Programmed cell death protein 1 activation preferentially inhibits CD28.CAR-T cells.

abstract：BACKGROUND:Mesenchymal stromal cells (MSC) are pluripotent progenitor cells that can be found in human bone marrow (BM). These cells have low immunogenicity and could suppress alloreactive T-cell responses. In the current study, MSC were tested for their capacity to carry and deliver the erythropoietin (EPO) gene in vi...

journal_title：Cytotherapy

authors： Mok PL,Cheong SK,Leong CF,Othman A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Apoptosis of radiosensitive cells in the bone marrow and gut is a serious, at times life-threatening, complication arising from radiation exposure. METHODS:We investigated whether adoptive transfer of allogeneic bone marrow-derived mesenchymal stromal cells (MSC) could exert cytoprotective and life-spa...

journal_title：Cytotherapy

authors： François M,Birman E,Forner KA,Gaboury L,Galipeau J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AIMS:The term "cerebral palsy" (CP) encompasses many syndromes that emerge from brain damage at early stages of ontogenesis and manifest as the inability to retain a normal body position or perform controlled movements. Existing methods of CP treatment, including various rehabilitation strategies and surgica...

journal_title：Cytotherapy

authors： Romanov YA,Tarakanov OP,Radaev SM,Dugina TN,Ryaskina SS,Darevskaya AN,Morozova YV,Khachatryan WA,Lebedev KE,Zotova NS,Burkova AS,Sukhikh GT,Smirnov VN

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AIMS:Enumeration of CD34(+) cells in leukocyte-rich cell suspensions is important for clinical decision-making in stem cell transplantation. Single-platform flow cytometry assays offer the significant advantages of speed and reproducibility, and have therefore become the gold standard in stem cell enumeratio...

journal_title：Cytotherapy

authors： Dauber K,Becker D,Odendahl M,Seifried E,Bonig H,Tonn T

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AIMS:CD1d-restricted invariant natural killer (iNK) T cells are rare regulatory T cells that may contribute to the immune-regulation in allogeneic stem cell transplantation (ASCT). Here, we sought to develop an effective strategy to expand human iNK T cells for use in cell therapy to prevent graft-versus-hos...

journal_title：Cytotherapy

authors： Trujillo-Ocampo A,Cho HW,Herrmann AC,Ruiz-Vazquez W,Thornton AB,He H,Li D,Qazilbash MA,Ma Q,Porcelli SA,Shpall EJ,Molldrem J,Im JS

更新日期：2018-08-01 00:00:00

abstract：:More precise quantitation of cellular immune responses has become possible with the advent of single-cell assays of immune function, such as cytokine flow cytometry, enzyme-linked immunospot (ELISPOT), and MHC-peptide multimers. Cytokine flow cytometry is an attractive technique because it allows the detection of resp...

journal_title：Cytotherapy

authors： Ghanekar SA,Maecker HT

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) may be useful in a range of clinical applications. The placenta has been suggested as an abundant, ethically acceptable, less immunogenic and easily accessible source of MSC. The aim of this study was to evaluate the capacity of induced placental MSC to differentiate into...

journal_title：Cytotherapy

authors： Yust-Katz S,Fisher-Shoval Y,Barhum Y,Ben-Zur T,Barzilay R,Lev N,Hod M,Melamed E,Offen D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AIMS:Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system and have been under intense study with regard to their use in immunotherapy against cancer and infectious disease agents. In the present study, DCs were employed to assess their value in protection against live virus...

journal_title：Cytotherapy

authors： Ghasemi M,Erturk M,Buruk K,Sonmez M

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AIMS:Cutaneous wound management is a major health problem and imposes a huge economic burden worldwide. Previous studies have demonstrated that wound healing is a highly coordinated process including epithelialization, angiogenesis, remodeling and scarring. This progression requires self-renewal, preservatio...

journal_title：Cytotherapy

authors： Chen X,Yang R,Wang J,Ruan S,Lin Z,Xin Q,Yang R,Xie J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AIMS:Corticosteroids are the standard first-line treatment for acute graft-versus-host disease (aGVHD), but they are associated with many complications, and less than half of patients have a sustained response. METHODS:To improve outcomes, we performed a retrospective study to analyze the efficacy of the ad...

journal_title：Cytotherapy

authors： Sestili S,Eder S,Belhocine R,Dulery R,Battipaglia G,Brissot E,Mediavilla C,Banet A,van de Wyngaert Z,Paviglianiti A,Ledraa T,Bonin A,Mohty M,Malard F

