当前位置： SCI文献检索 > CYTOTHERAPY期刊下所有文献 > Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions.

Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions.

Abstract：

BACKGROUND AIMS:Intrauterine adhesion (IUA) is a common uterine cavity disease characterized by the unsatisfactory regeneration of damaged endometria. Recently, stem cell transplantation has been proposed to promote the recovery process. Here we investigated whether human amniotic mesenchymal stromal cells (hAMSCs), a valuable resource for transplantation therapy, could improve endometrial regeneration in rodent IUA models. METHODS:Forty female Sprague-Dawley rats were randomly assigned to five groups: normal, sham-operated, mechanical injury, hAMSC transplantation, and negative control group. One week after intervention and transplantation, histological analyses were performed, and immunofluorescent and immunohistochemical expression of cell-specific markers and messenger RNA expression of cytokines were measured. RESULTS:Thicker endometria, increased gland numbers and fewer fibrotic areas were found in the hAMSC transplantation group compared with the mechanical injury group. Engraftment of hAMSCs was detected by the presence of anti-human nuclear antigen-positive cells in the endometrial glands of the transplantation uteri. Transplantation of hAMSCs significantly decreased messenger RNA levels of pro-inflammatory cytokines (tumor necrosis factor-α and interleukin-1β), and increased those of anti-inflammatory cytokines (basic fibroblast growth factor, and interleukin-6) compared with the injured uterine horns. Immunohistochemical expression of endometrial epithelial cells was revealed in specimens after hAMSC transplantation, whereas it was absent in the mechanically injured uteri. CONCLUSIONS:hAMSC transplantation promotes endometrial regeneration after injury in IUA rat models, possibly due to immunomodulatory properties. These cells provide a more easily accessible source of stem cells for future research into the impact of cell transplantation on damaged endometria.

journal_name

Cytotherapy

journal_title

Cytotherapy

authors

Gan L,Duan H,Xu Q,Tang YQ,Li JJ,Sun FQ,Wang S

doi

10.1016/j.jcyt.2017.02.003

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

603-616

issue

5

eissn

1465-3249

issn

1477-2566

pii

S1465-3249(17)30061-0

journal_volume

19

pub_type

杂志文章

相关文献

CYTOTHERAPY文献大全
  • Randomized, double-blind, phase I/II study of intravenous allogeneic mesenchymal stromal cells in acute myocardial infarction.

    abstract：BACKGROUND AIMS:Cell therapy is promising as an exploratory cardiovascular therapy. We have recently developed an investigational new drug named Stempeucel (bone marrow-derived allogeneic mesenchymal stromal cells) for patients with acute myocardial infarction (AMI) with ST-segment elevation. A phase I/II randomized, d...

    journal_title：Cytotherapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jcyt.2014.10.009

    authors： Chullikana A,Majumdar AS,Gottipamula S,Krishnamurthy S,Kumar AS,Prakash VS,Gupta PK

    更新日期：2015-03-01 00:00:00

  • Mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation.

    abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) enhance islet function both in vitro and in vivo, at least in part by secreting ligands that activate islet G-protein coupled receptors (GPCRs). We assessed whether pre-treatment with a defined "cocktail" of MSC-secreted GPCR ligands enhances islet functional survival in...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2018.07.007

    authors： Rackham CL,Amisten S,Persaud SJ,King AJF,Jones PM

    更新日期：2018-12-01 00:00:00

  • New allergies after cord blood transplantation.

    abstract：BACKGROUND AIMS:Umbilical cord blood transplantation (CBT) is an effective treatment for benign and malignant diseases. Late effects of CBT are not well described in the literature. In the present study, we present our experience of new-onset allergies in long-term survivors after CBT. METHODS:After an initial patient...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2013.05.018

    authors： Vaughan LA,Vu M,Sengsayadeth S,Lucid C,Clifton C,McCarty K,Hagaman D,Domm J,Kassim A,Chinratanalab W,Goodman S,Greer J,Frangoul H,Engelhardt BG,Jagasia M,Savani BN

    更新日期：2013-10-01 00:00:00

  • Adoptive transfer of PR1 cytotoxic T lymphocytes associated with reduced leukemia burden in a mouse acute myeloid leukemia xenograft model.

