Secretomes from bone marrow-derived mesenchymal stromal cells enhance periodontal tissue regeneration.

abstract：BACKGROUND AIMS:Retinal degeneration (RD) is an inherited eye disease characterized by irreversible photoreceptor loss. Conventionally, the activation of the resident microglia is secondary to the disease. Stem cell-based therapy has recently made rapid progress in treating RD. Although it has been demonstrated that th...

journal_title：Cytotherapy

authors： Li Z,Zeng Y,Chen X,Li Q,Wu W,Xue L,Xu H,Yin ZQ

更新日期：2016-06-01 00:00:00

abstract：:Initially used as an alternative hematopoietic stem cell source for patients without a human leukocyte antigen-matched bone marrow or peripheral blood stem cell donor, unrelated cord blood (UCB) is now the preferred donor source when hematopoietic stem cell transplantation (HSCT) is used to treat patients with lysosom...

journal_title：Cytotherapy

authors： Aldenhoven M,Kurtzberg J

更新日期：2015-06-01 00:00:00

abstract：:he concept of particulates, while common to many in the pharmaceutical and blood transfusion disciplines, represents a distinct challenge in the field of cellular therapy. With newly discovered products advancing through clinical trials, the focus has shifted to ensuring products are manufactured in a reliable and saf...

journal_title：Cytotherapy

authors： Clarke D,Harati D,Martin J,Rowley J,Keller J,McCaman M,Carrion M,Karnieli O,Maziarz R,Perry R,Oh S,Stanton J

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND AIMS:We recently demonstrated that injection of conditioned medium (CM) generated from cells of the mesenchymal region of human amniotic membrane (AMTCs) reduces bleomycin-induced lung fibrosis in mice, suggesting a crucial role of paracrine factor(s) secreted by AMTCs in these beneficial effects. We fur...

journal_title：Cytotherapy

authors： Cargnoni A,Piccinelli EC,Ressel L,Rossi D,Magatti M,Toschi I,Cesari V,Albertini M,Mazzola S,Parolini O

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AIMS:Tumor antigen-specific cytotoxic T lymphocytes (CTL) have been used in the treatment of human cancer, including leukemia. Several studies have established PR1 peptide, an HLA-A2.1-restricted peptide derived from proteinase 3 (P3), as a human leukemia-associated antigen. PR1-specific CTL elicited in vitr...

journal_title：Cytotherapy

authors： Ma Q,Wang C,Jones D,Quintanilla KE,Li D,Wang Y,Wieder ED,Clise-Dwyer K,Alatrash G,Mj Y,Munsell MF,Lu S,Qazilbash MH,Molldrem JJ

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AIMS:Clinical results from acute myocardial infarction (AMI) patients treated with MultiStem®, a large-scale expanded adherent multipotent progenitor cell population (MAPC), have demonstrated a strong safety and benefit profile for these cells. The mechanism of benefit with MAPC treatment is a result, in par...

journal_title：Cytotherapy

authors： Lehman N,Cutrone R,Raber A,Perry R,Van't Hof W,Deans R,Ting AE,Woda J

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) are gaining in popularity as an experimental therapy for a number of conditions that often require expansion ex vivo prior to use. Data comparing clinical-grade MSC from various ages of donors are scant. We hypothesized that MSC from older donors may display differences i...

journal_title：Cytotherapy

authors： Lund TC,Kobs A,Blazar BR,Tolar J

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Container integrity is critical for maintaining sterility of cryopreserved cellular therapy products. We investigated a series of catastrophic bag failures, first noticed in early 2001. METHODS:Process records were reviewed for all PBPC and lymphocyte products cryopreserved in bags from January 2000 through...

journal_title：Cytotherapy

authors： Khuu HM,Cowley H,David-Ocampo V,Carter CS,Kasten-Sportes C,Wayne AS,Solomon SR,Bishop MR,Childs RM,Read EJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AIMS:Regenerative medicine strategies based on cell therapy are considered a promising approach to repair bone defects. The aims of this study were to evaluate the effect of subculturing on the osteogenic potential of osteoblasts derived from newborn rat calvaria and the effect of these osteoblasts on bone r...

journal_title：Cytotherapy

authors： Souza ATP,Freitas GP,Lopes HB,Ferraz EP,Oliveira FS,Beloti MM,Rosa AL

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AIMS:Cutaneous wound management is a major health problem and imposes a huge economic burden worldwide. Previous studies have demonstrated that wound healing is a highly coordinated process including epithelialization, angiogenesis, remodeling and scarring. This progression requires self-renewal, preservatio...

