Abstract:
:Patients with acute coronary syndromes and severe multivessel or left main coronary artery disease have better outcomes when prompt revascularization is performed in addition to optimal medical therapy (OMT). However, in patients with stable ischemic heart disease, randomized strategy trials have revealed equipoise between initial strategies of OMT alone and OMT plus revascularization. Conducted in diverse stable ischemic heart disease patient populations and throughout the spectrum of atherosclerotic and ischemic burden, the RITA-2, MASS II, COURAGE, BARI 2D and FAME 2 trials demonstrate that OMT alone and OMT plus revascularization yield similar outcomes with respect to mortality and myocardial infarction. What remains unclear is whether there may be one or more subsets of patients with stable ischemic heart disease in whom revascularization may be associated with a reduction in mortality or myocardial infarction, which is to be addressed in the ongoing ISCHEMIA trial.
journal_name
J Comp Eff Resjournal_title
Journal of comparative effectiveness researchauthors
Torosoff MT,Sidhu MS,Desai KP,Fein SA,Boden WEdoi
10.2217/cer.15.37subject
Has Abstractpub_date
2015-09-01 00:00:00pages
505-14issue
5eissn
2042-6305issn
2042-6313journal_volume
4pub_type
杂志文章,评审abstract:AIMS:This study aimed to identify methods to engage hard-to-reach patients in the research process. MATERIALS & METHODS:With funding from the Patient-Centered Outcomes Research Institute (Washington, DC, USA), the University of Maryland (MD, USA) conducted 20 focus groups and one individual interview. The sample consi...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.13.11
更新日期:2013-05-01 00:00:00
abstract:AIM:Details of data quality and how quality issues were solved have not been reported in published comparative effectiveness studies using electronic health record data. METHODS:We developed a conceptual framework of data quality assessment and preprocessing and apply it to a study comparing angiotensin-converting enz...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2015-0022
更新日期:2016-07-01 00:00:00
abstract:AIM:To estimate healthcare utilization and costs in amyloid light-chain (AL) amyloidosis. PATIENTS & METHODS:AL amyloidosis patients were identified in 2007-2015 claims databases if they had ≥1 inpatient/≥2 outpatient claims consistent with AL amyloidosis and received ≥1 AL-specific treatment. Descriptive statistics w...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,多中心研究
doi:10.2217/cer-2017-0100
更新日期:2018-06-01 00:00:00
abstract::Aim: Dedicated brain imaging is advocated by the National Comprehensive Cancer Network guidelines for newly diagnosed non-small-cell cancer (NSCLC) patients beyond stage I. The current study assessed the performance characteristics of this recommendation. Methods: Through accessing the Surveillance, Epidemiology and E...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2018-0148
更新日期:2019-06-01 00:00:00
abstract::AIMS: Stakeholder engagement is fundamental to comparative effectiveness research (CER), but lacks consistent terminology. This paper aims to define stakeholder engagement and present a conceptual model for involving stakeholders in CER. MATERIALS #ENTITYSTARTX00026; METHODS: The definitions and model were developed f...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.12.7
更新日期:2012-03-01 00:00:00
abstract:AIM:Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients. PATIENTS & METHODS:Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-d...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2217/cer-2016-0076
更新日期:2017-07-01 00:00:00
abstract::The 11 big health data networks participating in the AcademyHealth Electronic Data Methods Forum represent cutting-edge efforts to harness the power of big health data for research and quality improvement. This paper is a comparative case study based on site visits conducted with a subset of these large infrastructure...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.14.72
更新日期:2014-11-01 00:00:00
abstract:AIM:To provide an overview of thresholds for incremental cost-effectiveness ratios (ICERs) representing willingness-to-pay (WTP) across multiple countries and insights into exemptions pertaining to the ICER (e.g., cancer). To compare ICER thresholds to individual country's estimated ability-to-pay. MATERIALS & METHODS...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.38
更新日期:2015-09-01 00:00:00
abstract:AIM:To identify ongoing practices and opportunities for improving national comparative effectiveness research (CER) translation through dissemination and implementation (D&I) via NIH-funded Clinical and Translational Science Award (CTSA) institutions. MATERIALS & METHODS:Key informant interviews were conducted with 18...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.13.10
更新日期:2013-03-01 00:00:00
abstract::As the Senior Editors of the Journal of Comparative Effectiveness Research (JCER) we are delighted to present you with the first issue of this exciting new publication, focusing on the socially and clinically impactful field of comparative effectiveness research (CER). ...