    abstract：BACKGROUND AIMS:Tumor antigen-specific cytotoxic T lymphocytes (CTL) have been used in the treatment of human cancer, including leukemia. Several studies have established PR1 peptide, an HLA-A2.1-restricted peptide derived from proteinase 3 (P3), as a human leukemia-associated antigen. PR1-specific CTL elicited in vitr...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653249.2010.506506

    authors： Ma Q,Wang C,Jones D,Quintanilla KE,Li D,Wang Y,Wieder ED,Clise-Dwyer K,Alatrash G,Mj Y,Munsell MF,Lu S,Qazilbash MH,Molldrem JJ

    更新日期：2010-12-01 00:00:00

  • Cord blood is the optimal graft source for the treatment of pediatric patients with lysosomal storage diseases: clinical outcomes and future directions.

    abstract：:Initially used as an alternative hematopoietic stem cell source for patients without a human leukocyte antigen-matched bone marrow or peripheral blood stem cell donor, unrelated cord blood (UCB) is now the preferred donor source when hematopoietic stem cell transplantation (HSCT) is used to treat patients with lysosom...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2015.03.609

    authors： Aldenhoven M,Kurtzberg J

    更新日期：2015-06-01 00:00:00

  • Cytokine flow cytometry: multiparametric approach to immune function analysis.

    abstract：:More precise quantitation of cellular immune responses has become possible with the advent of single-cell assays of immune function, such as cytokine flow cytometry, enzyme-linked immunospot (ELISPOT), and MHC-peptide multimers. Cytokine flow cytometry is an attractive technique because it allows the detection of resp...

    journal_title：Cytotherapy

    pub_type： 杂志文章,评审

    doi：10.1080/14653240310000029

    authors： Ghanekar SA,Maecker HT

    更新日期：2003-01-01 00:00:00

  • Induction of potent protection against acute and latent herpes simplex virus infection in mice vaccinated with dendritic cells.

    abstract：BACKGROUND AIMS:Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system and have been under intense study with regard to their use in immunotherapy against cancer and infectious disease agents. In the present study, DCs were employed to assess their value in protection against live virus...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2012.11.012

    authors： Ghasemi M,Erturk M,Buruk K,Sonmez M

    更新日期：2013-03-01 00:00:00

  • Comparative analysis of the immunomodulatory capacities of human bone marrow- and adipose tissue-derived mesenchymal stromal cells from the same donor.

    abstract：BACKGROUND AIMS:The immunomodulatory properties of mesenchymal stromal cells (MSCs), together with their tissue regenerative potential, make them interesting candidates for clinical application. METHODS:In the current study, we analyzed the in vitro immunomodulatory effects of MSCs derived from bone marrow (BM-MSCs) a...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2016.07.006

    authors： Valencia J,Blanco B,Yáñez R,Vázquez M,Herrero Sánchez C,Fernández-García M,Rodríguez Serrano C,Pescador D,Blanco JF,Hernando-Rodríguez M,Sánchez-Guijo F,Lamana ML,Segovia JC,Vicente Á,Del Cañizo C,Zapata AG

    更新日期：2016-10-01 00:00:00

  • Selective depletion strategies in allogeneic stem cell transplantation.

    abstract：:Despite improved prophylaxis and treatment, GvHD remains a major limitation to optimal allogeneic stem cell transplantation. Ex vivo selective depletion (SD) is a strategy to prevent GvHD, in which host-reactive donor lymphocytes are selectively eliminated from a PBSC allograft while useful donor immune function is pr...

    journal_title：Cytotherapy

    pub_type： 杂志文章,评审

    doi：10.1080/14653240510018172

    authors： Mielke S,Solomon SR,Barrett AJ

    更新日期：2005-01-01 00:00:00

  • A roundtable on responsible innovation with autologous stem cells in Australia, Japan and Singapore.

    abstract：:We report on a roundtable event hosted in Singapore that sought to identify some of the ethical and regulatory challenges in translating autologous cell-based interventions, particularly those claiming to involve stem cells, into safe and effective therapies and to propose some solutions to encourage responsible innov...

    journal_title：Cytotherapy

    pub_type：

    doi：10.1016/j.jcyt.2018.06.004

    authors： Lysaght T,Munsie M,Castricum A,Hui JHP,Okada K,Sato Y,Sawa Y,Stewart C,Tan LK,Tan LHY,Sugii S

