Abstract:
:A 3-year-old girl with severe aplastic anemia (SAA) that was unresponsive to steroid, cyclosporine and filgrastim treatments received bone marrow (BM) mesenchymal stromal cells (MSC; 1.25 x 10(6)/kg), granulocyte colony-stimulating factor (G-CSF)-mobilized BM and peripheral blood stem cell grafts from her father. Prior to stem cell transplantation, she had experienced repeated bacterial infections and received 44 blood transfusions during 8 months after diagnosis. The conditioning regimen consisted of fludarabine, cyclophosphamide and busulfan, and prophylaxis of acute graft-versus-host disease (GvHD) was performed by administration of anti-CD25 monoclonal antibody, cyclosporine A, methotrexate, mycophenolate mofetil and anti-thymocyte globulin. The patient achieved rapid hematopoietic engraftment of donor origin and no acute or chronic GvHD was observed. She is now alive with a good performance status, and the dose of cyclosporine A is being tapered. The novel regimen described here might be a suitable option for children with SAA who lack immediate access to HLA-matched sources.
journal_name
Cytotherapyjournal_title
Cytotherapyauthors
Wang H,Wang Z,Xue M,Liu J,Yan H,Guo Zdoi
10.3109/14653241003695059subject
Has Abstractpub_date
2010-07-01 00:00:00pages
563-5issue
4eissn
1465-3249issn
1477-2566pii
S1465-3249(10)70419-9journal_volume
12pub_type
信件相关文献
CYTOTHERAPY文献大全abstract:BACKGROUND AIMS:Adipose tissue has therapeutic potential for spinal cord injury (SCI) because it contains multipotent cells known as adipose-derived stem/stromal cells (ASCs). In this study, we attempted intravenous ASC transplantation in rats with SCI to examine the effect on functional recovery. METHODS:ASCs (2.5 × ...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2017.04.002
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) suppress T-cell proliferation, especially after activation with inflammatory cytokines. We compared the dynamic action of unprimed and interferon (IFN)-γ plus tumor necrosis factor (TNF)-α-pretreated human bone marrow-derived MSCs on resting or activated T cells. METHOD...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2013.11.008
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AIMS:Mesenchymal stromal cells (MSC) may be useful in a range of clinical applications. The placenta has been suggested as an abundant, ethically acceptable, less immunogenic and easily accessible source of MSC. The aim of this study was to evaluate the capacity of induced placental MSC to differentiate into...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653249.2011.613928
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AIMS:Mesenchymal stromal cells (MSCs), derived from several tissues including bone marrow and adipose tissue, are being evaluated in clinical trials for a range of diseases. Virtually all tissues of the body contain stromal cells, yet it is unknown whether these sources are similar in phenotype and function....
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2015.07.009
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Umbilical cord blood (UCB) is an alternative graft source for hematopoietic stem cell transplantation and has been shown to give results comparable to transplantation with other stem cell sources. Donor lymphocyte infusion (DLI) is an effective treatment for relapsed malignancies after hematopoietic stem cel...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2014.08.001
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND AIMS:Adipose tissue is a rich and very convenient source of cells for regenerative medicine therapeutic approaches. However, a characterization of the population of adipose-derived stromal and stem cells (ASCs) with the greatest therapeutic potential remains unclear. Under the authority of International Fede...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2013.02.006
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AIMS:Circulating monocytes have been exploited as an important progenitor cell resource for hepatocytes in vitro and are instrumental in the removal of fibrosis. We investigated the significance of monocytes in peripheral blood stem cells (PBSC) for the treatment of liver cirrhosis. METHODS:Rat CD14+ monocy...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653249.2010.515578
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AIMS:Apoptosis of radiosensitive cells in the bone marrow and gut is a serious, at times life-threatening, complication arising from radiation exposure. METHODS:We investigated whether adoptive transfer of allogeneic bone marrow-derived mesenchymal stromal cells (MSC) could exert cytoprotective and life-spa...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653249.2012.684378
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AIMS:Existing treatments have limited success in modifying the course of peripheral artery disease, which may eventually lead to limb-threatening ulcers and amputation. Cellular therapies have the potential to provide a new treatment option for this condition, but isolation of cells by conventional means has...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2015.10.013
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AIMS:During bone formation, angiogenesis and osteogenesis are regulated by hypoxia, which is able to induce blood vessel formation, as well as recruit and differentiate human mesenchymal stromal cells (hMSCs). The molecular mechanisms involved in HIF-1α response and hMSC differentiation during bone formation...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2017.09.007
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AIMS:Adipose-derived stem cells are easily accessed and have a relatively high density compared with other mesenchymal stromal cells. Isolation protocols of adipose-derived stem cells (ASC) rely on the cell's ability to adhere to tissue culture plastic overnight. It was evaluated whether the floating ASC fra...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2013.04.009
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AIMS:The types of proteins released from mesenchymal stromal cells (MSC) are still unclear. Our aim was to compare apoptosis scores and the expression of myelin-associated glycoprotein (MAG), myelin basic protein (MBP), neural cell adhesion molecule (NCAM)-1,matrix metalloproteinase (MMP)-1A, tissue inhibito...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653249.2011.651530
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Post-infarct congestive heart failure is one of the leading causes of morbidity and mortality in industrialized countries. The main purpose of this study was to investigate whether transplantation of embryonic stem cell-derived cardiomyocytes (ESCM) directly into the infarcted myocardium could improve cardia...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1080/14653240701247838
更新日期:2007-01-01 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial hyperproliferation and dysfunction. Restoration of endothelial function is a common goal of available treatments. In the present study, human adipose-derived mesenchymal stromal cells (ASCs) were co-cultured with monocrotaline pyr...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2019.02.011
