当前位置： SCI文献检索 > CYTOTHERAPY期刊下所有文献 > Adoptive transfer of mesenchymal stromal cells accelerates intestinal epithelium recovery of irradiated mice in an interleukin-6-dependent manner.

Adoptive transfer of mesenchymal stromal cells accelerates intestinal epithelium recovery of irradiated mice in an interleukin-6-dependent manner.

Abstract：

BACKGROUND AIMS:Apoptosis of radiosensitive cells in the bone marrow and gut is a serious, at times life-threatening, complication arising from radiation exposure. METHODS:We investigated whether adoptive transfer of allogeneic bone marrow-derived mesenchymal stromal cells (MSC) could exert cytoprotective and life-sparing effects in a mouse model of sublethal total body irradiation (TBI). RESULTS:We demonstrated that a single intraperitoneal injection of C57Bl/6 MSC given to major histocompatibility complex (MHC)-mismatched Balb/c mice within 24 h of sublethal TBI significantly reduced mortality in a dose-dependent manner. Histologic analysis and Ki67 immunostaining of jejunum sections collected 3 and 6 days post-TBI indicated that MSC protected the gastrointestinal epithelium from TBI-induced damage and significantly accelerated recovery of the gut by stimulating proliferation of the crypt cell pool. Using interleukin-6(-/-) (IL-6) MSC, we demonstrated that IL-6 expressed by MSC played a role in gastrointestinal epithelium regeneration. CONCLUSIONS:Our results suggest that allogeneic MHC-mismatched MSC may be exploited to reduce gastrointestinal complications and mortality arising from ionizing radiation exposure.

journal_name

Cytotherapy

journal_title

Cytotherapy

authors

François M,Birman E,Forner KA,Gaboury L,Galipeau J

doi

10.3109/14653249.2012.684378

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1164-70

issue

10

eissn

1465-3249

issn

1477-2566

pii

S1465-3249(12)71235-5

journal_volume

14

pub_type

杂志文章

相关文献

CYTOTHERAPY文献大全
  • Large-scale production and directed induction of functional dendritic cells ex vivo from serum-free expanded human hematopoietic stem cells.

    abstract：BACKGROUND:Dendritic cells (DCs) that are derived from hematopoietic stem cells (HSCs) are the most potent antigen-presenting cells and play a pivotal role in initiating the immune response. Hence, large-scale production and direct induction of functional DCs ex vivo from HSCs are crucial to HSC research and clinical p...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2019.04.059

    authors： Hsu SC,Lu LC,Chan KY,Huang CH,Cheng SL,Chan YS,Yang YS,Lai YT,Yao CL

    更新日期：2019-07-01 00:00:00

  • Factors modulating circulation of hematopoietic progenitor cells in cord blood and neonates.

    abstract：BACKGROUND:Hematopoietic progenitor cells (HPC) circulate at high levels at birth and disappear rapidly afterwards, but the underlying mechanism it is not known. The aim of this study was to assess circulating HPC in cord blood at different gestational ages and shortly after birth and concomitantly study the biologic m...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240802499148

    authors： Gonzalez S,Amat L,Azqueta C,Madrigal JA,Laïlla JM,Garcia J,Querol S

    更新日期：2009-01-01 00:00:00

  • Stem cell comparison: what can we learn clinically from unrelated cord blood transplantation as an alternative stem cell source?

    abstract：:Allogeneic hematopoietic cell transplantation (HCT) is an important therapeutic option for a variety of malignant and non-malignant disorders (NMD). The use of umbilical cord blood transplantation (UCBT) has made HCT available to many more patients. The increased level of human leukocyte antigen disparity that can be ...

    journal_title：Cytotherapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.jcyt.2015.03.003

    authors： Milano F,Boelens JJ

    更新日期：2015-06-01 00:00:00

  • Yield and proliferation rate of adipose-derived stromal cells as a function of age, body mass index and harvest site-increasing the yield by use of adherent and supernatant fractions?

