Big data, advanced analytics and the future of comparative effectiveness research.


:The intense competition that accompanied the growth of internet-based companies ushered in the era of 'big data' characterized by major innovations in processing of very large amounts of data and the application of advanced analytics including data mining and machine learning. Healthcare is on the cusp of its own era of big data, catalyzed by the changing regulatory and competitive environments, fueled by growing adoption of electronic health records, as well as efforts to integrate medical claims, electronic health records and other novel data sources. Applying the lessons from big data pioneers will require healthcare and life science organizations to make investments in new hardware and software, as well as in individuals with different skills. For life science companies, this will impact the entire pharmaceutical value chain from early research to postcommercialization support. More generally, this will revolutionize comparative effectiveness research.


J Comp Eff Res


Berger ML,Doban V




Has Abstract


2014-03-01 00:00:00












  • Hospital cost impact of orbital atherectomy with angioplasty for critical limb ischemia treatment: a modeling approach.

    abstract:AIM:The incremental cost of peripheral orbital atherectomy system (OAS) plus balloon angioplasty (BA) versus BA-only for critical limb ischemia was estimated. MATERIALS & METHODS:A deterministic simulation model used clinical and healthcare utilization data from the CALCIUM 360° trial and current cost data. Incrementa...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Shammas NW,Boyes CW,Palli SR,Rizzo JA,Martinsen BJ,Kotlarz H,Mustapha JA

    更新日期:2018-04-01 00:00:00

  • Comparison of amlodipine versus other calcium channel blockers on blood pressure variability in hypertensive patients in China: a retrospective propensity score-matched analysis.

    abstract:AIM:Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-establishe...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Zhang L,Yang J,Li L,Liu D,Xie X,Dong P,Lin Y

    更新日期:2018-07-01 00:00:00

  • Importance of assessing and adjusting for cross-study heterogeneity in network meta-analysis: a case study of psoriasis.

    abstract:AIM:The importance of adjusting for cross-study heterogeneity when conducting network meta-analyses (NMAs) was demonstrated using a case study of biologic therapies for moderate-to-severe plaque psoriasis. METHODS:Bayesian NMAs were conducted for Psoriasis Area and Severity Index 90 response. Several covariates were c...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Cameron C,Hutton B,Druchok C,McElligott S,Nair S,Schubert A,Situ A,Varu A,Villacorta R

    更新日期:2018-11-01 00:00:00

  • Stroke Administrative Severity Index: using administrative data for 30-day poststroke outcomes prediction.

    abstract:AIM:Current stroke severity scales cannot be used for archival data. We develop and validate a measure of stroke severity at hospital discharge (Stroke Administrative Severity Index [SASI]) for use in billing data. METHODS:We used the NIH Stroke Scale (NIHSS) as the theoretical framework and identified 285 relevant In...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Simpson AN,Wilmskoetter J,Hong I,Li CY,Jauch EC,Bonilha HS,Anderson K,Harvey J,Simpson KN

    更新日期:2018-04-01 00:00:00

  • A meta-analysis platform methodology for determining the comparative effectiveness of antihepatitis C virus regimens.

    abstract:AIM:Many hepatitis C virus regimens are unlikely to be compared head to head. In more difficult to treat populations where there is no standard of care, trials are single arm. We describe a flexible meta-analysis platform in this setting. METHODS:Our meta-analysis is literature based. We illustrate our methodology and...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,meta分析,评审


    authors: Broglio KR,Daar ES,Quintana M,Yuan Y,Kalsekar A,Spellberg B,Lewis RJ,Akker Dv,Detry MA,Le T,Berry SM

    更新日期:2015-03-01 00:00:00

  • Depression, anxiety and stress severities in multiple sclerosis patients using injectable versus oral treatments.

    abstract:AIM:Studies on multiple sclerosis in Saudi Arabia remain scant, particularly studies on the psychological aspects. This study measures severities of depression, anxiety and stress, and compares them to the used disease-modifying treatment. MATERIALS & METHODS:Cross-sectional study using a phone questionnaire targeting...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Al-Hussain F,Al-Salloum N,Alazwary N,Saeedi J,Howaidi S,Daif A

