Combined cellular immunotherapy and chemotherapy improves clinical outcome in patients with gastric carcinoma.

abstract：BACKGROUND:Post-infarct congestive heart failure is one of the leading causes of morbidity and mortality in industrialized countries. The main purpose of this study was to investigate whether transplantation of embryonic stem cell-derived cardiomyocytes (ESCM) directly into the infarcted myocardium could improve cardia...

journal_title：Cytotherapy

authors： Cai J,Yi FF,Yang XC,Lin GS,Jiang H,Wang T,Xia Z

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AIMS:Bone marrow (BM) stromal cells, also referred to as mesenchymal stromal cells (MSC), can be expanded ex vivo and are able to differentiate along multiple lineages, including chondrocytes, osteoblasts and adipocytes. MSC are known to secrete a number of cytokines and regulatory molecules implicated in di...

journal_title：Cytotherapy

authors： Lazzarotto-Silva C,Binato R,Rocher BD,Costa JA,Pizzatti L,Bouzas LF,Abdelhay E

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Chimerism is an important outcome measure in hematopoietic cell transplantation as well as somatic cell therapy. Commonly used methods to estimate chimerism are restricted by either gender or inefficient sensitivity. In principle, real-time polymerase chain reaction (PCR)-based assays can be used to ass...

journal_title：Cytotherapy

authors： Chen X,Hofmann TJ,Otsuru S,Jethva R,Lind C,Monos D,Horwitz EM

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) are gaining in popularity as an experimental therapy for a number of conditions that often require expansion ex vivo prior to use. Data comparing clinical-grade MSC from various ages of donors are scant. We hypothesized that MSC from older donors may display differences i...

journal_title：Cytotherapy

authors： Lund TC,Kobs A,Blazar BR,Tolar J

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:In vitro primary cultures of microvascular endothelial cells from endocrine pancreas are difficult to obtain, but can be a very helpful tool for studies of islet biology, transplantation and regenerative medicine. METHODS:We applied a protocol recently described for the isolation and culture of brain microv...

journal_title：Cytotherapy

authors： Sordi V,Ferri A,Ceserani V,Ciusani E,Dugnani E,Pellegrini S,Nano R,Pecciarini L,Pessina A,Pascucci L,Piemonti L,Alessandri G

更新日期：2017-01-01 00:00:00

abstract：:More precise quantitation of cellular immune responses has become possible with the advent of single-cell assays of immune function, such as cytokine flow cytometry, enzyme-linked immunospot (ELISPOT), and MHC-peptide multimers. Cytokine flow cytometry is an attractive technique because it allows the detection of resp...

journal_title：Cytotherapy

authors： Ghanekar SA,Maecker HT

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) suppress T-cell proliferation, especially after activation with inflammatory cytokines. We compared the dynamic action of unprimed and interferon (IFN)-γ plus tumor necrosis factor (TNF)-α-pretreated human bone marrow-derived MSCs on resting or activated T cells. METHOD...

journal_title：Cytotherapy

authors： Cuerquis J,Romieu-Mourez R,François M,Routy JP,Young YK,Zhao J,Eliopoulos N

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AIMS:The aim was to evaluate cartilage regeneration in animal models involving induced knee joint damage. Through cell-mediated gene therapy methods, a cell mixture comprising a 3:1 ratio of genetically unmodified human chondrocytes and transforming growth factor beta-1 (TGF-beta1)-secreting human chondrocyt...

journal_title：Cytotherapy

authors： Noh MJ,Copeland RO,Yi Y,Choi KB,Meschter C,Hwang S,Lim CL,Yip V,Hyun JP,Lee HY,Lee KH

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Patients with ulcerative colitis (UC) have elevated/activated myeloid lineage leucocytes and may respond favorably to adsorptive granulocyte/monocyte apheresis (GMA). However, there are patients who respond well to GMA, and patients who do not benefit. Therefore, predictive factors of GMA efficacy need to be...

journal_title：Cytotherapy

authors： Yokoyama Y,Watanabe K,Ito H,Nishishita M,Sawada K,Okuyama Y,Okazaki K,Fujii H,Nakase H,Masuda T,Fukunaga K,Andoh A,Nakamura S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:DS60 is a novel buoyant density solution, whose density has been adjusted to enrich PBSC from subjects who have been mobilized with cytokines alone, or cytokines plus chemotherapy. This report describes the use of BDS60 to enrich autologous PBSC that were used for hematological reconstitution after myeloabla...

journal_title：Cytotherapy

authors： Laport GG,Valone FH,Zimmerman TM,Grinblatt DL,Van Vlasselaer P,Still BJ,Williams SF

