Ab therapy of AML: native anti-CD33 Ab and drug conjugates.

abstract：BACKGROUND AIMS:Adipose tissue is a rich and very convenient source of cells for regenerative medicine therapeutic approaches. However, a characterization of the population of adipose-derived stromal and stem cells (ASCs) with the greatest therapeutic potential remains unclear. Under the authority of International Fede...

journal_title：Cytotherapy

authors： Bourin P,Bunnell BA,Casteilla L,Dominici M,Katz AJ,March KL,Redl H,Rubin JP,Yoshimura K,Gimble JM

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Adipose tissue contains a stromal vascular fraction that can be easily isolated and provides a rich source of adipose tissue-derived mesenchymal stem cells (ASC). These ASC are a potential source of cells for tissue engineering. We studied whether the yield and growth characteristics of ASC were affected by ...

journal_title：Cytotherapy

authors： Oedayrajsingh-Varma MJ,van Ham SM,Knippenberg M,Helder MN,Klein-Nulend J,Schouten TE,Ritt MJ,van Milligen FJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AIMS:Behcet's disease (BD) is a chronic, multisystemic inflammatory disorder with arthritic, gastrointestinal, mucocutaneous, ocular, vascular and central nervous system involvement. It is well known that CD4(+) CD25(+) T-regulatory (Treg) cells prevent harmful immune responses to self- and non-self-antigens...

journal_title：Cytotherapy

authors： Shim J,Lee ES,Park S,Bang D,Sohn S

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AIMS:Bone marrow-derived mesenchymal stromal cells (MSCs) have been reported to suppress T-cell proliferation and used to alleviate the symptoms of graft-versus-host disease (GVHD). MSCs are a mixed cell population and at this time there are no tools to isolate the cells responsible for the T-cell suppressio...

journal_title：Cytotherapy

authors： McClain-Caldwell I,Vitale-Cross L,Mayer B,Krepuska M,Boyajian M,Myneni V,Martin D,GENOMICS AND COMPUTATIONAL BIOLOGY CORE.,Marko K,Nemeth K,Mezey E

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Ex vivo T-cell depletion of allogeneic BM (BM) grafts can effectively reduce graft versus host disease (GvHD) and may also apply to transplantation of allogeneic peripheral blood stem cell (PBSC) transplants. METHODS:Here we have evaluated T-cell depletion and progenitor cell recovery by antibody-mediated c...

journal_title：Cytotherapy

authors： Williams RJ,Clarke E,Blair A,Evely R,Hale G,Waldmann H,Brookes S,Pamphilon DH

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AIMS:Human gamma-delta (γδ) T cells are potent effector lymphocytes of innate immunity involved in anti-tumor immune surveillance. However, the Vδ1 γδ T-cell subset targeting multiple myeloma (MM) has not previously been investigated. METHODS:Vδ1 T cells were purified from peripheral blood mononuclear cells...

journal_title：Cytotherapy

authors： Knight A,Mackinnon S,Lowdell MW

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AIMS:Intrauterine adhesion (IUA) is a common uterine cavity disease characterized by the unsatisfactory regeneration of damaged endometria. Recently, stem cell transplantation has been proposed to promote the recovery process. Here we investigated whether human amniotic mesenchymal stromal cells (hAMSCs), a ...

journal_title：Cytotherapy

authors： Gan L,Duan H,Xu Q,Tang YQ,Li JJ,Sun FQ,Wang S

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AIMS:Tumor antigen-specific cytotoxic T lymphocytes (CTL) have been used in the treatment of human cancer, including leukemia. Several studies have established PR1 peptide, an HLA-A2.1-restricted peptide derived from proteinase 3 (P3), as a human leukemia-associated antigen. PR1-specific CTL elicited in vitr...

journal_title：Cytotherapy

authors： Ma Q,Wang C,Jones D,Quintanilla KE,Li D,Wang Y,Wieder ED,Clise-Dwyer K,Alatrash G,Mj Y,Munsell MF,Lu S,Qazilbash MH,Molldrem JJ

更新日期：2010-12-01 00:00:00

abstract：:Cellular & Gene Therapies (CGTs) are complex products, which have been key foci of the International Society for Cell & Gene Therapy (ISCT). For this ISCT North American Legal & Regulatory Affairs Committee review publication, CGTs include but are not limited to somatic cell-based therapies, pluripotent cell-derived c...