    更新日期：2018-09-01 00:00:00

  • In vitro cardiomyocyte differentiation of umbilical cord blood cells: crucial role for c-kit(+) cells.

    abstract：BACKGROUND AIMS:Although bone marrow c-kit(+) progenitor cells support myocardial regeneration, the cardiomyocyte differentiation potential of umbilical cord blood (UCB) c-kit(+) cells is unknown. METHODS:UCB mononuclear cells (MNCs) and c-kit(+) cells purified by use of immunomagnetic beads were used. Cardiomyocyte d...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2015.07.012

    authors： Iachininoto MG,Capodimonti S,Podda MV,Valentini CG,Bianchi M,Leone AM,Teofili L,Leone G

    更新日期：2015-11-01 00:00:00

  • Endothelial progenitor cells may inhibit apoptosis of pulmonary microvascular endothelial cells: new insights into cell therapy for pulmonary arterial hypertension.

    abstract：BACKGROUND AIMS:Endothelial apoptosis underlies the pathophysiology of pulmonary arterial hypertension (PAH). Some factors/cytokines released by endothelial progenitor cells (EPC) have been revealed as potent inhibitors of apoptosis. The aim of this study was to investigate the effects of EPC on pulmonary microvascular...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240902960460

    authors： Xia L,Fu GS,Yang JX,Zhang FR,Wang XX

    更新日期：2009-01-01 00:00:00

  • Neuropeptides to replace serum in cryopreservation of mesenchymal stromal cells?

    abstract：BACKGROUND AIMS:The therapeutic potential of human mesenchymal stromal cells (MSCs) has generated considerable interest in a wide variety of areas. MSC banking is feasible, but the optimal technique of cryopreservation remains to be determined. METHODS:To reduce dimethyl sulfoxide (DMSO) concentration in cryopreservat...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2013.06.012

    authors： Briquet A,Halleux A,Lechanteur C,Beguin Y

    更新日期：2013-11-01 00:00:00

  • Growth factor and cytokine expression of human mesenchymal stromal cells is not altered in an in vitro model of tissue damage.

    abstract：BACKGROUND AIMS:The beneficial effect of human (h) mesenchymal stromal cell (MSC) transplantation in a variety of cell-based intervention strategies is widely believed to be because of paracrine mechanisms. The modification of hMSC cytokine and growth-factor expression patterns were studied following exposure to lipopo...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653249.2010.501789

    authors： Montzka K,Führmann T,Müller-Ehmsen J,Wöltje M,Brook GA

    更新日期：2010-11-01 00:00:00

  • Extracorporeal photopheresis as first-line strategy in the treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation: A single-center experience.

    abstract：BACKGROUND AIMS:Corticosteroids are the standard first-line treatment for acute graft-versus-host disease (aGVHD), but they are associated with many complications, and less than half of patients have a sustained response. METHODS:To improve outcomes, we performed a retrospective study to analyze the efficacy of the ad...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2020.03.003

    authors： Sestili S,Eder S,Belhocine R,Dulery R,Battipaglia G,Brissot E,Mediavilla C,Banet A,van de Wyngaert Z,Paviglianiti A,Ledraa T,Bonin A,Mohty M,Malard F

    更新日期：2020-08-01 00:00:00

  • Hematopoietic stem-cell transplantation for Hodgkin's disease (HD): current status.

    abstract：:Not all patients with Hodgkin's disease (HD) respond to standard chemotherapy and/or radiation, and hematopoietic stem-cell transplantation has been gaining increasing acceptance in the management of HD. Phase II and, to a lesser extent, phase III studies of high-dose chemotherapy and autologous stem cell transplantat...

    journal_title：Cytotherapy

    pub_type： 杂志文章,评审

    doi：10.1080/146532402320219754

    authors： Anderlini P

    更新日期：2002-01-01 00:00:00

  • T lymphocytes engineered to express a CD16-chimeric antigen receptor redirect T-cell immune responses against immunoglobulin G-opsonized target cells.

    abstract：BACKGROUND AIMS:Chimeric antigen receptors (CARs) designed for adoptive immunotherapy need to achieve two functions: antigen recognition and triggering of the lytic machinery of reprogrammed effector cells. Cytotoxic T cells have been engineered with FcγRIII (CD16) chimeric molecules to be redirected against malignant ...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2015.10.014

    authors： D'Aloia MM,Caratelli S,Palumbo C,Battella S,Arriga R,Lauro D,Palmieri G,Sconocchia G,Alimandi M