journal_title：Cytotherapy

authors： Chen X,Yang R,Wang J,Ruan S,Lin Z,Xin Q,Yang R,Xie J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AIMS:Imatinib (IM), a tyrosine kinase inhibitor targeting the BCR-ABL oncoprotein, remains a major therapeutic strategy for patients with chronic myelogenous leukemia (CML). However, IM resistance is still a challenge in the treatment of CML. Recently, it was reported that exosomes (Exo) were involved in dru...

journal_title：Cytotherapy

authors： Liu Y,Song B,Wei Y,Chen F,Chi Y,Fan H,Liu N,Li Z,Han Z,Ma F

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AIMS:Endoscopy is the gold standard for the diagnosis and follow-up of patients with Crohn disease (CD). However, a less invasive approach is now being sought for the management of these patients. The objective of this study was to examine whether (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (...

journal_title：Cytotherapy

authors： Kuwaki K,Mitsuyama K,Kaida H,Takedatsu H,Yoshioka S,Yamasaki H,Yamauchi R,Fukunaga S,Abe T,Tsuruta O,Torimura T

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AIMS:T cells can be redirected to reject cancer by retroviral transduction with a chimeric antigen receptor (CAR) or by administration of a bispecific T cell engager (BiTE). We demonstrate that transfection of T cells with messenger (m) RNA coding for CAR is an alternative strategy. METHODS:We describe the ...

journal_title：Cytotherapy

authors： Almåsbak H,Rian E,Hoel HJ,Pulè M,Wälchli S,Kvalheim G,Gaudernack G,Rasmussen AM

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AIMS:Stem cell therapy for liver diseases has recently emerged as a promising alternative to liver transplantation. Eligible cells should have an appropriate immunophenotype. The aim of the present study was to define the immunological profile of two human liver-derived mesenchymal stromal cell populations, ...

journal_title：Cytotherapy

authors： Raicevic G,Najar M,Najimi M,El Taghdouini A,van Grunsven LA,Sokal E,Toungouz M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Retroviral vectors are regularly used to transduce stem cells and their derivatives for experimental and therapeutic purposes. Because these vectors integrate semi-randomly into the cellular genome, analysis of integranated retroviral DNA/host cell DNA junctions (IHJ) facilitates clonality studies of engraft...

journal_title：Cytotherapy

authors： Pule MA,Rousseau A,Vera J,Heslop HE,Brenner MK,Vanin EF

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Intrauterine adhesion (IUA) is a common uterine cavity disease characterized by the unsatisfactory regeneration of damaged endometria. Recently, stem cell transplantation has been proposed to promote the recovery process. Here we investigated whether human amniotic mesenchymal stromal cells (hAMSCs), a ...

journal_title：Cytotherapy

authors： Gan L,Duan H,Xu Q,Tang YQ,Li JJ,Sun FQ,Wang S

更新日期：2017-05-01 00:00:00

abstract：:Regulatory T cells (Tregs) play a fundamental role in the maintenance of self-tolerance and immune homeostasis. Defects in Treg function and/or frequencies have been reported in multiple disease models. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting upper and lower motor neur...

journal_title：Cytotherapy

authors： Alsuliman A,Appel SH,Beers DR,Basar R,Shaim H,Kaur I,Zulovich J,Yvon E,Muftuoglu M,Imahashi N,Kondo K,Liu E,Shpall EJ,Rezvani K

更新日期：2016-10-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BM-MSCs) hold great promise for tissue regeneration. With increasing numbers of clinical trials, the safety of BM-MSCs attracts great interest. Previously, we determined that rat BM-MSCs possessed spontaneous calcification without osteogenic induction after continuous cultur...

journal_title：Cytotherapy

authors： Huang YZ,Cai JQ,Lv FJ,Xie HL,Yang ZM,Huang YC,Deng L

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AIMS:Acute liver failure (ALF), a life-threatening disease characterized by the sudden loss of hepatic function, can occur after an accidental or intentional acetaminophen overdose. METHODS:With the use of an ALF mouse model, we examined both the preventive and therapeutic potential of intravenously adminis...

journal_title：Cytotherapy

authors： Liu Z,Meng F,Li C,Zhou X,Zeng X,He Y,Mrsny RJ,Liu M,Hu X,Hu JF,Li T

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AIMS:Cartilage tissue engineering with human mesenchymal stromal cells (hMSC) is promising for allogeneic cell therapy. To achieve large-scale hMSC propagation, scalable microcarrier-based cultures are preferred over conventional static cultures on tissue culture plastic. Yet it remains unclear how microcarr...

