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Expanded umbilical cord blood T cells used as donor lymphocyte infusions after umbilical cord blood transplantation.

Abstract：

BACKGROUND:Umbilical cord blood (UCB) is an alternative graft source for hematopoietic stem cell transplantation and has been shown to give results comparable to transplantation with other stem cell sources. Donor lymphocyte infusion (DLI) is an effective treatment for relapsed malignancies after hematopoietic stem cell transplantation. However, DLI is not available after UCB transplantation. METHODS:In this study, in vitro-cultured T cells from the UCB graft were explored as an alternative to conventional DLI. The main aim was to study the safety of the cultured UCB T cells used as DLI because such cell preparations have not been used in this context previously. We also assessed potential benefits of the treatment. RESULTS:The cultured UCB T cells (UCB DLI) were given to 4 patients with mixed chimerism (n = 2), minimal residual disease (n = 1) and graft failure (n = 1). No adverse reactions were seen at transfusion. Three of the patients did not show any signs of graft-versus-host disease (GVHD) after UCB DLI, but GVHD could not be excluded in the last patient. In the patient with minimal residual disease treated with UCB DLI, the malignant cell clone was detectable shortly before infusion but undetectable at treatment and for 3 months after infusion. In 1 patient with mixed chimerism, the percentage of recipient cells decreased in temporal association with UCB DLI treatment. CONCLUSIONS:We saw no certain adverse effects of treatment with UCB DLI. Events that could indicate possible benefits were seen but with no certain causal association with the treatment.

journal_name

Cytotherapy

journal_title

Cytotherapy

authors

Berglund S,Gertow J,Uhlin M,Mattsson J

doi

10.1016/j.jcyt.2014.08.001

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1528-1536

issue

11

eissn

1465-3249

issn

1477-2566

pii

S1465-3249(14)00711-7

journal_volume

16

pub_type

杂志文章

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