    更新日期：2016-02-01 00:00:00

  • bFGF influences human articular chondrocyte differentiation.

    abstract：BACKGROUND:The possible functional role of basic fibroblast growth factor (bFGF) in regulating the mitotic and metabolic activity of primary human articular chondrocytes was investigated. METHODS:[EF1]Chondrocytes were enzymatically isolated from femoral head cartilage, and were cultured in vitro in monolayer. bFGF-de...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240601182846

    authors： Schmal H,Zwingmann J,Fehrenbach M,Finkenzeller G,Stark GB,Südkamp NP,Hartl D,Mehlhorn AT

    更新日期：2007-01-01 00:00:00

  • Cellular transplants in amyotrophic lateral sclerosis patients: an observational study.

    abstract：BACKGROUND AIMS:Cytotherapy is a promising option for neurodegenerative disease treatment. Because of the fatal prognosis and imperative need for effective treatment, amyotrophic lateral sclerosis (ALS) patients request this therapy before its effectiveness has been verified. The increase in clinics offering cytotherap...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653241003774037

    authors： Gamez J,Carmona F,Raguer N,Ferrer-Sancho J,Martín-Henao GA,Martí-Beltrán S,Badia M,Gratacós M,Rodriguez-Gónzalez E,Seoane JL,Pallero-Castillo M,Burgos R,Puiggros C,Pasarin A,Bori-Fortuny I

    更新日期：2010-09-01 00:00:00

  • Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products.

    abstract：BACKGROUND:Cell therapy has been proposed as a salvage limb procedure in critical limb ischemia (CLI). In spite of the fact that clinical trials found some efficacy, the mechanism of action remains elusive. The objective of this study was to characterize two autologous cell therapy products (CTPs) obtained from patient...

    journal_title：Cytotherapy

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jcyt.2016.10.013

    authors： Tournois C,Pignon B,Sevestre MA,Al-Rifai R,Creuza V,Poitevin G,François C,Nguyen P

    更新日期：2017-02-01 00:00:00

  • Ex vivo expansion of mafosfamide-purged PBPC products.

    abstract：BACKGROUND:Multiple studies have demonstrated that 'purging' of autografts with 4-hydroperoxycyclophosphamide (4HC) or the related compound mafosfamide (Mf), to eradicate residual leukemia, produces the best results associated with autologous blood and marrow transplantation for AML. However, 4HC purging results in pro...

    journal_title：Cytotherapy

    pub_type： 临床试验,杂志文章

    doi：10.1080/14653240600905353

    authors： McNiece I,Civin C,Harrington J,Kellner J,Malehorn M,Turney J,Barber J,Jones R

    更新日期：2006-01-01 00:00:00

  • Bone marrow-derived mesenchymal stromal cells support rat pancreatic islet survival and insulin secretory function in vitro.

    abstract：BACKGROUND AIMS:Recent evidence has suggested that transplanted bone marrow (BM)-derived mesenchymal stromal cells (MSC) are able to engraft and repair non-hematopoietic tissues successfully, including central nervous system, renal, pulmonary and skin tissue, and may possibly contribute to tissue regeneration. We exami...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653249.2010.518608

    authors： Jung EJ,Kim SC,Wee YM,Kim YH,Choi MY,Jeong SH,Lee J,Lim DG,Han DJ

    更新日期：2011-01-01 00:00:00

  • Expansion in microcarrier-spinner cultures improves the chondrogenic potential of human early mesenchymal stromal cells.

    abstract：BACKGROUND AIMS:Cartilage tissue engineering with human mesenchymal stromal cells (hMSC) is promising for allogeneic cell therapy. To achieve large-scale hMSC propagation, scalable microcarrier-based cultures are preferred over conventional static cultures on tissue culture plastic. Yet it remains unclear how microcarr...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2016.03.293

    authors： Lin YM,Lim JF,Lee J,Choolani M,Chan JK,Reuveny S,Oh SK

    更新日期：2016-06-01 00:00:00

  • Hyperbaric oxygen treatment effects on in vitro cultured umbilical cord blood CD34+ cells.

