment patterns among elderly patients with stage IV breast cancer treated with HER-2-targeted therapy.

    abstract:AIM:To evaluate treatment patterns among elderly, newly diagnosed stage IV breast cancer patients receiving HER-2-targeted therapy. METHODS:Women aged 65+ with an incident diagnosis of stage IV breast cancer (index) and no history of other cancer were identified from 2006 to 2010 linked Surveillance, Epidemiology and ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Lang K,Hao Y,Huang H,Lin I,Rogerio JW,Menzin J

    更新日期:2014-09-01 00:00:00

  • Is routine baseline brain imaging needed for all newly diagnosed non-small-cell lung cancer patients?

    abstract::Aim: Dedicated brain imaging is advocated by the National Comprehensive Cancer Network guidelines for newly diagnosed non-small-cell cancer (NSCLC) patients beyond stage I. The current study assessed the performance characteristics of this recommendation. Methods: Through accessing the Surveillance, Epidemiology and E...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Abdel-Rahman O

    更新日期:2019-06-01 00:00:00

  • Welcome to the Journal of Comparative Effectiveness Research.

    abstract::As the Senior Editors of the Journal of Comparative Effectiveness Research (JCER) we are delighted to present you with the first issue of this exciting new publication, focusing on the socially and clinically impactful field of comparative effectiveness research (CER). ...

    journal_title:Journal of comparative effectiveness research



    authors: Greenfield S,Rich E

    更新日期:2012-01-01 00:00:00

  • Health benefits and economic advantages associated with increased utilization of a smoking cessation program.

    abstract::Rationale, aim & objective: The goal of this study was to examine the health and economic impacts related to increased utilization of the Duke Smoking Cessation Program resulting from the addition of two relatively new referral methods - Best Practice Advisory and Population Outreach. Materials & methods: In a compani...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Datta SK,Dennis PA,Davis JM

    更新日期:2020-08-01 00:00:00

  • When is evidence sufficient for decision-making? A framework for understanding the pace of evidence adoption.

    abstract::Translation of medical evidence into practice has not kept pace with the growth of medical technology and knowledge. We present three case studies--statins, drug eluting stents and bone marrow transplantation for breast cancer--to propose a framework for describing five factors that may influence the rate of adoption....

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Dubois RW,Lauer M,Perfetto E

    更新日期:2013-07-01 00:00:00

  • Depression, anxiety and stress severities in multiple sclerosis patients using injectable versus oral treatments.

    abstract:AIM:Studies on multiple sclerosis in Saudi Arabia remain scant, particularly studies on the psychological aspects. This study measures severities of depression, anxiety and stress, and compares them to the used disease-modifying treatment. MATERIALS & METHODS:Cross-sectional study using a phone questionnaire targeting...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Al-Hussain F,Al-Salloum N,Alazwary N,Saeedi J,Howaidi S,Daif A

    更新日期:2017-07-01 00:00:00

  • Using big data for quality assessment in oncology.

    abstract::There is increasing attention in the US healthcare system on the delivery of high-quality care, an issue central to oncology. In the report 'Crossing the Quality Chasm', the Institute of Medicine identified six aims for improving healthcare quality: safe, effective, patient-centered, timely, efficient and equitable. T...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Broughman JR,Chen RC

    更新日期:2016-05-01 00:00:00

  • Web-based decision aids to support breast cancer screening decisions: systematic review and meta-analysis.

    abstract::Aim: Breast cancer is a leading cause of cancer among women. Because guidelines on screening for breast cancer for certain ages are controversial, many experts advocate the use of shared decision making (SDM) using validated decision aids (DAs). Recent studies have concluded that DAs are beneficial; however, the resul...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Yu L,Li P,Yang S,Guo P,Zhang X,Liu N,Wang J,Zhang W

    更新日期:2020-10-01 00:00:00

  • Reporting and analyses of sex/gender and race/ethnicity in randomized controlled trials of interventions published in the highest-ranking anesthesiology journals.

    abstract::Aim: We assessed reporting of data on sex/gender and race/ethnicity in randomized controlled trials of interventions published in the highest-ranking anesthesiology journals from 2014 to 2017. Methods: We extracted data regarding terminology for sex/gender, proportion of participants according to the race/gender and r...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Begic D,Janda-Martinac C,Vrdoljak M,Puljak L

