Abstract：
:Since 2010, four oral anticoagulants have been approved for marketing in addition to warfarin for treatment of thromboembolic disease. Limited head-to-head data exist comparing these treatments, leaving patients and clinicians with little guidance for selecting a strategy that balances recurrence reduction with bleeding risk. In the dabigatran, apixaban, rivaroxban, edoxaban and warfarin comparative effectiveness research study, we compare all five currently available oral anticoagulant agents for the extended treatment of deep venous thrombosis and pulmonary embolism, as well as no extended treatment, and evaluate whether results differ in specific sub-populations. As our population includes Medicare novel anticoagulant users and large numbers of commercially insured and Medicaid patients, our results will likely be transportable to the majority of US patients experiencing a DVT or pulmonary embolism. CLINICAL TRIALS REGISTRATION:NCT03271450.
journal_name
J Comp Eff Resjournal_title
Journal of comparative effectiveness researchauthors
Krumme AA,Pawar A,Schneeweiss S,Glynn RJ,Choudhry NK,Kulldorff M,Ortiz AS,Avorn J,Gagne JJdoi
10.2217/cer-2017-0053subject
Has Abstractpub_date
2018-01-01 00:00:00pages
57-66issue
1eissn
2042-6305issn
2042-6313journal_volume
7pub_type
杂志文章abstract：:Aim: We assessed reporting of data on sex/gender and race/ethnicity in randomized controlled trials of interventions published in the highest-ranking anesthesiology journals from 2014 to 2017. Methods: We extracted data regarding terminology for sex/gender, proportion of participants according to the race/gender and r...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2019-0071
更新日期：2019-12-01 00:00:00
abstract：AIM:Quantify hematopoietic stem cell transplantation (HSCT) costs in German patients with acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). METHODS:The primary outcome was direct and indirect costs in patients with ALL/DLBCL/FL who received HSCT between 2010 and 20...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2018-0100
更新日期：2019-01-01 00:00:00
abstract：AIM:To estimate healthcare utilization and costs in amyloid light-chain (AL) amyloidosis. PATIENTS & METHODS:AL amyloidosis patients were identified in 2007-2015 claims databases if they had ≥1 inpatient/≥2 outpatient claims consistent with AL amyloidosis and received ≥1 AL-specific treatment. Descriptive statistics w...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章,多中心研究
doi：10.2217/cer-2017-0100
更新日期：2018-06-01 00:00:00
abstract：AIM:To evaluate overall survival (OS) in unresectable American Joint Committee on Cancer (AJCC) stage I/II hepatocellular carcinoma (HCC) treated with drug-eluting-bead transarterial chemoembolization (DEB-TACE) versus best supportive care. MATERIALS & METHODS:OS in consecutive patients with AJCC stage I/II unresectab...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer.15.54
更新日期：2016-03-01 00:00:00
abstract：AIM:Current stroke severity scales cannot be used for archival data. We develop and validate a measure of stroke severity at hospital discharge (Stroke Administrative Severity Index [SASI]) for use in billing data. METHODS:We used the NIH Stroke Scale (NIHSS) as the theoretical framework and identified 285 relevant In...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2017-0058
更新日期：2018-04-01 00:00:00
abstract：:There is increasing attention in the US healthcare system on the delivery of high-quality care, an issue central to oncology. In the report 'Crossing the Quality Chasm', the Institute of Medicine identified six aims for improving healthcare quality: safe, effective, patient-centered, timely, efficient and equitable. T...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2015-0021
更新日期：2016-05-01 00:00:00
abstract：:Aim: Indirect treatment comparisons are used when no direct comparison is available. Comparison networks should satisfy the transitivity assumption, that is, equal likelihood of treatment assignment for a given patient based on comparability of studies. Materials & methods: Seven criteria were evaluated across 18 rand...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2019-0064
更新日期：2019-11-01 00:00:00
abstract：:Aim: Dedicated brain imaging is advocated by the National Comprehensive Cancer Network guidelines for newly diagnosed non-small-cell cancer (NSCLC) patients beyond stage I. The current study assessed the performance characteristics of this recommendation. Methods: Through accessing the Surveillance, Epidemiology and E...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2018-0148
更新日期：2019-06-01 00:00:00
abstract：:Aim: Breast cancer is a leading cause of cancer among women. Because guidelines on screening for breast cancer for certain ages are controversial, many experts advocate the use of shared decision making (SDM) using validated decision aids (DAs). Recent studies have concluded that DAs are beneficial; however, the resul...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2020-0052
更新日期：2020-10-01 00:00:00
abstract：AIM:Details of data quality and how quality issues were solved have not been reported in published comparative effectiveness studies using electronic health record data. METHODS:We developed a conceptual framework of data quality assessment and preprocessing and apply it to a study comparing angiotensin-converting enz...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2015-0022
更新日期：2016-07-01 00:00:00
abstract：:Clinical trial designs often fail to deliver data that jointly satisfy evolving demands of both regulatory and reimbursement authorities. We propose a new multi-tiered trial design to integrate efficacy and effectiveness, and address the evolving needs of authorities. The mixed randomized trial allocates patients firs...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2016-0034
更新日期：2016-11-01 00:00:00
abstract：AIM:To measure the private and social benefits of donor insemination (DI). METHODS:An empirical model investigates the general public and DI clients' willingness to pay (WTP) for DI, and the willingness of potential donors to become altruistic or paid sperm donors. RESULTS:The general public and DI clients value DI a...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章,多中心研究
doi：10.2217/cer-2016-0066
更新日期：2017-03-01 00:00:00
abstract：:AIMS: Stakeholder engagement is fundamental to comparative effectiveness research (CER), but lacks consistent terminology. This paper aims to define stakeholder engagement and present a conceptual model for involving stakeholders in CER. MATERIALS #ENTITYSTARTX00026; METHODS: The definitions and model were developed f...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer.12.7