journal_title:Journal of comparative effectiveness research
pub_type:
doi:10.2217/cer.11.13
更新日期:2012-01-01 00:00:00
abstract:AIM:Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS:Academic and community partners coll...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0008
更新日期:2017-07-01 00:00:00
abstract::Aim: We assessed reporting of data on sex/gender and race/ethnicity in randomized controlled trials of interventions published in the highest-ranking anesthesiology journals from 2014 to 2017. Methods: We extracted data regarding terminology for sex/gender, proportion of participants according to the race/gender and r...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2019-0071
更新日期:2019-12-01 00:00:00
abstract::Since 2010, four oral anticoagulants have been approved for marketing in addition to warfarin for treatment of thromboembolic disease. Limited head-to-head data exist comparing these treatments, leaving patients and clinicians with little guidance for selecting a strategy that balances recurrence reduction with bleedi...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0053
更新日期:2018-01-01 00:00:00
abstract::There is increasing attention in the US healthcare system on the delivery of high-quality care, an issue central to oncology. In the report 'Crossing the Quality Chasm', the Institute of Medicine identified six aims for improving healthcare quality: safe, effective, patient-centered, timely, efficient and equitable. T...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2015-0021
更新日期:2016-05-01 00:00:00
abstract::Choice-based conjoint (CBC) is used to understand how individuals develop preferences for decision alternatives. When decision alternatives can be described in terms of attributes, researchers want to determine the value respondents attach to various attribute levels. Popular in psychology, marketing, economics and ot...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2019-0115
更新日期:2020-01-01 00:00:00
abstract:AIM:To measure the private and social benefits of donor insemination (DI). METHODS:An empirical model investigates the general public and DI clients' willingness to pay (WTP) for DI, and the willingness of potential donors to become altruistic or paid sperm donors. RESULTS:The general public and DI clients value DI a...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,多中心研究
doi:10.2217/cer-2016-0066
更新日期:2017-03-01 00:00:00
abstract:AIMS:To analyze administrative claims data from Medicaid, Medicare and commercial insurance sources to estimate stroke risk, bleeding risk, and the use of antithrombotic treatment in patients with atrial fibrillation (AF). METHODS:Included patients were aged ≥18 years with a new or existing diagnosis of AF. Outcomes w...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.48
更新日期:2016-01-01 00:00:00
abstract:AIM:Explore perspectives of adolescent and young adult (AYA) and parent stakeholders regarding their engagement in comparative effectiveness research (CER) evaluating cholesterol screening and treatment strategies for 17-21 year olds. METHODS:All nine AYAs and parent stakeholders participating in a 20-member panel of ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2016-0025
更新日期:2016-08-01 00:00:00
abstract:AIM:The importance of adjusting for cross-study heterogeneity when conducting network meta-analyses (NMAs) was demonstrated using a case study of biologic therapies for moderate-to-severe plaque psoriasis. METHODS:Bayesian NMAs were conducted for Psoriasis Area and Severity Index 90 response. Several covariates were c...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2018-0065
更新日期:2018-11-01 00:00:00
abstract::Comparative effectiveness research (CER) calls for substantial changes in the way clinical research is conducted, interpreted and practically applied in the USA, in order to produce useful clinical evidence. Departing from classic efficacy and effectiveness research, the evolving CER paradigm requires structural and s...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,评审
doi:10.2217/CER.12.23
更新日期:2012-05-01 00:00:00
abstract:AIM:Quantify hematopoietic stem cell transplantation (HSCT) costs in German patients with acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). METHODS:The primary outcome was direct and indirect costs in patients with ALL/DLBCL/FL who received HSCT between 2010 and 20...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2018-0100
更新日期:2019-01-01 00:00:00
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journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2016-0063
更新日期:2017-05-01 00:00:00
abstract::Alternative approaches to the current rebate system are being considered by policymakers and stakeholders in the private insurance market. This paper presents an analysis of three alternative options to the current rebate model: retaining retroactive rebates but requiring 100% pass-through of rebates and fees to plan ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2019-0094
更新日期:2019-10-01 00:00:00
abstract::Aim: To compare efficacy between total gastrectomy (TG) and proximal gastrectomy (PG) for upper-third gastric cancer. Materials & methods: PubMed, Embase and Cochrane library were searched to select suitable researches. Stata was used for meta-analysis including 5-year overall survival rate, recurrence rate, complicat...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,meta分析
doi:10.2217/cer-2019-0016
更新日期:2019-07-01 00:00:00
abstract:AIM:GNE myopathy, a rare, severe, progressive myopathy, presents with lower extremity distal muscle weakness. The GNE myopathy functional activity scale (GNEM-FAS) evaluates the impact of GNE myopathy on functioning in adults. This paper presents the psychometric validation of the GNEM-FAS. PATIENTS & METHODS:Validati...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0062
更新日期:2018-04-01 00:00:00
abstract::The COVID-19 pandemic is revealing the unacceptable health disparities across New York City and in this country. The mortality rates of vulnerable and minority populations alone suggest a need to re-evaluate clinical decision making protocols, especially given the recently passed Emergency or Disaster Treatment Protec...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2020-0090
更新日期:2020-08-01 00:00:00
abstract:AIM:We conducted a meta-analysis to compare the efficacy and safety of oral and intravenous applications of tranexamic acid (TXA) in total hip arthroplasty (THA). MATERIALS & METHODS:Electronic databases, including PubMed, Cochrane CENTRAL, ScienceDirect and Embase, were searched to identify the studies comparing the ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,meta分析
doi:10.2217/cer-2018-0120
更新日期:2019-04-01 00:00:00
abstract:AIM:To evaluate overall survival (OS) in unresectable American Joint Committee on Cancer (AJCC) stage I/II hepatocellular carcinoma (HCC) treated with drug-eluting-bead transarterial chemoembolization (DEB-TACE) versus best supportive care. MATERIALS & METHODS:OS in consecutive patients with AJCC stage I/II unresectab...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.54
更新日期:2016-03-01 00:00:00
abstract::Aim: Increasing use of selective serotonin-reuptake inhibitors (SSRIs) in Scotland, coupled with safety concerns with some SSRIs, and the increasing availability of generic SSRIs, have resulted in multiple initiatives to improve the quality and efficiency of their prescribing in Scotland. Our aim is to assess their in...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
abstract:AIM:Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-establishe...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,多中心研究
doi:10.2217/cer-2017-0063
更新日期:2018-07-01 00:00:00