    abstract：BACKGROUND AIMS:Adipose-derived stem cells are easily accessed and have a relatively high density compared with other mesenchymal stromal cells. Isolation protocols of adipose-derived stem cells (ASC) rely on the cell's ability to adhere to tissue culture plastic overnight. It was evaluated whether the floating ASC fra...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2013.04.009

    authors： Buschmann J,Gao S,Härter L,Hemmi S,Welti M,Werner CM,Calcagni M,Cinelli P,Wanner GA

    更新日期：2013-09-01 00:00:00

  • T lymphocytes engineered to express a CD16-chimeric antigen receptor redirect T-cell immune responses against immunoglobulin G-opsonized target cells.

    abstract：BACKGROUND AIMS:Chimeric antigen receptors (CARs) designed for adoptive immunotherapy need to achieve two functions: antigen recognition and triggering of the lytic machinery of reprogrammed effector cells. Cytotoxic T cells have been engineered with FcγRIII (CD16) chimeric molecules to be redirected against malignant ...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2015.10.014

    authors： D'Aloia MM,Caratelli S,Palumbo C,Battella S,Arriga R,Lauro D,Palmieri G,Sconocchia G,Alimandi M

    更新日期：2016-02-01 00:00:00

  • Nicotine-reduced endothelial progenitor cell senescence through augmentation of telomerase activity via the PI3K/Akt pathway.

    abstract：BACKGROUND AIMS:Previous studies have shown that nicotine increases endothelial progenitor cell (EPC) numbers and functional activity. However, the mechanisms by which nicotine increases EPC numbers and activity remain to be determined. Recent studies have demonstrated that EPC numbers and activity are associated with ...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240902887267

    authors： Junhui Z,Xiaojing H,Binquan Z,Xudong X,Junzhu C,Guosheng F

    更新日期：2009-01-01 00:00:00

  • Mesenchymal stromal cells from dermal and adipose tissues induce macrophage polarization to a pro-repair phenotype and improve skin wound healing.

    abstract：:The process of wound healing restores skin homeostasis but not full functionality; thus, novel therapeutic strategies are needed to accelerate wound closure and improve the quality of healing. In this context, tissue engineering and cellular therapies are promising approaches. Although sharing essential characteristic...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2020.02.003

    authors： Zomer HD,Jeremias TDS,Ratner B,Trentin AG

    更新日期：2020-05-01 00:00:00

  • Factors associated with treatment outcome, and long-term prognosis of patients with ulcerative colitis undergoing selective depletion of myeloid lineage leucocytes: a prospective multicenter study.

    abstract：BACKGROUND:Patients with ulcerative colitis (UC) have elevated/activated myeloid lineage leucocytes and may respond favorably to adsorptive granulocyte/monocyte apheresis (GMA). However, there are patients who respond well to GMA, and patients who do not benefit. Therefore, predictive factors of GMA efficacy need to be...

    journal_title：Cytotherapy

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jcyt.2015.02.007

    authors： Yokoyama Y,Watanabe K,Ito H,Nishishita M,Sawada K,Okuyama Y,Okazaki K,Fujii H,Nakase H,Masuda T,Fukunaga K,Andoh A,Nakamura S

    更新日期：2015-05-01 00:00:00

  • Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure.

    abstract：BACKGROUND:Adipose tissue contains a stromal vascular fraction that can be easily isolated and provides a rich source of adipose tissue-derived mesenchymal stem cells (ASC). These ASC are a potential source of cells for tissue engineering. We studied whether the yield and growth characteristics of ASC were affected by ...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240600621125

    authors： Oedayrajsingh-Varma MJ,van Ham SM,Knippenberg M,Helder MN,Klein-Nulend J,Schouten TE,Ritt MJ,van Milligen FJ

    更新日期：2006-01-01 00:00:00

  • Ex vivo expansion of mafosfamide-purged PBPC products.

    abstract：BACKGROUND:Multiple studies have demonstrated that 'purging' of autografts with 4-hydroperoxycyclophosphamide (4HC) or the related compound mafosfamide (Mf), to eradicate residual leukemia, produces the best results associated with autologous blood and marrow transplantation for AML. However, 4HC purging results in pro...

    journal_title：Cytotherapy

    pub_type： 临床试验,杂志文章

    doi：10.1080/14653240600905353

    authors： McNiece I,Civin C,Harrington J,Kellner J,Malehorn M,Turney J,Barber J,Jones R

