Importance of assessing and adjusting for cross-study heterogeneity in network meta-analysis: a case study of psoriasis.


AIM:The importance of adjusting for cross-study heterogeneity when conducting network meta-analyses (NMAs) was demonstrated using a case study of biologic therapies for moderate-to-severe plaque psoriasis. METHODS:Bayesian NMAs were conducted for Psoriasis Area and Severity Index 90 response. Several covariates were considered to account for cross-trial differences: baseline risk (i.e., placebo response), prior biologic use, body weight, psoriasis duration, age, race and baseline Psoriasis Area and Severity Index score. Model fit was evaluated. RESULTS:The baseline risk-adjusted NMA, which adjusts for multiple observed and unobserved effect modifiers, was associated with the best model fit. Lack of adjustment for cross-trial differences led to different clinical interpretations of findings. CONCLUSION:Failure to adjust for cross-trial differences in NMA can have important implications for clinical interpretations when studying the comparative efficacy of healthcare interventions.


J Comp Eff Res


Cameron C,Hutton B,Druchok C,McElligott S,Nair S,Schubert A,Situ A,Varu A,Villacorta R




Has Abstract


2018-11-01 00:00:00












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    abstract:AIM:To evaluate overall survival (OS) in unresectable American Joint Committee on Cancer (AJCC) stage I/II hepatocellular carcinoma (HCC) treated with drug-eluting-bead transarterial chemoembolization (DEB-TACE) versus best supportive care. MATERIALS & METHODS:OS in consecutive patients with AJCC stage I/II unresectab...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Xing M,Kokabi N,Prajapati HJ,Close O,Ludwig JM,Kim HS

    更新日期:2016-03-01 00:00:00

  • Is routine baseline brain imaging needed for all newly diagnosed non-small-cell lung cancer patients?

    abstract::Aim: Dedicated brain imaging is advocated by the National Comprehensive Cancer Network guidelines for newly diagnosed non-small-cell cancer (NSCLC) patients beyond stage I. The current study assessed the performance characteristics of this recommendation. Methods: Through accessing the Surveillance, Epidemiology and E...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Abdel-Rahman O

    更新日期:2019-06-01 00:00:00

  • Ongoing initiatives within the Scottish National Health Service to affect the prescribing of selective serotonin reuptake inhibitors and their influence.

    abstract::Aim: Increasing use of selective serotonin-reuptake inhibitors (SSRIs) in Scotland, coupled with safety concerns with some SSRIs, and the increasing availability of generic SSRIs, have resulted in multiple initiatives to improve the quality and efficiency of their prescribing in Scotland. Our aim is to assess their in...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Godman B,Kurdi A,McCabe H,Johnson CF,Barbui C,MacBride-Stewart S,Hurding S,Leporowski A,Bennie M,Morton A

    更新日期:2019-05-01 00:00:00

  • Experiences of cancer patients with outpatient care in the USA: a population-based study.

    abstract::Aim: To evaluate the patterns of cancer patients-assessed quality of outpatient care in the USA. Materials & methods: Medical Expenditure Panel Survey datasets for the years 2011, 2013, 2015 and 2017 were accessed and adult participants with a history of cancer diagnosis were reviewed. Participants' assessments of dif...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Abdel-Rahman O

    更新日期:2020-09-01 00:00:00

  • No protocol and no liability: a call for COVID crisis guidelines that protect vulnerable populations.

    abstract::The COVID-19 pandemic is revealing the unacceptable health disparities across New York City and in this country. The mortality rates of vulnerable and minority populations alone suggest a need to re-evaluate clinical decision making protocols, especially given the recently passed Emergency or Disaster Treatment Protec...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Caraccio C,White RS,Jotwani R

    更新日期:2020-08-01 00:00:00

  • Show me the money! An analysis of underserved stakeholders' funding priorities in Patient Centered Outcomes Research domains.

    abstract:AIM:Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS:Academic and community partners coll...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Cargill SS,Baker LL,Goold SD

    更新日期:2017-07-01 00:00:00

  • Engaging hard-to-reach patients in patient-centered outcomes research.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Kauffman KS,Dosreis S,Ross M,Barnet B,Onukwugha E,Mullins CD

    更新日期:2013-05-01 00:00:00

  • Treatment patterns among elderly patients with stage IV breast cancer treated with HER-2-targeted therapy.

    abstract:AIM:To evaluate treatment patterns among elderly, newly diagnosed stage IV breast cancer patients receiving HER-2-targeted therapy. METHODS:Women aged 65+ with an incident diagnosis of stage IV breast cancer (index) and no history of other cancer were identified from 2006 to 2010 linked Surveillance, Epidemiology and ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Lang K,Hao Y,Huang H,Lin I,Rogerio JW,Menzin J

    更新日期:2014-09-01 00:00:00

  • Antithrombotic use and bleeding risk in patients with atrial fibrillation: findings from a multipayer analysis.

    abstract:AIMS:To analyze administrative claims data from Medicaid, Medicare and commercial insurance sources to estimate stroke risk, bleeding risk, and the use of antithrombotic treatment in patients with atrial fibrillation (AF). METHODS:Included patients were aged ≥18 years with a new or existing diagnosis of AF. Outcomes w...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Lang K,Federico V,Patel AA,Munsell M,Nelson WW,Owens G,Mody SH,Schein J,Menzin J

    更新日期:2016-01-01 00:00:00

  • Missing laboratory results data in electronic health databases: implications for monitoring diabetes risk.

