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Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas.

Abstract：

:Mesenchymal stromal cells (MSCs) are a type of adult stem cell that has been exploited for the treatment of a variety of diseases, including cancer. In particular, MSCs have been studied extensively for their ability to treat glioblastoma (GBM), the most common and deadly form of brain cancer in adults. MSCs are attractive therapeutics because they can be obtained relatively easily from patients, are capable of being expanded numerically in vitro, can be easily engineered and are inherently capable of homing to tumors, making them ideal vehicles for delivering biological antitumoral agents. Oncolytic viruses are promising biological therapeutic agents that have been used in the treatment of GBMs, and MSCs are currently being explored as a means of delivering these viruses. Here we review the role of MSCs in the treatment of GBMs, focusing on the intersection of MSCs and oncolytic viruses.

journal_name

Cytotherapy

journal_title

Cytotherapy

authors

Parker Kerrigan BC,Shimizu Y,Andreeff M,Lang FF

doi

10.1016/j.jcyt.2017.02.002

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

445-457

issue

4

eissn

1465-3249

issn

1477-2566

pii

S1465-3249(17)30045-2

journal_volume

19

pub_type

杂志文章,评审

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