Big data, advanced analytics and the future of comparative effectiveness research.

abstract：AIM:The incremental cost of peripheral orbital atherectomy system (OAS) plus balloon angioplasty (BA) versus BA-only for critical limb ischemia was estimated. MATERIALS & METHODS:A deterministic simulation model used clinical and healthcare utilization data from the CALCIUM 360° trial and current cost data. Incrementa...

journal_title：Journal of comparative effectiveness research

authors： Shammas NW,Boyes CW,Palli SR,Rizzo JA,Martinsen BJ,Kotlarz H,Mustapha JA

更新日期：2018-04-01 00:00:00

abstract：AIM:Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-establishe...

journal_title：Journal of comparative effectiveness research

authors： Zhang L,Yang J,Li L,Liu D,Xie X,Dong P,Lin Y

更新日期：2018-07-01 00:00:00

abstract：AIM:The importance of adjusting for cross-study heterogeneity when conducting network meta-analyses (NMAs) was demonstrated using a case study of biologic therapies for moderate-to-severe plaque psoriasis. METHODS:Bayesian NMAs were conducted for Psoriasis Area and Severity Index 90 response. Several covariates were c...

journal_title：Journal of comparative effectiveness research

authors： Cameron C,Hutton B,Druchok C,McElligott S,Nair S,Schubert A,Situ A,Varu A,Villacorta R

更新日期：2018-11-01 00:00:00

abstract：AIM:Current stroke severity scales cannot be used for archival data. We develop and validate a measure of stroke severity at hospital discharge (Stroke Administrative Severity Index [SASI]) for use in billing data. METHODS:We used the NIH Stroke Scale (NIHSS) as the theoretical framework and identified 285 relevant In...

journal_title：Journal of comparative effectiveness research

authors： Simpson AN,Wilmskoetter J,Hong I,Li CY,Jauch EC,Bonilha HS,Anderson K,Harvey J,Simpson KN

更新日期：2018-04-01 00:00:00

abstract：AIM:Many hepatitis C virus regimens are unlikely to be compared head to head. In more difficult to treat populations where there is no standard of care, trials are single arm. We describe a flexible meta-analysis platform in this setting. METHODS:Our meta-analysis is literature based. We illustrate our methodology and...

journal_title：Journal of comparative effectiveness research

authors： Broglio KR,Daar ES,Quintana M,Yuan Y,Kalsekar A,Spellberg B,Lewis RJ,Akker Dv,Detry MA,Le T,Berry SM

更新日期：2015-03-01 00:00:00

abstract：AIM:Studies on multiple sclerosis in Saudi Arabia remain scant, particularly studies on the psychological aspects. This study measures severities of depression, anxiety and stress, and compares them to the used disease-modifying treatment. MATERIALS & METHODS:Cross-sectional study using a phone questionnaire targeting...

journal_title：Journal of comparative effectiveness research

authors： Al-Hussain F,Al-Salloum N,Alazwary N,Saeedi J,Howaidi S,Daif A

更新日期：2017-07-01 00:00:00

abstract：:Aim: To evaluate the patterns of cancer patients-assessed quality of outpatient care in the USA. Materials & methods: Medical Expenditure Panel Survey datasets for the years 2011, 2013, 2015 and 2017 were accessed and adult participants with a history of cancer diagnosis were reviewed. Participants' assessments of dif...

journal_title：Journal of comparative effectiveness research

authors： Abdel-Rahman O

更新日期：2020-09-01 00:00:00

abstract：AIM:To provide an overview of thresholds for incremental cost-effectiveness ratios (ICERs) representing willingness-to-pay (WTP) across multiple countries and insights into exemptions pertaining to the ICER (e.g., cancer). To compare ICER thresholds to individual country's estimated ability-to-pay. MATERIALS & METHODS...

journal_title：Journal of comparative effectiveness research

authors： Schwarzer R,Rochau U,Saverno K,Jahn B,Bornschein B,Muehlberger N,Flatscher-Thoeni M,Schnell-Inderst P,Sroczynski G,Lackner M,Schall I,Hebborn A,Pugner K,Fehervary A,Brixner D,Siebert U

更新日期：2015-09-01 00:00:00

abstract：:Comparative effectiveness research (CER) calls for substantial changes in the way clinical research is conducted, interpreted and practically applied in the USA, in order to produce useful clinical evidence. Departing from classic efficacy and effectiveness research, the evolving CER paradigm requires structural and s...

journal_title：Journal of comparative effectiveness research

authors： Greenfield S,Kaplan SH

更新日期：2012-05-01 00:00:00

abstract：AIM:Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS:Academic and community partners coll...

