A criterion-based approach to systematic and transparent comparative effectiveness: a case study in psoriatic arthritis.

Abstract:

:Aim: Indirect treatment comparisons are used when no direct comparison is available. Comparison networks should satisfy the transitivity assumption, that is, equal likelihood of treatment assignment for a given patient based on comparability of studies. Materials & methods: Seven criteria were evaluated across 18 randomized controlled trials in psoriatic arthritis: inclusion/exclusion criteria, clinical trial design and follow-up, patient-level baseline characteristics, disease severity, prior therapies, concomitant and extended-trial treatment and placebo response differences. Results: Across studies, placebo was a common comparator, and key efficacy end points were reported. Collectively, several potential sources of insufficient transitivity were identified, most often related to trial design and population differences. Conclusion: Potential challenges in satisfying transitivity occur frequently and should be evaluated thoroughly.

journal_name

J Comp Eff Res

authors

Tremblay G,Westley T,Forsythe A,Pelletier C,Briggs A

doi

10.2217/cer-2019-0064

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1265-1298

issue

15

eissn

2042-6305

issn

2042-6313

journal_volume

8

pub_type

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