journal_title：Cytotherapy

authors： Lin YM,Lim JF,Lee J,Choolani M,Chan JK,Reuveny S,Oh SK

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) have been used to minimize and repair radiation-induced normal tissue injury in the intestine, salivary gland, liver, skin, lungs and cardiac muscle. This study investigated the ability of adipose tissue-derived MSCs (aMSCs) to minimize and/or repair single dose radiatio...

journal_title：Cytotherapy

authors： Maria OM,Shalaby M,Syme A,Eliopoulos N,Muanza T

更新日期：2016-09-01 00:00:00

abstract：:Despite improved prophylaxis and treatment, GvHD remains a major limitation to optimal allogeneic stem cell transplantation. Ex vivo selective depletion (SD) is a strategy to prevent GvHD, in which host-reactive donor lymphocytes are selectively eliminated from a PBSC allograft while useful donor immune function is pr...

journal_title：Cytotherapy

authors： Mielke S,Solomon SR,Barrett AJ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AIMS:The Quantum® Cell Expansion System (Quantum; Terumo BCT, Inc, Lakewood, CO, USA) is a novel hollow fiber-based device that automates and closes the cell culture process, reducing labor intensive tasks such as manual cell culture feeding and harvesting. The manual cell selection and expansion processes f...

journal_title：Cytotherapy

authors： Jones M,Varella-Garcia M,Skokan M,Bryce S,Schowinsky J,Peters R,Vang B,Brecheisen M,Startz T,Frank N,Nankervis B

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AIMS:Umbilical cord blood transplantation (UCBT) is increasingly used to treat acute leukemias. UCB units are thawed and infused in their entirety at transplant, precluding later use as immunotherapy to prevent or treat leukemia relapse. METHODS:We developed a device that selectively thaws only 1 mL of the ...

journal_title：Cytotherapy

authors： Vasu S,Berg M,Davidson-Moncada J,Tian X,Cullis H,Childs RW

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AIMS:Adoptive transfer of tumor-infiltrating lymphocytes (TIL) has proven effective in metastatic melanoma and should therefore be explored in other types of cancer. The aim of this study was to examine the feasibility of potentially expanding clinically relevant quantities of tumor-specific T-cell cultures ...

journal_title：Cytotherapy

authors： Junker N,Andersen MH,Wenandy L,Dombernowsky SL,Kiss K,Sørensen CH,Therkildsen MH,Von Buchwald C,Andersen E,Straten PT,Svane IM

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AIMS:Allogeneic hematopoietic stem cell transplantation is curative for sickle cell disease, and the use of matched related donors, non-myeloablative conditioning and sirolimus immunosuppression results in stable mixed chimerism without graft-versus-host disease (GVHD). However, the time to terminate sirolim...

journal_title：Cytotherapy

authors： Raines LN,Hsieh MM,Nassehi T,Drysdale CM,Tisdale JF,Uchida N

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The efficiency of chimeric antigen receptor (CAR) T-cell-based therapies depends on a sufficient expansion of CAR T cells in vivo and can be weakened by intra-tumoral suppression of CAR T cell functions, leading to a failure of therapy. For example, certain B-cell malignancies such as chronic lymphocytic leu...

journal_title：Cytotherapy

authors： Štach M,Ptáčková P,Mucha M,Musil J,Klener P,Otáhal P

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AIMS:The immunomodulatory properties of mesenchymal stromal cells (MSCs), together with their tissue regenerative potential, make them interesting candidates for clinical application. METHODS:In the current study, we analyzed the in vitro immunomodulatory effects of MSCs derived from bone marrow (BM-MSCs) a...

journal_title：Cytotherapy

authors： Valencia J,Blanco B,Yáñez R,Vázquez M,Herrero Sánchez C,Fernández-García M,Rodríguez Serrano C,Pescador D,Blanco JF,Hernando-Rodríguez M,Sánchez-Guijo F,Lamana ML,Segovia JC,Vicente Á,Del Cañizo C,Zapata AG

更新日期：2016-10-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a type of adult stem cell that has been exploited for the treatment of a variety of diseases, including cancer. In particular, MSCs have been studied extensively for their ability to treat glioblastoma (GBM), the most common and deadly form of brain cancer in adults. MSCs are attra...

journal_title：Cytotherapy

authors： Parker Kerrigan BC,Shimizu Y,Andreeff M,Lang FF

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AIMS:We have confirmed that aortic aneurysm (AA) can be regressed by the administration of bone marrow-derived mesenchymal stromal cells (BM-MSCs). We investigated the kinetics of signaling pathways in AA following treatment with BM-MSCs. METHODS:Angiotensin II-infused apolipoprotein E-deficient mice were t...

journal_title：Cytotherapy

authors： Yamawaki-Ogata A,Oshima H,Usui A,Narita Y

更新日期：2017-10-01 00:00:00