    更新日期:2017-07-01 00:00:00

  • Experiences of cancer patients with outpatient care in the USA: a population-based study.

    abstract::Aim: To evaluate the patterns of cancer patients-assessed quality of outpatient care in the USA. Materials & methods: Medical Expenditure Panel Survey datasets for the years 2011, 2013, 2015 and 2017 were accessed and adult participants with a history of cancer diagnosis were reviewed. Participants' assessments of dif...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Abdel-Rahman O

    更新日期:2020-09-01 00:00:00

  • Systematic overview of cost-effectiveness thresholds in ten countries across four continents.

    abstract:AIM:To provide an overview of thresholds for incremental cost-effectiveness ratios (ICERs) representing willingness-to-pay (WTP) across multiple countries and insights into exemptions pertaining to the ICER (e.g., cancer). To compare ICER thresholds to individual country's estimated ability-to-pay. MATERIALS & METHODS...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Schwarzer R,Rochau U,Saverno K,Jahn B,Bornschein B,Muehlberger N,Flatscher-Thoeni M,Schnell-Inderst P,Sroczynski G,Lackner M,Schall I,Hebborn A,Pugner K,Fehervary A,Brixner D,Siebert U

    更新日期:2015-09-01 00:00:00

  • Building useful evidence: changing the clinical research paradigm to account for comparative effectiveness research.

    abstract::Comparative effectiveness research (CER) calls for substantial changes in the way clinical research is conducted, interpreted and practically applied in the USA, in order to produce useful clinical evidence. Departing from classic efficacy and effectiveness research, the evolving CER paradigm requires structural and s...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,评审


    authors: Greenfield S,Kaplan SH

    更新日期:2012-05-01 00:00:00

  • Show me the money! An analysis of underserved stakeholders' funding priorities in Patient Centered Outcomes Research domains.

    abstract:AIM:Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS:Academic and community partners coll...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Cargill SS,Baker LL,Goold SD

    更新日期:2017-07-01 00:00:00

  • A criterion-based approach to systematic and transparent comparative effectiveness: a case study in psoriatic arthritis.

    abstract::Aim: Indirect treatment comparisons are used when no direct comparison is available. Comparison networks should satisfy the transitivity assumption, that is, equal likelihood of treatment assignment for a given patient based on comparability of studies. Materials & methods: Seven criteria were evaluated across 18 rand...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Tremblay G,Westley T,Forsythe A,Pelletier C,Briggs A

    更新日期:2019-11-01 00:00:00

  • Approaches to the management of functional tricuspid regurgitation.

    abstract::Functional tricuspid regurgitation (FTR) is an acquired valvular abnormality that is most frequently encountered during the evaluation and operative management of left-sided heart failure and left heart valve disease. Observational studies have demonstrated that uncorrected significant FTR during mitral valve surgery ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Rogers JH,Bolling SF

    更新日期:2015-11-01 00:00:00

  • Policy perspectives on alternative models for pharmaceutical rebates: a report from the Institute for Clinical and Economic Review Policy Summit.

    abstract::Alternative approaches to the current rebate system are being considered by policymakers and stakeholders in the private insurance market. This paper presents an analysis of three alternative options to the current rebate model: retaining retroactive rebates but requiring 100% pass-through of rebates and fees to plan ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Pearson SD,Segel C,Cole A,Henshall C,Towse A

    更新日期:2019-10-01 00:00:00

  • Matching-adjusted indirect comparison: secukinumab versus infliximab in biologic-naive patients with psoriatic arthritis.

    abstract::Aim: To compare secukinumab with infliximab in biologic-naive patients with psoriatic arthritis using matching-adjusted indirect comparison. Patients & methods: Individual patient baseline data for secukinumab were matched to published aggregate data for infliximab by key baseline characteristics, with matching weight...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Strand V,McInnes I,Mease P,Nash P,Thom H,Kalyvas C,Hunger M,Gandhi K,Pricop L,Jugl S,Choy E

