Low-dose computed tomography screening for lung cancer: results of the first screening round.

Abstract:

:Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose computed tomography (LDCT) screening rather than chest x-ray (CXR) screening. This paper from the US NLST research team focuses on the results of the initial round of LDCT for lung cancer. A total of 53,439 participants were included and randomly assigned to LDCT screening (n = 26,715) or CXR screening (n = 26,724). In total, 27.3% of the participants in the LDCT group and 9.2% in the CXR group had a positive screening result. As a result, 3.8% (LDCT group) and 5.7% (CXR group) of these subjects were diagnosed with lung cancer. The sensitivity (93.8%) and specificity (73.4%) for lung cancer were higher for LDCT compared with CXR screening; 73.5 and 91.3%, respectively.

journal_name

J Comp Eff Res

authors

Horeweg N,Nackaerts K,Oudkerk M,de Koning HJ

doi

10.2217/cer.13.57

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

433-6

issue

5

eissn

2042-6305

issn

2042-6313

journal_volume

2

pub_type

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