    abstract:AIM:Laboratory test (lab) results may be useful to detect incident diabetes in electronic health record and claims-based studies. RESEARCH DESIGN & METHODS:Using the Mini-Sentinel distributed database, we assessed the value of lab results added to diagnosis codes and dispensing claims to identify incident diabetes. R...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Flory JH,Roy J,Gagne JJ,Haynes K,Herrinton L,Lu C,Patorno E,Shoaibi A,Raebel MA

    更新日期:2017-01-01 00:00:00

  • Hospital cost impact of orbital atherectomy with angioplasty for critical limb ischemia treatment: a modeling approach.

    abstract:AIM:The incremental cost of peripheral orbital atherectomy system (OAS) plus balloon angioplasty (BA) versus BA-only for critical limb ischemia was estimated. MATERIALS & METHODS:A deterministic simulation model used clinical and healthcare utilization data from the CALCIUM 360° trial and current cost data. Incrementa...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Shammas NW,Boyes CW,Palli SR,Rizzo JA,Martinsen BJ,Kotlarz H,Mustapha JA

    更新日期:2018-04-01 00:00:00

  • Health benefits and economic advantages associated with increased utilization of a smoking cessation program.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Datta SK,Dennis PA,Davis JM

    更新日期:2020-08-01 00:00:00

  • Matching-adjusted indirect comparison: secukinumab versus infliximab in biologic-naive patients with psoriatic arthritis.

    abstract::Aim: To compare secukinumab with infliximab in biologic-naive patients with psoriatic arthritis using matching-adjusted indirect comparison. Patients & methods: Individual patient baseline data for secukinumab were matched to published aggregate data for infliximab by key baseline characteristics, with matching weight...

    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Strand V,McInnes I,Mease P,Nash P,Thom H,Kalyvas C,Hunger M,Gandhi K,Pricop L,Jugl S,Choy E

    更新日期:2019-05-01 00:00:00

  • A national data infrastructure for patient-centered outcomes research.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Dymek C,Gingold J,Shanbhag A,Fridsma D,Yong PL

    更新日期:2015-01-01 00:00:00

  • Comparison between oral and intravenous application of tranexamic acid for total hip arthroplasty: a meta-analysis.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,meta分析


    authors: Wang L,Cao JG,Liu J

    更新日期:2019-04-01 00:00:00

  • The utilization of telephone follow-up in the advanced cancer population: a review of the literature.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,评审


    authors: Zhou M,Holden L,Bedard G,Zeng L,Lam H,Chu D,Lao N,Lauzon N,Chow E

    更新日期:2012-11-01 00:00:00

  • Big data, advanced analytics and the future of comparative effectiveness research.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Berger ML,Doban V

    更新日期:2014-03-01 00:00:00

  • Web-based decision aids to support breast cancer screening decisions: systematic review and meta-analysis.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Yu L,Li P,Yang S,Guo P,Zhang X,Liu N,Wang J,Zhang W

    更新日期:2020-10-01 00:00:00

  • Low-dose computed tomography screening for lung cancer: results of the first screening round.

    abstract::Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose ...

    journal_title:Journal of comparative effectiveness research

    pub_type: 评论,杂志文章


    authors: Horeweg N,Nackaerts K,Oudkerk M,de Koning HJ

    更新日期:2013-09-01 00:00:00

  • Randomized comparative efficacy and safety study of intermittent simvastatin versus fenofibrate in hemodialysis.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Abdel Magid AM,Abbassi MM,Iskander EEM,Mohamady O,Farid SF

    更新日期:2017-07-01 00:00:00

  • Continuous infusion of levodopa-carbidopa intestinal gel in Parkinson's disease.

    abstract::Evaluation of: Olanow CW, Kieburtz K, Odin P et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 13(2), 141-149 (2014). Levodopa-induced motor complications, including mot...

    journal_title:Journal of comparative effectiveness research

    pub_type: 评论,杂志文章


    authors: Guthikonda LN,Lyons KE,Pahwa R

    更新日期:2014-07-01 00:00:00

  • Principles for planning and conducting comparative effectiveness research.

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Luce BR,Drummond MF,Dubois RW,Neumann PJ,Jönsson B,Siebert U,Schwartz JS

    更新日期:2012-09-01 00:00:00

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Schwarzer R,Rochau U,Saverno K,Jahn B,Bornschein B,Muehlberger N,Flatscher-Thoeni M,Schnell-Inderst P,Sroczynski G,Lackner M,Schall I,Hebborn A,Pugner K,Fehervary A,Brixner D,Siebert U

    更新日期:2015-09-01 00:00:00

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Maman SR,Andreae MH,Gaber-Baylis LK,Turnbull ZA,White RS

    更新日期:2019-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Ruile G,Djanatliev A,Kriza C,Meier F,Leb I,Kalender WA,Kolominsky-Rabas PL,National Leading-Edge Cluster Medical Technologies ‘Medical Valley EMN’.

    更新日期:2015-11-01 00:00:00

  • Welcome to the Journal of Comparative Effectiveness Research.

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    journal_title:Journal of comparative effectiveness research



    authors: Greenfield S,Rich E

    更新日期:2012-01-01 00:00:00

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,评审


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    更新日期:2013-01-01 00:00:00

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Deverka PA,Lavallee DC,Desai PJ,Esmail LC,Ramsey SD,Veenstra DL,Tunis SR

    更新日期:2012-03-01 00:00:00

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章


    authors: Huang Y,Voorham J,Haaijer-Ruskamp FM

    更新日期:2016-07-01 00:00:00

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    journal_title:Journal of comparative effectiveness research

    pub_type: 杂志文章,多中心研究


    authors: Gonen LD

    更新日期:2017-03-01 00:00:00