journal_title：Journal of comparative effectiveness research

authors： Cargill SS,Baker LL,Goold SD

更新日期：2017-07-01 00:00:00

abstract：:Aim: Indirect treatment comparisons are used when no direct comparison is available. Comparison networks should satisfy the transitivity assumption, that is, equal likelihood of treatment assignment for a given patient based on comparability of studies. Materials & methods: Seven criteria were evaluated across 18 rand...

journal_title：Journal of comparative effectiveness research

authors： Tremblay G,Westley T,Forsythe A,Pelletier C,Briggs A

更新日期：2019-11-01 00:00:00

abstract：:Functional tricuspid regurgitation (FTR) is an acquired valvular abnormality that is most frequently encountered during the evaluation and operative management of left-sided heart failure and left heart valve disease. Observational studies have demonstrated that uncorrected significant FTR during mitral valve surgery ...

journal_title：Journal of comparative effectiveness research

authors： Rogers JH,Bolling SF

更新日期：2015-11-01 00:00:00

abstract：:Alternative approaches to the current rebate system are being considered by policymakers and stakeholders in the private insurance market. This paper presents an analysis of three alternative options to the current rebate model: retaining retroactive rebates but requiring 100% pass-through of rebates and fees to plan ...

journal_title：Journal of comparative effectiveness research

authors： Pearson SD,Segel C,Cole A,Henshall C,Towse A

更新日期：2019-10-01 00:00:00

abstract：:Aim: To compare secukinumab with infliximab in biologic-naive patients with psoriatic arthritis using matching-adjusted indirect comparison. Patients & methods: Individual patient baseline data for secukinumab were matched to published aggregate data for infliximab by key baseline characteristics, with matching weight...

journal_title：Journal of comparative effectiveness research

authors： Strand V,McInnes I,Mease P,Nash P,Thom H,Kalyvas C,Hunger M,Gandhi K,Pricop L,Jugl S,Choy E

更新日期：2019-05-01 00:00:00

abstract：AIMS:To analyze administrative claims data from Medicaid, Medicare and commercial insurance sources to estimate stroke risk, bleeding risk, and the use of antithrombotic treatment in patients with atrial fibrillation (AF). METHODS:Included patients were aged ≥18 years with a new or existing diagnosis of AF. Outcomes w...

journal_title：Journal of comparative effectiveness research

authors： Lang K,Federico V,Patel AA,Munsell M,Nelson WW,Owens G,Mody SH,Schein J,Menzin J

更新日期：2016-01-01 00:00:00

abstract：AIM:Quantify hematopoietic stem cell transplantation (HSCT) costs in German patients with acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). METHODS:The primary outcome was direct and indirect costs in patients with ALL/DLBCL/FL who received HSCT between 2010 and 20...

journal_title：Journal of comparative effectiveness research

authors： Mayerhoff L,Lehne M,Hickstein L,Salimullah T,Prieur S,Thomas SK,Zhang J

更新日期：2019-01-01 00:00:00

abstract：:Aim: The systematic review assessed the effect of mindfulness-based interventions on the quality of life among women with breast cancer. Methods: PubMed, Cochrane library, EMBASE, Web of Science and CINAHL databases were searched for studies published. Our review assessed the effect of mindfulness-based interventions ...

journal_title：Journal of comparative effectiveness research

authors： Zhang X,Liu D,Li Y,Zhang Y,Zhang B,Wang X,Wang G

更新日期：2019-08-01 00:00:00

abstract：AIMS:This study aimed to identify methods to engage hard-to-reach patients in the research process. MATERIALS & METHODS:With funding from the Patient-Centered Outcomes Research Institute (Washington, DC, USA), the University of Maryland (MD, USA) conducted 20 focus groups and one individual interview. The sample consi...

journal_title：Journal of comparative effectiveness research

authors： Kauffman KS,Dosreis S,Ross M,Barnet B,Onukwugha E,Mullins CD

更新日期：2013-05-01 00:00:00

abstract：:Aim: Dedicated brain imaging is advocated by the National Comprehensive Cancer Network guidelines for newly diagnosed non-small-cell cancer (NSCLC) patients beyond stage I. The current study assessed the performance characteristics of this recommendation. Methods: Through accessing the Surveillance, Epidemiology and E...

journal_title：Journal of comparative effectiveness research

authors： Abdel-Rahman O

更新日期：2019-06-01 00:00:00

abstract：:Aim: Breast cancer is a leading cause of cancer among women. Because guidelines on screening for breast cancer for certain ages are controversial, many experts advocate the use of shared decision making (SDM) using validated decision aids (DAs). Recent studies have concluded that DAs are beneficial; however, the resul...