更新日期：2012-03-01 00:00:00
abstract：AIMS:This study aimed to identify methods to engage hard-to-reach patients in the research process. MATERIALS & METHODS:With funding from the Patient-Centered Outcomes Research Institute (Washington, DC, USA), the University of Maryland (MD, USA) conducted 20 focus groups and one individual interview. The sample consi...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer.13.11
更新日期：2013-05-01 00:00:00
abstract：AIMS:The potential of dedicated Breast-CT is evaluated by simulating its impact onto the performance of the German breast cancer screening program. Attendance rates, cancer detection and economic implications are quantified. METHODS:Based on a prospective health technology assessment approach, we simulated screening i...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer.15.42
更新日期：2015-11-01 00:00:00
abstract：AIM:Studies on multiple sclerosis in Saudi Arabia remain scant, particularly studies on the psychological aspects. This study measures severities of depression, anxiety and stress, and compares them to the used disease-modifying treatment. MATERIALS & METHODS:Cross-sectional study using a phone questionnaire targeting...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章,多中心研究
doi：10.2217/cer-2016-0087
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Palliative cancer patients often require clinic or hospital follow-up after any treatment intervention they may have received. This is typically done in person at either a hospital or a clinic. In these advanced cancer patients, this may be burdensome and result in attrition. Telephone follow-up is becoming ...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章,评审
doi：10.2217/cer.12.63
更新日期：2012-11-01 00:00:00
abstract：AIM:Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-establishe...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章,多中心研究
doi：10.2217/cer-2017-0063
更新日期：2018-07-01 00:00:00
abstract：AIM:GNE myopathy, a rare, severe, progressive myopathy, presents with lower extremity distal muscle weakness. The GNE myopathy functional activity scale (GNEM-FAS) evaluates the impact of GNE myopathy on functioning in adults. This paper presents the psychometric validation of the GNEM-FAS. PATIENTS & METHODS:Validati...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2017-0062
更新日期：2018-04-01 00:00:00
abstract：:Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose ...
journal_title：Journal of comparative effectiveness research
pub_type： 评论,杂志文章
doi：10.2217/cer.13.57
更新日期：2013-09-01 00:00:00
abstract：AIMS:To develop principles for planning and conducting comparative effectiveness research (CER). METHODS:Beginning with a modified existing list of health technology assessment principles, we developed a set of CER principles using literature review, engagement of multiple experts and broad stakeholder feedback. RESU...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer.12.41
更新日期：2012-09-01 00:00:00
abstract：:The intense competition that accompanied the growth of internet-based companies ushered in the era of 'big data' characterized by major innovations in processing of very large amounts of data and the application of advanced analytics including data mining and machine learning. Healthcare is on the cusp of its own era ...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer.14.2
更新日期：2014-03-01 00:00:00
abstract：AIM:Laboratory test (lab) results may be useful to detect incident diabetes in electronic health record and claims-based studies. RESEARCH DESIGN & METHODS:Using the Mini-Sentinel distributed database, we assessed the value of lab results added to diagnosis codes and dispensing claims to identify incident diabetes. R...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2016-0033
更新日期：2017-01-01 00:00:00
abstract：:Translation of medical evidence into practice has not kept pace with the growth of medical technology and knowledge. We present three case studies--statins, drug eluting stents and bone marrow transplantation for breast cancer--to propose a framework for describing five factors that may influence the rate of adoption....
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer.13.39
更新日期：2013-07-01 00:00:00
abstract：AIM:The importance of adjusting for cross-study heterogeneity when conducting network meta-analyses (NMAs) was demonstrated using a case study of biologic therapies for moderate-to-severe plaque psoriasis. METHODS:Bayesian NMAs were conducted for Psoriasis Area and Severity Index 90 response. Several covariates were c...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2018-0065
更新日期：2018-11-01 00:00:00
abstract：AIM:Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS:Academic and community partners coll...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2017-0008
更新日期：2017-07-01 00:00:00
abstract：AIM:To understand researcher capability for and interest in patient-centered comparative effectiveness research (PC-CER), particularly related to engaging with patients/caregivers. MATERIALS & METHODS:Web-based survey of 508 health researchers recruited via professional health research organizations. RESULTS:Most res...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer-2016-0063
更新日期：2017-05-01 00:00:00
abstract：:Evaluation of: Olanow CW, Kieburtz K, Odin P et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 13(2), 141-149 (2014). Levodopa-induced motor complications, including mot...
journal_title：Journal of comparative effectiveness research
pub_type： 评论,杂志文章
doi：10.2217/cer.14.33
更新日期：2014-07-01 00:00:00
abstract：:Functional tricuspid regurgitation (FTR) is an acquired valvular abnormality that is most frequently encountered during the evaluation and operative management of left-sided heart failure and left heart valve disease. Observational studies have demonstrated that uncorrected significant FTR during mitral valve surgery ...
journal_title：Journal of comparative effectiveness research
pub_type： 杂志文章
doi：10.2217/cer.15.46
更新日期：2015-11-01 00:00:00
abstract：:As the Senior Editors of the Journal of Comparative Effectiveness Research (JCER) we are delighted to present you with the first issue of this exciting new publication, focusing on the socially and clinically impactful field of comparative effectiveness research (CER). ...
journal_title：Journal of comparative effectiveness research
pub_type：
doi：10.2217/cer.11.13
更新日期：2012-01-01 00:00:00