journal_title：Cytotherapy

authors： Mendicino M,Fan Y,Griffin D,Gunter KC,Nichols K

更新日期：2019-07-01 00:00:00

abstract：:Initially used as an alternative hematopoietic stem cell source for patients without a human leukocyte antigen-matched bone marrow or peripheral blood stem cell donor, unrelated cord blood (UCB) is now the preferred donor source when hematopoietic stem cell transplantation (HSCT) is used to treat patients with lysosom...

journal_title：Cytotherapy

authors： Aldenhoven M,Kurtzberg J

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Umbilical cord blood (UCB) is an alternative graft source for hematopoietic stem cell transplantation and has been shown to give results comparable to transplantation with other stem cell sources. Donor lymphocyte infusion (DLI) is an effective treatment for relapsed malignancies after hematopoietic stem cel...

journal_title：Cytotherapy

authors： Berglund S,Gertow J,Uhlin M,Mattsson J

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The possible functional role of basic fibroblast growth factor (bFGF) in regulating the mitotic and metabolic activity of primary human articular chondrocytes was investigated. METHODS:[EF1]Chondrocytes were enzymatically isolated from femoral head cartilage, and were cultured in vitro in monolayer. bFGF-de...

journal_title：Cytotherapy

authors： Schmal H,Zwingmann J,Fehrenbach M,Finkenzeller G,Stark GB,Südkamp NP,Hartl D,Mehlhorn AT

更新日期：2007-01-01 00:00:00

abstract：:Not all patients with Hodgkin's disease (HD) respond to standard chemotherapy and/or radiation, and hematopoietic stem-cell transplantation has been gaining increasing acceptance in the management of HD. Phase II and, to a lesser extent, phase III studies of high-dose chemotherapy and autologous stem cell transplantat...

journal_title：Cytotherapy

authors： Anderlini P

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AIMS:Hepatic stellate cells (HSCs) are liver-resident mesenchymal cells involved in essential processes in the liver. However, knowledge concerning these cells in human livers is limited because of the lack of a simple isolation method. METHODS:We isolated fetal and adult human liver cells by immunomagnetic...

journal_title：Cytotherapy

authors： Patil PB,Joshi M,Kuna VK,Xu B,Johannesson L,Olausson M,Sumitran-Holgersson S

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSC) have shown diverse therapeutic potential. While characterization of human and mouse MSC has seen significant advances, rat bone marrow-derived MSC (rBM-MSC) remain under-characterized. We detail the isolation, expansion, differentiation, and detailed immunocharacterization of ...

journal_title：Cytotherapy

authors： Harting M,Jimenez F,Pati S,Baumgartner J,Cox C Jr

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Cutaneous wound management is a major health problem and imposes a huge economic burden worldwide. Previous studies have demonstrated that wound healing is a highly coordinated process including epithelialization, angiogenesis, remodeling and scarring. This progression requires self-renewal, preservatio...

journal_title：Cytotherapy

authors： Chen X,Yang R,Wang J,Ruan S,Lin Z,Xin Q,Yang R,Xie J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Lentiviral vectors have the capacity to transduce stably non-dividing, differentiated and undifferentiated cells of various tissues, including liver. To obtain high-level expression of transgenes, vectors often rely on viral promoters. However, recent data suggest that the supraphysiologic expression from ub...

journal_title：Cytotherapy

authors： Picanço V,Heinz S,Bott D,Behrmann M,Covas DT,Seifried E,Tonn T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Contaminating breast cancer cells in leukapheresis harvested for reinfusion to rebuild hemopoiesis after high-dose therapy have been described by several investigators. Methods for tumor cell detection are conventional immunocytochemistry, culture techniques and reverse transcriptase PCR. The percentage of t...

journal_title：Cytotherapy

authors： Krüger W,Tögel F,Rössing S,Kröger N,Zander AR

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AIMS:The therapeutic potential of human mesenchymal stromal cells (MSCs) has generated considerable interest in a wide variety of areas. MSC banking is feasible, but the optimal technique of cryopreservation remains to be determined. METHODS:To reduce dimethyl sulfoxide (DMSO) concentration in cryopreservat...

journal_title：Cytotherapy

authors： Briquet A,Halleux A,Lechanteur C,Beguin Y

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AIMS:Umbilical cord blood transplantation (CBT) is an effective treatment for benign and malignant diseases. Late effects of CBT are not well described in the literature. In the present study, we present our experience of new-onset allergies in long-term survivors after CBT. METHODS:After an initial patient...

journal_title：Cytotherapy

authors： Vaughan LA,Vu M,Sengsayadeth S,Lucid C,Clifton C,McCarty K,Hagaman D,Domm J,Kassim A,Chinratanalab W,Goodman S,Greer J,Frangoul H,Engelhardt BG,Jagasia M,Savani BN