    abstract：BACKGROUND AIMS:Umbilical cord blood (UCB) provides an alternative source for hematopoietic stem/progenitor cells (HSPCs) in the treatment of hematological malignancies. However, clinical usage is limited due to the low quantity of HSPCs in each unit of cord blood and defects in bone marrow homing. Hyperbaric oxygen (H...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2017.08.020

    authors： Cheung KY,Berry A,Li D,Aljitawi OS

    更新日期：2018-01-01 00:00:00

  • Bone marrow-derived mesenchymal stromal cells regress aortic aneurysm via the NF-kB, Smad3 and Akt signaling pathways.

    abstract：BACKGROUND AIMS:We have confirmed that aortic aneurysm (AA) can be regressed by the administration of bone marrow-derived mesenchymal stromal cells (BM-MSCs). We investigated the kinetics of signaling pathways in AA following treatment with BM-MSCs. METHODS:Angiotensin II-infused apolipoprotein E-deficient mice were t...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2017.07.010

    authors： Yamawaki-Ogata A,Oshima H,Usui A,Narita Y

    更新日期：2017-10-01 00:00:00

  • Comparison of two single-platform ISHAGE-based CD34 enumeration protocols on BD FACSCalibur and FACSCanto flow cytometers.

    abstract：BACKGROUND AIMS:Enumeration of viable CD34(+) cells provides critical information for the bone marrow (BM) transplant physician. The single-platform ISHAGE protocol is the most reliable method currently available to quantitate accurately this important subset of cells. Previous studies have shown that 5 CD34(+) cells/m...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240902923161

    authors： Sutherland DR,Nayyar R,Acton E,Giftakis A,Dean S,Mosiman VL

    更新日期：2009-01-01 00:00:00

  • Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure.

    abstract：BACKGROUND:Adipose tissue contains a stromal vascular fraction that can be easily isolated and provides a rich source of adipose tissue-derived mesenchymal stem cells (ASC). These ASC are a potential source of cells for tissue engineering. We studied whether the yield and growth characteristics of ASC were affected by ...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1080/14653240600621125

    authors： Oedayrajsingh-Varma MJ,van Ham SM,Knippenberg M,Helder MN,Klein-Nulend J,Schouten TE,Ritt MJ,van Milligen FJ

    更新日期：2006-01-01 00:00:00

  • Efficient expansion of mesenchymal stromal cells from umbilical cord under low serum conditions.

    abstract：BACKGROUND:Mesenchymal stromal cells (MSC) are of clinical interest for their potential use in regenerative medicine and immunotherapy. Originally derived from bone marrow (BM), MSC have now been isolated from most tissues, including umbilical cord (UC) and UC blood (UCB). If MSC from UC are biologically equivalent to ...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.3109/14653240903079401

    authors： Girdlestone J,Limbani VA,Cutler AJ,Navarrete CV

    更新日期：2009-01-01 00:00:00

  • Adipose-derived mesenchymal stromal cells improve hemodynamic function in pulmonary arterial hypertension: identification of microRNAs implicated in modulating endothelial function.

    abstract：:Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial hyperproliferation and dysfunction. Restoration of endothelial function is a common goal of available treatments. In the present study, human adipose-derived mesenchymal stromal cells (ASCs) were co-cultured with monocrotaline pyr...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2019.02.011

    authors： Wang P,Zhang C,Li J,Luo L,Zhang S,Dong F,Tang Z,Ni S

    更新日期：2019-04-01 00:00:00

  • Generation of potent dendritic cells with improved migration ability through p-cofilin and sarco/endoplasmic reticulum Ca(2+) transport ATPase 2 regulation.

    abstract：BACKGROUND AIMS:It is important to improve the migratory ability of dendritic cells (DCs) and to increase DC potency for successful DC-based cancer immunotherapy. The intracellular Ca(2+) signaling pathway has an important role on the regulation of DC migration. Our preliminary studies revealed that sarco/endoplasmic r...

    journal_title：Cytotherapy

    pub_type： 杂志文章

    doi：10.1016/j.jcyt.2015.06.002

    authors： Choi NR,Lee HJ,Jung SH,Hong CY,Vo MC,Hoang MD,Kim HJ,Lee JJ

    更新日期：2015-10-01 00:00:00