    更新日期：2006-01-01 00:00:00

  • Ex vivo immunological evaluation of stable mixed chimeric patients after matched related donor allogeneic transplantation in sickle cell disease.

    abstract：BACKGROUND AIMS:Allogeneic hematopoietic stem cell transplantation is curative for sickle cell disease, and the use of matched related donors, non-myeloablative conditioning and sirolimus immunosuppression results in stable mixed chimerism without graft-versus-host disease (GVHD). However, the time to terminate sirolim...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2019.10.003

    authors： Raines LN,Hsieh MM,Nassehi T,Drysdale CM,Tisdale JF,Uchida N

    更新日期：2019-12-01 00:00:00

  • Cryopreserved mesenchymal stromal cell treatment is safe and feasible for severe dilated ischemic cardiomyopathy.

    abstract：BACKGROUND AIMS:Bone marrow (BM) mesenchymal stromal cells (MSC) represent a novel therapy for severe heart failure with extensive myocardial scarring, especially when performed concurrently with conventional revascularization. However, stem cells are difficult to transport in culture media without risk of contaminatio...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653240903313966

    authors： Chin SP,Poey AC,Wong CY,Chang SK,Teh W,Mohr TJ,Cheong SK

    更新日期：2010-01-01 00:00:00

  • A strategy for single nucleotide polymorphism analysis of chimerism for somatic cell therapy.

    abstract：BACKGROUND AIMS:Chimerism is an important outcome measure in hematopoietic cell transplantation as well as somatic cell therapy. Commonly used methods to estimate chimerism are restricted by either gender or inefficient sensitivity. In principle, real-time polymerase chain reaction (PCR)-based assays can be used to ass...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653241003774029

    authors： Chen X,Hofmann TJ,Otsuru S,Jethva R,Lind C,Monos D,Horwitz EM

    更新日期：2010-12-01 00:00:00

  • Building blocks for institutional preparation of CTL019 delivery.

    abstract：:Chimeric antigen receptor (CAR) T-cell therapy is an investigational immunocellular therapy that reprograms a patient's cytotoxic T cells to engage and eliminate malignant cells. CAR T-cell therapies targeting the CD19 antigen have demonstrated high efficacy in clinical trials for patients with B-cell malignancies and...

    journal_title：Cytotherapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.jcyt.2017.06.001

    authors： McGuirk J,Waller EK,Qayed M,Abhyankar S,Ericson S,Holman P,Keir C,Myers GD

    更新日期：2017-09-01 00:00:00

  • In vitro expression of erythropoietin by transfected human mesenchymal stromal cells.

    abstract：BACKGROUND:Mesenchymal stromal cells (MSC) are pluripotent progenitor cells that can be found in human bone marrow (BM). These cells have low immunogenicity and could suppress alloreactive T-cell responses. In the current study, MSC were tested for their capacity to carry and deliver the erythropoietin (EPO) gene in vi...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240701816996

    authors： Mok PL,Cheong SK,Leong CF,Othman A

    更新日期：2008-01-01 00:00:00

  • Transplantation with low-density autologous PBSC prepared with BDS60 for women with Stage II, III and IV breast cancer.

    abstract：BACKGROUND:DS60 is a novel buoyant density solution, whose density has been adjusted to enrich PBSC from subjects who have been mobilized with cytokines alone, or cytokines plus chemotherapy. This report describes the use of BDS60 to enrich autologous PBSC that were used for hematological reconstitution after myeloabla...

    journal_title：Cytotherapy

    pub_type： 临床试验,杂志文章

    doi：10.1080/146532400539134

    authors： Laport GG,Valone FH,Zimmerman TM,Grinblatt DL,Van Vlasselaer P,Still BJ,Williams SF

    更新日期：2000-01-01 00:00:00

  • Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis.

    abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) have been used to minimize and repair radiation-induced normal tissue injury in the intestine, salivary gland, liver, skin, lungs and cardiac muscle. This study investigated the ability of adipose tissue-derived MSCs (aMSCs) to minimize and/or repair single dose radiatio...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2016.06.008

    authors： Maria OM,Shalaby M,Syme A,Eliopoulos N,Muanza T

    更新日期：2016-09-01 00:00:00

  • HLA tetramers and anti-CMV immune responses: from epitope to immunotherapy.

