Human umbilical cord mesenchymal stromal cells rescue mice from acetaminophen-induced acute liver failure.

abstract：:he concept of particulates, while common to many in the pharmaceutical and blood transfusion disciplines, represents a distinct challenge in the field of cellular therapy. With newly discovered products advancing through clinical trials, the focus has shifted to ensuring products are manufactured in a reliable and saf...

journal_title：Cytotherapy

authors： Clarke D,Harati D,Martin J,Rowley J,Keller J,McCaman M,Carrion M,Karnieli O,Maziarz R,Perry R,Oh S,Stanton J

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AIMS:Defocused low-energy shock wave (DLSW) therapy has shown effectiveness in regenerative medicine. The mechanism of action was mainly focused on the pathophysiological improvement at the wound tissues. In this study, the activation of stem cells treated by DLSW was first examined as an important pathway d...

journal_title：Cytotherapy

authors： Zhao Y,Wang J,Wang M,Sun P,Chen J,Jin X,Zhang H

更新日期：2013-12-01 00:00:00

abstract：:Kidney disease has reached epidemic proportions and is associated with high mortality and morbidity rates. Stem cell-based therapy may effectively treat kidney damage by cell transplantation. The breakthrough discovery using a combination of four transcription factors to reprogram genetically somatic cells into induce...

journal_title：Cytotherapy

authors： Wang WW,Wang W,Jiang Y,Han GF,Lu S,Li G,Zhang J

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AIMS:Bone marrow (BM) mesenchymal stromal cells (MSC) represent a novel therapy for severe heart failure with extensive myocardial scarring, especially when performed concurrently with conventional revascularization. However, stem cells are difficult to transport in culture media without risk of contaminatio...

journal_title：Cytotherapy

authors： Chin SP,Poey AC,Wong CY,Chang SK,Teh W,Mohr TJ,Cheong SK

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AIMS:The Quantum® Cell Expansion System (Quantum; Terumo BCT, Inc, Lakewood, CO, USA) is a novel hollow fiber-based device that automates and closes the cell culture process, reducing labor intensive tasks such as manual cell culture feeding and harvesting. The manual cell selection and expansion processes f...

journal_title：Cytotherapy

authors： Jones M,Varella-Garcia M,Skokan M,Bryce S,Schowinsky J,Peters R,Vang B,Brecheisen M,Startz T,Frank N,Nankervis B

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AIMS:Shipment of therapeutic somatic cells between a current good manufacturing practice (cGMP) facility and a clinic or between different cGMP facilities requires validated standard operating procedures (SOP). Under National Heart Lung & Blood Institute (NHLBI) sponsorship, the Production Assistance for Cel...

journal_title：Cytotherapy

authors： Whiteside TL,Griffin DL,Stanson J,Gooding W,McKenna D,Sumstad D,Kadidlo D,Gee A,Durett A,Lindblad R,Wood D,Styers D

更新日期：2011-02-01 00:00:00

abstract：:There is rapidly increasing interest in the use of magnetic resonance imaging (MRI) to track cell migration in vivo. Iron oxide MR contrast agents can be detected at micromolar concentrations of iron, and offer sufficient sensitivity for T2*-weighted imaging. Cellular MRI shows potential for assessing aspects of cardi...

journal_title：Cytotherapy

authors： Zhang Z,Mascheri N,Dharmakumar R,Li D

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a hematologic cancer caused by the abnormal expansion of plasma cells, but the exact mechanism underlying MM development is not completely known. Recently, multiple long noncoding RNAs (lncRNAs) were implicated in the regulation of MM development. METHODS:Samples from patients with ...

journal_title：Cytotherapy

authors： Deng M,Yuan H,Liu S,Hu Z,Xiao H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AIMS:Circulating monocytes have been exploited as an important progenitor cell resource for hepatocytes in vitro and are instrumental in the removal of fibrosis. We investigated the significance of monocytes in peripheral blood stem cells (PBSC) for the treatment of liver cirrhosis. METHODS:Rat CD14+ monocy...

journal_title：Cytotherapy

authors： Wang J,Zhou X,Cui L,Yan L,Liang J,Cheng X,Qiao L,Shi Y,Han Z,Cao Y,Han Y,Fan D

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AIMS:Behcet's disease (BD) is a chronic, multisystemic inflammatory disorder with arthritic, gastrointestinal, mucocutaneous, ocular, vascular and central nervous system involvement. It is well known that CD4(+) CD25(+) T-regulatory (Treg) cells prevent harmful immune responses to self- and non-self-antigens...