更新日期：2013-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) are multipotent cells that differentiate into osteoblasts, myocytes, chondrocytes and adipocytes as well as insulin-producing cells. The mechanism underlying their in vivo differentiation is not clear and is thought to be caused by spontaneous cell fusion or factors present in the microenv...

journal_title：Cytotherapy

authors： Kode JA,Mukherjee S,Joglekar MV,Hardikar AA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) may be useful in a range of clinical applications. The placenta has been suggested as an abundant, ethically acceptable, less immunogenic and easily accessible source of MSC. The aim of this study was to evaluate the capacity of induced placental MSC to differentiate into...

journal_title：Cytotherapy

authors： Yust-Katz S,Fisher-Shoval Y,Barhum Y,Ben-Zur T,Barzilay R,Lev N,Hod M,Melamed E,Offen D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AIMS:Platelet transfusion can be a life-saving procedure in different medical settings. Thus, there is an increasing demand for platelets, of which shelf-life is only 5 days. The efficient ex vivo biomanufacturing of platelets would allow overcoming the shortages of donated platelets. METHODS:We exploited a...

journal_title：Cytotherapy

authors： Hatami J,Andrade PZ,Alves de Matos AP,Djokovic D,Lilaia C,Ferreira FC,Cabral JM,da Silva CL

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AIMS:Cell therapy is promising as an exploratory cardiovascular therapy. We have recently developed an investigational new drug named Stempeucel (bone marrow-derived allogeneic mesenchymal stromal cells) for patients with acute myocardial infarction (AMI) with ST-segment elevation. A phase I/II randomized, d...

journal_title：Cytotherapy

authors： Chullikana A,Majumdar AS,Gottipamula S,Krishnamurthy S,Kumar AS,Prakash VS,Gupta PK

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Adverse events (AE) represent a significant clinical problem after infusion of cryopreserved HPC. However, the factors playing a role in the pathogenesis have not yet been fully established. METHODS:We prospectively collected data on AE that occurred with 179 HPC infusions performed on patients affected wit...

journal_title：Cytotherapy

authors： Milone G,Mercurio S,Strano A,Leotta S,Pinto V,Battiato K,Coppoletta S,Murgano P,Farsaci B,Privitera A,Giustolisi R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Tumor cell lines have enormous value for the study of different aspects of cancer biology and have also recently gained great importance in autologous cell-based anti-tumor therapies. However, the use of these cells is still limited because in vitro growth is hampered by suboptimal culture conditions and cur...

journal_title：Cytotherapy

authors： Stadler G,Wieser M,Steindl F,Grillari J,Katinger H,Pfragner R,Voglauer R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AIMS:Multiple cell-therapy products require density separation as a part of manufacturing. The traditional method for Ficoll separation, layering cell suspensions over Ficoll in tubes, followed by centrifugation and collection of cells from the interface, is too cumbersome and poses too high a risk of contam...

journal_title：Cytotherapy

authors： Janssen WE,Ribickas A,Meyer LV,Smilee RC

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Current efforts to direct differentiation of human embryonic stem cells (hESC) into a particular cell lineage usually lead to a heterogeneous cell population with only a fraction of the desired cell type present. We show the generation of an essentially pure population of human cardiomyocytes from hESC using...

journal_title：Cytotherapy

authors： Xu XQ,Zweigerdt R,Soo SY,Ngoh ZX,Tham SC,Wang ST,Graichen R,Davidson B,Colman A,Sun W

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The use of myeloma Ag-loaded mature DC vaccines, cryopreserved in single-use aliquots, is an attractive immunotherapeutic strategy. In this study we investigated the retention of phenotype, viability and potency of DC vaccines after freezing and thawing. METHODS:Plastic-adherent monocytes, derived from a st...

journal_title：Cytotherapy

authors： Szmania S,Yi Q,Cottler-Fox M,Rosen NA,Freeman J,Kordsmeier BJ,Moreno A,Shi J,Barlogie B,Tricot G,van Rhee F

更新日期：2005-01-01 00:00:00

abstract：:Targeted adoptive immunotherapy with engineered T cells is a promising treatment for refractory hematologic malignancies. However, many patients achieving early complete remissions ultimately relapse. Immunosuppressive ligands are expressed on tumor and supportive cells in the tumor microenvironment (TME). When activa...

journal_title：Cytotherapy

authors： Zolov SN,Rietberg SP,Bonifant CL

更新日期：2018-10-01 00:00:00