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An APC for every occasion: induction and expansion of human Ag-specific CD4 and CD8 T cells using cellular and non-cellular APC.

Abstract：

:APC are used extensively to induce and expand Ag-specific T cells as well as to test their specificity and function. In the treatment of malignant and infectious diseases, APC are used to stimulate and expand Ag-specific T cells for adoptive transfer, or used directly in vivo to present Ag. The choice of APC to use depends on the particular application and on practical considerations, which include ease of production, availability, reproducibility and (for clinical use) established safety. The diversity of APC in use partly reflects the fact that no single technique of Ag presentation is ideal. For the clinician and laboratory worker alike the field can seem illogical and confusing. In this review we outline the functional requirements of APC for the induction of T cells, classify the APC in common use and describe their laboratory and clinical applications.

journal_name

Cytotherapy

journal_title

Cytotherapy

authors

Grübe M,Melenhorst JJ,Barrett AJ

doi

10.1080/14653240410005230

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

440-9

issue

5

eissn

1465-3249

issn

1477-2566

pii

JAWFTBQ0C7UNK521

journal_volume

6

pub_type

杂志文章,评审

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