    更新日期:2019-05-01 00:00:00

  • Antithrombotic use and bleeding risk in patients with atrial fibrillation: findings from a multipayer analysis.

    abstract:AIMS:To analyze administrative claims data from Medicaid, Medicare and commercial insurance sources to estimate stroke risk, bleeding risk, and the use of antithrombotic treatment in patients with atrial fibrillation (AF). METHODS:Included patients were aged ≥18 years with a new or existing diagnosis of AF. Outcomes w...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Lang K,Federico V,Patel AA,Munsell M,Nelson WW,Owens G,Mody SH,Schein J,Menzin J

    更新日期:2016-01-01 00:00:00

  • Cost associated with hematopoietic stem cell transplantation: a retrospective claims data analysis in Germany.

    abstract:AIM:Quantify hematopoietic stem cell transplantation (HSCT) costs in German patients with acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). METHODS:The primary outcome was direct and indirect costs in patients with ALL/DLBCL/FL who received HSCT between 2010 and 20...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Mayerhoff L,Lehne M,Hickstein L,Salimullah T,Prieur S,Thomas SK,Zhang J

    更新日期:2019-01-01 00:00:00

  • Effects of mindfulness-based interventions on quality of life of women with breast cancer: a systematic review.

    abstract::Aim: The systematic review assessed the effect of mindfulness-based interventions on the quality of life among women with breast cancer. Methods: PubMed, Cochrane library, EMBASE, Web of Science and CINAHL databases were searched for studies published. Our review assessed the effect of mindfulness-based interventions ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Zhang X,Liu D,Li Y,Zhang Y,Zhang B,Wang X,Wang G

    更新日期:2019-08-01 00:00:00

  • Engaging hard-to-reach patients in patient-centered outcomes research.

    abstract:AIMS:This study aimed to identify methods to engage hard-to-reach patients in the research process. MATERIALS & METHODS:With funding from the Patient-Centered Outcomes Research Institute (Washington, DC, USA), the University of Maryland (MD, USA) conducted 20 focus groups and one individual interview. The sample consi...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Kauffman KS,Dosreis S,Ross M,Barnet B,Onukwugha E,Mullins CD

    更新日期:2013-05-01 00:00:00

  • Is routine baseline brain imaging needed for all newly diagnosed non-small-cell lung cancer patients?

    abstract::Aim: Dedicated brain imaging is advocated by the National Comprehensive Cancer Network guidelines for newly diagnosed non-small-cell cancer (NSCLC) patients beyond stage I. The current study assessed the performance characteristics of this recommendation. Methods: Through accessing the Surveillance, Epidemiology and E...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Abdel-Rahman O

    更新日期:2019-06-01 00:00:00

  • Web-based decision aids to support breast cancer screening decisions: systematic review and meta-analysis.

    abstract::Aim: Breast cancer is a leading cause of cancer among women. Because guidelines on screening for breast cancer for certain ages are controversial, many experts advocate the use of shared decision making (SDM) using validated decision aids (DAs). Recent studies have concluded that DAs are beneficial; however, the resul...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Yu L,Li P,Yang S,Guo P,Zhang X,Liu N,Wang J,Zhang W

    更新日期:2020-10-01 00:00:00

  • Continuous infusion of levodopa-carbidopa intestinal gel in Parkinson's disease.

    abstract::Evaluation of: Olanow CW, Kieburtz K, Odin P et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 13(2), 141-149 (2014). Levodopa-induced motor complications, including mot...

    journal_title:Journal of comparative effectiveness research

    pub_type: 评论,杂志文章


    authors: Guthikonda LN,Lyons KE,Pahwa R

    更新日期:2014-07-01 00:00:00

  • Treatment patterns among elderly patients with stage IV breast cancer treated with HER-2-targeted therapy.

    abstract:AIM:To evaluate treatment patterns among elderly, newly diagnosed stage IV breast cancer patients receiving HER-2-targeted therapy. METHODS:Women aged 65+ with an incident diagnosis of stage IV breast cancer (index) and no history of other cancer were identified from 2006 to 2010 linked Surveillance, Epidemiology and ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Lang K,Hao Y,Huang H,Lin I,Rogerio JW,Menzin J