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND AIMS:The term "cerebral palsy" (CP) encompasses many syndromes that emerge from brain damage at early stages of ontogenesis and manifest as the inability to retain a normal body position or perform controlled movements. Existing methods of CP treatment, including various rehabilitation strategies and surgica...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2015.02.010
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AIMS:Adipose tissue represents a practical source of autologous mesenchymal stromal cells (MSCs) and vascular-endothelial progenitor cells, available for regenerative therapy without in vitro expansion. One of the problems confronting the therapeutic application of such cells is how to immobilize them at the...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2012.10.009
更新日期:2013-01-01 00:00:00
abstract::Broader application of adoptive transfer of tumor-specific T-lymphocytes is accompanied by the need for effective suicide genes to ensure the safety of this cell-based therapy. In vivo elimination of T-lymphocytes expressing the herpes simplex virus-derived thymidine kinase gene has demonstrated the feasibility of thi...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1080/14653240310001497
更新日期:2003-01-01 00:00:00
abstract::Cell therapy products are frequently developed and produced without incorporating cost considerations into process development, contributing to prohibitively costly products. Herein we contextualize individual process development decisions within a broad framework for cost-efficient therapeutic manufacturing. This roa...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1016/j.jcyt.2017.06.009
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Umbilical cord blood (UCB) has been used as an alternative source of donor hematopoietic stem cells for hematologic transplant setting over the past decade. This study attempted to evaluate potential predictors of cord blood quality. METHODS:A total of 750 UCB samples were studied (male, n = 365; female, n ...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2014.09.002
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Intracoronary application of BM-derived cells for the treatment of acute myocardial infarction (AMI) is currently being studied intensively. Simultaneously, strict legal requirements surround the production of cells for clinical studies. Thus good manufacturing practice (GMP)-compliant collection and prepara...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1080/14653240601052734
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AIMS:The immunomodulatory and anti-inflammatory effects of mesenchymal stromal cells (MSC) could prove to be a potential therapeutic approach for prolongation of survival of cell xenotransplantation. Adipose (Ad) MSC from genetically modified pigs could be an abundant source of pig donor-specific MSC. METHO...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653249.2011.651529
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The mechanism of platelet recovery after hematopoietic stem cell transplantation and the factors that influence its time-course are not fully understood. Rapid hematopoietic recovery results in a reduction of transplantation-related complications. In the present study, we questioned and analyzed whether ther...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1080/14653240701561337
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AIMS:Specific and effective therapy for prevention or reversal of bronchiolitis obliterans (BO) is lacking. In this study, we evaluated the therapeutic effect of hepatocyte growth factor (HGF) gene modified mesenchymal stromal cells (MSCs) on BO. METHODS:A mouse model of experimental BO was established by s...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2015.12.006
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:We have previously demonstrated that bovine dialyzable leukocyte extract (bDLE) induces death through an apoptosis mechanism in MCF-7 breast cancer cells. Depending on the cell type and stimulus, activating protein-1 (AP-1) has been shown to regulate cell proliferation and differentiation, the stress respons...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1080/14653240801891659
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AIMS:Retinal degeneration (RD) is an inherited eye disease characterized by irreversible photoreceptor loss. Conventionally, the activation of the resident microglia is secondary to the disease. Stem cell-based therapy has recently made rapid progress in treating RD. Although it has been demonstrated that th...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2016.03.001
更新日期:2016-06-01 00:00:00
abstract::Allogeneic hematopoietic cell transplantation (HCT) is an important therapeutic option for a variety of malignant and non-malignant disorders (NMD). The use of umbilical cord blood transplantation (UCBT) has made HCT available to many more patients. The increased level of human leukocyte antigen disparity that can be ...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1016/j.jcyt.2015.03.003
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Mesenchymal stromal cells (MSC) are of clinical interest for their potential use in regenerative medicine and immunotherapy. Originally derived from bone marrow (BM), MSC have now been isolated from most tissues, including umbilical cord (UC) and UC blood (UCB). If MSC from UC are biologically equivalent to ...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653240903079401
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AIMS:Adoptive immunotherapy with the use of chimeric antigen receptor (CAR)-engineered T cells specific for CD19 has shown promising results for the treatment of B-cell lymphomas and leukemia. This therapy involves the transduction of autologous T cells with a viral vector and the subsequent cell expansion. ...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2013.06.003
更新日期:2013-11-01 00:00:00
abstract::Natural killer (NK) cells are members of the innate immune system that recognize target cells via activating and inhibitory signals received through cell receptors. Derived from the lymphoid lineage, NK cells are able to produce cytokines and exert a cytotoxic effect on viral infected and malignant cells. It is their ...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1016/j.jcyt.2016.05.018
更新日期:2016-11-01 00:00:00
abstract::Cellular & Gene Therapies (CGTs) are complex products, which have been key foci of the International Society for Cell & Gene Therapy (ISCT). For this ISCT North American Legal & Regulatory Affairs Committee review publication, CGTs include but are not limited to somatic cell-based therapies, pluripotent cell-derived c...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1016/j.jcyt.2019.04.002
更新日期:2019-07-01 00:00:00