Abstract:
AIM:Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients. PATIENTS & METHODS:Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment. RESULTS:After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0.05) and no significant changes in C-reactive protein (p > 0.05) were observed in both groups. Both drugs were well tolerated with no serious side effects reported by the patients. CONCLUSION:Both drugs have comparable efficacy and safety when used as intermittent low dose regimen in hemodialysis. Larger studies with longer follow-up periods are needed to confirm our new findings.
journal_name
J Comp Eff Resjournal_title
Journal of comparative effectiveness researchauthors
Abdel Magid AM,Abbassi MM,Iskander EEM,Mohamady O,Farid SFdoi
10.2217/cer-2016-0076subject
Has Abstractpub_date
2017-07-01 00:00:00pages
413-424issue
5eissn
2042-6305issn
2042-6313journal_volume
6pub_type
杂志文章,多中心研究,随机对照试验abstract::Concerted efforts are underway to improve healthcare decision-making through patient-centered outcomes research. These efforts are supported by the Patient-Centered Outcomes Research Trust Fund, which was established within the Patient Protection and Affordable Care Act. This article focuses on describing national dat...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.14.54
更新日期:2015-01-01 00:00:00
abstract::Since 2010, four oral anticoagulants have been approved for marketing in addition to warfarin for treatment of thromboembolic disease. Limited head-to-head data exist comparing these treatments, leaving patients and clinicians with little guidance for selecting a strategy that balances recurrence reduction with bleedi...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0053
更新日期:2018-01-01 00:00:00
abstract::The COVID-19 pandemic is revealing the unacceptable health disparities across New York City and in this country. The mortality rates of vulnerable and minority populations alone suggest a need to re-evaluate clinical decision making protocols, especially given the recently passed Emergency or Disaster Treatment Protec...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2020-0090
更新日期:2020-08-01 00:00:00
abstract::As the Senior Editors of the Journal of Comparative Effectiveness Research (JCER) we are delighted to present you with the first issue of this exciting new publication, focusing on the socially and clinically impactful field of comparative effectiveness research (CER). ...
journal_title:Journal of comparative effectiveness research
pub_type:
doi:10.2217/cer.11.13
更新日期:2012-01-01 00:00:00
abstract:AIM:Laboratory test (lab) results may be useful to detect incident diabetes in electronic health record and claims-based studies. RESEARCH DESIGN & METHODS:Using the Mini-Sentinel distributed database, we assessed the value of lab results added to diagnosis codes and dispensing claims to identify incident diabetes. R...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2016-0033
更新日期:2017-01-01 00:00:00
abstract::Aim: Increasing use of selective serotonin-reuptake inhibitors (SSRIs) in Scotland, coupled with safety concerns with some SSRIs, and the increasing availability of generic SSRIs, have resulted in multiple initiatives to improve the quality and efficiency of their prescribing in Scotland. Our aim is to assess their in...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2018-0132
更新日期:2019-05-01 00:00:00
abstract:AIM:To evaluate treatment patterns among elderly, newly diagnosed stage IV breast cancer patients receiving HER-2-targeted therapy. METHODS:Women aged 65+ with an incident diagnosis of stage IV breast cancer (index) and no history of other cancer were identified from 2006 to 2010 linked Surveillance, Epidemiology and ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.14.39
更新日期:2014-09-01 00:00:00
abstract::Functional tricuspid regurgitation (FTR) is an acquired valvular abnormality that is most frequently encountered during the evaluation and operative management of left-sided heart failure and left heart valve disease. Observational studies have demonstrated that uncorrected significant FTR during mitral valve surgery ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.46
更新日期:2015-11-01 00:00:00
abstract:AIMS:The potential of dedicated Breast-CT is evaluated by simulating its impact onto the performance of the German breast cancer screening program. Attendance rates, cancer detection and economic implications are quantified. METHODS:Based on a prospective health technology assessment approach, we simulated screening i...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.42
更新日期:2015-11-01 00:00:00
abstract:AIM:To evaluate overall survival (OS) in unresectable American Joint Committee on Cancer (AJCC) stage I/II hepatocellular carcinoma (HCC) treated with drug-eluting-bead transarterial chemoembolization (DEB-TACE) versus best supportive care. MATERIALS & METHODS:OS in consecutive patients with AJCC stage I/II unresectab...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.54
更新日期:2016-03-01 00:00:00
abstract:AIMS:This study aimed to identify methods to engage hard-to-reach patients in the research process. MATERIALS & METHODS:With funding from the Patient-Centered Outcomes Research Institute (Washington, DC, USA), the University of Maryland (MD, USA) conducted 20 focus groups and one individual interview. The sample consi...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.13.11
更新日期:2013-05-01 00:00:00
abstract:AIM:GNE myopathy, a rare, severe, progressive myopathy, presents with lower extremity distal muscle weakness. The GNE myopathy functional activity scale (GNEM-FAS) evaluates the impact of GNE myopathy on functioning in adults. This paper presents the psychometric validation of the GNEM-FAS. PATIENTS & METHODS:Validati...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0062
更新日期:2018-04-01 00:00:00
abstract::Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose ...