journal_title：Cytotherapy

authors： Shim J,Lee ES,Park S,Bang D,Sohn S

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AIMS:Platelet transfusion can be a life-saving procedure in different medical settings. Thus, there is an increasing demand for platelets, of which shelf-life is only 5 days. The efficient ex vivo biomanufacturing of platelets would allow overcoming the shortages of donated platelets. METHODS:We exploited a...

journal_title：Cytotherapy

authors： Hatami J,Andrade PZ,Alves de Matos AP,Djokovic D,Lilaia C,Ferreira FC,Cabral JM,da Silva CL

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) enhance islet function both in vitro and in vivo, at least in part by secreting ligands that activate islet G-protein coupled receptors (GPCRs). We assessed whether pre-treatment with a defined "cocktail" of MSC-secreted GPCR ligands enhances islet functional survival in...

journal_title：Cytotherapy

authors： Rackham CL,Amisten S,Persaud SJ,King AJF,Jones PM

更新日期：2018-12-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BM-MSCs) hold great promise for tissue regeneration. With increasing numbers of clinical trials, the safety of BM-MSCs attracts great interest. Previously, we determined that rat BM-MSCs possessed spontaneous calcification without osteogenic induction after continuous cultur...

journal_title：Cytotherapy

authors： Huang YZ,Cai JQ,Lv FJ,Xie HL,Yang ZM,Huang YC,Deng L

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The mechanism of platelet recovery after hematopoietic stem cell transplantation and the factors that influence its time-course are not fully understood. Rapid hematopoietic recovery results in a reduction of transplantation-related complications. In the present study, we questioned and analyzed whether ther...

journal_title：Cytotherapy

authors： Woo KS,Goh RY,Kim SH,Kwon HC,Kim HJ,Lee YH,Han JY

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AIMS:Enumeration of viable CD34(+) cells provides critical information for the bone marrow (BM) transplant physician. The single-platform ISHAGE protocol is the most reliable method currently available to quantitate accurately this important subset of cells. Previous studies have shown that 5 CD34(+) cells/m...

journal_title：Cytotherapy

authors： Sutherland DR,Nayyar R,Acton E,Giftakis A,Dean S,Mosiman VL

更新日期：2009-01-01 00:00:00

abstract：:Because of their well-recognized immunomodulatory properties, mesenchymal stromal cells (MSCs) represent an attractive cell population for therapeutic purposes. In particular, there is growing interest in the use of MSCs as cellular immunotherapeutics for tolerance induction in allogeneic transplantations and the trea...

journal_title：Cytotherapy

authors： Najar M,Raicevic G,Fayyad-Kazan H,Bron D,Toungouz M,Lagneaux L

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Traditionally, following high-dose therapy (HDT), unmanipulated autologous PBPC are infused. Alternatively, purified CD34+ cells can now be obtained by immunomagnetic separation using the CliniMACS device. Limited data currently exist examining hemopoietic recovery with such cells. METHODS:Ten patients with...

journal_title：Cytotherapy

authors： Prince HM,Wall D,Rischin D,Toner GC,Seymour JF,Blakey D,Haylock D,Simmons P,Wolf M,Januszewicz EH,Westerman D,Richardson G,Scarlett J,Briggs P

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AIMS:We have confirmed that aortic aneurysm (AA) can be regressed by the administration of bone marrow-derived mesenchymal stromal cells (BM-MSCs). We investigated the kinetics of signaling pathways in AA following treatment with BM-MSCs. METHODS:Angiotensin II-infused apolipoprotein E-deficient mice were t...

journal_title：Cytotherapy

authors： Yamawaki-Ogata A,Oshima H,Usui A,Narita Y

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AIMS:Cell therapy is promising as an exploratory cardiovascular therapy. We have recently developed an investigational new drug named Stempeucel (bone marrow-derived allogeneic mesenchymal stromal cells) for patients with acute myocardial infarction (AMI) with ST-segment elevation. A phase I/II randomized, d...

journal_title：Cytotherapy

authors： Chullikana A,Majumdar AS,Gottipamula S,Krishnamurthy S,Kumar AS,Prakash VS,Gupta PK

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSC) are of clinical interest for their potential use in regenerative medicine and immunotherapy. Originally derived from bone marrow (BM), MSC have now been isolated from most tissues, including umbilical cord (UC) and UC blood (UCB). If MSC from UC are biologically equivalent to ...