    更新日期:2014-09-01 00:00:00

  • Healthcare resource utilization and costs in amyloid light-chain amyloidosis: a real-world study using US claims data.

    abstract:AIM:To estimate healthcare utilization and costs in amyloid light-chain (AL) amyloidosis. PATIENTS & METHODS:AL amyloidosis patients were identified in 2007-2015 claims databases if they had ≥1 inpatient/≥2 outpatient claims consistent with AL amyloidosis and received ≥1 AL-specific treatment. Descriptive statistics w...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Quock TP,Yan T,Chang E,Guthrie S,Broder MS

    更新日期:2018-06-01 00:00:00

  • Medicaid insurance status predicts postoperative mortality after total knee arthroplasty in state inpatient databases.

    abstract::Aim: Medicaid versus private primary insurance status may predict in-hospital mortality and morbidity after total knee arthroplasty (TKA). Materials & methods: Regression models were used to test our hypothesis in patients in the State Inpatient Database (SID) from five states who underwent primary TKA from January 20...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Maman SR,Andreae MH,Gaber-Baylis LK,Turnbull ZA,White RS

    更新日期:2019-10-01 00:00:00

  • No protocol and no liability: a call for COVID crisis guidelines that protect vulnerable populations.

    abstract::The COVID-19 pandemic is revealing the unacceptable health disparities across New York City and in this country. The mortality rates of vulnerable and minority populations alone suggest a need to re-evaluate clinical decision making protocols, especially given the recently passed Emergency or Disaster Treatment Protec...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Caraccio C,White RS,Jotwani R

    更新日期:2020-08-01 00:00:00

  • Health benefits and economic advantages associated with increased utilization of a smoking cessation program.

    abstract::Rationale, aim & objective: The goal of this study was to examine the health and economic impacts related to increased utilization of the Duke Smoking Cessation Program resulting from the addition of two relatively new referral methods - Best Practice Advisory and Population Outreach. Materials & methods: In a compani...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Datta SK,Dennis PA,Davis JM

    更新日期:2020-08-01 00:00:00

  • Comparison between oral and intravenous application of tranexamic acid for total hip arthroplasty: a meta-analysis.

    abstract:AIM:We conducted a meta-analysis to compare the efficacy and safety of oral and intravenous applications of tranexamic acid (TXA) in total hip arthroplasty (THA). MATERIALS & METHODS:Electronic databases, including PubMed, Cochrane CENTRAL, ScienceDirect and Embase, were searched to identify the studies comparing the ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,meta分析


    authors: Wang L,Cao JG,Liu J

    更新日期:2019-04-01 00:00:00

  • The mixed randomized trial: combining randomized, pragmatic and observational clinical trial designs.

    abstract::Clinical trial designs often fail to deliver data that jointly satisfy evolving demands of both regulatory and reimbursement authorities. We propose a new multi-tiered trial design to integrate efficacy and effectiveness, and address the evolving needs of authorities. The mixed randomized trial allocates patients firs...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Alsop J,Scott M,Archey W

    更新日期:2016-11-01 00:00:00

  • Health researcher views on comparative effectiveness research and research engagement.

    abstract:AIM:To understand researcher capability for and interest in patient-centered comparative effectiveness research (PC-CER), particularly related to engaging with patients/caregivers. MATERIALS & METHODS:Web-based survey of 508 health researchers recruited via professional health research organizations. RESULTS:Most res...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Forsythe LP,Frank LB,Workman TA,Borsky A,Hilliard T,Harwell D,Fayish L

    更新日期:2017-05-01 00:00:00

  • Using big data for quality assessment in oncology.

    abstract::There is increasing attention in the US healthcare system on the delivery of high-quality care, an issue central to oncology. In the report 'Crossing the Quality Chasm', the Institute of Medicine identified six aims for improving healthcare quality: safe, effective, patient-centered, timely, efficient and equitable. T...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Broughman JR,Chen RC

    更新日期:2016-05-01 00:00:00