Comparison between oral and intravenous application of tranexamic acid for total hip arthroplasty: a meta-analysis.

Abstract:

AIM:We conducted a meta-analysis to compare the efficacy and safety of oral and intravenous applications of tranexamic acid (TXA) in total hip arthroplasty (THA). MATERIALS & METHODS:Electronic databases, including PubMed, Cochrane CENTRAL, ScienceDirect and Embase, were searched to identify the studies comparing the efficacy and safety of oral and intravenous applications of TXA in THA. Relevant journals and conference proceedings were manually searched. The pooled data were analyzed using RevMan 5.1. RESULTS:Four randomized control trials and one retrospective study were identified. A meta-analysis showed no significant differences in hemoglobin reduction, total blood loss and transfusion requirements. CONCLUSION:Oral applications of TXA are comparable to intravenous applications of TXA in primary unilateral THA for blood conservation and cost-saving measures.

journal_name

J Comp Eff Res

authors

Wang L,Cao JG,Liu J

doi

10.2217/cer-2018-0120

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

423-430

issue

6

eissn

2042-6305

issn

2042-6313

journal_volume

8

pub_type

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