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:We have previously demonstrated that bovine dialyzable leukocyte extract (bDLE) induces death through an apoptosis mechanism in MCF-7 breast cancer cells. Depending on the cell type and stimulus, activating protein-1 (AP-1) has been shown to regulate cell proliferation and differentiation, the stress respons...

journal_title：Cytotherapy

authors： Mendoza-Gamboa E,Franco-Molina MA,Zapata-Benavides P,Castillo-Tello P,Vera-García ME,Tamez-Guerra RS,Rodríguez-Padilla C

更新日期：2008-01-01 00:00:00

abstract：:Despite improved prophylaxis and treatment, GvHD remains a major limitation to optimal allogeneic stem cell transplantation. Ex vivo selective depletion (SD) is a strategy to prevent GvHD, in which host-reactive donor lymphocytes are selectively eliminated from a PBSC allograft while useful donor immune function is pr...

journal_title：Cytotherapy

authors： Mielke S,Solomon SR,Barrett AJ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Hematopoietic progenitor cells (HPC) circulate at high levels at birth and disappear rapidly afterwards, but the underlying mechanism it is not known. The aim of this study was to assess circulating HPC in cord blood at different gestational ages and shortly after birth and concomitantly study the biologic m...

journal_title：Cytotherapy

authors： Gonzalez S,Amat L,Azqueta C,Madrigal JA,Laïlla JM,Garcia J,Querol S

更新日期：2009-01-01 00:00:00

abstract：:The process of wound healing restores skin homeostasis but not full functionality; thus, novel therapeutic strategies are needed to accelerate wound closure and improve the quality of healing. In this context, tissue engineering and cellular therapies are promising approaches. Although sharing essential characteristic...

journal_title：Cytotherapy

authors： Zomer HD,Jeremias TDS,Ratner B,Trentin AG

更新日期：2020-05-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (HCT) is an important therapeutic option for a variety of malignant and non-malignant disorders (NMD). The use of umbilical cord blood transplantation (UCBT) has made HCT available to many more patients. The increased level of human leukocyte antigen disparity that can be ...

journal_title：Cytotherapy

authors： Milano F,Boelens JJ

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Bone marrow (BM)-derived mesenchymal stromal cells (MSC) are promising candidate cells for the development of neuroregenerative therapies. We have previously introduced the pro-neural conversion of human MSC to neural stem cell-like cells (m-NSC) by culturing them in suspension culture under serum-free condi...

journal_title：Cytotherapy

authors： Habisch HJ,Fiedler J,Ludolph AC,Storch A,Brenner RE

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Pooled human platelet lysate (HPL) is becoming the new gold standard as supplement for ex vivo cell culture for clinical protocols. However, the risk of pathogen contamination of HPL increases with the platelet pool size. We hypothesized that hollow fiber anion exchange membrane chromatography using Qyu...

journal_title：Cytotherapy

authors： Kao YC,Bailey A,Samminger B,Tanimoto J,Burnouf T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AIMS:Adoptive transfer of tumor-specific lymphocytes is a promising strategy in the treatment of cancer. We conducted intratumoral administration of an allogeneic irradiated continuous T-cell line (C-Cure 709) expressing an HLA-A2-restricted MART-1-specific T-cell receptor (TCR) into HLA-A2(+) melanoma patie...

journal_title：Cytotherapy

authors： Køllgaard T,Duval L,Schmidt H,Kaltoft K,Seremet T,Andersen MH,Maase Hv,Straten Pt,Hadrup SR

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The isolation of lymphocytes - and removal of platelets (PLTs) and red blood cells (RBCs) - from an initial blood sample prior to culture is a key enabling step for effective manufacture of cellular therapies. Unfortunately, currently available methods suffer from various drawbacks, including low cell recove...

journal_title：Cytotherapy

authors： Strachan BC,Xia H,Vörös E,Gifford SC,Shevkoplyas SS

更新日期：2019-02-01 00:00:00

abstract：:A 3-year-old girl with severe aplastic anemia (SAA) that was unresponsive to steroid, cyclosporine and filgrastim treatments received bone marrow (BM) mesenchymal stromal cells (MSC; 1.25 x 10(6)/kg), granulocyte colony-stimulating factor (G-CSF)-mobilized BM and peripheral blood stem cell grafts from her father. Prio...