journal_title：Journal of comparative effectiveness research

authors： Yu L,Li P,Yang S,Guo P,Zhang X,Liu N,Wang J,Zhang W

更新日期：2020-10-01 00:00:00

abstract：:Evaluation of: Olanow CW, Kieburtz K, Odin P et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 13(2), 141-149 (2014). Levodopa-induced motor complications, including mot...

journal_title：Journal of comparative effectiveness research

authors： Guthikonda LN,Lyons KE,Pahwa R

更新日期：2014-07-01 00:00:00

abstract：AIM:To evaluate treatment patterns among elderly, newly diagnosed stage IV breast cancer patients receiving HER-2-targeted therapy. METHODS:Women aged 65+ with an incident diagnosis of stage IV breast cancer (index) and no history of other cancer were identified from 2006 to 2010 linked Surveillance, Epidemiology and ...

journal_title：Journal of comparative effectiveness research

authors： Lang K,Hao Y,Huang H,Lin I,Rogerio JW,Menzin J

更新日期：2014-09-01 00:00:00

abstract：AIM:To estimate healthcare utilization and costs in amyloid light-chain (AL) amyloidosis. PATIENTS & METHODS:AL amyloidosis patients were identified in 2007-2015 claims databases if they had ≥1 inpatient/≥2 outpatient claims consistent with AL amyloidosis and received ≥1 AL-specific treatment. Descriptive statistics w...

journal_title：Journal of comparative effectiveness research

authors： Quock TP,Yan T,Chang E,Guthrie S,Broder MS

更新日期：2018-06-01 00:00:00

abstract：:Aim: Medicaid versus private primary insurance status may predict in-hospital mortality and morbidity after total knee arthroplasty (TKA). Materials & methods: Regression models were used to test our hypothesis in patients in the State Inpatient Database (SID) from five states who underwent primary TKA from January 20...

journal_title：Journal of comparative effectiveness research

authors： Maman SR,Andreae MH,Gaber-Baylis LK,Turnbull ZA,White RS

更新日期：2019-10-01 00:00:00

abstract：:The COVID-19 pandemic is revealing the unacceptable health disparities across New York City and in this country. The mortality rates of vulnerable and minority populations alone suggest a need to re-evaluate clinical decision making protocols, especially given the recently passed Emergency or Disaster Treatment Protec...

journal_title：Journal of comparative effectiveness research

authors： Caraccio C,White RS,Jotwani R

更新日期：2020-08-01 00:00:00

abstract：:Rationale, aim & objective: The goal of this study was to examine the health and economic impacts related to increased utilization of the Duke Smoking Cessation Program resulting from the addition of two relatively new referral methods - Best Practice Advisory and Population Outreach. Materials & methods: In a compani...

journal_title：Journal of comparative effectiveness research

authors： Datta SK,Dennis PA,Davis JM

更新日期：2020-08-01 00:00:00

abstract：AIM:We conducted a meta-analysis to compare the efficacy and safety of oral and intravenous applications of tranexamic acid (TXA) in total hip arthroplasty (THA). MATERIALS & METHODS:Electronic databases, including PubMed, Cochrane CENTRAL, ScienceDirect and Embase, were searched to identify the studies comparing the ...

journal_title：Journal of comparative effectiveness research

authors： Wang L,Cao JG,Liu J

更新日期：2019-04-01 00:00:00

abstract：:Clinical trial designs often fail to deliver data that jointly satisfy evolving demands of both regulatory and reimbursement authorities. We propose a new multi-tiered trial design to integrate efficacy and effectiveness, and address the evolving needs of authorities. The mixed randomized trial allocates patients firs...

journal_title：Journal of comparative effectiveness research

authors： Alsop J,Scott M,Archey W

更新日期：2016-11-01 00:00:00

abstract：AIM:To understand researcher capability for and interest in patient-centered comparative effectiveness research (PC-CER), particularly related to engaging with patients/caregivers. MATERIALS & METHODS:Web-based survey of 508 health researchers recruited via professional health research organizations. RESULTS:Most res...

journal_title：Journal of comparative effectiveness research

authors： Forsythe LP,Frank LB,Workman TA,Borsky A,Hilliard T,Harwell D,Fayish L

更新日期：2017-05-01 00:00:00

abstract：:There is increasing attention in the US healthcare system on the delivery of high-quality care, an issue central to oncology. In the report 'Crossing the Quality Chasm', the Institute of Medicine identified six aims for improving healthcare quality: safe, effective, patient-centered, timely, efficient and equitable. T...

journal_title：Journal of comparative effectiveness research

authors： Broughman JR,Chen RC

更新日期：2016-05-01 00:00:00