更新日期：2000-01-01 00:00:00

abstract：:Not until recently have Natural killer (NK) cells stepped out of the shadow of T-cells to be considered for cellular therapy of malignant diseases. This evolution has been facilitated by the discovery of specific receptors on NK cells that interact with HLA molecules on target cells but also the discovery of specific ...

journal_title：Cytotherapy

authors： Klingemann HG

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AIMS:The aim of this study was to evaluate the efficacy and safety of cytokine-induced killer (CIK) cell therapy for solid carcinomas. METHODS:We performed a computerized search of phase II/III clinical trial databases of CIK cell-based therapy using a combination of the terms 'cytokine-induced killer cells...

journal_title：Cytotherapy

authors： Ma Y,Zhang Z,Tang L,Xu YC,Xie ZM,Gu XF,Wang HX

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Adverse events (AE) represent a significant clinical problem after infusion of cryopreserved HPC. However, the factors playing a role in the pathogenesis have not yet been fully established. METHODS:We prospectively collected data on AE that occurred with 179 HPC infusions performed on patients affected wit...

journal_title：Cytotherapy

authors： Milone G,Mercurio S,Strano A,Leotta S,Pinto V,Battiato K,Coppoletta S,Murgano P,Farsaci B,Privitera A,Giustolisi R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AIMS:Enumeration of CD34(+) cells in leukocyte-rich cell suspensions is important for clinical decision-making in stem cell transplantation. Single-platform flow cytometry assays offer the significant advantages of speed and reproducibility, and have therefore become the gold standard in stem cell enumeratio...

journal_title：Cytotherapy

authors： Dauber K,Becker D,Odendahl M,Seifried E,Bonig H,Tonn T

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:When stem-cell grafts are infused into the venous circulation and stem/progenitor cells egress from BM, pulmonary capillary beds are the first microcirculation site that they encounter. This provides the potential for circulating progenitor cells to be trapped in the pulmonary circulation. METHODS:We compar...

journal_title：Cytotherapy

authors： Watanabe T,Kajiume T,Takaue Y,Kawano Y,Kanamaru S,Okamura S,Onishi T,Suzuya H,Nakagawa R,Kuroda Y,Talmadge JE

更新日期：2001-01-01 00:00:00

abstract：:Cellular & Gene Therapies (CGTs) are complex products, which have been key foci of the International Society for Cell & Gene Therapy (ISCT). For this ISCT North American Legal & Regulatory Affairs Committee review publication, CGTs include but are not limited to somatic cell-based therapies, pluripotent cell-derived c...

journal_title：Cytotherapy

authors： Mendicino M,Fan Y,Griffin D,Gunter KC,Nichols K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AIMS:Existing treatments have limited success in modifying the course of peripheral artery disease, which may eventually lead to limb-threatening ulcers and amputation. Cellular therapies have the potential to provide a new treatment option for this condition, but isolation of cells by conventional means has...

journal_title：Cytotherapy

authors： Koch JM,D'Souza SS,Schwahn DJ,Dixon I,Hacker TA

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:CAMPATH-1 Abs have been used for T-cell depletion in stem-cell transplantation since the early 1980s. During that time there has been substantial progress in manufacturing techniques and quality control procedures. This article summarizes the methods used to produce the Abs for clinical use and describes res...

journal_title：Cytotherapy

authors： Phillips J,Drumm A,Harrison P,Bird P,Bhamra K,Berrie E,Hale G

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AIMS:The immunomodulatory properties of mesenchymal stromal cells (MSCs), together with their tissue regenerative potential, make them interesting candidates for clinical application. METHODS:In the current study, we analyzed the in vitro immunomodulatory effects of MSCs derived from bone marrow (BM-MSCs) a...

journal_title：Cytotherapy

authors： Valencia J,Blanco B,Yáñez R,Vázquez M,Herrero Sánchez C,Fernández-García M,Rodríguez Serrano C,Pescador D,Blanco JF,Hernando-Rodríguez M,Sánchez-Guijo F,Lamana ML,Segovia JC,Vicente Á,Del Cañizo C,Zapata AG

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Contaminating breast cancer cells in leukapheresis harvested for reinfusion to rebuild hemopoiesis after high-dose therapy have been described by several investigators. Methods for tumor cell detection are conventional immunocytochemistry, culture techniques and reverse transcriptase PCR. The percentage of t...

journal_title：Cytotherapy

authors： Krüger W,Tögel F,Rössing S,Kröger N,Zander AR

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AIMS:During bone formation, angiogenesis and osteogenesis are regulated by hypoxia, which is able to induce blood vessel formation, as well as recruit and differentiate human mesenchymal stromal cells (hMSCs). The molecular mechanisms involved in HIF-1α response and hMSC differentiation during bone formation...