    abstract：BACKGROUND:Identification of HLA class I-restricted CMV epitopes, and the subsequent synthesis of HLA class I-peptide tetrameric complexes, have provided investigators with an important tool for visualising and quantifying the precise in vivo CTL response to CMV reactivation following stem cell transplantation. In conj...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/146532402317251518

    authors： Chen FE,Aubert G,Travers P,Dodi IA,Madrigal JA

    更新日期：2002-01-01 00:00:00

  • CD4(+) CD25(+) regulatory T cells ameliorate Behcet's disease-like symptoms in a mouse model.

    abstract：BACKGROUND AIMS:Behcet's disease (BD) is a chronic, multisystemic inflammatory disorder with arthritic, gastrointestinal, mucocutaneous, ocular, vascular and central nervous system involvement. It is well known that CD4(+) CD25(+) T-regulatory (Treg) cells prevent harmful immune responses to self- and non-self-antigens...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653249.2011.571245

    authors： Shim J,Lee ES,Park S,Bang D,Sohn S

    更新日期：2011-08-01 00:00:00

  • Co-transfusion of haplo-identical hematopoietic and mesenchymal stromal cells to treat a patient with severe aplastic.

    abstract：:A 3-year-old girl with severe aplastic anemia (SAA) that was unresponsive to steroid, cyclosporine and filgrastim treatments received bone marrow (BM) mesenchymal stromal cells (MSC; 1.25 x 10(6)/kg), granulocyte colony-stimulating factor (G-CSF)-mobilized BM and peripheral blood stem cell grafts from her father. Prio...

    journal_title：Cytotherapy

    pub_type： 信件

    doi：10.3109/14653241003695059

    authors： Wang H,Wang Z,Xue M,Liu J,Yan H,Guo Z

    更新日期：2010-07-01 00:00:00

  • Cord blood is the optimal graft source for the treatment of pediatric patients with lysosomal storage diseases: clinical outcomes and future directions.

    abstract：:Initially used as an alternative hematopoietic stem cell source for patients without a human leukocyte antigen-matched bone marrow or peripheral blood stem cell donor, unrelated cord blood (UCB) is now the preferred donor source when hematopoietic stem cell transplantation (HSCT) is used to treat patients with lysosom...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2015.03.609

    authors： Aldenhoven M,Kurtzberg J

    更新日期：2015-06-01 00:00:00

  • Identification of new cytokine combinations for antigen-specific T-cell therapy products via a high-throughput multi-parameter assay.

    abstract：:Infusion of viral-specific T cells (VSTs) is an effective treatment for viral infection after stem cell transplant. Current manufacturing approaches are rapid, but growth conditions can still be further improved. To optimize VST cell products, the authors designed a high-throughput flow cytometry-based assay using 40 ...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2020.08.006

    authors： Lazarski CA,Datar AA,Reynolds EK,Keller MD,Bollard CM,Hanley PJ

    更新日期：2021-01-01 00:00:00

  • Expression and role of Toll-like receptors on human umbilical cord mesenchymal stromal cells.

    abstract：BACKGROUND AIMS:Toll-like receptors (TLRs) play an important role in innate and adaptive immunity by recognizing pathogen-associated molecular patterns (PAMPs). METHODS:In the present study, we investigated the expression and role of TLRs on human umbilical cord mesenchymal stromal cells (UC-MSCs). The proliferation, ...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2012.12.001

    authors： Chen D,Ma F,Xu S,Yang S,Chen F,Rong L,Chi Y,Zhao Q,Lu S,Han Z,Pang A,Han Z

    更新日期：2013-04-01 00:00:00

  • Microbial contamination of cellular products for hematolymphoid transplantation therapy: assessment of the problem and strategies to minimize the clinical impact.

    abstract：BACKGROUND:Hematopoietic progenitor stem cells (HPSC) are a specialized transfusion product used for transplantation. Microbial contamination may occur during harvest or subsequent manipulation of these cells. The same difficulties in ensuring a safe, sterile, final product are faced in the preparation of other cell-th...

