Abstract:
:There is rapidly increasing interest in the use of magnetic resonance imaging (MRI) to track cell migration in vivo. Iron oxide MR contrast agents can be detected at micromolar concentrations of iron, and offer sufficient sensitivity for T2*-weighted imaging. Cellular MRI shows potential for assessing aspects of cardiovascular disease. Labeling in vivo and tracking macrophages using iron oxide nanoparticles has been a goal for cellular MRI because macrophages play a pivotal role in the pathophysiology of many human diseases, including atherosclerosis. Cellular MRI has also been using to track transplanted therapeutic cells in myocardial regeneration. This review looked at iron oxide nanoparticles, methods of cell labeling, image acquisition techniques and limitations encountered for visualization. Particular attention was paid to stem cells and macrophages for the cardiovascular system.
journal_name
Cytotherapyjournal_title
Cytotherapyauthors
Zhang Z,Mascheri N,Dharmakumar R,Li Ddoi
10.1080/14653240802165699subject
Has Abstractpub_date
2008-01-01 00:00:00pages
575-86issue
6eissn
1465-3249issn
1477-2566pii
793971154journal_volume
10pub_type
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