journal_title：Cytotherapy

authors： Wang H,Wang Z,Xue M,Liu J,Yan H,Guo Z

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AIMS:To assess the impacts of stem cell therapy on clinical outcomes in patients with non-ischemic cardiomyopathy (NICM). The effect of stem cell therapy on prognosis is unclear and controversial. METHODS:The authors performed a systematic review and meta-analysis of the effects of autologous stem cell tran...

journal_title：Cytotherapy

authors： Xia L,Zeng L,Pan J,Ding Y

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Amniotic membrane is a highly promising cell source for tissue engineering. Being part of the placenta, this tissue is abundantly available. It can be processed easily to yield large amounts of epithelial and mesenchymal cells that have shown broad differentiation potential. For tissue-engineering purposes, ...

journal_title：Cytotherapy

authors： Stadler G,Hennerbichler S,Lindenmair A,Peterbauer A,Hofer K,van Griensven M,Gabriel C,Redl H,Wolbank S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:CAMPATH-1 Abs have been used for T-cell depletion in stem-cell transplantation since the early 1980s. During that time there has been substantial progress in manufacturing techniques and quality control procedures. This article summarizes the methods used to produce the Abs for clinical use and describes res...

journal_title：Cytotherapy

authors： Phillips J,Drumm A,Harrison P,Bird P,Bhamra K,Berrie E,Hale G

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AIMS:Platelet transfusion can be a life-saving procedure in different medical settings. Thus, there is an increasing demand for platelets, of which shelf-life is only 5 days. The efficient ex vivo biomanufacturing of platelets would allow overcoming the shortages of donated platelets. METHODS:We exploited a...

journal_title：Cytotherapy

authors： Hatami J,Andrade PZ,Alves de Matos AP,Djokovic D,Lilaia C,Ferreira FC,Cabral JM,da Silva CL

更新日期：2015-04-01 00:00:00

abstract：:The efficacy of cord blood (CB) transplantation is limited by the low cell dose available. Low cell doses at transplant are correlated with delayed engraftment, prolonged neutropenia and thrombocytopenia and elevated risk of graft failure. To potentially improve the efficacy of CB transplantation, approaches have been...

journal_title：Cytotherapy

authors： Robinson S,Niu T,de Lima M,Ng J,Yang H,McMannis J,Karandish S,Sadeghi T,Fu P,del Angel M,O'Connor S,Champlin R,Shpall E

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AIMS:Virus-specific T-cell immunotherapy is emerging as a promising management strategy for virus infections in patients after hematopoietic stem cell transplant (HSCT). Here we present outcomes of 10 adult patients who received multi-virus-specific T cells prophylactically after HSCT. METHODS:Donor-derived...

journal_title：Cytotherapy

authors： Ma CK,Blyth E,Clancy L,Simms R,Burgess J,Brown R,Deo S,Micklethwaite KP,Gottlieb DJ

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AIMS:Umbilical cord blood transplantation (CBT) is an effective treatment for benign and malignant diseases. Late effects of CBT are not well described in the literature. In the present study, we present our experience of new-onset allergies in long-term survivors after CBT. METHODS:After an initial patient...

journal_title：Cytotherapy

authors： Vaughan LA,Vu M,Sengsayadeth S,Lucid C,Clifton C,McCarty K,Hagaman D,Domm J,Kassim A,Chinratanalab W,Goodman S,Greer J,Frangoul H,Engelhardt BG,Jagasia M,Savani BN

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. METHODS:MSC isolated...

journal_title：Cytotherapy

authors： Sun B,Roh KH,Park JR,Lee SR,Park SB,Jung JW,Kang SK,Lee YS,Kang KS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Our previous study has demonstrated the stem cell-like properties of human umbilical cord lining epithelial cells (CLECs) and their capability for epidermal reconstitution in organotypic skin culture; however, the immunogenicity of these cells has not been clearly defined. We assessed several aspects of...

journal_title：Cytotherapy

authors： Cai YJ,Huang L,Leung TY,Burd A

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AIMS:Adipose-derived stem cells are easily accessed and have a relatively high density compared with other mesenchymal stromal cells. Isolation protocols of adipose-derived stem cells (ASC) rely on the cell's ability to adhere to tissue culture plastic overnight. It was evaluated whether the floating ASC fra...

journal_title：Cytotherapy

authors： Buschmann J,Gao S,Härter L,Hemmi S,Welti M,Werner CM,Calcagni M,Cinelli P,Wanner GA

更新日期：2013-09-01 00:00:00