journal_title:Journal of comparative effectiveness research
pub_type: 评论,杂志文章
doi:10.2217/cer.13.57
更新日期:2013-09-01 00:00:00
abstract:AIMS:To analyze administrative claims data from Medicaid, Medicare and commercial insurance sources to estimate stroke risk, bleeding risk, and the use of antithrombotic treatment in patients with atrial fibrillation (AF). METHODS:Included patients were aged ≥18 years with a new or existing diagnosis of AF. Outcomes w...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.48
更新日期:2016-01-01 00:00:00
abstract:AIM:Details of data quality and how quality issues were solved have not been reported in published comparative effectiveness studies using electronic health record data. METHODS:We developed a conceptual framework of data quality assessment and preprocessing and apply it to a study comparing angiotensin-converting enz...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2015-0022
更新日期:2016-07-01 00:00:00
abstract::Evaluation of: Olanow CW, Kieburtz K, Odin P et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 13(2), 141-149 (2014). Levodopa-induced motor complications, including mot...
journal_title:Journal of comparative effectiveness research
pub_type: 评论,杂志文章
doi:10.2217/cer.14.33
更新日期:2014-07-01 00:00:00
abstract::Aim: Dedicated brain imaging is advocated by the National Comprehensive Cancer Network guidelines for newly diagnosed non-small-cell cancer (NSCLC) patients beyond stage I. The current study assessed the performance characteristics of this recommendation. Methods: Through accessing the Surveillance, Epidemiology and E...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2018-0148
更新日期:2019-06-01 00:00:00
abstract::Alternative approaches to the current rebate system are being considered by policymakers and stakeholders in the private insurance market. This paper presents an analysis of three alternative options to the current rebate model: retaining retroactive rebates but requiring 100% pass-through of rebates and fees to plan ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2019-0094
更新日期:2019-10-01 00:00:00
abstract:AIM:Explore perspectives of adolescent and young adult (AYA) and parent stakeholders regarding their engagement in comparative effectiveness research (CER) evaluating cholesterol screening and treatment strategies for 17-21 year olds. METHODS:All nine AYAs and parent stakeholders participating in a 20-member panel of ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2016-0025
更新日期:2016-08-01 00:00:00
abstract:AIM:We conducted a meta-analysis to compare the efficacy and safety of oral and intravenous applications of tranexamic acid (TXA) in total hip arthroplasty (THA). MATERIALS & METHODS:Electronic databases, including PubMed, Cochrane CENTRAL, ScienceDirect and Embase, were searched to identify the studies comparing the ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,meta分析
doi:10.2217/cer-2018-0120
更新日期:2019-04-01 00:00:00
abstract:AIM:To understand researcher capability for and interest in patient-centered comparative effectiveness research (PC-CER), particularly related to engaging with patients/caregivers. MATERIALS & METHODS:Web-based survey of 508 health researchers recruited via professional health research organizations. RESULTS:Most res...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2016-0063
更新日期:2017-05-01 00:00:00
abstract::Aim: The systematic review assessed the effect of mindfulness-based interventions on the quality of life among women with breast cancer. Methods: PubMed, Cochrane library, EMBASE, Web of Science and CINAHL databases were searched for studies published. Our review assessed the effect of mindfulness-based interventions ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2019-0053
更新日期:2019-08-01 00:00:00
abstract::AIMS: Stakeholder engagement is fundamental to comparative effectiveness research (CER), but lacks consistent terminology. This paper aims to define stakeholder engagement and present a conceptual model for involving stakeholders in CER. MATERIALS #ENTITYSTARTX00026; METHODS: The definitions and model were developed f...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.12.7
更新日期:2012-03-01 00:00:00
abstract::Rationale, aim & objective: The goal of this study was to examine the health and economic impacts related to increased utilization of the Duke Smoking Cessation Program resulting from the addition of two relatively new referral methods - Best Practice Advisory and Population Outreach. Materials & methods: In a compani...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2020-0005
更新日期:2020-08-01 00:00:00
abstract:AIM:The incremental cost of peripheral orbital atherectomy system (OAS) plus balloon angioplasty (BA) versus BA-only for critical limb ischemia was estimated. MATERIALS & METHODS:A deterministic simulation model used clinical and healthcare utilization data from the CALCIUM 360° trial and current cost data. Incrementa...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0070
更新日期:2018-04-01 00:00:00
abstract:AIM:To estimate healthcare utilization and costs in amyloid light-chain (AL) amyloidosis. PATIENTS & METHODS:AL amyloidosis patients were identified in 2007-2015 claims databases if they had ≥1 inpatient/≥2 outpatient claims consistent with AL amyloidosis and received ≥1 AL-specific treatment. Descriptive statistics w...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,多中心研究
doi:10.2217/cer-2017-0100
更新日期:2018-06-01 00:00:00
abstract::The 11 big health data networks participating in the AcademyHealth Electronic Data Methods Forum represent cutting-edge efforts to harness the power of big health data for research and quality improvement. This paper is a comparative case study based on site visits conducted with a subset of these large infrastructure...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.14.72
更新日期:2014-11-01 00:00:00
abstract::The intense competition that accompanied the growth of internet-based companies ushered in the era of 'big data' characterized by major innovations in processing of very large amounts of data and the application of advanced analytics including data mining and machine learning. Healthcare is on the cusp of its own era ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.14.2
更新日期:2014-03-01 00:00:00
abstract:AIM:The importance of adjusting for cross-study heterogeneity when conducting network meta-analyses (NMAs) was demonstrated using a case study of biologic therapies for moderate-to-severe plaque psoriasis. METHODS:Bayesian NMAs were conducted for Psoriasis Area and Severity Index 90 response. Several covariates were c...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2018-0065
更新日期:2018-11-01 00:00:00
abstract:AIM:Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS:Academic and community partners coll...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0008
更新日期:2017-07-01 00:00:00