    更新日期:2019-12-01 00:00:00

  • Young adult and parent stakeholder perspectives on participation in patient-centered comparative effectiveness research.

    abstract:AIM:Explore perspectives of adolescent and young adult (AYA) and parent stakeholders regarding their engagement in comparative effectiveness research (CER) evaluating cholesterol screening and treatment strategies for 17-21 year olds. METHODS:All nine AYAs and parent stakeholders participating in a 20-member panel of ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Saunders T,Mackie TI,Shah S,Gooding H,de Ferranti SD,Leslie LK

    更新日期:2016-08-01 00:00:00

  • Cost associated with hematopoietic stem cell transplantation: a retrospective claims data analysis in Germany.

    abstract:AIM:Quantify hematopoietic stem cell transplantation (HSCT) costs in German patients with acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). METHODS:The primary outcome was direct and indirect costs in patients with ALL/DLBCL/FL who received HSCT between 2010 and 20...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Mayerhoff L,Lehne M,Hickstein L,Salimullah T,Prieur S,Thomas SK,Zhang J

    更新日期:2019-01-01 00:00:00

  • Missing laboratory results data in electronic health databases: implications for monitoring diabetes risk.

    abstract:AIM:Laboratory test (lab) results may be useful to detect incident diabetes in electronic health record and claims-based studies. RESEARCH DESIGN & METHODS:Using the Mini-Sentinel distributed database, we assessed the value of lab results added to diagnosis codes and dispensing claims to identify incident diabetes. R...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Flory JH,Roy J,Gagne JJ,Haynes K,Herrinton L,Lu C,Patorno E,Shoaibi A,Raebel MA

    更新日期:2017-01-01 00:00:00

  • Policy perspectives on alternative models for pharmaceutical rebates: a report from the Institute for Clinical and Economic Review Policy Summit.

    abstract::Alternative approaches to the current rebate system are being considered by policymakers and stakeholders in the private insurance market. This paper presents an analysis of three alternative options to the current rebate model: retaining retroactive rebates but requiring 100% pass-through of rebates and fees to plan ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Pearson SD,Segel C,Cole A,Henshall C,Towse A

    更新日期:2019-10-01 00:00:00

  • Hospital cost impact of orbital atherectomy with angioplasty for critical limb ischemia treatment: a modeling approach.

    abstract:AIM:The incremental cost of peripheral orbital atherectomy system (OAS) plus balloon angioplasty (BA) versus BA-only for critical limb ischemia was estimated. MATERIALS & METHODS:A deterministic simulation model used clinical and healthcare utilization data from the CALCIUM 360° trial and current cost data. Incrementa...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Shammas NW,Boyes CW,Palli SR,Rizzo JA,Martinsen BJ,Kotlarz H,Mustapha JA

    更新日期:2018-04-01 00:00:00

  • Using primary care electronic health record data for comparative effectiveness research: experience of data quality assessment and preprocessing in The Netherlands.

    abstract:AIM:Details of data quality and how quality issues were solved have not been reported in published comparative effectiveness studies using electronic health record data. METHODS:We developed a conceptual framework of data quality assessment and preprocessing and apply it to a study comparing angiotensin-converting enz...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Huang Y,Voorham J,Haaijer-Ruskamp FM

    更新日期:2016-07-01 00:00:00

  • Revascularization options in stable coronary artery disease: it is not how to revascularize, it is whether and when to revascularize.

    abstract::Patients with acute coronary syndromes and severe multivessel or left main coronary artery disease have better outcomes when prompt revascularization is performed in addition to optimal medical therapy (OMT). However, in patients with stable ischemic heart disease, randomized strategy trials have revealed equipoise be...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,评审


    authors: Torosoff MT,Sidhu MS,Desai KP,Fein SA,Boden WE

    更新日期:2015-09-01 00:00:00

  • Stroke Administrative Severity Index: using administrative data for 30-day poststroke outcomes prediction.

    abstract:AIM:Current stroke severity scales cannot be used for archival data. We develop and validate a measure of stroke severity at hospital discharge (Stroke Administrative Severity Index [SASI]) for use in billing data. METHODS:We used the NIH Stroke Scale (NIHSS) as the theoretical framework and identified 285 relevant In...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Simpson AN,Wilmskoetter J,Hong I,Li CY,Jauch EC,Bonilha HS,Anderson K,Harvey J,Simpson KN

    更新日期:2018-04-01 00:00:00