Abstract:
:Aim: Indirect treatment comparisons are used when no direct comparison is available. Comparison networks should satisfy the transitivity assumption, that is, equal likelihood of treatment assignment for a given patient based on comparability of studies. Materials & methods: Seven criteria were evaluated across 18 randomized controlled trials in psoriatic arthritis: inclusion/exclusion criteria, clinical trial design and follow-up, patient-level baseline characteristics, disease severity, prior therapies, concomitant and extended-trial treatment and placebo response differences. Results: Across studies, placebo was a common comparator, and key efficacy end points were reported. Collectively, several potential sources of insufficient transitivity were identified, most often related to trial design and population differences. Conclusion: Potential challenges in satisfying transitivity occur frequently and should be evaluated thoroughly.
journal_name
J Comp Eff Resjournal_title
Journal of comparative effectiveness researchauthors
Tremblay G,Westley T,Forsythe A,Pelletier C,Briggs Adoi
10.2217/cer-2019-0064subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1265-1298issue
15eissn
2042-6305issn
2042-6313journal_volume
8pub_type
杂志文章abstract::Aim: To compare efficacy between total gastrectomy (TG) and proximal gastrectomy (PG) for upper-third gastric cancer. Materials & methods: PubMed, Embase and Cochrane library were searched to select suitable researches. Stata was used for meta-analysis including 5-year overall survival rate, recurrence rate, complicat...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,meta分析
doi:10.2217/cer-2019-0016
更新日期:2019-07-01 00:00:00
abstract:AIM:To evaluate overall survival (OS) in unresectable American Joint Committee on Cancer (AJCC) stage I/II hepatocellular carcinoma (HCC) treated with drug-eluting-bead transarterial chemoembolization (DEB-TACE) versus best supportive care. MATERIALS & METHODS:OS in consecutive patients with AJCC stage I/II unresectab...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.54
更新日期:2016-03-01 00:00:00
abstract::Comparative effectiveness research (CER) calls for substantial changes in the way clinical research is conducted, interpreted and practically applied in the USA, in order to produce useful clinical evidence. Departing from classic efficacy and effectiveness research, the evolving CER paradigm requires structural and s...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,评审
doi:10.2217/CER.12.23
更新日期:2012-05-01 00:00:00
abstract::There is increasing attention in the US healthcare system on the delivery of high-quality care, an issue central to oncology. In the report 'Crossing the Quality Chasm', the Institute of Medicine identified six aims for improving healthcare quality: safe, effective, patient-centered, timely, efficient and equitable. T...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2015-0021
更新日期:2016-05-01 00:00:00
abstract:AIM:GNE myopathy, a rare, severe, progressive myopathy, presents with lower extremity distal muscle weakness. The GNE myopathy functional activity scale (GNEM-FAS) evaluates the impact of GNE myopathy on functioning in adults. This paper presents the psychometric validation of the GNEM-FAS. PATIENTS & METHODS:Validati...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0062
更新日期:2018-04-01 00:00:00
abstract:AIM:Laboratory test (lab) results may be useful to detect incident diabetes in electronic health record and claims-based studies. RESEARCH DESIGN & METHODS:Using the Mini-Sentinel distributed database, we assessed the value of lab results added to diagnosis codes and dispensing claims to identify incident diabetes. R...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2016-0033
更新日期:2017-01-01 00:00:00
abstract::Aim: Medicaid versus private primary insurance status may predict in-hospital mortality and morbidity after total knee arthroplasty (TKA). Materials & methods: Regression models were used to test our hypothesis in patients in the State Inpatient Database (SID) from five states who underwent primary TKA from January 20...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2019-0027
更新日期:2019-10-01 00:00:00
abstract:AIM:To evaluate treatment patterns among elderly, newly diagnosed stage IV breast cancer patients receiving HER-2-targeted therapy. METHODS:Women aged 65+ with an incident diagnosis of stage IV breast cancer (index) and no history of other cancer were identified from 2006 to 2010 linked Surveillance, Epidemiology and ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.14.39
更新日期:2014-09-01 00:00:00
abstract:AIM:To provide an overview of thresholds for incremental cost-effectiveness ratios (ICERs) representing willingness-to-pay (WTP) across multiple countries and insights into exemptions pertaining to the ICER (e.g., cancer). To compare ICER thresholds to individual country's estimated ability-to-pay. MATERIALS & METHODS...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.38
更新日期:2015-09-01 00:00:00
abstract::The 11 big health data networks participating in the AcademyHealth Electronic Data Methods Forum represent cutting-edge efforts to harness the power of big health data for research and quality improvement. This paper is a comparative case study based on site visits conducted with a subset of these large infrastructure...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.14.72
更新日期:2014-11-01 00:00:00
abstract::Rationale, aim & objective: The goal of this study was to examine the health and economic impacts related to increased utilization of the Duke Smoking Cessation Program resulting from the addition of two relatively new referral methods - Best Practice Advisory and Population Outreach. Materials & methods: In a compani...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2020-0005
更新日期:2020-08-01 00:00:00
abstract:AIM:Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-establishe...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,多中心研究
doi:10.2217/cer-2017-0063
更新日期:2018-07-01 00:00:00
abstract::Aim: Increasing use of selective serotonin-reuptake inhibitors (SSRIs) in Scotland, coupled with safety concerns with some SSRIs, and the increasing availability of generic SSRIs, have resulted in multiple initiatives to improve the quality and efficiency of their prescribing in Scotland. Our aim is to assess their in...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2018-0132
更新日期:2019-05-01 00:00:00
abstract:AIM:Details of data quality and how quality issues were solved have not been reported in published comparative effectiveness studies using electronic health record data. METHODS:We developed a conceptual framework of data quality assessment and preprocessing and apply it to a study comparing angiotensin-converting enz...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2015-0022
更新日期:2016-07-01 00:00:00
abstract::Functional tricuspid regurgitation (FTR) is an acquired valvular abnormality that is most frequently encountered during the evaluation and operative management of left-sided heart failure and left heart valve disease. Observational studies have demonstrated that uncorrected significant FTR during mitral valve surgery ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.46
更新日期:2015-11-01 00:00:00
abstract::As the Senior Editors of the Journal of Comparative Effectiveness Research (JCER) we are delighted to present you with the first issue of this exciting new publication, focusing on the socially and clinically impactful field of comparative effectiveness research (CER). ...