journal_title：Cytotherapy

authors： Costa V,Raimondi L,Conigliaro A,Salamanna F,Carina V,De Luca A,Bellavia D,Alessandro R,Fini M,Giavaresi G

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AIMS:Bone marrow mononuclear cells (BM-MNCs) and bone marrow-derived mesenchymal stem stromal cells (BM-MSCs) could have therapeutic potential for numerous conditions, including ischemia-related injury. Cells transplanted intravascularly may become entrapped in the lungs, which potentially decreases their th...

journal_title：Cytotherapy

authors： Mäkelä T,Takalo R,Arvola O,Haapanen H,Yannopoulos F,Blanco R,Ahvenjärvi L,Kiviluoma K,Kerkelä E,Nystedt J,Juvonen T,Lehenkari P

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AIMS:Apoptosis of radiosensitive cells in the bone marrow and gut is a serious, at times life-threatening, complication arising from radiation exposure. METHODS:We investigated whether adoptive transfer of allogeneic bone marrow-derived mesenchymal stromal cells (MSC) could exert cytoprotective and life-spa...

journal_title：Cytotherapy

authors： François M,Birman E,Forner KA,Gaboury L,Galipeau J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate preservation of anti-leukemic activity and protection from opportunistic infections after transplantation of allogeneic + cells in patients with hematologic malignancies and bad prognosis. Methods Thirty-three patients [median age 42 years, range 23-55 years, diagnosi...

journal_title：Cytotherapy

authors： Kobbe G,Fenk R,Neumann F,Bernhardt A,Steidl U,Kondakci M,Graef T,Aivado M,Vaupel M,Huenerlituerkoglu AN,Kronenwett R,Pape H,Hildebrand B,Germing U,Haas R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AIMS:The microenvironment of the chronically injured spinal cord does not allow for axonal regeneration due to glial scarring. To ameliorate this, several therapeutic strategies have been used. We investigated whether combined transplantation of chondroitinase ABC (chABC) and mesenchymal stromal cells (MSCs)...

journal_title：Cytotherapy

authors： Lee SH,Kim Y,Rhew D,Kim A,Jo KR,Yoon Y,Choi KU,Jung T,Kim WH,Kweon OK

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Adipose tissue contains a stromal vascular fraction that can be easily isolated and provides a rich source of adipose tissue-derived mesenchymal stem cells (ASC). These ASC are a potential source of cells for tissue engineering. We studied whether the yield and growth characteristics of ASC were affected by ...

journal_title：Cytotherapy

authors： Oedayrajsingh-Varma MJ,van Ham SM,Knippenberg M,Helder MN,Klein-Nulend J,Schouten TE,Ritt MJ,van Milligen FJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AIMS:Shipment of therapeutic somatic cells between a current good manufacturing practice (cGMP) facility and a clinic or between different cGMP facilities requires validated standard operating procedures (SOP). Under National Heart Lung & Blood Institute (NHLBI) sponsorship, the Production Assistance for Cel...

journal_title：Cytotherapy

authors： Whiteside TL,Griffin DL,Stanson J,Gooding W,McKenna D,Sumstad D,Kadidlo D,Gee A,Durett A,Lindblad R,Wood D,Styers D

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) have been applied to patients in cell therapy for various diseases. Recently, we introduced a novel MSC separation filter device which could yield approximately 2.5-fold more MSCs from bone marrow in a closed system compared with the conventional open density gradient ce...

journal_title：Cytotherapy

authors： Otsuru S,Hofmann TJ,Raman P,Olson TS,Guess AJ,Dominici M,Horwitz EM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AIMS:The therapeutic potential of human mesenchymal stromal cells (MSCs) has generated considerable interest in a wide variety of areas. MSC banking is feasible, but the optimal technique of cryopreservation remains to be determined. METHODS:To reduce dimethyl sulfoxide (DMSO) concentration in cryopreservat...

journal_title：Cytotherapy

authors： Briquet A,Halleux A,Lechanteur C,Beguin Y

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Identification of HLA class I-restricted CMV epitopes, and the subsequent synthesis of HLA class I-peptide tetrameric complexes, have provided investigators with an important tool for visualising and quantifying the precise in vivo CTL response to CMV reactivation following stem cell transplantation. In conj...

journal_title：Cytotherapy

authors： Chen FE,Aubert G,Travers P,Dodi IA,Madrigal JA

更新日期：2002-01-01 00:00:00