    journal_title：Cytotherapy

    pub_type： 杂志文章,评审

    doi：10.1080/14653240310003044

    authors： Lowder JN,Whelton P

    更新日期：2003-01-01 00:00:00

  • Transplantation of tendon-derived stem cells pre-treated with connective tissue growth factor and ascorbic acid in vitro promoted better tendon repair in a patellar tendon window injury rat model.

    abstract：BACKGROUND AIMS:Treatment of tendon-derived stem cells (TDSCs) with connective tissue growth factor (CTGF) and ascorbic acid promoted their tenogenic differentiation. We investigated the effects of TDSCs pre-treated with CTGF and ascorbic acid on tendon repair in a patellar tendon window injury rat model. METHODS:Gree...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2015.10.005

    authors： Lui PP,Wong OT,Lee YW

    更新日期：2016-01-01 00:00:00

  • Combined immunotherapy with whole tumor lysate-pulsed interleukin-15-activated dendritic cells and cucurbitacin I promotes strong CD8(+) T-cell responses and cures highly aggressive lymphoma.

    abstract：BACKGROUND AIMS:Dendritic cell (DC)-based therapies could be important strategies for lymphoma treatment. METHODS:AKR/J mice with Dalton's lymphoma were treated with recombinant interleukin-15 (rIL-15)-activated autologous DCs and pulsed with whole tumor cell lysates in the presence or absence of suboptimal doses of t...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2015.01.006

    authors： Hira SK,Mondal I,Manna PP

    更新日期：2015-05-01 00:00:00

  • Labeling of mesenchymal stromal cells with iron oxide-poly(L-lactide) nanoparticles for magnetic resonance imaging: uptake, persistence, effects on cellular function and magnetic resonance imaging properties.

    abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) are the focus of research in regenerative medicine aiming at the regulatory approval of these cells for specific indications. To cope with the regulatory requirements for somatic cell therapy, novel approaches that do not interfere with the natural behavior of the cells a...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653249.2011.571246

    authors： Schmidtke-Schrezenmeier G,Urban M,Musyanovych A,Mailänder V,Rojewski M,Fekete N,Menard C,Deak E,Tarte K,Rasche V,Landfester K,Schrezenmeier H

    更新日期：2011-09-01 00:00:00

  • Reprogramming of mouse renal tubular epithelial cells to induced pluripotent stem cells.

    abstract：:Kidney disease has reached epidemic proportions and is associated with high mortality and morbidity rates. Stem cell-based therapy may effectively treat kidney damage by cell transplantation. The breakthrough discovery using a combination of four transcription factors to reprogram genetically somatic cells into induce...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2013.01.008

    authors： Wang WW,Wang W,Jiang Y,Han GF,Lu S,Li G,Zhang J

    更新日期：2013-05-01 00:00:00

  • An APC for every occasion: induction and expansion of human Ag-specific CD4 and CD8 T cells using cellular and non-cellular APC.

    abstract：:APC are used extensively to induce and expand Ag-specific T cells as well as to test their specificity and function. In the treatment of malignant and infectious diseases, APC are used to stimulate and expand Ag-specific T cells for adoptive transfer, or used directly in vivo to present Ag. The choice of APC to use de...

    journal_title：Cytotherapy

    pub_type： 杂志文章,评审

    doi：10.1080/14653240410005230

    authors： Grübe M,Melenhorst JJ,Barrett AJ

    更新日期：2004-01-01 00:00:00

  • Endothelial progenitor cells may inhibit apoptosis of pulmonary microvascular endothelial cells: new insights into cell therapy for pulmonary arterial hypertension.

    abstract：BACKGROUND AIMS:Endothelial apoptosis underlies the pathophysiology of pulmonary arterial hypertension (PAH). Some factors/cytokines released by endothelial progenitor cells (EPC) have been revealed as potent inhibitors of apoptosis. The aim of this study was to investigate the effects of EPC on pulmonary microvascular...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240902960460

    authors： Xia L,Fu GS,Yang JX,Zhang FR,Wang XX

    更新日期：2009-01-01 00:00:00