journal_title:Journal of comparative effectiveness research
pub_type:
doi:10.2217/cer.11.13
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Palliative cancer patients often require clinic or hospital follow-up after any treatment intervention they may have received. This is typically done in person at either a hospital or a clinic. In these advanced cancer patients, this may be burdensome and result in attrition. Telephone follow-up is becoming ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,评审
doi:10.2217/cer.12.63
更新日期:2012-11-01 00:00:00
abstract::Aim: We assessed reporting of data on sex/gender and race/ethnicity in randomized controlled trials of interventions published in the highest-ranking anesthesiology journals from 2014 to 2017. Methods: We extracted data regarding terminology for sex/gender, proportion of participants according to the race/gender and r...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2019-0071
更新日期:2019-12-01 00:00:00
abstract:AIM:To measure the private and social benefits of donor insemination (DI). METHODS:An empirical model investigates the general public and DI clients' willingness to pay (WTP) for DI, and the willingness of potential donors to become altruistic or paid sperm donors. RESULTS:The general public and DI clients value DI a...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,多中心研究
doi:10.2217/cer-2016-0066
更新日期:2017-03-01 00:00:00
abstract:AIM:To identify ongoing practices and opportunities for improving national comparative effectiveness research (CER) translation through dissemination and implementation (D&I) via NIH-funded Clinical and Translational Science Award (CTSA) institutions. MATERIALS & METHODS:Key informant interviews were conducted with 18...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.13.10
更新日期:2013-03-01 00:00:00
abstract:AIM:Develop an accessible exercise to engage underserved populations about research funding priorities; analyze the criteria they use to prioritize research; contrast these criteria to those currently used by Patient Centered Outcomes Research Institute (PCORI). MATERIALS & METHODS:Academic and community partners coll...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2017-0008
更新日期:2017-07-01 00:00:00
abstract:AIMS:To analyze administrative claims data from Medicaid, Medicare and commercial insurance sources to estimate stroke risk, bleeding risk, and the use of antithrombotic treatment in patients with atrial fibrillation (AF). METHODS:Included patients were aged ≥18 years with a new or existing diagnosis of AF. Outcomes w...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.15.48
更新日期:2016-01-01 00:00:00
abstract::Concerted efforts are underway to improve healthcare decision-making through patient-centered outcomes research. These efforts are supported by the Patient-Centered Outcomes Research Trust Fund, which was established within the Patient Protection and Affordable Care Act. This article focuses on describing national dat...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.14.54
更新日期:2015-01-01 00:00:00
abstract:AIM:We conducted a meta-analysis to compare the efficacy and safety of oral and intravenous applications of tranexamic acid (TXA) in total hip arthroplasty (THA). MATERIALS & METHODS:Electronic databases, including PubMed, Cochrane CENTRAL, ScienceDirect and Embase, were searched to identify the studies comparing the ...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,meta分析
doi:10.2217/cer-2018-0120
更新日期:2019-04-01 00:00:00
abstract:AIM:Many hepatitis C virus regimens are unlikely to be compared head to head. In more difficult to treat populations where there is no standard of care, trials are single arm. We describe a flexible meta-analysis platform in this setting. METHODS:Our meta-analysis is literature based. We illustrate our methodology and...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章,meta分析,评审
doi:10.2217/cer.14.69
更新日期:2015-03-01 00:00:00
abstract::Aim: Breast cancer is a leading cause of cancer among women. Because guidelines on screening for breast cancer for certain ages are controversial, many experts advocate the use of shared decision making (SDM) using validated decision aids (DAs). Recent studies have concluded that DAs are beneficial; however, the resul...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2020-0052
更新日期:2020-10-01 00:00:00
abstract::Evaluation of: Olanow CW, Kieburtz K, Odin P et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 13(2), 141-149 (2014). Levodopa-induced motor complications, including mot...
journal_title:Journal of comparative effectiveness research
pub_type: 评论,杂志文章
doi:10.2217/cer.14.33
更新日期:2014-07-01 00:00:00
abstract:AIM:To understand researcher capability for and interest in patient-centered comparative effectiveness research (PC-CER), particularly related to engaging with patients/caregivers. MATERIALS & METHODS:Web-based survey of 508 health researchers recruited via professional health research organizations. RESULTS:Most res...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2016-0063
更新日期:2017-05-01 00:00:00
abstract::Translation of medical evidence into practice has not kept pace with the growth of medical technology and knowledge. We present three case studies--statins, drug eluting stents and bone marrow transplantation for breast cancer--to propose a framework for describing five factors that may influence the rate of adoption....
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer.13.39
更新日期:2013-07-01 00:00:00
abstract::Aim: To compare secukinumab with infliximab in biologic-naive patients with psoriatic arthritis using matching-adjusted indirect comparison. Patients & methods: Individual patient baseline data for secukinumab were matched to published aggregate data for infliximab by key baseline characteristics, with matching weight...
journal_title:Journal of comparative effectiveness research
pub_type: 杂志文章
doi:10.2217/cer-2018-0141
更新日期:2019-05-01 00:00:00