journal_title：Cytotherapy

authors： Girdlestone J,Limbani VA,Cutler AJ,Navarrete CV

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The use of myeloma Ag-loaded mature DC vaccines, cryopreserved in single-use aliquots, is an attractive immunotherapeutic strategy. In this study we investigated the retention of phenotype, viability and potency of DC vaccines after freezing and thawing. METHODS:Plastic-adherent monocytes, derived from a st...

journal_title：Cytotherapy

authors： Szmania S,Yi Q,Cottler-Fox M,Rosen NA,Freeman J,Kordsmeier BJ,Moreno A,Shi J,Barlogie B,Tricot G,van Rhee F

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Since 1978, 856 hematopoietic stem-cell transplantations have been performed for adult patients in Turkey. METHODS AND RESULTS:Data were collected on the source of hematopoietic progenitor cells, recipient diagnosis, conditioning regimen, DFS and mortality. The data were analyzed by the national registry sy...

journal_title：Cytotherapy

authors： Blood and Marrow Transplantation Subcommittee, Turkish Societ of Hematology.

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) that are derived from hematopoietic stem cells (HSCs) are the most potent antigen-presenting cells and play a pivotal role in initiating the immune response. Hence, large-scale production and direct induction of functional DCs ex vivo from HSCs are crucial to HSC research and clinical p...

journal_title：Cytotherapy

authors： Hsu SC,Lu LC,Chan KY,Huang CH,Cheng SL,Chan YS,Yang YS,Lai YT,Yao CL

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AIMS:The therapeutic potential of human mesenchymal stromal cells (MSCs) has generated considerable interest in a wide variety of areas. MSC banking is feasible, but the optimal technique of cryopreservation remains to be determined. METHODS:To reduce dimethyl sulfoxide (DMSO) concentration in cryopreservat...

journal_title：Cytotherapy

authors： Briquet A,Halleux A,Lechanteur C,Beguin Y

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AIMS:Chimeric antigen receptors (CARs) designed for adoptive immunotherapy need to achieve two functions: antigen recognition and triggering of the lytic machinery of reprogrammed effector cells. Cytotoxic T cells have been engineered with FcγRIII (CD16) chimeric molecules to be redirected against malignant ...

journal_title：Cytotherapy

authors： D'Aloia MM,Caratelli S,Palumbo C,Battella S,Arriga R,Lauro D,Palmieri G,Sconocchia G,Alimandi M

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:BM mesenchymal stem cells (MSC) have the capacity for renewal and the potential to differentiate into multiple tissues. In this study, we compared different enrichment methods to obtain MSC from BM. METHODS:Three different methods were compared with a view to obtaining MSC more rapidly from BM: negative sel...

journal_title：Cytotherapy

authors： Tondreau T,Lagneaux L,Dejeneffe M,Delforge A,Massy M,Mortier C,Bron D

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AIMS:To assess the impacts of stem cell therapy on clinical outcomes in patients with non-ischemic cardiomyopathy (NICM). The effect of stem cell therapy on prognosis is unclear and controversial. METHODS:The authors performed a systematic review and meta-analysis of the effects of autologous stem cell tran...

journal_title：Cytotherapy

authors： Xia L,Zeng L,Pan J,Ding Y

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) may be useful in a range of clinical applications. The placenta has been suggested as an abundant, ethically acceptable, less immunogenic and easily accessible source of MSC. The aim of this study was to evaluate the capacity of induced placental MSC to differentiate into...

journal_title：Cytotherapy

authors： Yust-Katz S,Fisher-Shoval Y,Barhum Y,Ben-Zur T,Barzilay R,Lev N,Hod M,Melamed E,Offen D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AIMS:Umbilical cord blood (UCB) is a rich source of stem cells, the characterization and isolation of which requires specific stem cell markers and reliable and reproducible protocols. METHODS:We assessed CD133 isolation in 39 UCB samples, using a commercial immunomagnetic cell-sorting protocol, and, becaus...

journal_title：Cytotherapy

authors： Pelagiadis I,Relakis K,Kalmanti L,Dimitriou H

更新日期：2012-07-01 00:00:00

abstract：:In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful collaborative public initiative funded by the Spanish government for the support of nationwide translational research in this important area. Thirty-two research groups organized in three programs devo...

journal_title：Cytotherapy

authors： Sánchez-Guijo F,García-Olmo D,Prósper F,Martínez S,Zapata A,Fernández-Avilés F,Toledo-Aral JJ,Torres M,Fariñas I,Badimón L,Labandeira-García JL,García-Sancho J,Moraleda JM,TerCel.

更新日期：2020-01-01 00:00:00